Proton NMR Investigation of Substrate-Bound Heme Oxygenase: Evidence for Electronic and Steric Contributions to Stereoselective Heme Cleavage

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

1983 • 3,150 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

Human heme oxygenase cDNA and induction of its mRNA by hemin

1988 • 320 citations

Reversal of long-term potentiation by inhibitors of haem oxygenase

1993 • 265 citations

Rat liver heme oxygenase. High level expression of a truncated soluble form and nature of the meso-hydroxylating species.

1993 • 251 citations

Electronic structure of cyanide complexes of hemes and heme proteins

1971 • 211 citations

A new method for water suppression in the proton NMR spectra of aqueous solutions

1983 • 210 citations

Purification and properties of heme oxygenase from pig spleen microsomes.

1978 • 189 citations

Heme orientational disorder in reconstituted and native sperm whale myoglobin

1983 • 162 citations

Purification and properties of bovine spleen heme oxygenase. Amino acid composition and sites of action of inhibitors of heme oxidation.

1982 • 160 citations

Biosynthesis of phycobilins

1993 • 159 citations

NMR determination of the orientation of the magnetic susceptibility tensor in cyanometmyoglobin: a new probe of steric tilt of bound ligand

1990 • 147 citations

Solution structural characterization of cyanometmyoglobin: resonance assignment of heme cavity residues by two-dimensional NMR

1990 • 133 citations

Proton NMR characterization of the catalytically relevant proximal and distal hydrogen-bonding networks in ligated resting state horseradish peroxidase

1988 • 122 citations

Analysis of the principal g-tensors in single crystals of ferrimyoglobin complexes

1971 • 121 citations

Purification and properties of heme oxygenase from rat liver microsomes.

1979 • 112 citations

Heme-heme oxygenase complex. Structure of the catalytic site and its implication for oxygen activation.

1994 • 110 citations

Identification of the catalytically important amino acid residue resonances in ferric low-spin horseradish peroxidase with nuclear Overhauser effect measurements

1987 • 95 citations

Proton magnetic resonance determination of the relative heme orientations in disordered native and reconstituted ferricytochrome b5. Assignment of heme resonances by deuterium labeling.

1981 • 92 citations

Resonance Raman and EPR spectroscopic studies on heme-heme oxygenase complexes

1993 • 86 citations

Proton nuclear magnetic resonance study of the relaxation behavior and kinetic lability of exchangeable protons in the heme pocket of cyanometmyoglobin

1981 • 82 citations

Proton NMR characterization of metastable and equilibrium heme orientational heterogeneity in reconstituted and native human hemoglobin

1985 • 74 citations

Determination of the orientation of the magnetic axes of the cyano-MetMb complexes of point mutants of myoglobin by solution 1H NMR: influence of his E7 .fwdarw. Gly and Arg CD3 .fwdarw. Gly substitutions

1992 • 59 citations

Manipulation of vinyl groups in protoporphyrin IX: introduction of deuterium and carbon-13 labels for spectroscopic studies

1983 • 58 citations

Purification and characterization of heme oxygenase from chick liver

1990 • 51 citations

Domains of Rat Heme Oxygenase-2: The Amino Terminus and Histidine 151 Are Required for Heme Oxidation

1993 • 45 citations

Importance of histidine residue 25 of rat heme oxygenase for its catalytic activity

1992 • 45 citations

Cloning, sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins

1991 • 39 citations

Novel heteronuclear methods of assignment transfer from a diamagnetic to a paramagnetic protein: application to rat cytochrome b5

1993 • 38 citations

Heme catabolism: a new look at substrates and enzymes

1987 • 34 citations

Characterization of heme orientational disorder in myoglobin by proton nuclear Overhauser effects

1985 • 32 citations

Solution structure determination of the heme cavity in the E7 His .fwdarw. Val cyano-Met myoglobin point mutant based on the proton NMR detected dipolar field of the iron: Evidence for contraction of the heme pocket

1993 • 31 citations

Methyl deuteration reactions in vinylporphyrins: protoporphyrins IX, III, and XIII

1986 • 30 citations

Proton nuclear magnetic resonance study of the molecular and electronic structure of the heme cavity in Aplysia cyanometmyoglobin

1989 • 30 citations

Interpretation of hyperfine shift patterns in ferricytochromes b5 in terms of angular position of the heme: a sensitive probe for peripheral heme protein interactions

1993 • 28 citations

Solution Nuclear Magnetic Resonance Determination of Active Site Structure for a Paramagnetic Protein: Cyanomet Aplysia Myoglobin

1993 • 25 citations

The homonuclear Overhauser effect in H2O solution of low-spin hemeproteins

1986 • 21 citations

Determination of interproton distances from NOESY spectra in the active site of paramagnetic metalloenzymes: cyanide-inhibited horseradish peroxidase

1993 • 20 citations

Syntheses of derivatives of protoporphyrin IX bearing deuteriated methyls on the propionate (C and D) rings

1986 • 20 citations

A nuclear Overhauser study of heme orientational isomerism in monomeric Chironomus hemoglobins

1988 • 16 citations

Heme oxygenase: Expression of an active truncated, form and nature of the heme hydroxylating species.

1993 • 3 citations