Functional reassembly of membrane proteins in planar lipid bilayers

Handbook of Sensory Physiology

1975 • 7,212 citations

Single-channel currents recorded from membrane of denervated frog muscle fibres

1976 • 2,456 citations

Formation of Bimolecular Membranes from Lipid Monolayers and a Study of Their Electrical Properties

1972 • 1,746 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Reconstitution of Cell Membrane Structure in vitro and its Transformation into an Excitable System

1962 • 1,380 citations

Handbook of Sensory Physiology

1973 • 1,056 citations

Bacteriorhodopsin: a light-driven proton pump in Halobacterium Halobium

1975 • 994 citations

Voltage clamp analysis of acetylcholine produced end‐plate current fluctuations at frog neuromuscular junction

1973 • 992 citations

Phosphorylated Proteins as Physiological Effectors

1978 • 975 citations

Responses of retinal rods to single photons.

1979 • 971 citations

The statistical nature of the acetylcholine potential and its molecular components

1972 • 960 citations

Bacteriorhodopsin and the purple membrane of halobacteria

1979 • 909 citations

Local anaesthetics transiently block currents through single acetylcholine‐receptor channels.

1978 • 864 citations

Control of acetylcholine receptors in skeletal muscle

1979 • 770 citations

Characterization of the Major Envelope Protein from Escherichia coli

1974 • 743 citations

Rhodopsin content in the outer segment membranes of bovine and frog retinal rods

1974 • 730 citations

Reconstitution of Purple Membrane Vesicles Catalyzing Light-driven Proton Uptake and Adenosine Triphosphate Formation

1974 • 714 citations

A quantitative description of end‐plate currents

1972 • 625 citations

Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist

1980 • 608 citations

Acetylcholine Receptor: Complex of Homologous Subunits

1980 • 594 citations

The Outer Membrane of Gram-negative Bacteria

1980 • 588 citations

A different genetic code in human mitochondria

1979 • 558 citations

Formation of large, ion-permeable membrane channels by the matrix protein (porin) of Escherichia coli

1978 • 515 citations

Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from paramecium mitochondria

1976 • 501 citations

The Visual Process: Excitatory Mechanisms in the Primary Receptor Cells

1972 • 482 citations

The structural basis of the functioning of bacteriorhodopsin: An overview

1979 • 459 citations

A candidate for the permeability pathway of the outer mitochondrial membrane

1979 • 459 citations

Single Na+ channel currents observed in cultured rat muscle cells

1980 • 452 citations

CIS-TRANS ISOMERS OF VITAMIN A AND RETINENE IN THE RHODOPSIN SYSTEM

1952 • 422 citations

Methods in Membrane Biology

1978 • 417 citations

Structural and Functional Properties of the Acetylcholine Receptor Protein in its Purified and Membrane-Bound States

1978 • 399 citations

Molecular Sieving by theBacillus megateriumCell Wall and Protoplast

1971 • 398 citations

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments.

1980 • 391 citations

Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica

1978 • 384 citations

Large‐Scale Purification of the Acetylcholine‐Receptor Protein in Its Membrane‐Bound and Detergent‐Extracted Forms from Torpedo marmorata Electric Organ

1977 • 375 citations

The permeability of the endplate channel to organic cations in frog muscle.

1980 • 362 citations

Identification of the outer membrane protein of E.coli that produces transmembrane channels in reconstituted vesicle membranes

1976 • 362 citations

Light-activated phosphodiesterase of the rod outer segment. Kinetics and parameters of activation and deactivation.

1978 • 353 citations

Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.

1979 • 350 citations

THE PURPLE MEMBRANE FROM HALOBACTERIUM HALOBIUM

1977 • 336 citations

Kinetics of the Photocurrent of Retinal Rods

1972 • 334 citations

The permeability of endplate channels to monovalent and divalent metal cations.

1980 • 333 citations

Calcium Transport in Sarcoplasmic Reticulum

1975 • 328 citations

Outer membrane of Salmonella. Isolation of protein complex that produces transmembrane channels.

