Effect of advanced glycation endproducts on cell cycle and their relevance for Alzheimer’s disease

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

1997 • 803 citations

The Pathogenesis of Senile Plaques

1997 • 717 citations

Pharmacology of methylglyoxal: formation, modification of proteins and nucleic acids, and enzymatic detoxification-A role in pathogenesis and antiproliferative chemotherapy

1996 • 579 citations

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis.

1998 • 505 citations

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

1997 • 416 citations

Advanced glycation end products increase retinal vascular endothelial growth factor expression.

1998 • 413 citations

Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor

1994 • 317 citations

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1998 • 292 citations

Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins

1997 • 283 citations

Cyclin-dependent kinases as a therapeutic target for stroke

2000 • 276 citations

Advanced Glycation End Products-driven Angiogenesis in Vitro

1997 • 272 citations

Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimerʼs disease

1996 • 244 citations

Involvement of Cell Cycle Elements, Cyclin-dependent Kinases, pRb, and E2F·DP, in B-amyloid-induced Neuronal Death

1999 • 242 citations

Redox metals and neu rodegenerative disease

1999 • 218 citations

Crosslinking of α-synuclein by advanced glycation endproducts — an early pathophysiological step in Lewy body formation?

2000 • 215 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

Induction of cytokines in glial cells surrounding cortical β‐amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology

2000 • 198 citations

High molecular weight hyaluronic acid inhibits advanced glycation endproduct‐induced NF‐κB activation and cytokine expression

1999 • 195 citations

Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of β-amyloid peptide

1997 • 171 citations

Presenilins: Genes for Life and Death

1997 • 149 citations

Aging, Metabolism, and Alzheimer Disease: Review and Hypotheses

1997 • 146 citations

CELLULAR AND MOLECULAR BIOLOGY OF ALZHEIMER'S DISEASE AND ANIMAL MODELS

1994 • 130 citations

Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's disease

1996 • 119 citations

AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?

2001 • 117 citations

Transition metal‐mediated glycoxidation accelerates cross‐linking of β‐amyloid peptide

2000 • 109 citations

Interaction of Alzheimer β-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-α

1997 • 109 citations

τ Protein from Alzheimer's Disease Patients Is Glycated at Its Tubulin‐Binding Domain

1995 • 107 citations

Elevated expression of p21ras is an early event in Alzheimer's disease and precedes neurofibrillary degeneration

1999 • 94 citations

Induction of p21ras in Alzheimer pathology

1995 • 79 citations

Advanced glycation endproducts stimulate the MAP‐kinase pathway in tubulus cell line LLC‐PK₁

1997 • 77 citations

Advanced Glycation Endproducts Stimulate Mitogen-Activated Protein Kinase and Proliferation in Rabbit Vascular Smooth Muscle Cells

1997 • 64 citations

Growth modulation of retinal microvascular cells by early and advanced glycation products

1997 • 35 citations

Advanced glycation end product-induced proliferation in NRK-49F cells is dependent on the JAK2/STAT5 pathway and cyclin D1

2001 • 32 citations

Differential expression of advanced glycosylation end-products in neurons of different species

1994 • 31 citations

Tau glycation is involved in aggregation of the protein but not in the formation of filaments.

1998 • 25 citations

110th Conference of the Gesellschaft für Biologische Chemie. Autumn Meeting of the Study Group Neurochemistry

1993 • 7 citations

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