Molecular Cloning, Expression, and Characterization of Metabotropic Glutamate Receptor Subtypes

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

1991 • 2,629 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones

1986 • 1,842 citations

Excitatory amino acid neurotoxicity and neurodegenerative disease

1990 • 1,781 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

Sequence and expression of a metabotropic glutamate receptor

1991 • 1,200 citations

The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction

1993 • 905 citations

A family of metabotropic glutamate receptors

1992 • 873 citations

Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction.

1992 • 814 citations

Metabotropic glutamate receptors in brain function and pathology

1993 • 799 citations

Chimeric α ₂ -,β ₂ -Adrenergic Receptors: Delineation of Domains Involved in Effector Coupling and Ligand Binding Specificity

1988 • 766 citations

Glutamate stimulates inositol phosphate formation in striatal neurones

1985 • 734 citations

Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate

1993 • 724 citations

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

1993 • 695 citations

Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria

1993 • 678 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR1) in the central nervous system: An in situ hybridization study in adult and developing rat

1992 • 645 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

1993 • 554 citations

Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor, mGluRl, in transfected CHO cells

1992 • 539 citations

Cellular localization of a metabotropic glutamate receptor in rat brain

1992 • 539 citations

Cloning, Expression, and Gene Structure of a G Protein-Coupled Glutamate Receptor from Rat Brain

1991 • 524 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study

1993 • 518 citations

G protein-coupled mechanisms and nervous signaling

1992 • 474 citations

Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction.

1994 • 466 citations

Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors

1990 • 464 citations

Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus

1986 • 444 citations

Agonists at metabotropic glutamate receptors presynaptically inhibit EPSCs in neonatal rat hippocampus.

1991 • 431 citations

Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors.

1986 • 399 citations

Rhodopsin Mutants That Bind But Fail to Activate Transducin

1990 • 377 citations

Excitatory amino acids and synaptic transmission: the evidence for a physiological function

1990 • 370 citations

Of urfs and orfs : a primer on how to analyze devised amino acid sequences

1986 • 370 citations

Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons

1990 • 355 citations

Trans-ACPD, a selective agonist of the phosphoinositide-coupled excitatory amino acid receptor

1989 • 318 citations

Micromolar L-2-amino-4-phosphonobutyric acid selectively inhibits perforant path synapses from lateral entorhinal cortex

1981 • 307 citations

The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro

1987 • 268 citations

Novel stereospecificity of the L-arabinose-binding protein

1984 • 262 citations

Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases

1988 • 258 citations

G proteins and regulation of adenylyl cyclase

1995 • 250 citations

Presynaptic glutamate receptors depress excitatory monosynaptic transmission between mouse hippocampal neurones.

1990 • 249 citations

Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria.

1993 • 248 citations

Periplasmic binding protein structure and function

1989 • 229 citations

Alternative splicing generates metabotropic glutamate receptors inducing different patterns of calcium release in Xenopus oocytes.

1992 • 226 citations

Competitive antagonism at metabotropic glutamate receptors by (S) -4-carboxyphenylglycine and (RS) -α-methyl-4-carboxyphenylglycine

1993 • 219 citations

Atomic structures of periplasmic binding proteins and the high-affinity active transport systems in bacteria

1990 • 213 citations

L-AP4 inhibits calcium currents and synaptic transmission via a G- protein-coupled glutamate receptor

1992 • 210 citations

Domains involved in the specificity of G protein activation in phospholipase C-coupled metabotropic glutamate receptors.

1994 • 197 citations

3,5-Dihydroxyphenylglycine

1992 • 195 citations

Agonist analysis of 2‐(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells

1992 • 189 citations

Excitatory Amino Acid Agonist‐Antagonist Interactions at 2‐Amino‐4‐Phosphonobutyric Acid‐Sensitive Quisqualate Receptors Coupled to Phosphoinositide Hydrolysis in Slices of Rat Hippocampus

1988 • 181 citations

Location of a region of the muscarinic acetylcholine receptor involved in selective effector coupling

1988 • 167 citations

Excitatory amino acid receptors of the retina: diversity of subtypes and conductance mechanisms

1986 • 165 citations

Glutamate receptor subtypes may be classified into two major categories: A study on Xenopus oocytes injected with rat brain mRNA

1989 • 163 citations

Molecular recognition of inositol polyphosphates by intracellular receptors and metabolic enzymes

1989 • 163 citations

Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.

