Patients with Allergic Contact Dermatitis to Nickel and Nonallergic Individuals Display Different Nickel-Specific T Cell Responses. Evidence for the Presence of Effector CD8+ and Regulatory CD4+ T Cells

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

1993 • 1,409 citations

Human IL-10 is produced by both type 1 helper (Th1) and type 2 helper (Th2) T cell clones and inhibits their antigen-specific proliferation and cytokine production.

1993 • 945 citations

ELAM-1 is an adhesion molecule for skin-homing T cells

1991 • 843 citations

Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells

1997 • 582 citations

Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance.

1993 • 526 citations

Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity

1998 • 518 citations

T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells.

1996 • 398 citations

Limiting Dilution Analysis of Cells in the Immune System

1979 • 384 citations

Limiting Dilution Analysis of Cells in the Immune System

1980 • 325 citations

Nickel sensitivity in the general population

1979 • 317 citations

Roles of CD4+ and CD8+ T cells in murine contact sensitivity revealed by in vivo monoclonal antibody depletion.

1990 • 315 citations

Major histocompatibility complex class I‐restricted CD8⁺ T cells and class II‐restricted CD4⁺ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene

1995 • 291 citations

Circulating allergen-reactive T cells from patients with atopic dermatitis and allergic contact dermatitis express the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen.

1995 • 291 citations

Human atopen-specific types 1 and 2 T helper cell clones.

1991 • 273 citations

Differential effect of IL-10 on dendritic cell-induced T cell proliferation and IFN-gamma production.

1993 • 251 citations

Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses.

1995 • 243 citations

Induction of hapten-specific tolerance by interleukin 10 in vivo.

1994 • 232 citations

Th1 Lymphokine Production Profiles of Nickel-Specific CD4+ T-Lymphocyte Clones from Nickel Contact Allergic and Non-Allergic Individuals

1992 • 189 citations

Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis.

1985 • 186 citations

Cyclic regulation of CD45 isoform expression in a long term human CD4+CD45RA+ T cell line.

1991 • 186 citations

Regulation of contact hypersensitivity by interleukin 10.

1994 • 168 citations

IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo.

1995 • 139 citations

Interleukin 10 inhibits allogeneic proliferative and cytotoxic T cell responses generated in primary mixed lymphocyte cultures

1992 • 133 citations

Dichotomy of blood- and skin-derived IL-4-producing allergen-specific T cells and restricted V beta repertoire in nickel-mediated contact dermatitis.

1997 • 112 citations

Enrichment and function of urushiol (poison ivy)-specific T lymphocytes in lesions of allergic contact dermatitis to urushiol.

1990 • 108 citations

Neutralization of IL-12 in vivo prevents induction of contact hypersensitivity and induces hapten-specific tolerance.

1996 • 107 citations

Cultured Epidermal Langerhans Cells Activate Effector T Cells for Contact Sensitivity

1990 • 105 citations

Heterogeneity of the human CD4+ T-cell population: two distinct CD4+ T- cell subsets characterized by coexpression of CD45RA and CD45RO isoforms

1996 • 101 citations

Nickel‐specific T lymphocyte clones derived from allergic nickel‐contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigen‐presenting cell subsets

1987 • 88 citations

Anti-inflammatory action of IL-4. Negative regulation of contact sensitivity to trinitrochlorobenzene.

1992 • 80 citations

Characterization of epitopes recognized by hapten-specific CD4+ T cells.

1995 • 80 citations

Dominance of the BV17 element in nickel‐specific human T cell receptors relates to severity of contact sensitivity

1997 • 78 citations

Cytokine Gene Expression during the Elicitation Phase of Contact Sensitivity: Regulation By Endogenous IL-4

1997 • 76 citations

Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptides.

1992 • 74 citations

Skin-homing T lymphocytes: detection of cutaneous lymphocyteassociated antigen (CLA) by HECA-452 in normal human skin

1993 • 69 citations

In Vitro Studies in Nickel Allergy: Diagnostic Value of a Dual Parameter Analysis

1987 • 69 citations

Diminished Contact Hypersensitivity Response in IL‐4 Deficient Mice at a Late Phase of the Elicitation Reaction

1997 • 58 citations

Diagnostic value of the lymphocyte proliferation test in nickel contact allergy and provocation in occupational coin dermatitis

1992 • 56 citations

Non-Specific Lymphocyte Transformation In Vitro By Nickel Acetate**From the Departments of Internal Medicine an Dermatology, University of Cologne. Cologne, West Germany. Reprint requests to: Priv. Doz. Dr. C. E. Orfanos, Dermatological Clinic of the University of Cologne, 5, Köln-Lindenthal, West Germany.

1970 • 55 citations

Lymphocyte transformation induced by nickel sulphate: an in vitro study of subjects with and without a positive nickel patch test

1978 • 52 citations

High and low doses of haptens dictate whether dermal or epidermal antigen‐presenting cells promote contact hypersensitivity

1997 • 50 citations

HLA-DR, -DQ and -DP Alleles in Nickel, Chromium, and/or Cobalt-Sensitive Individuals: Genomic Analysis Based on Restriction Fragment Length Polymorphisms

1993 • 47 citations

Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity.

1990 • 42 citations

T‐cell and antibody response to Parietaria Judaica allergenic fractions in atopic and nonatopic individuals

1993 • 39 citations

Atopic and non‐atopic individuals react to nickel challenge in a similar way. A study of the cytokine profile in nickel‐induced contact dermatitis

1997 • 38 citations

Pre‐treatment of nickel test areas with sodium lauryl sulfate detects nickel sensitivity in subjects reacting negatively to routinely performed patch tests

1996 • 29 citations

Lymphocyte proliferative responses to the purified Dermatophagoides farinae major allergen in untreated and hyposensitized atopic patients

1988 • 25 citations

Idiopathic CD4+ lymphocyte deficiency. Report of an unusual case associated with atopic dermatitis and allergic contact dermatitis and review of the literature

1993 • 25 citations

Phosphatidylserine enhances the ability of epidermal Langerhans cells to induce contact hypersensitivity.

1993 • 17 citations

Idiopathic CD4+ Lymphocyte Deficiency

1993 • 15 citations

Allergic contact dermatitis in HIV‐positive patients

1994 • 13 citations