Autoimmune Response to Acetylcholine Receptors in Myasthenia Gravis and Its Animal Model

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Nerve, Muscle and Synapse

1966 • 1,431 citations

Antibody to acetylcholine receptor in myasthenia gravis

1998 • 1,149 citations

Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value

1976 • 1,123 citations

Autoimmune Response to Acetylcholine Receptor

1973 • 1,019 citations

Membrane Asymmetry

1977 • 965 citations

The statistical nature of the acetylcholine potential and its molecular components

1972 • 960 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Neuromuscular Junction in Myasthenia Gravis: Decreased Acetylcholine Receptors

1973 • 633 citations

Myasthenia Gravis: A New Hypothesis

1960 • 585 citations

The binding of acetylcholine to receptors and its removal from the synaptic cleft

1973 • 576 citations

Chemistry and Pharmacology of Polypeptide Toxins in Snake Venoms

1972 • 479 citations

Myasthenia Gravis: Passive Transfer from Man to Mouse

1975 • 430 citations

Myasthenia Gravis

1977 • 428 citations

Myasthenic Antibodies Cross-Link Acetylcholine Receptors to Accelerate Degradation

1978 • 425 citations

Quantitation of junctional and extrajunctional acetylcholine receptors by electron microscope autoradiography after (125)I-α-bungarotoxin binding at mouse neuromuscular junctions

1976 • 398 citations

Cholinesterase is associated with the basal lamina at the neuromuscular junction

1978 • 397 citations

Plasmapheresis and Immunosuppressive Drug Therapy in Myasthenia Gravis

1977 • 396 citations

REMISSION OF MYASTHENIA GRAVIS FOLLOWING PLASMA-EXCHANGE

1976 • 392 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Large‐Scale Purification of the Acetylcholine‐Receptor Protein in Its Membrane‐Bound and Detergent‐Extracted Forms from Torpedo marmorata Electric Organ

1977 • 375 citations

Serum Globulin in Myasthenia Gravis: Inhibition of α-Bungarotoxin Binding to Acetylcholine Receptors

1974 • 365 citations

Acetylcholine receptor turnover in membranes of developing muscle fibers.

1975 • 364 citations

Myasthenia Gravis

1978 • 341 citations

An electrophysiological investigation of neuro‐muscular transmission in myasthenia gravis

1964 • 333 citations

Experimental autoimmune myasthenia: A model of myasthenia gravis in rats and guinea pigs.

1975 • 325 citations

The number of transmitter molecules in a quantum: an estimate from iontophoretic application of acetylcholine at the neuromuscular synapse.

1975 • 325 citations

Localization of Acetylcholine Receptor by ¹²⁵ I-Labeled α-Bungarotoxin Binding at Mouse Motor Endplates

1974 • 306 citations

QUANTAL COMPONENTS OF END‐PLATE POTENTIALS IN THE MYASTHENIC SYNDROME*

1971 • 304 citations

THE PATHOLOGY OF THE THYMUS GLAND IN MYASTHENIA GRAVIS

1966 • 300 citations

An assay for antibodies to human acetylcholine receptor in serum from patients with myasthenia gravis

1977 • 283 citations

EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS AND MYASTHENIA GRAVIS: BIOCHEMICAL AND IMMUNOCHEMICAL ASPECTS*

1976 • 275 citations

Function of circulating antibody to acetylcholine receptor in myasthenia gravis

1978 • 275 citations

The Value of Thymectomy in Myasthenia Gravis

1976 • 268 citations

Myasthenic Immunoglobulin Accelerates Acetylcholine Receptor Degradation

1977 • 260 citations

In Vitro excitation of purified membrane fragments by cholinergic agonists

1971 • 250 citations

Ultrastructural localization of the acetylcholine receptor in myasthenia gravis and in its experimental autoimmune model

1977 • 244 citations

Thymic Muscle Cells Bear Acetylcholine Receptors: Possible Relation to Myasthenia Gravis

1977 • 244 citations

Role of complement in the pathogenesis of experimental autoimmune myasthenia gravis.

1978 • 239 citations

Experimental Staphylococcus Infection in Man

1960 • 237 citations

AN EVALUATION OF THYMECTOMY IN MYASTHENIA GRAVIS

1958 • 236 citations

Pathological mechanisms in experimental autoimmune myasthenia gravis. II. Passive transfer of experimental autoimmune myasthenia gravis in rats with anti-acetylcholine recepotr antibodies.