1976 • 304 citations

Matrix protein from Escherichia coli outer membranes forms voltage-controlled channels in lipid bilayers.

1978 • 298 citations

Ionic selectivity of pores formed by the matrix protein (porin) of Escherichia coli

1979 • 293 citations

Proton-pumping cytochrome c oxidase

1979 • 280 citations

Purification and properties of the light-activated cyclic nucleotide phosphodiesterase of rod outer segments

1975 • 271 citations

Three-dimensional crystals of an integral membrane protein: an initial x-ray analysis.

1980 • 268 citations

Ion Transport and Respiratory Control in Vesicles Formed from Cytochrome Oxidase and Phospholipids

1972 • 257 citations

Synaptic transmission and neuronal interaction

1975 • 256 citations

A two-subunit cytochrome c oxidase (cytochrome aa3) from Paracoccus dentrificans.

1980 • 254 citations

In Vitro excitation of purified membrane fragments by cholinergic agonists

1971 • 250 citations

Lipid requirements for rhodopsin regenerability

1973 • 250 citations

Dicyclohexylcarbodiimide binds specifically and covalently to cytochrome c oxidase while inhibiting its H+-translocating activity.

1980 • 244 citations

Affinity-labeling of purified acetylcholine receptor from Torpedo californica

1974 • 243 citations

Biochemical properties of acetylcholine receptor subunits from Torpedo californica

1979 • 239 citations

The antagonism between tubocurarine and substances which depolarize the motor end‐plate

1960 • 235 citations

Three-dimensional crystals of membrane proteins: bacteriorhodopsin.

1980 • 234 citations

Reconstruction of the electrical responses of turtle cones to flashes and steps of light

1974 • 233 citations

Direct measurement of electric current generation by cytochrome oxidase, H+-ATPase and bacteriorhodopsin.

1974 • 229 citations

Single channel recordings of K+ currents in squid axons

1980 • 226 citations

Voltage-gated cation conductance channel from fragmented sarcoplasmic reticulum: Steady-state electrical properties

1978 • 226 citations

Voltage-dependent channels in planar lipid bilayer membranes.

1981 • 225 citations

Fusion of phospholipid vesicles with planar phospholipid bilayer membranes. II. Incorporation of a vesicular membrane marker into the planar membrane.

1980 • 225 citations

A new procedure for the reconstitution of biologically active phospholipid vesicles

1973 • 225 citations

The control of phosphodiesterase in rod disk membranes: Kinetics, possible mechanisms and significance for vision

1979 • 224 citations

Cytochrome oxidase.

1969 • 218 citations

Arrangement of cytochrome oxidase molecules in two-dimensional vesicle crystals

1977 • 215 citations

Mitochondrial outer membrane contains a protein producing nonspecific diffusion channels.

1980 • 214 citations

Rhodopsin. Purification and recombination with phospholipids assayed by the metarhodopsin I .far. metarhodopsin II transition

1974 • 214 citations

Vertebrate Photoreception

1979 • 213 citations

Ca++-induced fusion of fragmented sarcoplasmic reticulum with artificial planar bilayers

1976 • 212 citations

A light-activated GTPase in vertebrate photoreceptors: Regulation of light-activated cyclic GMP phosphodiesterase

1977 • 208 citations

Structure of cytochrome c oxidase in deoxycholate-derived two-dimensional crystals

1979 • 208 citations

Assembly of the mitochondrial membrane system. Sequence of the oxi 2 gene of yeast mitochondrial DNA.

1980 • 202 citations

Light-induced calcium release by intact retinal rods.

1980 • 200 citations

Purification of the carbodiimide-reactive protein component of the ATP energy-transducing system of Escherichia coli.

1976 • 197 citations

A voltage-gated anion channel from the electric organ of Torpedo californica.

1979 • 193 citations

Voltage dependence of agonist effectiveness at the frog neuromuscular junction: resolution of a paradox.

