Establishment and Functional Implications of B‐cell Connectivity

Evolution by Gene Duplication

1970 • 6,000 citations

Towards a network theory of the immune system.

1974 • 3,379 citations

The clonal selection theory of acquired immunity

1959 • 1,576 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

The somatic generation of immune recognition

1971 • 974 citations

Naturally occurring antibodies against nine common antigens in human sera. I. Detection, isolation and characterization.

1982 • 665 citations

Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines

1984 • 644 citations

The LY‐1B Cell Lineage

1986 • 603 citations

Progenitors for Ly-1 B cells are distinct from progenitors for other B cells.

1985 • 599 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Early Restriction of the Human Antibody Repertoire

1987 • 546 citations

ANTI-IDIOTYPIC SUPPRESSION OF AUTOANTIBODIES TO FACTOR VIII (ANTIHAEMOPHILIC FACTOR) BY HIGH-DOSE INTRAVENOUS GAMMAGLOBULIN

1984 • 485 citations

Regulation of Genome Rearrangement Events during Lymphocyte Differentiation

1986 • 422 citations

Molecular Biology and Chemistry of the Alternative Pathway of Complement

1980 • 409 citations

High frequency of natural autoantibodies in normal newborn mice.

1985 • 387 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Expansion and functional activity of Ly‐1⁺ B cells upon transfer of peritoneal cells into allotype‐congenic, newborn mice

1987 • 318 citations

Murine hybridomas secreting natural monoclonal antibodies reacting with self antigens.

1983 • 303 citations

Structure, Sequence and Polymorphism in the HLA‐D Region

1985 • 302 citations

Reactions among IgM antibodies derived from normal, neonatal mice

1984 • 231 citations

Rearrangement of genetic information may produce immunoglobulin diversity

1978 • 209 citations

Isotypes and specificities of immunoglobulins produced by germ‐free mice fed chemically defined ultrafiltered “antigen‐free” diet

1984 • 194 citations

Autonomous activation of B and T cells in antigen-free mice

1986 • 184 citations

Idiotype‐Directed Interactions during Ontogeny Play a Major Role in the Establishment of the Adult B Cell Repertoire

1986 • 166 citations

Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanism

1981 • 161 citations

Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment.

1988 • 139 citations

Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

1988 • 130 citations

Antibody Repertoires of Normal BALB/c Mice: B Lymphocyte Populations Defined by State of Activation

1986 • 129 citations

VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assay.

1986 • 127 citations

Evidence for a functional idiotypic network among natural antibodies in normal mice.

1989 • 124 citations

V_H‐gene expression in murine lipopolysaccharide blasts distributes over the nine known V_H‐gene groups and may be random

1985 • 122 citations

The high idiotypic connectivity of “natural” newborn antibodies is not found in adult mitogen‐reactive B cell repertoires

1986 • 119 citations

In vivo suppression of perinatal multispecific B cells results in a distortion of the adult B cell repertoire

1986 • 115 citations

Immunocompetent autoreactive B lymphocytes are activated cycling cells in normal mice.

1986 • 97 citations

High connectivity, natural antibodies preferentially use 7183 and QUPC52 V_H families

1987 • 88 citations

Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains.

1984 • 84 citations

Establishment of idiotypic helper T-cell repertoires early in life

1985 • 79 citations

Natural effector T lymphocytes in normal mice.

1985 • 70 citations

Expression of antibody V-regions is genetically and developmentally controlled and modulated by the B lymphocyte environment

1989 • 70 citations

Internal complementarities in the immune system: regulation of the expression of helper T-cell idiotypes.

1984 • 70 citations

Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors.

1984 • 65 citations

Frequencies of background immunoglobulin-secreting cells in mice as a function of organ, age, and immune status

1981 • 59 citations

Strain-dependent expression of VH gene families.

1988 • 53 citations

Immunoglobulin with complementary paratope and idiotope.

1986 • 50 citations

Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes.

1986 • 47 citations

The Participation of B Cells and Antibodies in the Selection and Maintenance of T Cell Repertoires

1988 • 43 citations

Suppression of antibody responses to the acetylcholine receptor by natural antibodies

1989 • 32 citations

The Uniqueness and Boundaries of the Idiotypic Self

1984 • 32 citations

Idiotypic determinants of natural IgM antibodies that resemble self Ia antigens.

1984 • 28 citations

Structural differences in a single gene encoding the V kappa Ser group of light chains explain the existence of two mouse light-chain genetic markers.

1986 • 27 citations

Activation of immunoglobulin mu gene expression involves stepwise demethylation.

1984 • 24 citations

Complete heavy and light chain variable region sequence of anti-arsonate monoclonal antibodies from BALB/c and A/J mice sharing the 36-60 idiotype are highly homologous.

1984 • 23 citations

Selection of antibody repertoires: transfer of mature T lymphocytes modifies V_H gene family usage in the actual and available B cell repertoires of athymic mice

1989 • 22 citations

The Origin of “Natural Antibodies” and the Internal Activity in the Immune System

1988 • 20 citations

Role of somatic mutation in the generation of lymphocyte diversity.

1987 • 18 citations

Natural lymphocyte activation in postnatal development of germ-free and conventional mice

1988 • 18 citations

B cell-deprived mice lack functional expression of certain T suppressor cell subsets.

1984 • 18 citations

Interstrain conservation of the murine GAT-specific antibody V kappa repertoire as analyzed at the germline gene level.

1983 • 16 citations