1976 • 218 citations

HISTOMETRIC ANALYSIS OF THE ULTRASTRUCTURE OF THE NEUROMUSCULAR JUNCTION IN MY ASTHENIA GRAVIS AND IN THE MYASTHENIC SYNDROME*

1971 • 210 citations

Modulation of acetylcholine receptor by antibody against the receptor

1977 • 201 citations

Purification and molecular properties of the acetylcholine receptor from Torpedo electroplax

1973 • 201 citations

Acetylcholine Receptor Antibodies in Myasthenia Gravis

1975 • 192 citations

Receptors, Antireceptor Antibodies and Mechanisms of Insulin Resistance

1979 • 192 citations

Gradually Increasing Doses of Prednisone in Myasthenia Gravis

1974 • 186 citations

MYASTHENIA GRAVIS: A SERUM FACTOR BLOCKING ACETYLCHOLINE RECEPTORS OF THE HUMAN NEUROMUSCULAR JUNCTION

1975 • 185 citations

EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS: CELLULAR AND HUMORAL IMMUNE RESPONSES*

1976 • 185 citations

Structural studies of a membrane-bound acetylcholine receptor from Torpedo californica

1977 • 183 citations

Reconstitution of carbamylcholine-dependent sodium ion flux and desensitization of the acetylcholine receptor from Torpedo californica.

1978 • 176 citations

Generation of end-plate potentials

1976 • 176 citations

Pathological mechanisms in experimental autoimmune myasthenia gravis. I. Immunogenicity of syngeneic muscle acetylcholine receptor and quantitative extraction of receptor and antibody-receptor complexes from muscles of rats with experimental automimmune myasthenia gravis.

1976 • 175 citations

Comparative Physiology: Electric Organs

1970 • 174 citations

HL-A Antigens as Markers for Disease Susceptibility and Autoimmunity in Graves' Disease

1974 • 173 citations

The characteristics of ‘end‐plate noise’ produced by different depolarizing drugs

1973 • 171 citations

A quantitative analysis of local anaesthetic alteration of miniature end‐plate currents and end‐plate current fluctuations.

1977 • 169 citations

THE MOTOR END PLATE IN MYASTHENIA GRAVIS AND IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS. A QUANTITATIVE ULTRASTRUCTURAL STUDY*

1976 • 168 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

An analysis of the dose‐response relationship at voltage‐clamped frog neuromuscular junctions.

1978 • 162 citations

PRESYNAPTIC NATURE OF NEUROMUSCULAR DEPRESSION

1962 • 161 citations

Myasthenia Gravis, Autoantibodies, and HL-A Antigens

1974 • 160 citations

Newly synthesized acetylcholine receptors are located in the Golgi apparatus.

1978 • 160 citations

Acetylcholine receptor metabolism in a nonfusing muscle cell line.

1977 • 160 citations

Increased extrajunctional acetylcholine sensitivity produced by chronic acetylcholine sensitivity produced by chronic post‐synaptic neuromuscular blockade.

1975 • 159 citations

Content of acetylcholine receptor and antibodies bound to receptor in myasthenia gravis, experimental autoimmune myasthenia gravis, and Eaton‐Lambert syndrome

1978 • 159 citations

Detection of Anti-Acetylcholine Receptor Factors in Serum and Thymus from Patients with Myasthenia Gravis

1976 • 155 citations

Characterization of Torpedo californica Acetylcholine Receptor: Its Subunit Composition and Ligand-binding Properties

1976 • 153 citations

Accelerated degradation of acetylcholine receptor from cultured rat myotubes with myasthenia gravis sera and globulins.

1977 • 150 citations

Distinct protein components from Torpedo marmorata membranes carry the acetylcholine receptor site and the binding site for local anesthetics and histrionicotoxin.

1978 • 150 citations

HUMORAL ANTIBODIES TO ACETYLCHOLINE RECEPTOR IN PATIENTS WITH MYASTHENIA GRAVIS

1975 • 148 citations

IN-VITRO SYNTHESIS OF ANTI-ACETYLCHOLINE-RECEPTOR ANTIBODY BY THYMIC LYMPHOCYTES IN MYASTHENIA GRAVIS

1978 • 148 citations

Studies on Purified Eel Acetylcholine Receptor and Anti-Acetylcholine Receptor Antibody

1973 • 148 citations

Facets of the Structures of Acetylcholine Receptors from Electrophorus and Torpedo

1976 • 142 citations

Turnover of junctional and extrajunctional acetylcholine receptors of the rat diaphragm

1975 • 140 citations

Kinetics of biosynthesis of acetylcholine receptor and subsequent incorporation into plasma membrane of cultured chick skeletal muscle

1977 • 140 citations

Immunization of rats with polypeptide chains from torpedo acetylcholine receptor causes an autoimmune response to receptors in rat muscle.