1975 • 190 citations

Light-induced calcium fluxes from outer segment layer of vertebrate retinas

1980 • 190 citations

Amplitude, kinetics, and reversibility of a light-induced decrease in guanosine 3',5'-cyclic monophosphate in frog photoreceptor membranes.

1979 • 186 citations

Molecular forms of acetylcholine receptor. Effects of calcium ions and a sulfhydryl reagent on the occurrence of oligomers

1977 • 185 citations

Purification of acetylcholine receptors, reconstitution into lipid vesicles, and study of agonist-induced cation channel regulation.

1980 • 182 citations

Formation of planar bilayers from artificial or native membrane vesicles

1980 • 182 citations

Single glutamate-activated channels in locust muscle

1979 • 182 citations

Visual Transduction in Vertebrate Photoreceptors

1979 • 182 citations

The Light Reaction in the Bleaching of Rhodopsin

1950 • 181 citations

Reconstitution of carbamylcholine-dependent sodium ion flux and desensitization of the acetylcholine receptor from Torpedo californica.

1978 • 176 citations

Generation of end-plate potentials

1976 • 176 citations

Isolation of a chloroplast N,N'-dicyclohexylcarbodiimide-binding proteolipid, active in proton translocation.

1977 • 171 citations

Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times

1980 • 170 citations

Reconstitution of D-glucose transport catalyzed by a protein fraction from human erythrocytes in sonicated liposomes.

1976 • 169 citations

Cation Flux Across Biomembranes

1979 • 168 citations

Limited-turnover studies on proton translocation in reconstituted cytochrome c oxidase-containing vesicles

1979 • 167 citations

Exchange and interactions between lipid layers at the surface of a liposome solution

1979 • 165 citations

An analysis of the dose‐response relationship at voltage‐clamped frog neuromuscular junctions.

1978 • 162 citations

Purified proton conductor in proton translocating adenosine triphosphatase of a thermophilic bacterium.

1977 • 159 citations

Perspectives in Membrane Biology

1974 • 158 citations

The Dicyclohexylcarbodiimide‐Binding Protein of the Mitochondrial ATPase Complex from Neurospora crassa and Saccharomyces cerevisiae

1979 • 158 citations

Electric signals associated with the photocycle of bacteriorhodopsin

1980 • 155 citations

Matrix protein in planar membranes: clusters of channels in a native environment and their functional reassembly.

1981 • 154 citations

Characterization of Torpedo californica Acetylcholine Receptor: Its Subunit Composition and Ligand-binding Properties

1976 • 153 citations

Time resolution of the intermediate steps in the bacteriorhodopsin‐linked electrogenesis

1978 • 152 citations

Functional acetylcholine receptor from Torpedo marmorata in planar membranes.

1980 • 151 citations

Cis-trans isomerization in the photochemistry of vision

1977 • 150 citations

Ultrastructure of a periodic protein layer in the outer membrane of Escherichia coli.

1977 • 148 citations

Energy Conservation in Biological Membranes

1978 • 147 citations

Evidence that cyclic GMP regulates membrane potential in rod photoreceptors

1979 • 144 citations

Photochemical functionality of rhodopsin-phospholipid recombinant membranes

1977 • 142 citations

Identification of the protein producing transmembrane diffusion pores in the outer membrane of Pseudomonas aeruginosa PA01

1979 • 142 citations

Facets of the Structures of Acetylcholine Receptors from Electrophorus and Torpedo

1976 • 142 citations

Reconstitution of purified acetylcholine receptors with functional ion channels in planar lipid bilayers.

1980 • 141 citations

Fusion of phospholipid vesicles with planar phospholipid bilayer membranes. I. Discharge of vesicular contents across the planar membrane.

1980 • 138 citations

Pore size and properties of channels from mitochondria isolated fromNeurospora crassa

1980 • 136 citations

Reconstitution of Biological Molecular generators of electric current. Bacteriorhodopsin.

1976 • 135 citations

Electrical and adaptive properties of rod photoreceptors in Bufo marinus. II. Effects of cyclic nucleotides and prostaglandins.

