CD44 structure and function

CD44 is the principal cell surface receptor for hyaluronate

1990 • 2,433 citations

A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells

1991 • 1,685 citations

CD44 and Its Interaction with Extracellular Matrix

1993 • 1,082 citations

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

1992 • 1,040 citations

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

1993 • 833 citations

ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.

1994 • 790 citations

A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

1989 • 680 citations

Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway.

1996 • 601 citations

Ezrin/Radixin/Moesin (ERM) Proteins Bind to a Positively Charged Amino Acid Cluster in the Juxta-Membrane Cytoplasmic Domain of CD44, CD43, and ICAM-2

1998 • 592 citations

The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells.

1991 • 587 citations

Requirement for CD44 in Activated T Cell Extravasation into an Inflammatory Site

1997 • 560 citations

Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin.

1992 • 542 citations

CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.

1995 • 434 citations

CD44 and its ligand hyaluronate mediate rolling under physiologic flow: a novel lymphocyte-endothelial cell primary adhesion pathway.

1996 • 421 citations

The hyaluronan receptor (CD44) participates in the uptake and degradation of hyaluronan.

1992 • 399 citations

Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

1994 • 384 citations

Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons.

1991 • 377 citations

Identification of hyaluronic acid binding sites in the extracellular domain of CD44

1993 • 370 citations

Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.

1994 • 346 citations

Solution Structure of the Link Module: A Hyaluronan-Binding Domain Involved in Extracellular Matrix Stability and Cell Migration

1996 • 313 citations

Splicing choice from ten variant exons establishes CD44 variability

1993 • 291 citations

A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion.

1992 • 287 citations

Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody.

1992 • 261 citations

Glycosylation of CD44 negatively regulates its recognition of hyaluronan.

1995 • 255 citations

Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon.

1995 • 253 citations

Induction of Apoptosis of Metastatic Mammary Carcinoma Cells In Vivo by Disruption of Tumor Cell Surface CD44 Function

1997 • 252 citations

Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function.

1994 • 249 citations

CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation.

1993 • 241 citations

Intercellular adhesion molecule-1 dimerization and its consequences for adhesion mediated by lymphocyte function associated-1.

1995 • 210 citations

Glycosylation Provides Both Stimulatory and Inhibitory Effects on Cell Surface and Soluble CD44 Binding to Hyaluronan

1998 • 206 citations

Forms and functions of CD44

1998 • 198 citations

Variant cell lines selected for alterations in the function of the hyaluronan receptor CD44 show differences in glycosylation.

1995 • 196 citations

Signaling through CD44 Is Mediated by Tyrosine Kinases

1996 • 189 citations

Glycosylation of CD44 is implicated in CD44-mediated cell adhesion to hyaluronan.

1996 • 187 citations

Identification of CD44 Residues Important for Hyaluronan Binding and Delineation of the Binding Site

1998 • 180 citations

Hyaluronic acid-induced lymphocyte signal transduction and HA receptor (GP85/CD44)-cytoskeleton interaction.

1993 • 170 citations

CD44 activation and associated primary adhesion is inducible via T cell receptor stimulation.

1997 • 163 citations

Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons.

1995 • 154 citations

Variations in the cytoskeletal interaction and posttranslational modification of the CD44 homing receptor in macrophages.

1991 • 146 citations

Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity.

1996 • 144 citations

CD44 and hyaluronan-dependent rolling interactions of lymphocytes on tonsillar stroma.

1996 • 142 citations

Assembly of pericellular matrices by COS-7 cells transfected with CD44 lymphocyte-homing receptor genes.

1993 • 141 citations

CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix.

1996 • 129 citations

Monoclonal antibodies to CD44 and their influence on hyaluronan recognition.

1995 • 129 citations

Integrin signaling in vascular biology.

1997 • 125 citations

Lymphoma protein kinase C is associated with the transmembrane glycoprotein, GP85, and may function in GP85-ankyrin binding

1989 • 120 citations

Antibody‐induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody

1993 • 120 citations

Role of CD44 cytoplasmic domain in hyaluronan binding

1995 • 119 citations

Lymph node (but not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent.