1978 • 140 citations

Antibodies from patients with myasthenia gravis recognize determinants unique to extrajunctional acetylcholine receptors.

1979 • 139 citations

Membranes Rich in Acetylcholine Receptor: Characterization and Reconstitution to Excitable Membranes from Exogenous Lipids

1978 • 132 citations

A morphological study of the cholinergic receptor protein from Torpedo marmorata in its membrane environment and in its detergent-extracted purified form

1978 • 130 citations

Strain differences in the autoimmune response of mice to acetylcholine receptors

1976 • 130 citations

Selectivity of cations and nonelectrolytes for acetylcholine-activated channels in cultured muscle cells.

1978 • 127 citations

Formation of disulfide-linked oligomers of acetylcholine receptor in membrane from Torpedo electric tissue

1979 • 124 citations

Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.

1975 • 122 citations

Conductance of channels opened by acetylcholine-like drugs in muscle end-plate

1975 • 121 citations

Molecular properties of the cholinergic receptor purified from Electrophorus electricus

1973 • 120 citations

Striated muscle fibres differentiate in monolayer cultures of adult thymus reticulum

1975 • 120 citations

Cellular Immunity in Myasthenia Gravis

1976 • 117 citations

Fate of α-Bungarotoxin Bound to Acetylcholine Receptors of Normal and Denervated Muscle

1974 • 116 citations

Ultrastructural Localization of Immune Complexes (IGG and C3) at the End-Plate in Experimental Autoimmune Myasthenia Gravis

1978 • 115 citations

An electrophysiological and morphological study of the neuromuscular junction in patients with myasthenia gravis

1976 • 114 citations

END‐PLATE POTENTIALS IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA GRAVIS IN RATS*

1976 • 114 citations

Immunological characterisation of the cholinergic receptor protein from Electrophorus electricus

1973 • 113 citations

Synaptic transmission and neuronal interaction

1974 • 113 citations

Effect of Myasthenic Immunoglobulin on Acetylcholine Receptors of Intact Mammalian Neuromuscular Junctions

1978 • 110 citations

Experimental autoimmune myasthenia induced in monkeys by purified acetylcholine receptor

1975 • 106 citations

Perhydrohistrionicotoxin: a potential ligand for the ion conductance modulator of the acetylcholine receptor.

1977 • 105 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 101 citations

Some Structural Properties of the Cholinergic Receptor Protein in Its Membrane Environment Relevant to Its Function as a Pharmacological Receptor

1976 • 99 citations

Cellular immune response to acetylcholine receptor-rich fraction, in patients with myasthenia gravis.

1975 • 98 citations

Influence of chronic neostigmine treatment on the number of acetylcholine receptors and the release of acetylcholine from the rat diaphragm

1973 • 97 citations

Acetylcholine receptors at the neuromuscular junction: Developmental change in receptor turnover

1977 • 96 citations

Penicillamine-associated myasthenia gravis, antiacetylcholine receptor and antistriational antibodies

1977 • 96 citations

The Assembly of Cell Membranes

1979 • 95 citations

Specificities of antibodies to acetylcholine receptors

1978 • 95 citations

Experimental Autoimmune Myasthenia Gravis: A Sequential and Quantitative Study of the Neuromuscular Junction Ultrastructure and Electrophysiologic Correlations

1976 • 95 citations

Modulation of acetylcholine receptor in rat diaphragm by anti-receptor sera

1978 • 94 citations

Evidence To Suggest That LATS Protector Stimulates the Human Thyroid Gland

1971 • 94 citations

Passively transferred experimental autoimmune myasthenia gravis

1979 • 93 citations

Immunological comparison of acetylcholine receptors and their subunits from species of electric ray

1977 • 89 citations

Human myasthenic sera reduce acetylcholine sensitivity of human muscle cells in tissue culture

1977 • 87 citations

Interconversion between Different States of Affinity for Acetylcholine of the Cholinergic Receptor Protein from Torpedo marmorata

1975 • 87 citations

Subunit structure of the acetylcholine receptor from denervated rat skeletal muscle

1977 • 86 citations

Corticosteroids

1974 • 83 citations

A radioimmunoassay for the quantitative evaluation of anti-human acetylcholine receptor antibodies in myasthenia gravis.

