Crystal structure of human heme oxygenase-1.

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Refinement of Macromolecular Structures by the Maximum-Likelihood Method

1997 • 14,729 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Protein Structure Comparison by Alignment of Distance Matrices

1993 • 3,989 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods

1997 • 1,905 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

SETOR: Hardware-lighted three-dimensional solid model representations of macromolecules

1993 • 1,295 citations

Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency

1999 • 1,237 citations

Heme oxygenase 1 is required for mammalian iron reutilization

1997 • 998 citations

Interactive computer graphics: FRODO

1985 • 848 citations

Mechanisms of Ligand Recognition in Myoglobin

1994 • 746 citations

Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes

1997 • 722 citations

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury

1999 • 694 citations

Expression of heme oxygenase-1 can determine cardiac xenograft survival

1998 • 621 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Structure of a cytochrome P450–redox partner electron-transfer complex

1999 • 492 citations

Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes

1998 • 466 citations

The Arabidopsis Photomorphogenic Mutant hy1 Is Deficient in Phytochrome Chromophore Biosynthesis as a Result of a Mutation in a Plastid Heme Oxygenase

1999 • 321 citations

Human heme oxygenase cDNA and induction of its mRNA by hemin

1988 • 320 citations

A Steric Mechanism for Inhibition of CO Binding to Heme Proteins

1999 • 310 citations

Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide

1997 • 235 citations

Utilization of host iron sources by Corynebacterium diphtheriae: identification of a gene whose product is homologous to eukaryotic heme oxygenases and is required for acquisition of iron from heme and hemoglobin

1997 • 230 citations

Computer Simulations of the Diffusion of a Substrate to an Active Site of an Enzyme

1987 • 224 citations

Heme Oxygenase Mechanism: Evidence for an Electrophilic, Ferric Peroxide Species

1998 • 220 citations

Nucleotide sequence and organization of the rat heme oxygenase gene.

1987 • 210 citations

Dioxygen and carbonyl binding to iron(II) porphyrins: a comparison of the "picket fence" and "pocket" porphyrins

1983 • 202 citations

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

1990 • 147 citations

Characterization of the enzyme

1994 • 134 citations

Phytobilin biosynthesis: cloning and expression of a gene encoding soluble ferredoxin‐dependent heme oxygenase from Synechocystis sp. PCC 6803

1998 • 127 citations

The use of Sayre's equation with solvent flattening and histogram matching for phase extension and refinement of protein structures

1990 • 114 citations

Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase

1995 • 113 citations

Heme-heme oxygenase complex. Structure of the catalytic site and its implication for oxygen activation.

1994 • 110 citations

Carbonyl Tilting and Bending Potential Energy Surface of Carbon Monoxyhemes

1996 • 103 citations

On the significance of hydrogen bonds for the discrimination between CO and O2 by myoglobin

1999 • 99 citations

On the mechanism of the chemical and enzymic oxygenations of alpha-oxyprotohemin IX to Fe.biliverdin IX alpha.

1986 • 88 citations

Resonance Raman and EPR spectroscopic studies on heme-heme oxygenase complexes

1993 • 86 citations

Heme-Heme Oxygenase Complex: Structure and Properties of the Catalytic Site from Resonance Raman Scattering

1994 • 82 citations

The Oxygen and Carbon Monoxide Reactions of Heme Oxygenase

1998 • 77 citations

Specificity of heme oxygenase: a study with synthetic hemins

1981 • 69 citations

Heme Oxygenase His25Ala Mutant: Replacement of the Proximal Histidine Iron Ligand by Exogenous Bases Restores Catalytic Activity

1995 • 63 citations

Structural differentiation of carbon monoxide and oxygen binding to iron porphyrins: polar pocket effects

1985 • 60 citations

Diffraction methods for biological macromolecules

1985 • 58 citations

Posttranslational and direct integration of heme oxygenase into microsomes

1989 • 57 citations

A Stoichiometric Study of Heme Degradation Catalyzed by the Reconstituted Heme Oxygenase System with Special Consideration of the Production of Hydrogen Peroxide during the Reaction1

1983 • 52 citations

Crystallization of recombinant human heme oxygenase-1

1998 • 49 citations

Oxidation of the meso-Methylmesoheme Regioisomers by Heme Oxygenase

1996 • 49 citations

Conversion of Mitochondrial Cytochrome b₅ into A Species Capable of Performing the Efficient Coupled Oxidation of Heme

1998 • 48 citations

Degradation of heme by a soluble peptide of heme oxygenase obtained from rat liver microsomes by mild trypsinization

1991 • 48 citations

Proton NMR Investigation of Substrate-Bound Heme Oxygenase: Evidence for Electronic and Steric Contributions to Stereoselective Heme Cleavage

1994 • 46 citations

Importance of histidine residue 25 of rat heme oxygenase for its catalytic activity

1992 • 45 citations

Oxidation of α-meso-Formylmesoheme by Heme Oxygenase

1997 • 42 citations

Linear free-energy relationships in binding of oxygen and carbon monoxide with heme model compounds and heme proteins

1984 • 41 citations

1,3-Adamantane-3,13-porphyrin-6,6-cyclophane: crystal structure of the free base and steric effects on ligation of the iron(II) complex

1984 • 33 citations

Crystallization and preliminary X-ray diffraction studies on the water soluble form of rat heme oxygenase-1 in complex with heme

1998 • 32 citations

Heme Oxygenase Active-Site Residues Identified by Heme−Protein Cross-Linking during Reduction of CBrCl₃

1998 • 29 citations

Orientation of oxygen in oxyhaemoproteins and its implications for haem catabolism

1981 • 28 citations

Effects of the Arrangement of a Distal Catalytic Residue on Regioselectivity and Reactivity in the Coupled Oxidation of Sperm Whale Myoglobin Mutants

1999 • 24 citations

MAGICSQUASH: More Versatile Non-crystallographic Averaging with Mulitple Constraints

1996 • 20 citations