Effects of chronic treatment with the c-kit ligand, stem cell factor, on immunoglobulin E-dependent anaphylaxis in mice. Genetically mast cell-deficient Sl/Sld mice acquire anaphylactic responsiveness, but the congenic normal mice do not exhibit augmented responses.

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium

1990 • 837 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

The kit ligand: A cell surface molecule altered in steel mutant fibroblasts

1990 • 777 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization.

1980 • 653 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Steel locus defines new multipotent growth factor

1990 • 509 citations

Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture

1992 • 436 citations

Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

1991 • 424 citations

Decreased production of mast cells in S1/S1d anemic mice

1979 • 372 citations

The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils.

1992 • 308 citations

Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells.

1992 • 289 citations

The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype.

1991 • 288 citations

The c-kit receptor, stem cell factor, and mast cells. What each is teaching us about the others.

1993 • 279 citations

c-kit ligand: a unique potentiator of mediator release by human lung mast cells.

1992 • 275 citations

Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand.

1993 • 264 citations

Pulmonary responses to bronchoconstrictor agonists in the mouse

1988 • 251 citations

Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells

1992 • 238 citations

Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand.

1992 • 208 citations

The Steel factor

1992 • 201 citations

Regulation of mouse peritoneal mast cell secretory function by stem cell factor, IL-3 or IL-4.

1993 • 154 citations

The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function.

1992 • 145 citations

Reversible expansion of primate mast cell populations in vivo by stem cell factor.

1993 • 127 citations

Mast cell-dependent amplification of an immunologically nonspecific inflammatory response. Mast cells are required for the full expression of cutaneous acute inflammation induced by phorbol 12-myristate 13-acetate.

1988 • 127 citations

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

1989 • 98 citations

Anaphylaxis in Mast Cell-Deficient Mice

1984 • 70 citations

Immune Response Potential of Mast Cell-Deficient W/W<sup>v</sup> Mice

1986 • 68 citations

Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses.

1991 • 53 citations

Development of large numbers of mast cells at sites of idiopathic chronic dermatitis in genetically mast cell-deficient WBB6F1-W/Wv mice

1987 • 52 citations

Induction of differentiation of human mast cells from bone marrow and peripheral blood mononuclear cells by recombinant human stem cell factor/kit-ligand in long-term culture

1992 • 33 citations

Systemic Anaphylaxis in Mast-Cell-Deficient Mice of W/W<sup>v</sup> and Sl/Sl<sup>d</sup> Genotypes

1987 • 23 citations