Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

Transformation of mammalian cells with genes from procaryotes and eucaryotes

1979 • 1,474 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Mutation selection and the natural history of cancer

2006 • 1,185 citations

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: Synergistic action of oncogenes in vivo

1987 • 796 citations

The Coupling of Neurotransmitter Receptors to Ion Channels in the Brain

1988 • 732 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

Stimulation of connective tissue cell growth by substance P and substance K

1985 • 681 citations

Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones

1982 • 658 citations

Overproduction of protein kinase C causesdisordered growth control in rat fibroblasts

1988 • 492 citations

Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains

1986 • 471 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Differential modulation of three separate K-conductances in hippocampal CA1 neurons by serotonin

1987 • 463 citations

Human-tumor-derived cell lines contain common and different transforming genes

1981 • 455 citations

Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.

1986 • 420 citations

The mas oncogene encodes an angiotensin receptor

1988 • 390 citations

5-Hydroxytryptamine Receptor Subtypes

1988 • 361 citations

5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterization

1988 • 354 citations

Stimulation of aortic smooth muscle cell mitogenesis by serotonin.

1986 • 327 citations

The origins of human cancer: molecular mechanisms of carcinogenesis and their implications for cancer prevention and treatment--twenty-seventh G.H.A. Clowes memorial award lecture.

1988 • 326 citations

Serotonin stimulates DNA synthesis in fibroblasts acting through 5–HT1B receptors coupled to a Gi-protein

1988 • 277 citations

A unique serotonin receptor in choroid plexus is linked to phosphatidylinositol turnover.

1986 • 265 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

New human transforming genes detected by a tumorigenicity assay.

1984 • 217 citations

Evidence that phospholipid turnover is the signal transducing system coupled to serotonin-S2 receptor sites.

1985 • 206 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells

1985 • 159 citations

Construction and Characterization of a Retroviral Vector Demonstrating Efficient Expression of Cloned cDNA Sequences

1988 • 157 citations

Evidence for G protein mediation of serotonin- and GABAB- induced hyperpolarization of rat dorsal raphe neurons

1988 • 146 citations

Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain.

1988 • 108 citations

Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons

1986 • 91 citations

5-HT1D receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in calf substantia nigra

1988 • 81 citations

Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells.

1983 • 74 citations

Dual effects of serotonin on a voltage-gated conductance in lymphocytes.

1988 • 46 citations

Flow cytometric identification and purification of cells by ligand-induced changes in intracellular calcium

1988 • 19 citations

Functional Expression of the S-HT1c Receptor in Neuronal and Nonneuronal Cells

1988 • 16 citations