1977 • 133 citations

Photocurrents generated by bacteriorhodopsin on planar bilayer membranes

1979 • 133 citations

Proton-translocating cytochrome c oxidase in artificial phospholipid vesicles

1978 • 130 citations

Light-induced dephosphorylation of two proteins in frog rod outer segments: influence of cyclic nucleotides and calcium.

1979 • 129 citations

N,N'-dicyclohexylcarbodiimide binds specifically to a single glutamyl residue of the proteolipid subunit of the mitochondrial adenosinetriphosphatases from Neurospora crassa and Saccharomyces cerevisiae.

1980 • 128 citations

THE ROLE OF LONG-RANGE FORCES IN THE COHESION OF LIPOPROTEINS

1962 • 128 citations

Structure and function of H+-ATPase

1979 • 127 citations

Formation of disulfide-linked oligomers of acetylcholine receptor in membrane from Torpedo electric tissue

1979 • 124 citations

Thermodynamic and kinetic studies of the gating behavior of a K+-selective channel from the sarcoplasmic reticulum membrane.

1980 • 124 citations

Incorporation of bacteriorhodopsin into a bilayer lipid membrane; a photoelectric‐spectroscopic study

1976 • 123 citations

Acetylcholine receptor-controlled ion fluxes in membrane vesicles investigated by fast reaction techniques

1979 • 121 citations

Ca++-induced fusion of proteoliposomes: Dependence on transmembrane osmotic gradient

1976 • 115 citations

Synaptic transmission and neuronal interaction

1974 • 113 citations

Interaction of the Acetylcholine (Nicotinic) Receptor Protein from Torpedo marmorata Electric Organ with Monolayers of Pure Lipids

1978 • 109 citations

Proteolipids. I. Formation of Phospholipid-Cytochrome c Complexes

1964 • 107 citations

Spreading of liposomes at the air/water interface

1978 • 106 citations

Light-driven proton translocations in Halobacterium halobium

1976 • 102 citations

Reconstitution of the purified acetylcholine receptor from Torpedo californica

1979 • 102 citations

Structure and function of proteolipids in myelin and non-myelin membranes

1979 • 101 citations

Rhodopsin and the visual process

1977 • 100 citations

Some Structural Properties of the Cholinergic Receptor Protein in Its Membrane Environment Relevant to Its Function as a Pharmacological Receptor

1976 • 99 citations

Structural and spectroscopic characteristics of bacteriorhodopsin in air-water interface films

1977 • 98 citations

Electrical demonstration of rapid light-induced conformational changes in bacteriorhodopsin

1977 • 96 citations

Purple membrane of halobacteria: a new light-energy converter

1980 • 95 citations

Voltage-dependent caesium blockade of a cation channel from fragmented sarcoplasmic reticulum

1979 • 95 citations

Proteolytic nicking of the acetylcholine receptor

1980 • 90 citations

Subunit structure and peptide mapping of junctional and extrajunctional acetylcholine receptors from rat muscle

1979 • 90 citations

Spreading of membranes at the air/water interface

1976 • 88 citations

Additional component required for activity and reconstitution of light-activated vertebrate photoreceptor GTPase.

1980 • 87 citations

The electrical response to light of bacteriorhodopsin in planar membranes

1978 • 87 citations

Reassembly of protein-lipid complexes into large bilayer vesicles: Perspectives for membrane reconstitution

1980 • 86 citations

EXPERIMENTAL MEMBRANES AND MECHANISMS OF BIOENERGY TRANSDUCTIONS

1976 • 84 citations

Energy-transducing H+-ATPase of Escherichia coli. Reconstitution of proton translocation activity of the intrinsic membrane sector.

1980 • 83 citations

Reconstitution of a functional acetylcholine regulator under defined conditions

1979 • 83 citations

Ion selectivity of the cation transport system of isolated intact cattle rod outer segments. Evidence for a direct communication between the rod plasma membrane and the rod disk membranes

1980 • 81 citations

Ion Transport in Membranes: Incorporation of Biological Ion-Translocating Proteins in Model Membrane Systems

1977 • 76 citations

Transmembrane channel formation in rhodopsin-containing bilayer membranes

1977 • 75 citations

Generation of electric current by chromatophores of Rhodospirillum rubrum and reconstitution of electrogenic function in subchromatophore pigment-protein complexes

1976 • 75 citations

Protease effects on the structure of acetylcholine receptor membranes from Torpedo californica.

