Heme oxygenase structure and mechanism

The Metabolic and Molecular Bases of Inherited Disease

1995 • 12,086 citations

Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Cytochrome P-450: Structure, Mechanism, and Biochemistry

1986 • 2,703 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

Porphyrins and metalloporphyrins

1976 • 1,942 citations

The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

1968 • 1,767 citations

Porphyrins and Metalloporphyrins

1978 • 1,741 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Cytochrome P450: Structure, mechanism, and biochemistry

1996 • 1,502 citations

The Genetic Basis of the Reduced Expression of Bilirubin UDP-Glucuronosyltransferase 1 in Gilbert's Syndrome

1995 • 1,424 citations

High-resolution crystal structure of cytochrome P450cam

1987 • 1,396 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

1999 • 1,237 citations

Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.

1996 • 1,116 citations

Heme oxygenase 1 is required for mammalian iron reutilization

1997 • 998 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

The heme synthesis and degradation pathways: role in oxidant sensitivity

2000 • 779 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

1997 • 722 citations

Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

1994 • 641 citations

Congenital familial nonhemolytic jaundice with kernicterus.

1952 • 541 citations

Haem oxygenase-1 prevents cell death by regulating cellular iron

1999 • 519 citations

Exogenous administration of heme oxygenase-1 by gene transfer provides protection against hyperoxia-induced lung injury

1999 • 493 citations

Structure of a cytochrome P450–redox partner electron-transfer complex

1999 • 492 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Does carbon monoxide have a physiological function?

1991 • 425 citations

The active center of catalase

1985 • 420 citations

Reversal of HO‐1 related cytoprotection with increased expression is due to reactive iron

1999 • 399 citations

High-Resolution Crystal Structures of Distal Histidine Mutants of Sperm Whale Myoglobin

1993 • 386 citations

Iron in Biochemistry and Medicine

1975 • 366 citations

Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme.

1996 • 353 citations

Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states.

1978 • 346 citations

Iron in biochemistry and medicine.

1974 • 341 citations

X-ray crystal structure of canine myeloperoxidase at 3 Å resolution

1992 • 312 citations

Gene regulation of heme oxygenase-1 as a therapeutic target

2000 • 301 citations

Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress

2000 • 300 citations

Heme Oxygenase-1 Inhibits Atherosclerotic Lesion Formation in LDL-Receptor Knockout Mice

2001 • 295 citations

Crystal structure of human heme oxygenase-1.

1999 • 288 citations

Heme binds to a short sequence that serves a regulatory function in diverse proteins.

1995 • 285 citations

Epoxidation of olefins by cytochrome P450: Evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant

1998 • 282 citations

The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis

1999 • 270 citations

Heme oxygenase-1: role in brain aging and neurodegeneration

2000 • 268 citations

Reversal of long-term potentiation by inhibitors of haem oxygenase

1993 • 265 citations

Heme Oxygenase: Clinical Applications and Functions

1992 • 264 citations

The Mechanism of Metmyoglobin Oxidation

1963 • 261 citations

Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform.

1986 • 260 citations

Hemin uptake system of Yersinia enterocolitica: similarities with other TonB-dependent systems in gram-negative bacteria.

1992 • 252 citations

Rat liver heme oxygenase. High level expression of a truncated soluble form and nature of the meso-hydroxylating species.

1993 • 251 citations

Immunochemical Evidence for an Association of Heme Oxygenase with the Microsomal Electron Transport System

1972 • 250 citations

Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin

1997 • 230 citations

Catalytic Sites of Hemoprotein Peroxidases

1992 • 230 citations

The Arabidopsis thaliana HY1 locus, required for phytochrome-chromophore biosynthesis, encodes a protein related to heme oxygenases

1999 • 228 citations

Homologues of Neisserial Heme Oxygenase in Gram-Negative Bacteria: Degradation of Heme by the Product of the pigA Gene of Pseudomonas aeruginosa

2001 • 226 citations

Structural implication of the heme-linked ionization of horseradish peroxidase probed by the Fe-histidine stretching Raman line.