1977 • 82 citations

The nicotinic cholinergic receptor protein: improved purification method, preliminary amino acid composition and observed auto‐immuno response

1974 • 82 citations

Synthesis of acetylcholine receptor by denervated rat diaphragm muscle.

1975 • 82 citations

A freeze-fracture and lanthanum tracer study of the complex junction between Sertoli cells of the canine testis.

1978 • 81 citations

The Acetylcholine Receptor as Part of a Protein Complex in Receptor-Enriched Membrane Fragments from Torpedo californica Electric Tissue

1978 • 79 citations

Blockade of Acetylcholine Receptors: A Model of Myasthenia Gravis

1975 • 79 citations

Antibody to acetylcholine receptor increases degradation of junctional and extrajunctional receptors in adult muscle

1978 • 78 citations

Fast Kinetic Studies on the Interaction of Cholinergic Agonists with the Membrane-Bound Acetylcholine Receptor from Torpedo marmorata as Revealed by Quinacrine Fluorescence

1977 • 76 citations

Neuromuscular transmission after immunization against acetylcholine receptors

1975 • 76 citations

Placental transmission of thyroid-stimulating immunoglobulins.

1975 • 75 citations

Induction of anti-idiotypic antibodies by immunisation with syngeneic spleen cells educated with acetylcholine receptor

1978 • 75 citations

Direct method for detection and characterization of cell surface receptors for insulin by means of 125I-labeled autoantibodies against the insulin receptor.

1976 • 74 citations

ALTERNATE‐DAY PREDNISONE: PRELIMINARY REPORT OF A DOUBLE‐BLIND CONTROLLED STUDY*

1976 • 72 citations

EFFECTS OF SOME IMMUNOSUPPRESSIVE PROCEDURES ON MYASTHENIA GRAVIS*

1976 • 70 citations

Penicillamine‐induced myasthenia gravis associated with antibodies to acetylcholine receptor

1978 • 70 citations

Skeletal muscle acetylcholine receptor. Purification, characterization, and turnover in muscle cell cultures.

1978 • 67 citations

Purification and Characterization of Acetylcholine Receptor-I from Electrophorus electricus

1974 • 67 citations

Studies on the effect of histrionicotoxin on the monocellular electroplax from Electrophorus electricus and on the binding of (3H)acetylcholine to membrane fragments from Torpedo marmorata.

1976 • 65 citations

Purification of an acetylcholine receptor from a nonfusing muscle cell line

1977 • 65 citations

Effect of myasthenic patients' immunoglobulin on acetylcholine receptor turnover: selectivity of degradation process.

1978 • 62 citations

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

1975 • 59 citations

Immunological studies of acetylcholine receptors

1976 • 58 citations

Antigenic modulation and receptor loss in experimental autoimmune myasthenia gravis

1979 • 56 citations

Plasmapheresis and the Immunobiology of Myasthenia Gravis

1980 • 55 citations

Purification and characterization of an acetylcholine receptor from mammalian skeletal muscle

1977 • 54 citations

Serum Autoantibodies in Myasthenia Gravis and Thymoma: Selective Affinity for I-Bands of Striated Muscle As a Guide to Identification of Antigen(s)

1967 • 53 citations

Histrionicotoxin enhances agonist-induced desensitization of acetylcholine receptor.

1977 • 53 citations

Passive transfer of experimental autoimmune myasthenia by lymph node cells in inbred guinea pigs.

1975 • 51 citations

Immunological characterization of an irreversibly denatured acetylcholine receptor

1977 • 51 citations

EXPERIMENTAL AUTOIMMUNE MYASTHENIA: CLINICAL, NEUROPHYSIOLOGIC, AND PHARMACOLOGIC ASPECTS*

1976 • 50 citations

Acetylcholine-induced channels and transmitter release at human endplates

1978 • 49 citations

Myasthenia Gravis and Acetylcholine Receptor

1975 • 49 citations

Functional acetylcholine receptor--electroplax membrane microsacs (vesicles): purification and characterization.

1977 • 49 citations

Experimental myasthenia in Balb/c mice immunized with rat acetylcholine receptor from rat denervated muscle.