1980 • 74 citations

Bacteriorhodopsin in model membranes. A new component of the displacement photocurrent in the microsecond time scale

1979 • 71 citations

Functional Equivalence of Monomeric and Dimeric Forms of Purified Acetylcholine Receptors from Torpedo californica in Reconstituted Lipid Vesicles

1980 • 71 citations

Preparation of right-side-out, acetylcholine receptor enriched intact vesicles from Torpedo californica electroplaque membranes

1979 • 67 citations

Proton transport by bacteriorhodopsin through an interface film

1977 • 66 citations

Structural details of membrane-bound acetylcholine receptor from Tropedo marmorata.

1980 • 65 citations

Transient photovoltages in purple membrane multilayers. Charge displacement in bacteriorhodopsin and its photointermediates

1978 • 65 citations

Functional reconstitution of photosynthetic reaction centers in planar lipid bilayers

1979 • 65 citations

Single-phase butanol extraction: A new tool for proteolipid isolation

1977 • 64 citations

Distribution of enzyme activities in subcellular fractions of bovine retina.

1976 • 61 citations

Carbamylcholine-induced rapid cation efflux from reconstituted membrane vesicles containing purified acetylcholine receptor

1979 • 60 citations

The amino‐terminal sequence of the 40 000 molecular weight subunit of the acetylcholine receptor protein from Torpedo marmorata

1979 • 58 citations

Reconstitution de photochemically active reaction centers in planar phospholipid membranes

1980 • 57 citations

Generation of electric potential by reaction center complexes from Rhodospirillum rubrum

1975 • 56 citations

Reconstitution of acetylcholine receptor from Torpedo californica with highly purified phospholipids: Effect of α-tocopherol, phylloquinone, and other terpenoid quinones

1980 • 56 citations

Structure of the cytochrome c oxidase complex: labeling by hydrophilic and hydrophobic protein modifying reagents

1980 • 56 citations

Molecular Aspects of Membrane Phenomena

1975 • 54 citations

Membrane potential generation by two reconstituted mitochondrial systems: Liposomes inlayed with cytochrome oxidase or with ATPase

1972 • 53 citations

Formation of decane‐soluble proteolipids: Influence of monovalent and divalent cations

1972 • 51 citations

THE ROLE OF LONG-RANGE FORCES IN THE COHESION OF LIPOPROTEINS

1962 • 49 citations

Reconstitution of functional membrane-bound acetylcholine receptor from isolated Torpedo californica receptor protein and electroplax lipids.

1980 • 44 citations

The isolation of dicyclohexylcarbodi-imide-binding proteins from mitochondrial membranes

1970 • 44 citations

Rhodopsin in model membranes: charge displacements in interfacial layers.

1977 • 42 citations

Rhodopsin in model membranes

1979 • 42 citations

Two distinct rhodopsin molecules within the disc membrane of vertebrate rod outer segments

1978 • 41 citations

Light-regulated permeability of rhodopsin:egg phosphatidylcholine recombinant membranes.

1977 • 39 citations

LIGHT‐INDUCED CONFORMATIONAL CHANGES IN CATTLE RHODOPSIN AS PROBED BY MEASUREMENTS OF THE INTEFFACE POTENTIAL

1979 • 37 citations

Isolation and Purification of the Nicotinic Acetylcholine Receptor and Its Functional Reconstitution into a Membrane Environment

1977 • 37 citations

Proton transport by bacteriorhodopsin in planar membranes assembled from air-water interface films.

1980 • 37 citations

Reaction center-phospholipid complex in organic solvents: formation and properties

1980 • 36 citations

Spreading of biomembranes at the air/water interface∗∗This work is part of the “these de Docteur-Ingénieur” of F. Pattus, obtained at the Provence University, October 1976.