1981 • 220 citations

Heme Oxygenase Mechanism: Evidence for an Electrophilic, Ferric Peroxide Species

1998 • 220 citations

The mechanism of heme oxygenase

2000 • 217 citations

Heme protein-induced chronic renal inflammation: Suppressive effect of induced heme oxygenase-1

2001 • 216 citations

Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2.

1998 • 213 citations

Transport of haemin across the cytoplasmic membrane through a haemin‐specific periplasmic binding‐protein‐dependent transport system in Yersinia enterocolitica

1994 • 203 citations

Expression and Characterization of a Heme Oxygenase (Hmu O) fromCorynebacterium diphtheriae

1998 • 201 citations

Assignment of the Fe—N_ϵ (His F8) stretching band in the resonance Raman spectra of deoxy myoglobin

1979 • 192 citations

Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4.

1996 • 191 citations

Purification and properties of heme oxygenase from pig spleen microsomes.

1978 • 189 citations

Human heme oxygenase-2: Characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal

1992 • 184 citations

Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer's Disease

2000 • 182 citations

Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis

1997 • 182 citations

Degradation of Heme in Gram-Negative Bacteria: the Product of the hemO Gene of Neisseriae Is a Heme Oxygenase

2000 • 180 citations

Studies on Cytochrome c Peroxidase

1967 • 179 citations

Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice

1995 • 171 citations

Mechanism of heme degradation by heme oxygenase

2000 • 166 citations

Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats.

1998 • 164 citations

Features of the reaction of heme degradation catalyzed by the reconstituted microsomal heme oxygenase system.

1978 • 163 citations

Pitfalls using metalloporphyrins in carbon monoxide research

1997 • 162 citations

Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation.

1982 • 160 citations

Corticosterone Regulates Heme Oxygenase‐2 and NO Synthase Transcription and Protein Expression In Rat Brain

1994 • 148 citations

Genetics and regulation of heme iron transport in Shigella dysenteriae and detection of an analogous system in Escherichia coli O157:H7

1995 • 148 citations

Crystal structure of rat heme oxygenase‐1 in complex with heme

2000 • 147 citations

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

1990 • 147 citations

Destruction of heme and hemoproteins mediated by liver microsomal reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase

1978 • 139 citations

Reaction Intermediates and Single Turnover Rate Constants for the Oxidation of Heme by Human Heme Oxygenase-1

2000 • 139 citations

Evidence for Oxidative Stress in Experimental Prion Disease

2000 • 137 citations

Heme pocket interactions in cytochrome c peroxidase studied by site-directed mutagenesis and resonance Raman spectroscopy

1988 • 137 citations

The effect of axial ligand plane orientation on the contact and pseudocontact shifts of low-spin ferriheme proteins

1998 • 136 citations

Transformation of haemins into bile pigments

1935 • 134 citations

Out-of-plane deformation modes in the resonance Raman spectra of metalloporphyrins and heme proteins

1983 • 133 citations

Studies of the Heme Coordination and Ligand Binding Properties of Soluble Guanylyl Cyclase (sGC): Characterization of Fe(II)sGC and Fe(II)sGC(CO) by Electronic Absorption and Magnetic Circular Dichroism Spectroscopies and Failure of CO To Activate the Enzyme

1995 • 128 citations

Phytobilin biosynthesis: cloning and expression of a gene encoding soluble ferredoxin‐dependent heme oxygenase from Synechocystis sp. PCC 6803

1998 • 127 citations

Oxygenated form of heme . heme oxygenase complex and requirement for second electron to initiate heme degradation from the oxygenated complex.

