Nuclear receptors for retinoids: mediators of retinoid effects on normal and malignant cells

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia

1988 • 2,380 citations

A human retinoic acid receptor which belongs to the family of nuclear receptors

1987 • 2,245 citations

Identification of a receptor for the morphogen retinoic acid

1987 • 2,007 citations

Nuclear receptor that identifies a novel retinoic acid response pathway

1990 • 1,529 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 • 1,349 citations

All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical results [see comments]

1990 • 1,224 citations

Effects of vitamin A and its analogs (retinoids) on normal and neoplastic cells

1980 • 1,094 citations

Nuclear receptors enhance our understanding of transcription regulation

1988 • 1,062 citations

Identification of a second human retinoic acid receptor

1988 • 1,049 citations

Identification of a retinoic acid responsive element in the retinoic acid receptor & beta;gene

1990 • 1,018 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Cloning of murine α and β retinoic acid receptors and a novel receptor γ predominantly expressed in skin

1989 • 804 citations

Cellular Biology and Biochemistry of the Retinoids

1984 • 730 citations

A third human retinoic acid receptor, hRAR-gamma.

1989 • 686 citations

Molecular Analysis of Acute Promyelocytic Leukemia Breakpoint Cluster Region on Chromosome 17

1990 • 650 citations

Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma

1985 • 644 citations

A new retinoic acid receptor identified from a hepatocellular carcinoma

1988 • 613 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Retinoic acid and thyroid hormone induce gene expression through a common responsive element

1988 • 586 citations

Expression of cellular homologues of retroviral onc genes in human hematopoietic cells.

1982 • 570 citations

Jun-Fos and receptors for vitamins A and D recognize a common response element in the human osteocalcin gene

1990 • 522 citations

Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer

1989 • 508 citations

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung.

1987 • 487 citations

Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene.

1990 • 487 citations

Differential expression of genes encoding α, β and γ retinoic acid receptors and CRABP in the developing limbs of the mouse

1989 • 482 citations

MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model

1990 • 428 citations

Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor

1990 • 403 citations

Differential expression and ligand regulation of the retinoic acid receptor alpha and beta genes.

1989 • 403 citations

Deletion of a DNA sequence at the chromosomal region 3p21 in all major types of lung cancer

1987 • 396 citations

All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship

1990 • 390 citations

Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product

1989 • 387 citations

Negative regulation of the rat stromelysin gene promoter by retinoic acid is mediated by an AP1 binding site.

1990 • 377 citations

Retinoids as preventive and therapeutic anticancer agents (Part I).

1987 • 361 citations

Specific spatial and temporal distribution of retinoic acid receptor gamma transcripts during mouse embryogenesis

1990 • 351 citations

Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).

1990 • 330 citations

Carcinogenesis: A superfamily of potentially oncogenic hormone receptors

1986 • 324 citations

A retinoic acid-responsive element is present in the 5' flanking region of the laminin B1 gene.

1989 • 314 citations

Dual regulatory role for thyroid-hormone receptors allows control of retinoic-acid receptor activity

1989 • 308 citations

Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

1990 • 304 citations

A Domain Containing Leucine-Zipper-Like Motifs Mediate Novelin VivoInteractions between the Thyroid Hormone and Retinoic Acid Receptors

1989 • 293 citations

A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma

1987 • 282 citations

Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers.

1989 • 260 citations

Retinoids, homeobox genes, and limb morphogenesis

1989 • 242 citations

Retinoic acid regulates growth hormone gene expression

1989 • 240 citations

A Retinoic Acid Receptor-Specific Element Controls the Retinoic Acid Receptor-β Promoter

1990 • 235 citations

Molecular cloning of gene sequences transcriptionally regulated by retinoic acid and dibutyryl cyclic AMP in cultured mouse teratocarcinoma cells

1985 • 215 citations

Multiple cell type-specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor

1990 • 211 citations

Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells.

1989 • 186 citations

Molecular cloning of the avian erythroblastosis virus genome and recovery of oncogenic virus by transfection of chicken cells

1980 • 184 citations

Chemistry and Biology of Synthetic Retinoids

2018 • 182 citations

Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells.

