CONTRIBUTING FACTORS TO THE PATHOBIOLOGY

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

1995 • 5,291 citations

Identification of the Cystic Fibrosis Gene: Genetic Analysis

1989 • 4,105 citations

Genetic Dissection of Complex Traits

1994 • 3,497 citations

Interleukin-13: Central Mediator of Allergic Asthma

1998 • 2,642 citations

Requirement for IL-13 Independently of IL-4 in Experimental Asthma

1998 • 1,869 citations

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

1999 • 1,715 citations

Linkage Analysis of IL4 and Other Chromosome 5q31.1 Markers and Total Serum Immunoglobulin E Concentrations

1994 • 1,025 citations

A Polymorphism* in the 5 ′ Flanking Region of the CD14 Gene Is Associated with Circulating Soluble CD14 Levels and with Total Serum Immunoglobulin E

1999 • 861 citations

A genome-wide search for quantitative trait loci underlying asthma

1996 • 797 citations

Amino-Terminal Polymorphisms of the Human .beta.2-Adrenergic Receptor Impart Distinct Agonist-Promoted Regulatory Properties

1994 • 780 citations

Genetic Susceptibility to Asthma — Bronchial Hyperresponsiveness Coinherited with a Major Gene for Atopy

1995 • 774 citations

The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor

1997 • 743 citations

A genome-wide search for asthma susceptibility loci in ethnically diverse populations

1997 • 712 citations

Mutations in the Gene Encoding for the β₂-adrenergic Receptor in Normal and Asthmatic Subjects

1993 • 633 citations

LINKAGE BETWEEN IMMUNOGLOBULIN E RESPONSES UNDERLYING ASTHMA AND RHINITIS AND CHROMOSOME 11q

1989 • 624 citations

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing.

1997 • 624 citations

The relative risks of sensitivity to grass pollen, house dust mite and cat dander in the development of childhood asthma

1989 • 611 citations

Positional cloning moves from perditional to traditional

1995 • 603 citations

A Gain-of-function Polymorphism in a G-protein Coupling Domain of the Human β1-Adrenergic Receptor

1999 • 588 citations

Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy

1995 • 557 citations

Positional cloning: Let's not call it reverse anymore

1992 • 485 citations

Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.

1995 • 443 citations

Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.

1995 • 407 citations

Association between atopy and variants of the β subunit of the high–affinity immunoglobulin E receptor

1994 • 406 citations

Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma

1998 • 396 citations

Evidence for a Locus Regulating Total Serum IgE Levels Mapping to Chromosome 5

1994 • 395 citations

The genetics of asthma.

1996 • 388 citations

Population choice in mapping genes for complex diseases

1999 • 356 citations

A Genome-wide Search for Linkage to Asthma22See the Appendix.

1999 • 351 citations

Maternal inheritance of atopic IgE responsiveness on chromosome 11 q

1992 • 347 citations

The FcεRIβ Subunit Functions as an Amplifier of FcεRIγ-Mediated Cell Activation Signals

1996 • 346 citations

Association between β2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics

1997 • 342 citations

Ragweed Hay Fever: Genetic Control and Linkage to HL-A Haplotypes

1972 • 340 citations

Association of Glu 27 β2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects

1995 • 298 citations

Localisation of atopy and β subunit of high-affinity IgE receptor (Fc∈RI) on chromosome 11q

1993 • 294 citations

An IL-13 promoter polymorphism associated with increased risk of allergic asthma

1999 • 292 citations

Atopy and asthma: genetic variants of IL-4 and IL-13 signalling

2000 • 281 citations

Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression.

1998 • 278 citations

Tumour necrosis factor haplotypes and asthma

1997 • 277 citations

Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice

1995 • 275 citations

Variation in the Interleukin 4–Receptor α Gene Confers Susceptibility to Asthma and Atopy in Ethnically Diverse Populations

2000 • 271 citations

Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness.