1980 • 127 citations

The heme oxygenase-carbon monoxide system: u regulator of hepatobiliary function

2000 • 127 citations

Crystal Structure of Heme Oxygenase from the Gram-Negative Pathogen Neisseria meningitidis and a Comparison with Mammalian Heme Oxygenase-1

2001 • 126 citations

Heme Oxygenase-1, Intermediates in Verdoheme Formation and the Requirement for Reduction Equivalents

1997 • 121 citations

Enzymic degradation of heme. Oxygenative cleavage requiring cytochrome P-450

1972 • 120 citations

Haem oxygenase-1: a novel player in cutaneous wound repair and psoriasis?

2001 • 119 citations

Free Radical produced in the Reaction of Metmyoglobin with Hydrogen Peroxide

1958 • 118 citations

Exhaled Carbon Monoxide Levels Elevated in Diabetes and Correlated With Glucose Concentration in Blood

1999 • 116 citations

Hydroperoxy-Heme Oxygenase Generated by Cryoreduction Catalyzes the Formation of α-meso-Hydroxyheme as Detected by EPR and ENDOR

1999 • 115 citations

Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2

1998 • 115 citations

Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase

1995 • 113 citations

Purification and properties of heme oxygenase from rat liver microsomes.

1979 • 112 citations

Laue diffraction study on the structure of cytochrome c peroxidase compound I

1994 • 112 citations

Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme.

2001 • 110 citations

Heme-heme oxygenase complex. Structure of the catalytic site and its implication for oxygen activation.

1994 • 110 citations

Interaction of heme oxygenase‐2 with nitric oxide donors

1999 • 109 citations

Transcription of the Corynebacterium diphtheriae hmuO gene is regulated by iron and heme

1997 • 108 citations

Use of Heme Compounds as Iron Sources by Pathogenic Neisseriae Requires the Product of the hemO Gene

2000 • 108 citations

Induction of the Heme Oxygenase-1 Gene by Metalloporphyrins

2000 • 105 citations

Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver.

1982 • 105 citations

Heme oxygenase (HO-1). Evidence for electrophilic oxygen addition to the porphyrin ring in the formation of alpha-meso-hydroxyheme.

1994 • 105 citations

5,10,15,20‐Tetra‐tert‐butylporphyrin and Its Remarkable Reactivity in the 5‐ and 15‐Positions

1994 • 104 citations

Replacement of the Proximal Histidine Iron Ligand by a Cysteine or Tyrosine Converts Heme Oxygenase to an Oxidase

1999 • 104 citations

Absorption of heme iron.

1998 • 104 citations

A Role for Highly Conserved Carboxylate, Aspartate-140, in Oxygen Activation and Heme Degradation by Heme Oxygenase-1

2001 • 103 citations

Identification of Histidine 25 as the Heme Ligand in Human Liver Heme Oxygenase

1994 • 102 citations

Oxygen and One Reducing Equivalent Are Both Required for the Conversion of α-Hydroxyhemin to Verdoheme in Heme Oxygenase

1996 • 101 citations

Human Biliverdin Reductase Is Autophosphorylated, and Phosphorylation Is Required for Bilirubin Formation

2001 • 99 citations

Carbon monoxide‐induced relaxation of the ductus arteriosus in the lamb: evidence against the prime role of guanylyl cyclase

1996 • 95 citations

HAEM catabolism and coupled oxidation of haemproteins

1969 • 94 citations

Disruption of an Active Site Hydrogen Bond Converts Human Heme Oxygenase-1 into a Peroxidase

2001 • 89 citations

On the mechanism of the chemical and enzymic oxygenations of alpha-oxyprotohemin IX to Fe.biliverdin IX alpha.

1986 • 88 citations

Oxygen-Bound Heme-Heme Oxygenase Complex: Evidence for a Highly Bent Structure of the Coordinated Oxygen

1995 • 87 citations

Heme oxygenase: who needs it?

1999 • 87 citations

Resonance Raman and EPR spectroscopic studies on heme-heme oxygenase complexes

1993 • 86 citations

Heme Oxygenase-2

1995 • 85 citations

Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants.