1988 • 160 citations

A Transfected m1 Muscarinic Acetylcholine Receptor Stimulates Adenylate Cyclase via Phosphatidylinositol Hydrolysis

1989 • 146 citations

Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells.

1988 • 145 citations

Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system

1993 • 144 citations

Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.

1993 • 141 citations

Actions of phenylglycine analogs at subtypes of the metabotropic glutamate receptor family

1994 • 139 citations

L-2-amino-4-phosphonobutyrate (L-AP4) is an agonist at the type iv metabotropic glutamate receptor which is negatively coupled to adenylate cyclase

1992 • 135 citations

New subtypes of muscarinic acetylcholine receptors.

1989 • 126 citations

Reconstitution of functional muscarinic receptors by co‐expression of amino‐ and carboxyl‐terminal receptor fragments

1993 • 123 citations

G Proteins and Regulation of Adenylyl Cyclase

1989 • 114 citations

Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors

1993 • 114 citations

A Variant of Metabotropic Glutamate Receptor Subtype 5: An Evolutionally Conserved Insertion with No Termination Codon

1993 • 103 citations

A Comparison of Two Alternatively Spliced Forms of a Metabotropic Glutamate Receptor Coupled to Phosphoinositide Turnover

1993 • 101 citations

A pharmacological characterization of the mGluR1α subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line

1993 • 96 citations

Excitatory Amino Acid Receptors

1980 • 96 citations

Current Aspects of the Neurosciences

1990 • 94 citations

Structure of the l-leucine-binding protein refined at 2.4 Å resolution and comparison with the Leu/Ile/Val-binding protein structure

1989 • 94 citations

Trans-ACPD and l-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA)

1992 • 80 citations

Selective inhibition of excitatory amino acid-stimulated phosphoinositide hydrolysis in the rat hippocampus by activation of protein kinase C

1988 • 77 citations

l-[3H]Glutamate labels the metabotropic excitatory amino acid receptor in rodent brain

1990 • 74 citations

Changes in Metabotropic Glutamate Receptor mRNA Levels Following Global Ischemia: Increase of a Putative Presynaptic Subtype (mGluR4) in Highly Vulnerable Rat Brain Areas

1994 • 67 citations

Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons

1991 • 57 citations

Development profile of metabotropic glutamate receptor mRNA in rat brain.

1992 • 56 citations

Expression pattern and pharmacology of the rat type IV metabotropic glutamate receptor

1993 • 56 citations

Glutamate and Quisqualate Regulate Expression of Metabotropic Glutamate Receptor mRNA in Cultured Cerebellar Granule Cells

1993 • 43 citations

Cloning and nucleotide sequence of braC, the structural gene for the leucine-, isoleucine-, and valine-binding protein of Pseudomonas aeruginosa PAO

1989 • 37 citations

Phorbol Esters Attenuate Glutamate‐Stimulated Inositol Phospholipid Hydrolysis in Neuronal Cultures

1988 • 36 citations

Quisqualate resolves two distinct metabotropic [3H]glutamate binding sites

1993 • 24 citations

4-carboxy-3-hydroxyphenylglycine, an antagonist at type I metabotropic glutamate receptors

1993 • 23 citations

Carboxyl domain of glutamate receptor directs its coupling to metabolic pathways

1993 • 22 citations

Effects of t-ACPD on neural survival and second messengers in cultured cerebral cortical neurones

1993 • 21 citations

Postnatal development of mRNA specific for a metabotropic glutamate receptor in the rat brain

1992 • 21 citations

Excitatory Amino Acid Receptors and Phosphoinositide Breakdown: Facts and Perspectives

1991 • 20 citations

Optical resolution by chromatography at low temperature

1975 • 13 citations

(R,S)‐α‐Amino‐3‐Hydroxy‐5‐Methylisoxazole‐4‐Propionic Acid (AMPA) Receptors Mediate a Calcium‐Dependent Inhibition of the Metabotropic Glutamate Receptor‐Stimulated Formation of Inositol 1,4,5‐Trisphosphate

1993 • 13 citations

Functional evidence for a l-AP3-sensitive metabotropic receptor different from glutamate metabotropic receptor mGluR1

1993 • 5 citations