Molecular Biology and Transductional Characteristics of 5-HT Receptors

International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin).

1994 • 2,935 citations

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

1995 • 1,264 citations

Aggressive Behavior and Altered Amounts of Brain Serotonin and Norepinephrine in Mice Lacking MAOA

1995 • 1,211 citations

Differential signal transduction by five splice variants of the PACAP receptor

1993 • 1,185 citations

STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS

1994 • 1,070 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

Enhanced Aggressive Behavior in Mice Lacking 5-HT _1B Receptor

1994 • 823 citations

Apolipoprotein E and Alzheimer disease.

1995 • 697 citations

Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor

1988 • 691 citations

A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms

1993 • 682 citations

Molecular biology of 5-HT receptors

1994 • 679 citations

Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family

1989 • 647 citations

Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.

1993 • 607 citations

The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor

1988 • 594 citations

Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

1993 • 588 citations

Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor

1989 • 522 citations

Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase.

1993 • 512 citations

Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

1993 • 510 citations

An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins

1987 • 509 citations

Cloning, functional expression, and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene.

1990 • 444 citations

A Novel Rat Serotonin (5-HT6) Receptor: Molecular Cloning, Localization and Stimulation of cAMP Accumulation

1993 • 407 citations

Structure and functional expression of cloned rat serotonin 5HT-2 receptor.

1988 • 381 citations

Cloning, Characterization, and Chromosomal Localization of a Human 5‐HT₆ Serotonin Receptor

1996 • 370 citations

Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation

1989 • 355 citations

Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain

1989 • 354 citations

The α Subunit of the GTP Binding Protein G _k Opens Atrial Potassium Channels

1987 • 317 citations

Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta.

1992 • 293 citations

Abnormal Fear Response and Aggressive Behavior in Mutant Mice Deficient for α-Calcium-Calmodulin Kinase II

1994 • 292 citations

Alignment of receptor nomenclature with the human genome: classification of 5-HT1B and 5-HT1D receptor subtypes

1996 • 285 citations

Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

1993 • 281 citations

The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

1990 • 280 citations

A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors

1992 • 279 citations

Effector Coupling Mechanisms of the Cloned 5-HT1A Receptor

1989 • 273 citations

Antisense oligonucleotide strategies in neuropharmacology

1994 • 265 citations

The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.

1995 • 246 citations

Molecular cloning of a mammalian serotonin receptor that activates adenylate cyclase.

1993 • 246 citations

A subfamily of 5-HT1D receptor genes

1992 • 230 citations

Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase.

1990 • 228 citations

Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists.

1990 • 227 citations

Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor.

1991 • 225 citations

Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers.

1992 • 221 citations

Molecular cloning and characterization of a rat brain cDNA encoding a 5-hydroxytryptamine1B receptor.

1991 • 216 citations

Behavioural Pharmacology of 5-HT

1990 • 203 citations

cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes.

1987 • 201 citations

Molecular Biology of Serotonin Receptors

1991 • 200 citations

Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization.

1993 • 199 citations

Cloning and functional characterization of the rat stomach fundus serotonin receptor.

1992 • 192 citations

Cloning and Expression of a 5‐Hydroxytryptamine₇ Receptor Positively Coupled to Adenylyl Cyclase

1994 • 185 citations

Molecular cloning, functional expression, and pharmacological characterization of a novel serotonin receptor (5-hydroxytryptamine2F) from rat stomach fundus.

1992 • 181 citations

Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain.

1993 • 179 citations

Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.

1995 • 179 citations

Determination of the role of the 5-ht6 receptor in the rat brain: a study using antisense oligonucleotides.

1995 • 177 citations

Detection of a Novel Serotonin Receptor Subtype (5‐HT_1E) in Human Brain: Interaction with a GTP‐Binding Protein

1989 • 176 citations

The molecular evolution of G protein-coupled receptors: Focus on 5-hydroxytryptamine receptors

1994 • 176 citations

Characterization of the human 5-hydroxytryptamine1B receptor.

1992 • 172 citations

Cloning of the human serotonin 5-HT2 and 5-HT1C receptor subtypes

1991 • 168 citations

The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1D beta receptor.

1992 • 167 citations

The role of conserved aspartate and serine residues in ligand binding and in function of the 5‐HT_1A receptor: A site‐directed mutation study

1992 • 164 citations

The mouse 5HT5 receptor reveals a remarkable heterogeneity within the 5HT1D receptor family.