1994 • 83 citations

Vasoregulatory function of the heme-heme oxygenase-carbon monoxide system

2001 • 83 citations

Heme-Heme Oxygenase Complex: Structure and Properties of the Catalytic Site from Resonance Raman Scattering

1994 • 82 citations

The Oxygen and Carbon Monoxide Reactions of Heme Oxygenase

1998 • 77 citations

Heme and the Endothelium

1998 • 77 citations

Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: Possible heme-binding site?

1991 • 74 citations

Heme Degradation as Catalyzed by a Recombinant Bacterial Heme Oxygenase (Hmu O) from Corynebacterium diphtheriae

1999 • 73 citations

Identification of a Two-Component Signal Transduction System from Corynebacterium diphtheriae That Activates Gene Expression in Response to the Presence of Heme and Hemoglobin

1999 • 71 citations

Crystal structure of rat biliverdin reductase.

2001 • 69 citations

Specificity of heme oxygenase: a study with synthetic hemins

1981 • 69 citations

Enzymatic heme oxygenase activity in soluble extracts of the unicellular red alga, Cyanidium caldarium

1984 • 69 citations

Resonance Raman studies of iron spin and axial coordination in distal pocket mutants of ferric myoglobin.

1990 • 66 citations

The heme oxygenase gene ( pbsA ) in the red alga Rhodella violacea is discontinuous and transcriptionally activated during iron limitation

1997 • 63 citations

Demonstration That Histidine-25, But Not Histidine-132, Is the Axial Heme Ligand in Rat Heme Oxygenase-1

1995 • 59 citations

Degradation of Mesoheme and Hydroxymesoheme Catalyzed by the Heme Oxygenase System: Involvement of Hydroxyheme in the Sequence of Heme Catabolism1

1981 • 59 citations

Mechanistic kinship between hydroxylation and desaturation reactions: acyl-carbon bond cleavage promoted by pig and human CYP17 (P-45017.alpha.; 17.alpha.-hydroxylase-17,20-lyase)

1995 • 58 citations

Efficient Coupled Oxidation of Heme by an Active Site Variant of Horse Heart Myoglobin

1996 • 57 citations

Association of Cytochromes P450 with Their Reductases: Opposite Sign of the Electrostatic Interactions in P450BM-3 As Compared with the Microsomal 2B4 System

2000 • 57 citations

Degradation of endogenous hepatic heme by pathways not yielding carbon monoxide. Studies in normal rat liver and in primary hepatocyte culture.

1980 • 57 citations

Crystal structure of a remarkably ruffled nonplanar porphyrin (pyridine)[5,10,15,20-tetra(tert-butyl)porphyrinato]zinc(II)

1995 • 55 citations

Bile pigment synthesis in plants. Mechanism of 18O incorporation into phycocyanobilin in the unicellular rhodophyte. Cyanidium caldarium.

1979 • 55 citations

Studies on the Iron(II) meso-Oxyporphyrin .pi.-Neutral Radical as a Reaction Intermediate in Heme Catabolism

1995 • 54 citations

Expression of rat heme oxygenase in Escherichia coli as a catalytically active, full‐length form that binds to bacterial membranes

1991 • 54 citations

Ferric α-Hydroxyheme Bound to Heme Oxygenase Can Be Converted to Verdoheme by Dioxygen in the Absence of Added Reducing Equivalents

1999 • 52 citations

Isomeric Bile Pigments as Products of the In Vitro Fission of Hæmin

1962 • 51 citations

Replacement of the Distal Glycine 139 Transforms Human Heme Oxygenase-1 into a Peroxidase

2000 • 51 citations

Stereospecific haem cleavage. A model for the formation of bile-pigment isomers in vivo and in vitro

1976 • 51 citations

Untitled

1997 • 50 citations

Verdohemochrome IX alpha: preparation and oxidoreductive cleavage to biliverdin IX alpha.

