Engineering of conformations of plasminogen activator inhibitor‐1

Molecular cloning: A laboratory manual

1990 • 85,659 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

WHAT IF: A molecular modeling and drug design program

1990 • 3,484 citations

A better cell line for making hybridomas secreting specific antibodies

1978 • 1,649 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

What do dysfunctional serpins tell us about molecular mobility and disease?

1995 • 420 citations

Plasminogen activator inhibitors: hormonally regulated serpins

1990 • 409 citations

cDNA cloning of human plasminogen activator-inhibitor from endothelial cells.

1986 • 350 citations

Inhibitory conformation of the reactive loop of α1-antitrypsin

1996 • 243 citations

Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates

1995 • 240 citations

Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation

1997 • 234 citations

Molecular evolution of plasminogen activator inhibitor-1 functional stability.

1995 • 215 citations

Plasminogen activator inhibitor type‐1 : reactive center and amino‐terminal heterogeneity determined by protein and cDNA sequencing

1986 • 207 citations

Modeling studies of the change in conformation required for cleavage of limited proteolytic sites

1994 • 204 citations

An atlas of serpin conformations

1998 • 196 citations

The Inhibition Mechanism of Serpins

1995 • 176 citations

Structural basis for serpin inhibitor activity

1995 • 157 citations

Serpin tertiary structure transformation

1991 • 155 citations

Structure of plasminogen activator inhibitor 1 (PAI-1) and its function in fibrinolysis: an update

1995 • 153 citations

Major proteinase movement upon stable serpin–proteinase complex formation

1997 • 127 citations

A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1

1995 • 123 citations

Monoclonal Antibodies to Human 54,000 Molecular Weight Plasminogen Activator Inhibitor from Fibrosarcoma Cells - Inhibitor Neutralization and One-Step Affinity Purification

1986 • 120 citations

Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1

1995 • 106 citations

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and α2-macroglobulin receptor in human breast carcinomas

1996 • 102 citations

The role of conformational change in serpin structure and function

1993 • 97 citations

Review

1996 • 96 citations

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1993 • 92 citations

Structure-function relationships in serpins: current concepts and controversies.

1998 • 86 citations

Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system

1997 • 84 citations

Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor

1998 • 84 citations

Divining the serpin inhibition mechanism: a suicide substrate ‘springe’?

1995 • 82 citations

Modulation of Plasminogen Activator Inhibitor 1 by Triton X-100 – Identification of Two Consecutive Conformational Transitions

1998 • 70 citations

An Ester Bond Linking a Fragment of a Serine Proteinase to Its Serpin Inhibitor

1998 • 64 citations

Type‐1 Plasminogen‐Activator Inhibitor

1997 • 58 citations

Type‐1 inhibitor of plasminogen activators

1991 • 54 citations

Conformational Changes of the Reactive‐Centre Loop and β‐Strand 5A Accompany Temperature‐Dependent Inhibitor‐Substrate Transition of Plasminogen‐Activator Inhibitor 1

1996 • 38 citations

A Model of the Reactive Form of Plasminogen Activator Inhibitor-1

1994 • 26 citations

Solvent Effects on Activity and Conformation of Plasminogen Activator Inhibitor-1

1999 • 26 citations

Rational Design of Complex Formation between Plasminogen Activator Inhibitor-1 and Its Target Proteinases

1997 • 16 citations

Stability of plasminogen activator inhibitor‐1: role of tyrosine²²¹

1998 • 13 citations