Tissue Plasminogen Activator (t-PA) Is Targeted to the Regulated Secretory Pathway

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Physiological consequences of loss of plasminogen activator gene function in mice

1994 • 1,051 citations

Pathways of Protein Secretion in Eukaryotes

1985 • 1,050 citations

Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

1993 • 841 citations

Pancreastatin, a novel pancreatic peptide that inhibits insulin secretion

1986 • 686 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Basic and clinical aspects of fibrinolysis and thrombolysis

1991 • 653 citations

The histological localisation of fibrinolysin activator

1959 • 617 citations

The granin-(chromogranin/secretogranin) family

1991 • 475 citations

Milieu-induced, selective aggregation of regulated secretory proteins in the trans-Golgi network.

1991 • 457 citations

Th molecular organization of adrenal chromaffin granules

1980 • 455 citations

A simple method for the isolation of adrenal chromaffin granules on a large scale

1967 • 439 citations

The composition of adrenal chromaffin granules: An assessment of controversial results

1976 • 435 citations

Mechanism of Plasminogen Activator and Factor VIII Increase after Vasoactive Drugs

1975 • 400 citations

Plasminogen Activator Release at the Neuronal Growth Cone

1981 • 388 citations

Extracellular proteolysis in the adult murine brain.

1993 • 345 citations

Adrenal medullary chromaffin cells in vitro

1984 • 325 citations

Plasminogen activator–plasmin system and neuronal migration

1982 • 256 citations

OBSERVATIONS ON FIBRINOLYSIS EXPERIMENTAL ACTIVITY PRODUCED BY EXERCISE OR ADRENALINE

1947 • 243 citations

Is chromogranin a prohormone?

1987 • 223 citations

Membrane depolarization induces calcium-dependent secretion of tissue plasminogen activator

1996 • 219 citations

Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor.

1989 • 208 citations

Neuronal plasminogen activators: cell surface binding sites and involvement in neurite outgrowth

1989 • 204 citations

A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice

1996 • 200 citations

Secretion from chromaffin cells is controlled by chromogranin A-derived peptides.

1988 • 193 citations

Thrombin-mediated release of factor VIII antigen from human umbilical vein endothelial cells in culture

1982 • 178 citations

OBSERVATIONS ON FIBRINOLYSIS SPONTANEOUS ACTIVITY ASSOCIATED WITH SURGICAL OPERATIONS, TRAUMA, &C.

1946 • 175 citations

Exocytotic exposure and recycling of membrane antigens of chromaffin granules: ultrastructural evaluation after immunolabeling.

1986 • 173 citations

Cytoplasmic domain of P-selectin (CD62) contains the signal for sorting into the regulated secretory pathway.

1992 • 156 citations

Molecular Sorting in the Secretory Pathway

1989 • 155 citations

Studies on the acute release of tissue-type plasminogen activator from human endothelial cells in vitro and in rats in vivo: evidence for a dynamic storage pool

1995 • 137 citations

The cell-binding domains of plasminogen and their function in plasma.

1988 • 134 citations

Regulation of the Acute Release of Tissue‐type Plasminogen Activator from the Endothelium by Coagulation Activation Products

1992 • 130 citations

ALTERATIONS OF FIBRINOLYSIS AND BLOOD COAGULATION INDUCED BY EXERCISE, AND THE ROLE OF BETA-ADRENERGIC-RECEPTOR STIMULATION

1968 • 121 citations

Biochemistry and Molecular Biology of the Vesicular Monoamine Transporter from Chromaffin Granules

1994 • 119 citations

Storage and release of acetylcholine by a clonal cell line.

1977 • 118 citations

Chromogranin B (secretogranin I), a secretory protein of the regulated pathway, is also present in a tightly membrane-associated form in PC12 cells.

1992 • 101 citations

Selective packaging of human growth hormone into synaptic vesicles in a rat neuronal (PC12) cell line.

1985 • 94 citations

Chromogranin A. Storage and release in hypertension.