1982 • 50 citations

Heme Oxygenase (HO-1): His-132 Stabilizes a Distal Water Ligand and Assists Catalysis

1996 • 50 citations

Crystallization of recombinant human heme oxygenase-1

1998 • 49 citations

Oxidation of the meso-Methylmesoheme Regioisomers by Heme Oxygenase

1996 • 49 citations

Conversion of Mitochondrial Cytochrome b₅ into A Species Capable of Performing the Efficient Coupled Oxidation of Heme

1998 • 48 citations

Bile Pigments and Jaundice

1987 • 48 citations

Solution¹H NMR Investigation of the Molecular and Electronic Structure of the Active Site of Substrate-Bound Human Heme Oxygenase: the Nature of the Distal Hydrogen Bond Donor to Bound Ligands

1998 • 46 citations

Proton NMR Investigation of Substrate-Bound Heme Oxygenase: Evidence for Electronic and Steric Contributions to Stereoselective Heme Cleavage

1994 • 46 citations

Coupled Oxidation of Heme by Myoglobin Is Mediated by Exogenous Peroxide

2001 • 46 citations

Pyrroles and related compounds. Part XIV. The structure and transformations of oxophlorins (oxyporphyrins)

1968 • 46 citations

Domains of Rat Heme Oxygenase-2: The Amino Terminus and Histidine 151 Are Required for Heme Oxidation

1993 • 45 citations

Histidine-132 Does Not Stabilize a Distal Water Ligand and Is Not an Important Residue for the Enzyme Activity in Heme Oxygenase-1

1997 • 45 citations

Mechanism of action of heme oxygenase. A study of heme degradation to bile pigment by 18O labeling.

1984 • 45 citations

Importance of histidine residue 25 of rat heme oxygenase for its catalytic activity

1992 • 45 citations

Heme oxygenase-1 in lesions of human cerebral malaria

2001 • 45 citations

The Heme Complex of Hmu O, a Bacterial Heme Degradation Enzyme from Corynebacterium diphtheriae

1999 • 45 citations

Roles of negatively charged surface residues of putidaredoxin in interactions with redox partners in P450cam monooxygenase system

1998 • 44 citations

Induction of heme oxygenase-1 by Ginkgo Biloba Extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage

2001 • 43 citations

Oxidation of α-meso-Formylmesoheme by Heme Oxygenase

1997 • 42 citations

Carbon monoxide and bilirubin production in neonates

2001 • 42 citations

Metabolism-based covalent bonding of the heme prosthetic group to its apoprotein during the reductive debromination of BrCCl3 by myoglobin.

1990 • 39 citations

Identification of the Proximal Ligand His-20 in Heme Oxygenase (Hmu O) from Corynebacterium diphtheriae

2000 • 37 citations

The structure of verdohemochrome and its implications for the mechanism of heme catabolism

1982 • 36 citations

Separation and identification of the regioisomers of verdoheme by reversed-phase ion-pair high-performance liquid chromatography, and characterization of their complexes with heme oxygenase

2000 • 35 citations

Heme catabolism: a new look at substrates and enzymes

1987 • 34 citations

Substituent Effects on the Choice of the Orbital Preferred for Electron Spin Delocalization in Two Paramagnetic Low-Spin Iron(III) Porphyrins: Mapping the Spin Density Distribution at the Pyrrole Positions by 1H COSY and NOESY Techniques

1994 • 34 citations

Participation of Carboxylate Amino Acid Side Chain in Regiospecific Oxidation of Heme by Heme Oxygenase

2000 • 32 citations

Solution 1H NMR of the Active Site of Substrate-bound, Cyanide-inhibited Human Heme Oxygenase

2001 • 32 citations

Heme/Hydrogen Peroxide Reactivity: Formation of Paramagnetic Iron Oxophlorin Isomers by Treatment of Iron Porphyrins with Hydrogen Peroxide