1996 • 263 citations

DOES T4 TOXICOSIS EXIST ?

1975 • 252 citations

Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy.

1996 • 250 citations

The polymorphisms S503P and Q576R in the interleukin‐4 receptor α gene are associated with atopy and influence the signal transduction

1999 • 248 citations

Tumor Necrosis Factor- α Gene Polymorphism in Chronic Bronchitis

1997 • 243 citations

Genome Screen for Asthma and Related Phenotypes in the French EGEA Study

2000 • 243 citations

Linkage of Asthma and Total Serum IgE Concentration to Markers on Chromosome 12q: Evidence from Afro-Caribbean and Caucasian Populations

1996 • 226 citations

Genetic linkage of T-cell receptor $alpha;/$delta; complex to specific IgE responses

1994 • 219 citations

Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families.

1998 • 215 citations

Allergy-Associated FcRβ Is a Molecular Amplifier of IgE- and IgG-Mediated In Vivo Responses

1998 • 210 citations

The amino sugars

1965 • 208 citations

Association of asthma and the interleukin‐4 promoter gene in Japanese

1998 • 202 citations

β₂-Adrenergic Receptor Haplotypes in Mild, Moderate and Fatal/Near Fatal Asthma

1998 • 201 citations

Genetic Control of Basal Serum Immunoglobulin E Level and Its Effect on Specific Reaginic Sensitivity

1974 • 200 citations

Evidence for Linkage Between Asthma/Atopy in Childhood and Chromosome 5q31-q33 in a Japanese Population

1997 • 187 citations

A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness

1996 • 177 citations

Association Between a Sequence Variant in the IL-4 Gene Promoter and FEV₁ in Asthma

1999 • 175 citations

Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy

1995 • 169 citations

Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor

1998 • 163 citations

A genetic study of immunoglobulin E.

1978 • 163 citations

Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13.

1992 • 162 citations

The glutamine 27 β-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families

1997 • 161 citations

HLA‐DR and HLA‐DP genotypes and immunoglobulin E responses to common major allergens

1994 • 158 citations

Cutting edge: dominant effect of Ile50Val variant of the human IL-4 receptor alpha-chain in IgE synthesis.

1999 • 158 citations

Fc(epsilon)RI-(beta) polymorphism and risk of atopy in a general population sample

1995 • 151 citations

Linkage and allelic association of atopy and markers flanking the IL4‐receptor gene

1998 • 151 citations

Association of polymorphisms within the tumour necrosis factor (TNF) genes and childhood asthma

1998 • 141 citations

Common Polymorphisms in the Coding Part of the IL4-Receptor Gene

1997 • 131 citations

A polymorphism of the CC16 gene is associated with an increased risk of asthma.

1998 • 117 citations

Cutting Edge: Dominant Effect of Ile50Val Variant of the Human IL-4 Receptor α-Chain in IgE Synthesis

1999 • 114 citations

Evidence for Linkage of Chromosome 12q15–q24.1 Markers to High Total Serum IgE Concentrations in Children of the German Multicenter Allergy Study

1997 • 113 citations

Maternal effects in atopic disease

1998 • 108 citations

Prevalence of Tumor Necrosis Factor- α and Angiotensin Converting Enzyme Polymorphisms in Mild/Moderate and Fatal/Near-Fatal Asthma

1999 • 103 citations

Linkage of Chromosome 5q and 11q Gene Markers to Asthma-associated Quantitative Traits in Australian Children

1998 • 98 citations

Genetic transmission of serum IgE levels

1981 • 95 citations

Atopy and bronchial hyperresponsiveness: exclusion of linkage to markers on chromosomes 11q and 6p

1992 • 89 citations

β₂-Adrenergic Receptor Arg16/Arg16 Genotype Is Associated with Reduced Lung Function, but Not with Asthma, in the Hutterites