1995 • 113 citations

Site-specific de-N-glycosylation of CD44 can activate hyaluronan binding, and CD44 activation states show distinct threshold densities for hyaluronan binding.

1998 • 109 citations

The importance of cellular environment to function of the CD44 matrix receptor

1997 • 106 citations

The cytoplasmic tail of CD44 is required for basolateral localization in epithelial MDCK cells but does not mediate association with the detergent-insoluble cytoskeleton of fibroblasts.

1993 • 104 citations

Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts

1995 • 102 citations

Acylation of the lymphoma transmembrane glycoprotein, GP85, may be required for GP85-ankyrin interaction

1991 • 98 citations

Identification and characterization of the human Pgp-1 glycoprotein

1986 • 97 citations

Variant Exons v6 and v7 Together Expand the Repertoire of Glycosaminoglycans Bound by CD44

1997 • 95 citations

Isolation of mouse CD44 cDNA: structural features are distinct from the primate cDNA.

1989 • 94 citations

Hyaluronate-independent metastatic behavior of CD44 variant-expressing pancreatic carcinoma cells.

1996 • 93 citations

Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain.

1995 • 90 citations

Keratan Sulfate Modification of CD44 Modulates Adhesion to Hyaluronate

1996 • 90 citations

Phorbol myristate acetate stimulates the dimerization of CD44 involving a cysteine in the transmembrane domain.

1997 • 89 citations

Evidence that the Pgp-1 glycoprotein is expressed on thymus-homing progenitor cells of the thymus

1985 • 88 citations

Characterization of soluble CD44 in the circulation of mice. Levels are affected by immune activity and tumor growth.

1994 • 88 citations

The role of the cytoplasmic domain in regulating CD44 function

1994 • 87 citations

Regulation of human CD44H and CD44E isoform binding to hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies.

1993 • 86 citations

CD44 expression on activated B cells. Differential capacity for CD44-dependent binding to hyaluronic acid.

1993 • 85 citations

Regulation of growth and dissemination of a human lymphoma by CD44 splice variants

1995 • 81 citations

Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1.

1994 • 79 citations

A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid.

1996 • 73 citations

Hyaluronan-dependent cell migration can be blocked by a CD44 cytoplasmic domain peptide containing a phosphoserine at position 325

1998 • 73 citations

A Di-hydrophobic Leu-Val Motif Regulates the Basolateral Localization of CD44 in Polarized Madin-Darby Canine Kidney Epithelial Cells

1996 • 70 citations

Adhesive Interactions between Alternatively Spliced CD44 Isoforms

1995 • 69 citations

Inducible binding of human lymphocytes to hyaluronate via CD44 does not require cytoskeleton association but does require new protein synthesis.

1994 • 64 citations

CD44 phosphorylation regulates melanoma cell and fibroblast migration on, but not attachment to, a hyaluronan substratum

1996 • 61 citations

Epican, a heparan/chondroitin sulfate proteoglycan form of CD44, mediates cell-cell adhesion

1994 • 60 citations

A New Alternatively Spliced Exon between v9 and v10 Provides a Molecular Basis for Synthesis of Soluble CD44

1996 • 59 citations

Elevated Serum CD44 Level Is Associated With Unfavorable Outcome in Non-Hodgkin's Lymphoma

1997 • 49 citations

Hyaluronan binding by CD44 is regulated by a phosphorylation‐independent mechanism

1995 • 43 citations

O-linked Glycosylation Modifies CD44 Adhesion to Hyaluronate in Colon Carcinoma Cells

1996 • 43 citations

Growth as a solid tumor or reduced glucose concentrations in culture reversibly induce CD44-mediated hyaluronan recognition by Chinese hamster ovary cells.

1997 • 36 citations

Role Of Lymphocyte Adhesion Receptors In Transient Interactions And Cell Locomotion

1991 • 32 citations

Binding of CD44 to Hyaluronic Acid Can Be Induced by Multiple Signals and Requires the CD44 Cytoplasmic Domain

1996 • 22 citations