1992 • 161 citations

Distribution of serotonin 5‐HT_1C receptor mRNA in adult rat brain

1989 • 161 citations

Behavioural Pharmacology of 5-HT

1989 • 158 citations

Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype.

1992 • 153 citations

Cloning and functional characterization of the human 5‐HT_2B serotonin receptor

1994 • 150 citations

Cloning and fnctional expression of an apparent splice variant of the murine 5-HT3 receptor A subunit

1993 • 147 citations

Cloning and characterisation of the human 5‐HT_5A serotonin receptor

1994 • 129 citations

Identification of a single amino acid residue responsible for the binding of a class of beta-adrenergic receptor antagonists to 5-hydroxytryptamine1A receptors.

1992 • 127 citations

New players in the 5-HT receptor field: genes and knockouts

1995 • 126 citations

Recent advances in the electrophysiological characterization of 5-HT3 receptors

1992 • 123 citations

New mouse 5‐HT2‐like receptor Expression in brain, heart and intestine

1992 • 123 citations

Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.

1992 • 122 citations

Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes.

1994 • 119 citations

Central serotonin1A receptors: Respective distributions of encoding mRNA, receptor protein and binding sites by in situ hybridization histochemistry, radioimmunohistochemistry and autoradiographic mapping in the rat brain

1991 • 115 citations

A single point mutation (Phe340-->Leu340) of a conserved phenylalanine abolishes 4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]mesulergine but not [3H]ketanserin binding to 5-hydroxytryptamine2 receptors.

1993 • 113 citations

Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.

1993 • 110 citations

Isolation of a mouse “5HT1E-like” serotonin receptor expressed predominantly in hippocampus.

1992 • 108 citations

Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: Structural and pharmacological comparison of the two cloned receptors

1992 • 106 citations

Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes.

1992 • 105 citations

Functional properties of a cloned 5‐hydroxytryptamine ionotropic receptor subunit: comparison with native mouse receptors.

1994 • 101 citations

Species variations in transmembrane region V of the 5-hydroxytryptamine type 2A receptor alter the structure-activity relationship of certain ergolines and tryptamines.

1994 • 100 citations

A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6.

1992 • 95 citations

Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.

1993 • 93 citations

Identification of residues important for ligand binding to the human 5-hydroxytryptamine1A serotonin receptor.

1993 • 90 citations

A Single Amino Acid Difference Accounts for the Pharmacological Distinctions Between the Rat and Human 5‐Hydroxytryptamine_1B Receptors

1993 • 89 citations

Site‐directed mutagenesis of a single residue changes the binding properties of the serotonin 5‐HT₂ receptor from a human to a rat pharmacology

1992 • 88 citations

Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors.

1994 • 88 citations

A Novel Rat Serotonin Receptor: Primary Structure, Pharmacology, and Expression Pattern in Distinct Brain Regions

1993 • 85 citations

Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor.

1992 • 81 citations

Conversion of the human 5-HT1Dβ serotonin receptor to the rat 5-HT1b ligand-binding phenotype by Thr355 ASN site directed mutagenesis

1992 • 78 citations

Activity of serotonin (5-HT) receptor agonists, partial agonists and antagonists at cloned human 5-HT1a receptors that are negatively coupled to adenylate cyclase in permanently transfected hela cells

1993 • 78 citations

4-[125I]iodo-(2,5-dimethoxy)phenylisopropylamine and [3H]ketanserin labeling of 5-hydroxytryptamine2 (5HT2) receptors in mammalian cells transfected with a rat 5HT2 cDNA: evidence for multiple states and not multiple 5HT2 receptor subtypes.

1990 • 76 citations

Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype.

1992 • 75 citations

Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter

1994 • 75 citations

Cloning and characterization of the rat 5‐HT_5Breceptor

1993 • 75 citations

[3H]-DOB(4-bromo-2,5-dimethoxyphenylisopropylamine) and [3H] ketanserin label two affinity states of the cloned human 5-hydroxytryptamine2 receptor.

1990 • 74 citations

Receptor reserve masks partial agonist activity of drugs in a cloned rat 5-hydroxytryptamine1B receptor expression system.

