Protein Kinase A RIβ Subunit Deficiency in Lupus T Lymphocytes: Bypassing a Block in RIβ Translation Reconstitutes Protein Kinase A Activity and Augments IL-2 Production

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

High gradient magnetic cell separation with MACS

1990 • 1,648 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

TRANSCRIPTIONAL REGULATION BY CYCLIC AMP

1997 • 967 citations

Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

2001 • 322 citations

Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

1993 • 208 citations

16 Structure, function, and regulation of human cAMP-dependent protein kinases

1997 • 162 citations

Protein kinase A-catalyzed phosphorylation of heat shock protein 60 chaperone regulates its attachment to histone 2B in the T lymphocyte plasma membrane

1998 • 113 citations

Phosphorylation of Phospholipase C-γ by cAMP-dependent Protein Kinase

1989 • 112 citations

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells

1996 • 108 citations

Holoenzymes of cAMP-dependent protein kinase containing the neural form of type I regulatory subunit have an increased sensitivity to cyclic nucleotides.

1990 • 106 citations

c-Jun N-terminal Kinase but Not Mitogen-activated Protein Kinase Is Sensitive to cAMP Inhibition in T Lymphocytes

1995 • 106 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.

1994 • 90 citations

Molecular aberrations in human systemic lupus erythematosus

2000 • 75 citations

Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus

1982 • 73 citations

Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RIβ of cAMP-dependent protein kinases

1991 • 72 citations

Lupus : molecular and cellular pathogenesis

1999 • 72 citations

Impaired translational response and increased protein kinase PKR expression in T cells from lupus patients

2000 • 55 citations

Human Regulatory Subunit RIβ of cAMP-Dependent Protein Kinases: Expression, Holoenzyme Formation and Microinjection into Living Cells

1994 • 49 citations

Early events of human T lymphocyte activation are associated with type I protein kinase A activity.

1993 • 45 citations

High prevalence of T cell type I protein kinase a deficiency in systemic lupus erythematosus

1999 • 35 citations

Defective cAMP-dependent phosphorylation of intact T lymphocytes in active systemic lupus erythematosus.

1990 • 34 citations

Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.

1999 • 33 citations

Diminished Levels of Protein Kinase A RIα and RIβ Transcripts and Proteins in Systemic Lupus Erythematosus T Lymphocytes

1999 • 27 citations

Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.

1996 • 27 citations

Characterization of in‐vitro‐translated human regulatory and catalytic subunits of cAMP‐dependent protein kinases

1994 • 21 citations

Cytokines in the Immunopathogenesis of Lupus

1999 • 20 citations

Lupus

1999 • 16 citations

Lupus

1999 • 12 citations