1990 • 173 citations

Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.

1990 • 162 citations

Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation.

1988 • 156 citations

Identification of a novel retinoic acid receptor in regenerative tissues of the newt

1989 • 155 citations

Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression

1990 • 139 citations

A dominant negative mutation of the alpha retinoic acid receptor gene in a retinoic acid-nonresponsive embryonal carcinoma cell.

1990 • 134 citations

The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages.

1988 • 128 citations

Retinoic acid rapidly reduces cartilage matrix synthesis by altering gene transcription in chondrocytes

1987 • 120 citations

Ectopic expression of c-jun leads to differentiation of P19 embryonal carcinoma cells.

1990 • 111 citations

Expression of a retinoic acid receptor gene in myeloid leukemia cells.

1989 • 107 citations

Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.

1989 • 100 citations

A Functional Retinoic Acid Receptor Encoded by the Gene on Human Chromosome 12

1990 • 99 citations

Nuclear receptors for retinoic acid and thyroid hormone regulate transcription of keratin genes.

1990 • 96 citations

Regulation of Epidermal Growth Factor Receptor Gene Expression by Retinoic Acid and Epidermal Growth Factor

1989 • 89 citations

Expression of retinoic acid receptor genes and the ligand-binding selectivity of retinoic acid receptors (RAR'S)

1990 • 84 citations

Retinoid-sensitive cells and cell lines

1990 • 80 citations

Retinoic acid receptor expression vector inhibits differentiation of F9 embryonal carcinoma cells.

1989 • 79 citations

Retinoic acid, dibutyryl-cAMP, and differentiation affect the expression of retinoic acid receptors in F9 cells.

1990 • 78 citations

The Regulation of Retinoic Acid Receptor mRNA Levels during Spermatogenesis

1990 • 76 citations

Differential expression of the homeobox gene Hox-1.3 in F9 embryonal carcinoma cells.

1988 • 72 citations

Prevention of alloimmunization against platelets [editorial]

1991 • 72 citations

Mapping of a retinoic acid-responsive element in the promoter region of the complement factor H gene

1990 • 72 citations

Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-α)

1990 • 70 citations

Regulation of Epidermal Growth Factor Receptor Gene Expression

1989 • 67 citations

Expression of retinoic acid receptor alpha mRNA in human leukemia cells

1989 • 65 citations

Opposing Influences of Glucocorticoid and Retinoic Acid on Transcriptional Control in Preosteoblasts

1989 • 65 citations

Modulation by Retinoids of mRNA Levels for Nuclear Retinoic Acid Receptors in Murine Melanoma Cells

1990 • 61 citations

Biological Activity of Retinoids Correlates with Affinity for Nuclear Receptors but Not for Cytosolic Binding Protein

1988 • 58 citations

Induction of phosphoenolpyruvate carboxykinase gene expression by retinoic acid in an adult rat hepatocyte line

1990 • 52 citations

Structure and inducible regulation of the human c-erb B2/neu promoter.

1990 • 51 citations

The Retinoic Acid Receptors α and β are Expressed in the Human Promyelocytic Leukemia Cell Line HL-60

1989 • 50 citations

Expression of retinoic acid receptor-alpha mRNA in human leukemia cells with variable responsiveness to retinoic acid.

1989 • 49 citations

Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene.

1990 • 44 citations

Differential expression of the α and β retinoic acid receptors in tissues of the rat

1989 • 43 citations

Structure and function of nuclear hormone receptors.

1990 • 36 citations

Retinoic acid receptors in myeloid leukemia: characterization of receptors in retinoic acid-resistant K-562 cells

1991 • 34 citations

Retinoic acid regulation of the expression of retinoic acid receptors in wild‐type and mutant embryonal carcinoma cells

1989 • 30 citations

Expression of nuclear retinoic acid receptors in wild-type and mutant embryonal carcinoma PCC4.aza1R cells.

1990 • 19 citations

Transcriptional activation of Gs alpha expression by retinoic acid and parathyroid hormone-related protein in F9 teratocarcinoma cells

1990 • 19 citations