1993 • 73 citations

Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase

1992 • 72 citations

Structure of the mouse 5-HT 1c 5-HT 2 and stomach fundus serotonin receptor genes

1992 • 72 citations

The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked

1991 • 70 citations

Cell-specific coupling of the cloned human 5-HT1F receptor to multiple signal transduction pathways

1993 • 65 citations

Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s).

1993 • 63 citations

Genomic organization of adrenergic and serotonin receptors in the mouse: Linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution

1991 • 63 citations

5-Hydroxytryptamine1A receptor synthetic peptides. Mechanisms of adenylyl cyclase inhibition

1994 • 62 citations

Expression and pharmacological characterization of a canine 5-hydroxytryptamine1D receptor subtype.

1991 • 59 citations

5-HT1 receptors mediating contraction in bovine cerebral arteries: a model for human cerebrovascular ‘5-HT1Dβ‘ receptors

1993 • 59 citations

Heterologously expressed serotonin 1A receptors couple to muscarinic K+ channels in heart.

1991 • 59 citations

Genomic organization, coding sequence and functional expression of human 5-HT2 and 5-HT1A receptor genes

1992 • 57 citations

Characterization of the human 5-HT2A receptor gene promoter

1995 • 56 citations

A single point mutation increases the affinity of serotonin 5-HT1Dα, 5-HT1Dβ, 5-HT1E and 5-HT1F receptors for β-adrenergic antagonists

1994 • 55 citations

Developmental Changes in the Differential Expression of Two Serotonin 5‐HT₃ Receptor Splice Variants in the Rat

1995 • 55 citations

The Human 5-HT1A Receptor Expressed in HeLa Cells Stimulates Sodium-dependent Phosphate Uptake via Protein Kinase C

1989 • 54 citations

Genomic organisation and functional expression of the gene encoding the human serotonin 5-HT2C receptor

1994 • 49 citations

The orphan receptor cDNA RDC4 encodes a 5-HT1D serotonin receptor

1991 • 49 citations

Pharmacological characterization of the apparent splice variants of the murine 5-HT3 R-A subunit expressed in Xenopus laevis oocytes

1994 • 49 citations

Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors.

1994 • 45 citations

Structure functional expression and spatial distribution of a cloned cDNA encoding a rat 5-HT_1D-likeReceptor

1993 • 42 citations

Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence

1995 • 41 citations

Cloning, Functional Expression and Role in Cell Growth Regulation of a Hamster 5-HT2 Receptor Subtype

1991 • 38 citations

Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype.

1992 • 33 citations

5-HT1-like receptors: six down and still counting

1993 • 30 citations

The cloned human 5-HT1E receptor couples to inhibition and activation of adenylyl cyclase via two distinct pathways in transfected BS-C-1 cells

1994 • 28 citations

Effects of tryptophan and serotonin uptake inhibitors on behavior in male transgenic transforming growth factor α mice

1993 • 27 citations

The human serotonin 5-hydroxytryptamine1D receptor pseudogene is transcribed

1995 • 26 citations

Agonist-induced down-regulation of human 5-HT1A and 5-HT2 receptors in Swiss 3T3 cells

1993 • 26 citations

Human S31 serotonin receptor clone encodes a 5-hydroxytryptamine1E-like serotonin receptor.

1993 • 22 citations

Binding properties of the naturally occurring human 5-HT1A receptor variant with the Ile28Val substitution in the extracellular domain

1995 • 21 citations

The cloning and expression of an OK cell cDNA encoding a 5-hydroxytryptamine1B receptor.

1994 • 21 citations

Allosteric Interactions Among Agonists and Antagonists at 5‐Hydroxytryptamine₃ Receptors

1995 • 19 citations

An Alu sequence interupts a human 5-hydroxytryptamine1D receptor pseudogene

1993 • 18 citations

The runaway brain

1993 • 17 citations

Effect of cocaine on the 5-HT3 receptor-mediated ion current inXenopus oocytes

1995 • 15 citations

Regulation of rat 5-hydroxytryptamine type 2 receptor gene activity: identification of cis elements that mediate basal and 5-hydroxytryptamine-dependent gene activation.

1995 • 15 citations

5-HT4, 5-HT6, 5-HT7; molecular pharmacology of adenylate cyclase stimulating receptors

1995 • 9 citations

Cloning, sequencing and phylogenetic analysis of a human 5-hydroxytryptamine1D receptor pseudogene

1993 • 6 citations