1990 • 93 citations

PC12 Cells Overexpressing Tissue Plasminogen Activator Regenerate Neurites to a Greater Extent and Migrate Faster than Control Cells in Complex Extracellular Matrix

1995 • 80 citations

The Chemical Estimation of Catecholamines and their Metabolites in Body Fluids and Tissue Extracts

1971 • 72 citations

Tissue plasminogen activator expression in the embryonic nervous system

1994 • 71 citations

Fibrinolytic response during exercise and epinephrine infusion in the same subjects

1992 • 69 citations

Secretory protein traffic. Chromogranin A contains a dominant targeting signal for the regulated pathway.

1993 • 68 citations

Immunocytochemical demonstration of tissue-type plasminogen activator in endocrine cells of the rat pituitary gland.

1985 • 61 citations

Chromogranin A: a multipurpose prohormone?

1994 • 61 citations

Tissue-type plasminogen activator in rat adrenal medulla

1986 • 46 citations

Plasminogen Activators and Plasminogen Activator Inhibitors in Neural Developmenta

1992 • 42 citations

FIBRINOLYSIS FOLLOWING ELECTRICALLY INDUCED CONVULSIONS

1948 • 39 citations

Fibrinolysis and the nervous system

1961 • 39 citations

[26] Plasminogen activators and their inhibitors

1988 • 37 citations

Distribution of tissue-type plasminogen activator (activity and antigen) in rat tissues.

1990 • 37 citations

Isolation and characterization of chromaffin granules from a pheochromocytoma (PC 12) cell line

1980 • 37 citations

Localization of human growth hormone to a sub-set of cytoplasmic vesicles in transfected PC12 cells

1990 • 31 citations

Stimulation of tissue plasminogen activator production by retinoic acid: synergistic effect on protein kinase C-mediated activation

1992 • 28 citations

Modulation of Proteolytic Activity During Neuritogenesis in the PC12 Nerve Cell: Differential Control of Plasminogen Activator and Plasminogen Activator Inhibitor Activities by Nerve Growth Factor and Dibutyryl‐Cyclic AMP

1991 • 28 citations

Factors Controlling Packaging of Peptide Hormones into Secretory Granulesa

1987 • 27 citations

Stimulation of tissue plasminogen activator production by retinoic acid: synergistic effect on protein kinase C-mediated activation

1992 • 27 citations

Hormone Storage Vesicle Proteins

1994 • 23 citations

Acute release of tissue-type plasminogen activator (t-PA) from the endothelium; regulatory mechanisms and therapeutic target

1994 • 19 citations

Processing of type 1 plasminogen activator inhibitor (PAI-1) into the regulated secretory pathway.

1994 • 18 citations

The Effect of Beta Adrenergic Blockade upon Exercise-Induced Changes in Blood Coagulation and Fibrinolysis

1976 • 18 citations

Characterization of Catecholamine‐Storage Organelles in Transplantable Phaeochromocytoma and Adrenal Glands of Rats

1982 • 16 citations

Enkephalins in human phaeochromocytomas: localization in immunoreactive, high molecular weight form to the soluble core of chromaffin granules

1988 • 15 citations

Influence of Two Different Beta‐Adrenergic Blocking Agents on the Increase in Fibrinolytic Activity and Factor VIII Activity during Submaximum and Maximum Exercise

1974 • 10 citations

Polarized secretion of tissue-plasminogen activator in cultured thyroid cells

1993 • 10 citations

Calcium-regulated secretion of tissue plasminogen activator and parathyroid hormone from human parathyroid cells.

1992 • 8 citations

Inactivation of human anaphylatoxin C5a and C5a des-Arg through cleavage by the plasminogen activator activity of a human fibrosarcoma cell line.

1994 • 7 citations

Role of the cell surface fibrinolytic system in processing of the chromaffin granule protein, chromogranin a (CgA)

1994 • 4 citations

16 Plasma insulin could regulate plasma PAI-1 concentration

1988 • 1 citations