8 PAX and HOX in Neoplasia

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Hox genes in vertebrate development

1994 • 2,057 citations

The multistep nature of cancer

1993 • 1,872 citations

Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers

1990 • 1,747 citations

The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

1990 • 1,531 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid

1991 • 1,007 citations

Homeo Boxes in the Study of Development

1987 • 905 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1993 • 884 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

1991 • 850 citations

Wnt genes

1992 • 799 citations

Homeodomain-DNA recognition

1994 • 784 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

The Gene for Familial Polyposis Coli Maps to the Long Arm of Chromosome 5

1987 • 683 citations

Murine Developmental Control Genes

1990 • 594 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

Roles of Pax-genes in developing and adult brain as suggested by expression patterns

1994 • 582 citations

Fusion of PAX7 to FKHR by the variant t(1;13)(p36;q14) translocation in alveolar rhabdomyosarcoma.

1994 • 580 citations

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

1990 • 577 citations

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

1993 • 565 citations

Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system

1990 • 562 citations

Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma

1993 • 546 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

Clonal genomic alterations in glioma malignancy stages.

1988 • 520 citations

WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour

1991 • 471 citations

HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally.

1990 • 466 citations

Pax: A murine multigene family of paired box-containing genes

1991 • 427 citations

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

1992 • 417 citations

Pax in development

1992 • 402 citations

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1993 • 391 citations

The murine paired box gene, Pax7, is expressed specifically during the development of the nervous and muscular system

1990 • 383 citations

Gastrulation in the mouse: The role of the homeobox gene goosecoid

1992 • 378 citations

Fusion of PAX3 to a member of the forkhead family of transcription factors in human alveolar rhabdomyosarcoma.

1993 • 373 citations

Prox 1, a prospero-related homeobox gene expressed during mouse development

1993 • 371 citations

The paired box encodes a second DNA-binding domain in the paired homeo domain protein.

1991 • 349 citations

Specific Chromosomal Abnormalities in Malignant Human Gliomas

1988 • 338 citations

Evolution and role of Pax genes

1993 • 337 citations

En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis.

1987 • 330 citations

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

1992 • 325 citations

Physical and functional interaction between WT1 and p53 proteins.

1993 • 308 citations

Pax 1, a member of a paired box homologous murine gene family, is expressed in segmented structures during development

1988 • 304 citations

Pax-8, a paired domain-containing protein, binds to a sequence overlapping the recognition site of a homeodomain and activates transcription from two thyroid-specific promoters.

1992 • 298 citations

p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

1992 • 297 citations

The homeobox gene goosecoid and the origin of organizer cells in the early chick blastoderm

1993 • 292 citations

Mitotic recombination of chromosome 17 in astrocytomas.

1989 • 288 citations

The molecular basis of the undulated/Pax-1 mutation

1991 • 273 citations

HUMAN TUMOR SUPPRESSOR GENES

1990 • 266 citations

Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts.

1988 • 259 citations

The WT1 Wilms tumor gene product: a developmentally regulated transcription factor in the kidney that functions as a tumor suppressor

1993 • 254 citations

The oncogenic potential of Pax genes.

1993 • 247 citations

Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene

1985 • 234 citations

PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and Wilms’ tumors

1992 • 223 citations

Chromosomal localization of seven PAX genes and cloning of a novel family member, PAX-9

1993 • 212 citations

Pax: Gene regulators in the developing nervous system

1993 • 195 citations

Mouse Cdx-1 expression during gastrulation

1993 • 187 citations

A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.

1990 • 185 citations

Homeobox gene expression plus autocrine growth factor production elicits myeloid leukemia.

1990 • 174 citations

Mesodermal Patterning by a Gradient of the Vertebrate Homeobox Gene goosecoid

1994 • 168 citations

E2A-Pbx1, the t(1;19) Translocation Protein of Human Pre-B-Cell Acute Lymphocytic Leukemia, Causes Acute Myeloid Leukemia in Mice

1993 • 151 citations

Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties.

1993 • 150 citations

DNA rearrangement of a homeobox gene in myeloid leukaemic cells.

1988 • 148 citations

Tumor suppressor genes

1993 • 147 citations

MAMMALIAN PAX GENES

1994 • 143 citations

Expression of homeobox-containing genes in primary and metastatic colorectal cancer

1993 • 143 citations

Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations

1986 • 139 citations

Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wall

1993 • 134 citations

Chromosomal patterns in human malignant astrocytomas

1987 • 122 citations

Molecular basis of splotch and Waardenburg Pax-3 mutations.

1994 • 114 citations

The oncogenic potential of deregulated homeobox genes.

1993 • 108 citations

Gene and chromosomal alterations associated with the development of human gliomas

1993 • 107 citations

E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice.

1993 • 96 citations

The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts.

1991 • 80 citations

PAX5 expression correlates with increasing malignancy in human astrocytomas.

1995 • 79 citations

Pax genes, mutants and molecular function

1992 • 55 citations

Homeobox genes: Potential candidates for the transcriptional control of the transformed and invasive phenotype

1994 • 51 citations

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin.

1989 • 48 citations

Inhibition of specific pathways of myeloid cell differentiation by an activated Hox-2.4 homeobox gene.

1992 • 40 citations

Aberrant Expression of Pax-2 in Danforth's Short Tail (Sd) Mice

1993 • 40 citations

Wilms' tumour gene and function

1993 • 38 citations

Genetics of the malignant progression of astrocytoma

1991 • 33 citations

The murine even-skipped-like gene Evx-2 is closely linked to the Hox-4 complex, but is transcribed in the opposite direction

1992 • 22 citations

Expression of a Wnt gene in embryonic epithelium of the leech

1992 • 20 citations

Deoxyribonucleic-binding homeobox proteins are augmented in human cancer.

1990 • 17 citations

The betrayal of homeo box genes in normal development: the link to cancer.

1990 • 10 citations

11 Heritable Cancer and Tumor Suppressor Genes: A Tentative Connection

1989 • 9 citations

Murine Paired Box Containing Genes

1993 • 7 citations