2000 • 32 citations

Molecular oxygen oxidizes the porphyrin ring of the ferric α-hydroxyheme in heme oxygenase in the absence of reducing equivalent

1999 • 31 citations

The mechanism of haem catabolism. A study of haem breakdown in spleen microsomal fraction and in a model system by 18O labelling and metal substitution

1978 • 31 citations

Oxygen Activation by Axial Ligand Mutants of Mitochondrial Cytochrome b₅: Oxidation of Heme to Verdoheme and Biliverdin

2000 • 31 citations

Regioselective Porphyrin Bridge Cleavage Controlled by Electronic Effects. Coupled Oxidation of 3-Demethyl-3-(trifluoromethyl)mesohemin IX and Identification of Its Four Biliverdin Derivatives

1998 • 30 citations

Features of Intermediary Steps around the 688-nm Substance in the Heme Oxygenase Reaction1

1984 • 30 citations

Heme oxygenase type 2 plays a role in formalin-induced nociception

2000 • 30 citations

Heme Oxygenase Active-Site Residues Identified by Heme−Protein Cross-Linking during Reduction of CBrCl₃

1998 • 29 citations

The oxidation of hemins by microsomal heme oxygenase

1984 • 29 citations

Histidine 20, the Crucial Proximal Axial Heme Ligand of Bacterial Heme Oxygenase Hmu O from Corynebacterium diphtheriae

2000 • 29 citations

Orientation of oxygen in oxyhaemoproteins and its implications for haem catabolism

1981 • 28 citations

Mechanism of bile-pigment synthesis in algae. 18O incorporation into phycocyanobilin in the unicellular rhodophyte, Cyanidium caldarium

1980 • 27 citations

Identification of Histidine 45 as the Axial Heme Iron Ligand of Heme Oxygenase-2

1998 • 26 citations

Oxidation of an α-Meso-Methyl-Substituted Heme to an α-Biliverdin by Heme Oxygenase. A Novel Heme Cleavage Reaction

1996 • 26 citations

Enzymic conversion of α-oxyprotohaem IX into biliverdin IXα by haem oxygenase

1990 • 26 citations

Cobalt Porphyrin Heme Oxygenase Complex. EPR Evidences for the Distal Heme Pocket Hydrogen Bonding

1998 • 25 citations

Effects of the Arrangement of a Distal Catalytic Residue on Regioselectivity and Reactivity in the Coupled Oxidation of Sperm Whale Myoglobin Mutants

1999 • 24 citations

1H NMR investigation of distal mutant deoxy myoglobins. Interpretation of proximal His contact shifts in terms of a localized distal water molecule.

1994 • 24 citations

Coupled Oxidation of Heme Covalently Attached to Cytochrome b₅₆₂ Yields a Novel Biliprotein

1999 • 21 citations

Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria

1987 • 21 citations

Crystallization and Preliminary X-Ray Diffraction Analysis of a Recombinant Bacterial Heme Oxygenase (Hmu O) from Corynebacterium diphtheriae

1999 • 15 citations

Synthesis and Assignment of the Four Possible meso-Methylmesoporphyrin IX Regioisomers

1995 • 15 citations

Axial Ligation States of Five-Coordinate Heme Oxygenase Proximal Histidine Mutants, as Revealed by EPR and Resonance Raman Spectroscopy

2000 • 11 citations

meso-Reactivity of porphyrins and related compounds. Part 9. Photo-oxygenation of octaethyloxophlorin

1987 • 11 citations

Haem degradation in human haemoglobin in vitro. Separation of the contribution of the α- and β-subunits

1984 • 10 citations

Absence of heme-localized strain in T state hemoglobin: Insensitivity of heme-imidazole resonance Raman frequencies to quaternary structure

1979 • 9 citations

Solution NMR Determination of the Seating(s) of Meso-nitro-etioheme-1 in Myoglobin: Implications for Steric Constraints to Meso Position Access in Heme Degradation by Coupled Oxidation

2001 • 8 citations