1978 • 36 citations

Energy transducing mechanisms

1975 • 35 citations

Incorporation of Rhodopsin Proteolipid into Bilayer Membranes

1973 • 34 citations

Rhodopsin-phospholipid complexes in apolar solvents: Formation and properties

1978 • 33 citations

Cation selectivity of acetylcholine-activated ionic channel of frog endplate.

1979 • 33 citations

Thin-proteolipid films: A new approach to the reconstitution of biological membranes

1972 • 32 citations

Rhodopsin-phospholipid complexes in apolar environments: photochemical characterization

1979 • 31 citations

The Visual Process

1973 • 31 citations

Formation, structure, and spectrophotometry of air-water interface films containing rhodopsin

1977 • 31 citations

Notizen: Flash Photolysis of Rhodopsin

1971 • 30 citations

Electron transfer across membranes and energy coupling.

1973 • 30 citations

The Use of Organic Solvents in Membrane Research

1977 • 29 citations

Incorporation of membrane proteins into large single bilayer vesicles. Application to rhodopsin.

1979 • 28 citations

CALCIUM IN EXCITATION OF VERTEBRATE RODS AND CONES: RETINAL EFFLUX OF CALCIUM STUDIED WITH DICHLOROPHOSPHONAZO III

1978 • 28 citations

Crystallization of part of the mitochondrial electron transfer chain: cytochrome c oxidase--cytochrome c complex.

1980 • 27 citations

Light increases the ion and non-electrolyte permeability of rhodopsin-phospholipid vesicles

1977 • 27 citations

Ions in Hydrocarbons

1963 • 24 citations

Proton Pumps in Bacterial Photosynthesis

1977 • 23 citations

LIPID-PROTEIN ASSEMBLY AND THE RECONSTITUTION OF BIOLOGICAL MEMBRANES

1974 • 21 citations

Autocatalytic transport of the peptide antibiotics suzukacillin and alamethicin across lipid membranes

1979 • 20 citations

Effect of light on artificial lipid membranes modified by photoreceptor membrane fragments

1977 • 17 citations

Formation of detergent‐free proteolipids from biological membranes: Application to rhodopsin

1977 • 16 citations

Evaluation of cooperativity for phase transitions in two- and three-dimensional systems

1980 • 13 citations

Ionophores and Ion Transport Across Natural Membranes

1979 • 13 citations

Investigation by focused laser beam scanning of the photoelectric activity of bacteriorhodopsin-containing lipid bilayers

1978 • 12 citations

Purified rhodopsin—phosphatidylcholine complex in hexane: Formation and characterization

1979 • 8 citations

A study of the incorporation of cytochrome oxidase into planar synthetic membranes

1979 • 7 citations

RHODOPSIN AND BACTERIORHODOPSIN IN MODEL MEMBRANES

1978 • 6 citations

A novel concept of membrane reconstitution applied to acetylcholine receptor from Torpedo and matrix protein from escherichia coli

1980 • 6 citations

Rhodopsin in Experimental Membranes: An Approach to Elucidate Its Role in the Process of Phototransduction

1975 • 4 citations

The study of photoconduction of artificial lipid membranes incorporating rhodopsin. The simultaneous changes of membrane conduction and rhodopsin fluorescence

1976 • 4 citations

THE ELECTRICAL RESPONSE OF CEPHALOPOD VISUAL CELL MEMBRANE FRAGMENTS

1980 • 4 citations

RESOLUTION AND RECONSTITUTION OF PROTON TRANSLOCATING ATPASE

1979 • 3 citations

RHODOPSIN IN MODEL MEMBRANES: THE KINETICS OF CHANNEL OPENING AND CLOSING IN RHODOPSIN‐CONTAINING PLANAR LIPID BILAYERS*

1980 • 2 citations

Observation d'un photopotentiel transitoire de la rhodopsine en préparation vésiculaire de membranes de bâtonnets rétiniens.

1979 • 1 citations