Wilms' tumour gene and function

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus

1990 • 1,882 citations

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

1990 • 1,300 citations

Germline mutations in the Wilms' tumor suppressor gene are associated with abnormal urogenital development in Denys-Drash syndrome

1991 • 944 citations

The candidate Wilms' tumour gene is involved in genitourinary development

1990 • 884 citations

Alternative splicing and genomic structure of the Wilms tumor gene WT1.

1991 • 628 citations

Binding of the Wilms' Tumor Locus Zinc Finger Protein to the EGR-1 Consensus Sequence

1990 • 588 citations

The expression of the Wilms' tumour gene, WT1, in the developing mammalian embryo

1993 • 582 citations

An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor

1990 • 577 citations

Repression of the Insulin-Like Growth Factor II Gene by the Wilms Tumor Suppressor WT1

1992 • 535 citations

Transcriptional Repression Mediated by the WT1 Wilms Tumor Gene Product

1991 • 492 citations

WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour

1991 • 471 citations

Expression of the Wilms' tumor gene WT1 in the murine urogenital system.

1991 • 447 citations

Monoallelic expression of the human H19 gene

1992 • 409 citations

Human platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1.

1992 • 226 citations

The Wilms' tumor gene product, WT1, represses transcription of the platelet-derived growth factor A-chain gene.

1992 • 225 citations

Modulation of DNA Binding Specificity by Alternative Splicing of the Wilms Tumor wt1 Gene Transcript

1992 • 221 citations

Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development

1992 • 191 citations

Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT.

1991 • 164 citations

Evidence that WT1 mutations in Denys — Drash syndrome patients may act in a dominant-negative fashion

1993 • 163 citations

Zinc finger point mutations within the WT1 gene in Wilms tumor patients.

1992 • 159 citations

Alternatively spliced transcripts of the Drosophila tramtrack gene encode zinc finger proteins with distinct DNA binding specificities.

1992 • 144 citations

Wilms Tumor Locus on 11p13 Defined by Multiple CpG Island-Associated Transcripts

1990 • 143 citations

Characterization of the zinc finger protein encoded by the WT1 Wilms' tumor locus.

1991 • 114 citations

Inherited WT1 mutation in Denys-Drash syndrome.

1992 • 114 citations

Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome

1992 • 112 citations

Wilms' tumour: reconciling genetics and biology

1992 • 107 citations

Submicroscopic deletions at the WAGR locus, revealed by nonradioactive in situ hybridization.

1992 • 96 citations

Role for the Wilms tumor gene in genital development?

1990 • 94 citations

Multiple Zinc Finger Forms Resulting from Developmentally Regulated Alternative Splicing of a Transcription Factor Gene

1992 • 94 citations

Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome.

1992 • 85 citations

Dominant negative mutations in the Wilms tumour (WT1) gene cause Denys-Drash syndrome—proof that a tumour-suppressor gene plays a crucial role in normal genitourinary development

1992 • 82 citations

Molecular cloning of rat Wilms' tumor complementary DNA and a study of messenger RNA expression in the urogenital system and the brain.

1992 • 81 citations

Structural rearrangements of the WT1 gene in Wilms' tumour cells.

1991 • 69 citations

Inactivation of the remaining allele of the WT1 gene in a Wilms' tumour from a WAGR patient.

1992 • 60 citations

Equivalent expression of paternally and maternally inherited WT1 alleles in normal fetal tissue and Wilms' tumours.

1992 • 53 citations

Intragenic homozygous deletion of the WT1 gene in Wilms' tumor.

1992 • 45 citations

Direct pulsed field gel electrophoresis of Wilms' tumors shows that dna deletions in 11 p 13 are rare

1991 • 43 citations

RNA polymerase chain reaction detects different levels of four alternatively spliced WT1 transcripts in Wilms' tumors.

1992 • 39 citations

Role of the WT1 gene in Wilms' tumour.

1992 • 34 citations

Wilms' tumour as a paradigm for the relationship of cancer to development.

1990 • 28 citations

Identification of the cellular protein encoded by the human Wilms' tumor (WT1) gene.

1992 • 19 citations