Isolation and characterization of a Chinese hamster ovary cell line resistant to bifunctional nitrogen mustards.

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Cell Surface P-Glycoprotein Associated with Multidrug Resistance in Mammalian Cell Lines

1983 • 1,001 citations

Metallothioneins: Proteins in search of function

1985 • 445 citations

Circumvention of vincristine and Adriamycin resistance in vitro and in vivo by calcium influx blockers.

1983 • 384 citations

Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.

1985 • 330 citations

Amplification of the metallothionein-I gene in cadmium-resistant mouse cells.

1981 • 314 citations

Interstrand cross-linking of DNA by difunctional alkylating agents

1967 • 278 citations

Daunorubicin-resistant Chinese hamster ovary cells expressing multidrug resistance and a cell-surface P-glycoprotein.

1983 • 201 citations

DNA-mediated transfer of multiple drug resistance and plasma membrane glycoprotein expression.

1982 • 201 citations

Multidrug-resistance phenotype in Chinese hamster ovary cells.

1983 • 194 citations

Increased glutathione-S-transferase activity in a cell line with acquired resistance to nitrogen mustards.

1985 • 165 citations

Dechlorination of l-phenylalanine mustard by sensitive and resistant tumor cells and its relationship to intracellular glutathione content

1983 • 154 citations

Alkylating agent resistance: in vitro studies with human cell lines.

1985 • 137 citations

Patterns of Resistance and Therapeutic Synergism among Alkylating Agents1

2015 • 133 citations

Increased synthesis of glutathione S-transferases in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA.

1983 • 124 citations

Reversal of acquired resistance to vinca alkaloids and anthracycline antibiotics.

1983 • 116 citations

Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant L1210 and cross-linking agent-resistant P388 cell lines.

1985 • 84 citations

Plasma cell myeloma: response of melphalan-resistant patients to high-dose intermittent cyclophosphamide.

1972 • 82 citations

The lethal action of monofunctional and bifunctional alkylating agents on T7 coliphage

1969 • 66 citations

Crosslinking of DNA by busulfan Formation of diguanyl derivatives

1980 • 66 citations

USE OF HIGH DOSE CIS‐DICHLORODIAMMINE PLATINUM (II) (NSC—119875)^† FOLLOWING FAILURE ON PREVIOUS CHEMOTHERAPY FOR ADVANCED CARCINOMA OF THE OVARY

1981 • 64 citations

Isolation and characterization of Chinese hamster ovary cell lines sensitive to mitomycin C and bleomycin.

1985 • 56 citations

Differential cytotoxicity and DNA cross-linking in normal and transformed human fibroblasts treated with cis-diamminedichloroplatinum(II).

1981 • 50 citations

Carbamoylation of glutathione reductase and changes in cellular and chromosome morphology in a rat cell line resistant to nitrogen mustards but collaterally sensitive to nitrosoureas.

1985 • 45 citations

Investigation of resistance to DNA cross-linking agents in 9L cell lines with different sensitivities to chloroethylnitrosoureas.

1985 • 38 citations

RANDOMISED TRIAL COMPARING LOW-DOSE CISPLATIN AND CHLORAMBUCIL WITH LOW-DOSE CISPLATIN, CHLORAMBUCIL, AND DOXORUBICIN IN ADVANCED OVARIAN CARCINOMA

1981 • 35 citations

Three years' experience with Ch1VPP (a combination of drugs of low toxicity) for the treatment of Hodgkin's disease

1979 • 34 citations

A phase III trial comparing prednimustine (LEO 1031) to chlorambucil plus prednisolone in advanced breast cancer

1983 • 32 citations

Structures of modified nucleotides isolated from calf thymus DNA alkylated with reductively activated mitomycin C

1982 • 29 citations

Dependence on treatment time of melphalan resistance and DNA cross-linking in human melanoma cell lines.

1984 • 28 citations

Zinc-induced resistance to alkylating agent toxicity.

1982 • 28 citations

Alterations in adenosine 3′,5′-monophosphate-binding protein in Walker carcinoma cells sensitive or resistant to alkylating agents

1976 • 27 citations

Adriamycin uptake, intracellular binding and cytotoxicity in Chinese hamster ovary cells

1985 • 26 citations

Collateral sensitivity to cross-linking agents exhibited by cultured L1210 cells resistant to oxazaphosphorines.

1985 • 25 citations

Selective cytotoxicity of haloethylnitrosoureas in a carcinoma cell line resistant to bifunctional nitrogen mustards.

1982 • 23 citations

Differential response of cultured human normal and tumor cells to trace element-induced resistance to the alkylating agent melphalan.

1985 • 18 citations

Studies on the Cytotoxicity of Myleran and Dimethyl Myleran

1972 • 9 citations