Retinoic acid negatively regulates p34cdc2 expression during human neuroblastoma differentiation.

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

1983 • 1,407 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase

1990 • 783 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

1988 • 535 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompanies activation during entry into mitosis

1989 • 453 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Driving the cell cycle: M phase kinase, its partners, and substrates

1990 • 404 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

Cytogenetic features of human neuroblastomas and cell lines.

1981 • 386 citations

Retinoic Acid-Induced Growth Inhibition and Morphologic Differentiation of Human Neuroblastoma Cells In Vitro<xref ref-type="fn" rid="fn2">2</xref>

1982 • 384 citations

Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts

1990 • 367 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

Cloning of Complementary DNA for GAP-43, a Neuronal Growth-Related Protein

1987 • 351 citations

Cis-Trans Models for Post-Transcriptional Gene Regulation

1989 • 322 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

1990 • 222 citations

cdc2 Gene Expression at the G ₁ to S Transition in Human T Lymphocytes

1990 • 220 citations

Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein

1988 • 189 citations

Constitutive uncoupling of pathways of gene expression that control growth and differentiation in myeloid leukemia: a model for the origin and progression of malignancy.

1980 • 189 citations

Characterization of Human Neuroblastoma Cell Lines Established Before and After Therapy<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1986 • 172 citations

Differential Phosphorylation of c-Abl in Cell Cycle Determined by cdc 2 Kinase and Phosphatase Activity

1990 • 157 citations

Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.

1990 • 149 citations

Cell cycle arrest caused by CLN gene deficiency in Saccharomyces cerevisiae resembles START-I arrest and is independent of the mating-pheromone signalling pathway.

1990 • 144 citations

The p53 nuclear localisation signal is structurally linked to a p34cdc2 kinase motif.

1990 • 135 citations

How are substrates recognized by the ubiquitin-mediated proteolytic system

1989 • 125 citations

Frequent loss of heterozygosity on chromosome 14q in neuroblastoma.

1989 • 119 citations

Structure and developmental expression of the chicken CDC2 kinase.

1989 • 103 citations

In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase

1989 • 98 citations

Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle.

1990 • 94 citations

Regulation of c-myb expression in human neuroblastoma cells during retinoic acid-induced differentiation.

1988 • 89 citations

The expression of multiple proto-oncogenes is differentially regulated during retinoic acid induced maturation of human neuroblastoma cell lines.

1988 • 58 citations

Synthesis of p34, the mammalian homolog of the yeast cdc2+/CDC28 protein kinase, is stimulated during adenovirus-induced proliferation of primary baby rat kidney cells.

1988 • 54 citations

Microinjection of a Conserved Peptide Sequence of p34 ^cdc2 Induces a Ca ²⁺ Transient in Oocytes

1990 • 37 citations

Intracellular localisation and expression of mammalian CDC2 protein during myogenic differentiation

1989 • 33 citations

Loss of heterozygosity for alleles on chromosomes 11q and 14q in neuroblastoma.

1991 • 26 citations

Importance of Clinical Exposure on Verapamil Enhancement of Adriamycin-Vincristine Cytotoxicity in Human Neuroblastoma

1984 • 19 citations