1976 • 48 citations

Binding of antibodies to acetylcholine receptors in Electrophorus and Torpedo electroplax membranes.

1978 • 48 citations

AN IMMUNOLOGICALLY INDUCED DEFECT OF NEUROMUSCULAR TRANSMISSION IN RATS AND RABBITS*

1976 • 47 citations

ANTIBODIES TO ACETYLCHOLINE RECEPTORS IN RABBITS: IMMUNOCHEMICAL AND ELECTROPHYSIOLOGICAL STUDIES*

1976 • 47 citations

Synthesis of acetylcholine receptor during differentiation of cultured embryonic muscle cells.

1975 • 47 citations

The interaction of thyroid‐stimulating antibodies with solubilised human thyrotrophin receptors

1977 • 45 citations

Studies of human myasthenia gravis: electrophysiological and ultrastructural evidence compatible with antibody attachment to acetylcholine receptor complex.

1976 • 44 citations

HLA antigens and myasthenia gravis in Japan

1977 • 44 citations

Anti-acetylcholine-receptor antibody concentrations after thymectomy in patients with myasthenia gravis.

1978 • 42 citations

MYASTHENIA GRAVIS AND MYASTHENIC SYNDROMES TREATED WITH PREDNISONE

1971 • 37 citations

Reduced muscle acetylcholine sensitivity in rats immunised with acetylcholine receptor

1976 • 37 citations

Muscle activity decreases rate of degradation of α-bungarotoxin bound to extrajunctional acetylcholine receptors

1976 • 37 citations

Myasthenia in frogs immunized against cholinergic-receptor protein

1979 • 36 citations

Thyroid-stimulating autoantibody production in vitro

1977 • 35 citations

Acetylcholine in human muscle

1976 • 35 citations

Preparation and immunochemical characterization of a water-soluble acetylcholine receptor fraction from the electric organ tissue of the electric eel

1975 • 35 citations

Stimulation of adenylate cyclase activity in retro-orbital tissue membranes by thyrotropin and an exophthalmogenic factor derived from thyrotropin

1975 • 34 citations

EXPERIMENTAL MYASTHENIA IN RABBITS: BIOCHEMICAL, IMMUNOLOGICAL, ELECTROPHYSIOLOGICAL, AND MORPHOLOGICAL ASPECTS

1976 • 31 citations

LONG‐TERM PREDNISONE FOLLOWED BY THYMECTOMY IN MYASTHENIA GRAVIS

1976 • 30 citations

The biochemistry of myasthenia gravis and muscular dystrophy

1978 • 29 citations

The acetylcholine receptor in normal and pathologic states

1976 • 29 citations

Immunosuppression of Experimental Autoimmune Myasthenia Gravis by Hydrocortisone and Azathioprine

1976 • 28 citations

Acetylcholine-induced conductance fluctuations in cultured human myotubes

1978 • 27 citations

HL-A TYPES IN MYASTHENIA GRAVIS

1973 • 26 citations

Myasthenia gravis: acetylcholine-receptor antibody titres after thymectomy.

1977 • 25 citations

Immunological of the Thyrotropin Receptor

1976 • 25 citations

Drainage of Thoracic Duct Lymph in Twelve Patients with Myasthenia gravis

1975 • 23 citations

Molecular Basis for Postjunctional Conductance Increases Induced by Acetylcholine

1976 • 22 citations

ACETYLCHOLINE RECEPTOR AND MYASTHENIA GRAVIS*

1976 • 22 citations

A CHOLINOCEPTOR ANTISERUM: ITS PHARMACOLOGICAL PROPERTIES

1976 • 17 citations

A MORPHOLOGICAL EXPLANATION OF THE TRANSMISSION DEFECT IN MYASTHENIA GRAVIS*

1971 • 16 citations

ISOLATION AND PROPERTIES OF ACETYLCHOLINE RECEPTORS FROM ELECTROPHORUS AND TORPEDO*

1976 • 16 citations

Cytophilic Antibodies in Experimental Autoimmune Myasthenia Gravis

1977 • 15 citations

Stimulation of Lymphocytes by Cholinergic Receptor in Myasthenia Gravis

1977 • 13 citations

The Immunology of the Insulin Receptor

1976 • 13 citations

Morphological observations on motor end-plates in rabbits with experimental myasthenia

1976 • 12 citations

Acetylcholine release in diaphragm of rats with chronic experimental autoimmune myasthenia gravis

1978 • 8 citations