Infection Genomics:Nramp1as a Major Determinant of Natural Resistance to Intracellular Infections

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

1996 • 1,174 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

1996 • 869 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Tuberculosis in twins: a re-analysis of the Prophit survey.

1978 • 441 citations

Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

1997 • 438 citations

Racial Differences in Susceptibility to Infection byMycobacterium tuberculosis

1990 • 407 citations

Genetic regulation of resistance to intracellular pathogens

1982 • 382 citations

Nramp defines a family of membrane proteins.

1995 • 355 citations

Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide.

1993 • 352 citations

Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice.

1981 • 343 citations

A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

1996 • 330 citations

Salmonella induces the formation of filamentous structures containing lysosomal membrane glycoproteins in epithelial cells.

1993 • 309 citations

Identification and characterization of a second mouse Nramp gene

1995 • 289 citations

Immunocytochemical characterization of the endocytic and phagolysosomal compartments in peritoneal macrophages.

1992 • 277 citations

Haplotype Mapping and Sequence Analysis of the Mouse Nramp Gene Predict Susceptibility to Infection with Intracellular Parasites

1994 • 261 citations

Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro.

1983 • 257 citations

Targeting of Salmonella typhimurium to vesicles containing lysosomal membrane glycoproteins bypasses compartments with mannose 6-phosphate receptors.

1995 • 256 citations

Biogenesis of phagolysosomes: the 'kiss and run' hypothesis

1995 • 252 citations

Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression.

1994 • 247 citations

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

1996 • 235 citations

Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene.

1995 • 174 citations

Genetic susceptibility to leishmanial infections: studies in mice and man

1996 • 170 citations

Structural conservation of ion conduction pathways in K channels and glutamate receptors.

1995 • 158 citations

Genomic Organization and Sequence of the Human NRAMP Gene: Identification and Mapping of a Promoter Region Polymorphism

1995 • 149 citations

Expression of the natural resistance gene Lsh in resident liver macrophages

1984 • 146 citations

Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade island.

1988 • 142 citations

Fusion of newly formed phagosomes with endosomes in intact cells and in a cell-free system.

1991 • 141 citations

Genetics and Resistance to Tuberculosis

1992 • 139 citations

Genetic control of host resistance to infection

1994 • 133 citations

The varied lifestyles of intracellular pathogens within eukaryotic vacuolar compartments

1995 • 133 citations

Phenotypic expression of genetically-controlled natural resistance to Mycobacterium bovis (BCG).

1984 • 128 citations

Resistance to intracellular infections: comparative genomic analysis of Nramp

1996 • 128 citations

Evidence for retrograde traffic between terminal lysosomes and the prelysosomal/late endosome compartment

1994 • 117 citations

Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG).

1983 • 116 citations

Cloning and characterization of a second human NRAMP gene on chromosome 12q13

1995 • 114 citations

Implication of phagosome-lysosome fusion in restriction of Mycobacterium avium growth in bone marrow macrophages from genetically resistant mice

1993 • 112 citations

Topology of the hydrophobic membrane-bound components of the histidine periplasmic permease. Comparison with other members of the family.

1992 • 110 citations

NH2-terminal sequence of macrophage-expressed natural resistance-associated macrophage protein (Nramp) encodes a proline/serine-rich putative Src homology 3-binding domain.

1994 • 93 citations

Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35.

1996 • 90 citations

Expression of the human NRAMP1 gene in professional primary phagocytes: studies in blood cells and in HL-60 promyelocytic leukemia

1997 • 85 citations

Complex segregation analysis of leprosy in Southern Vietnam

1995 • 80 citations

Immunogenetics in the analysis of resistance to intracellular pathogens

1995 • 75 citations

Genetic regulation of macrophage priming/activation: the Lsh gene story

1991 • 74 citations

Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein.

1992 • 73 citations

Genetics of infectious disease resistance

1996 • 69 citations

Regulation of host resistance toMycobacterium intracellulare in vivo and in vitro by theBcg gene

1989 • 69 citations

Endotoxins in the blood and cerebrospinal fluid of patients with African sleeping sickness

1996 • 63 citations

High-Resolution Linkage Map in the Vicinity of the Host Resistance Locus Bcg

1993 • 63 citations

Genetic control of innate resistance to mycobacterial infections

1991 • 63 citations

Genetic and Physical Mapping of 2q35 in the Region of the NRAMP and IL8R Genes: Identification of a Polymorphic Repeat in Exon 2 of NRAMP

1994 • 57 citations

An RFLP map for 2q33‐q37 from multicase mycobacterial and leishmanial disease families: no evidence for an Lsh/Ity/Bcg gene homologue influencing susceptibility to leprosy

1993 • 53 citations

Host genetics and infectious disease.

1996 • 52 citations

Role of mononuclear phagocytes in expression of resistance and susceptibility to Mycobacterium avium infections in mice

1986 • 51 citations

Killing of Mycobacterium smegmatis by Macrophages From Genetically Susceptible and Resistant Mice

1990 • 49 citations

Identification of a highly polymorphic length variant in the 3'UTR of NRAMP1

1995 • 43 citations

Physical Delineation of the Minimal Chromosomal Segment Encompassing the Murine Host Resistance Locus Bcg

1993 • 41 citations

Macrophage-Listeria interactions.

1994 • 38 citations

Host genetics and infectious disease

1996 • 34 citations

No evidence for linkage between leprosy susceptibility and the human natural resistance-associated macrophage protein 1 (NRAMP1) gene in French Polynesia.

1997 • 29 citations

Genetics of Leprosy

1991 • 29 citations

Identification of C to T mutation at position −236 bp in the humanNRAMP1 gene promoter

1996 • 25 citations

Genetic control of susceptibility to leprosy in French Polynesia; no evidence for linkage with markers on telomeric human chromosome 2.

1994 • 22 citations

The discovery of the immunological function of the thymus

1991 • 16 citations

Cloning of Entamoeba genes encoding proteolipids of putative vacuolar proton-translocating ATPases

1994 • 15 citations

Identification of C to T mutation at position ?236 bp in the human NRAMP1 gene promoter

1996 • 4 citations