Treatment of Inflammatory Diseases with a Monoclonal Antibody to Intercellular Adhesion Molecule 1

Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

1986 • 2,490 citations

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.

1986 • 1,439 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecule-1 (ICAM-1) is one of at least three mechanisms for lymphocyte adhesion to cultured endothelial cells.

1988 • 988 citations

Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families

1988 • 967 citations

Intercellular Adhesion Molecule-1 (ICAM-1) in the Pathogenesis of asthma

1990 • 916 citations

ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18).

1990 • 898 citations

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1990 • 709 citations

Adhesion of T lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1).

1988 • 680 citations

ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM

1988 • 631 citations

Recognition of an endothelial determinant for CD 18-dependent human neutrophil adherence and transendothelial migration.

1988 • 626 citations

Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system.

1990 • 388 citations

In vivo effects of monoclonal antibody to ICAM-1 (CD54) in nonhuman primates with renal allografts.

1990 • 369 citations

Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway

1993 • 353 citations

The function of human intercellular adhesion molecule‐1 (ICAM‐1) in the generation of an immune response

1988 • 351 citations

Intercellular adhesion molecule 1 (ICAM-1) has a central role in cell-cell contact-mediated immune mechanisms.

1988 • 312 citations

A PHASE I TRIAL OF IMMUNOSUPPRESSION WITH ANTIIC AM-1 (CD54) mAb IN RENAL ALLOGRAFT RECIPIENTS

1993 • 299 citations

Differential expression of intercellular adhesion molecule 1 in primary and metastatic melanoma lesions.

1990 • 274 citations

NEOPLASIA AND NEOPLASMS

1985 • 260 citations

Role of CD11/CD18 in shear rate-dependent leukocyte-endothelial cell interactions in cat mesenteric venules.

1991 • 258 citations

INTERCELLULAR ADHESION MOLECULE 1 ON LIVER ALLOGRAFTS DURING REJECTION

1989 • 238 citations

The induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-λ, tumor necrosis factor α, lymphotoxin, and interleukin-1: relevance to intracerebral antigen presentation

1989 • 227 citations

Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule

1991 • 207 citations

Reduction of central nervous system ischemic injury in rabbits using leukocyte adhesion antibody treatment.

1991 • 206 citations

Monoclonal Antibody to the ICAM-1 Adhesion Site Reduces Neurological Damage in a Rabbit Cerebral Embolism Stroke Model

1993 • 202 citations

The effect of anti-intercellular adhesion molecule-1 on phorbol-ester-induced rabbit lung inflammation.

1989 • 201 citations

Kinetics and characterization of intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes in various inflammatory skin lesions and malignant cutaneous lymphomas

1989 • 197 citations

Macrophage-lymphocyte interaction. II. Antigen-mediated physical interactions between immune guinea pig lymph node lymphocytes and syngeneic macrophages.

1975 • 194 citations

Leukocyte function-associated antigen 1 is an activation molecule for human T cells.

1989 • 177 citations

Monoclonal Antibodies to the Leukocyte Membrane CD18 Glycoprotein Complex and to Intercellular Adhesion Molecule-1 Inhibit Leukocyte-Endothelial Adhesion in Rabbits

1991 • 153 citations

Keratinocyte intercellular adhesion molecule-1 (ICAM-1) expression precedes dermal T lymphocytic infiltration in allergic contact dermatitis (Rhus dermatitis).

1989 • 150 citations

Increased expression of intercellular adhesion molecule 1 on bile ducts in primary biliary cirrhosis and primary sclerosing cholangitis

1991 • 118 citations

Characterization of a monoclonal antibody-defined human melanoma-associated antigen susceptible to induction by immune interferon.

1987 • 101 citations

Inhibition of leukocyte-endothelial adherence following thermal injury

1992 • 97 citations

Remote T cell co‐stimulation via LFA‐1/ICAM‐1 and CD2/LFA‐3: Demonstration with immobilized ligand/mAb and implication in monocyte‐mediated co‐stimulation

1991 • 94 citations

Cross-linking of ICAM-1 induces co-signaling of an oxidative burst from mononuclear leukocytes.

1994 • 86 citations

Adhesion molecules on endothelial cells in the central nervous system: An emerging area in the neuroimmunology of multiple sclerosis

1990 • 73 citations

Intercellular adhesion molecule‐1 (ICAM‐1) is involved in the cytolytic T lymphocyte interaction with a human synovial cell line

1988 • 46 citations

Inhibition of Leukocyte Adherence and Susceptibility to Infection

1993 • 34 citations

Intercellular Adhesion Molecule‐1 (ICAM‐1) Monoclonal Antibody Inhibits Cytotoxic T Lymphocyte Recognition

1988 • 9 citations