2000 • 87 citations

Genetic analysis of atopy in three large kindreds: no evidence of linkage to D11S97

1992 • 86 citations

Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families

1998 • 82 citations

Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy

1999 • 81 citations

Polymorphisms in the β₂‐adrenoreceptor gene are associated with decreased airway responsiveness

1999 • 80 citations

Lack of linkage between atopy and locus 11q13

1992 • 77 citations

Linkage of Circulating Eosinophils to Markers on Chromosome 5q

1998 • 76 citations

Linkage of Asthma to Markers on Chromosome 12 in a Sample of 240 Families Using Quantitative Phenotype Scores

1998 • 72 citations

Inheritance of total serum IgE (basal levels) in man.

1987 • 71 citations

Association between IgE response against Bet v I, the major allergen of Birch Pollen, and HLA-DRB alleles

1992 • 71 citations

Evidence for Mendelian inheritance of serum IgE levels in Hispanic and non-Hispanic white families.

1994 • 70 citations

Genetic analysis of the linkage between chromosome 11q and atopy

1992 • 68 citations

Extended tumour necrosis factor/HLA-DR haplotypes and asthma in an Australian population sample

1999 • 68 citations

A Genome-Wide Screen for Asthma-Associated Quantitative Trait Loci in a Mouse Model of Allergic Asthma

1999 • 67 citations

Genetic influences of chromosomes 5q31-q33 and 11q13 on specific IgE responsiveness to common inhaled allergens among African American families

1998 • 66 citations

Quantitative trait locus mapping of airway responsiveness to chromosomes 6 and 7 in inbred mice

1999 • 64 citations

Genome-wide screen for atopy susceptibility alleles in the Hutterites.

1999 • 62 citations

Linkage and Association of Atopic Asthma to Markers on Chromosome 13 in the Japanese Population

1999 • 61 citations

Relative risks of bronchial hyper‐responsiveness associated with skin‐prick test responses to common antigens in young adults

1991 • 59 citations

Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

1998 • 59 citations

Germline TCR-A restriction of immunoglobulin E responses to allergen

1997 • 47 citations

Suggestive Evidence for Genetic Linkage Between IgE Phenotypes and Chromosome 14q Markers

1999 • 44 citations

Indication of linkage of serum IgE levels to the interleukin-4 gene and exclusion of the contribution of the (-590 C to T) interleukin-4 promoter polymorphism to IgE variation

1999 • 42 citations

Mediators of allergic inflammation in the skin

1988 • 37 citations

Association between HLA-DRB3∗0101 and immunoglobulin-E responsiveness to Bet v I

1994 • 31 citations

Affected sib-pair and mutation analyses of the high affinity IgE receptor beta chain locus in Italian families with atopic asthmatic children.

1996 • 30 citations

Linkage and association studies of atopy and the chromosome 11q13 region.

1999 • 28 citations

Association of responsiveness to the major pollen allergen of Parietaria officinalis with HLA-DRB1∗ alleles a multicenter study

1996 • 27 citations

High frequency of IgE receptor FcεRIß variant (Leu181/Leu183) in Kuwaiti Arabs and its association with asthma

1998 • 26 citations

203 RA5 immune resposses, HLA antigens and complotypes

1985 • 25 citations

Association between asthma and an intragenic variant of CC16 on chromosome 11q13

1998 • 24 citations

Association between asthma and an intragenic variant of CC16 on chromosome 11q13

1998 • 16 citations

The genetics of specific allergy.

1996 • 15 citations

Handbook of Immune Response Genes

1998 • 13 citations

Specific IgE - one gene fits all?

1999 • 8 citations

Maternal Inheritance of Atopy at the FcεRlβ Locus in Japanese Sibs

1997 • 8 citations

Absence of mutations in the 6th exon of Fc epsilon RI-beta.

1996 • 6 citations

Absence of Mutations in the 6Th Exon of FcεRI-β

1996 • 5 citations