Lysosomes, Lysosomal Enzymes, and Cancer

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents.

1978 • 2,146 citations

Lysosomes in biology and pathology

1977 • 2,068 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Acid pH in tumors and its potential for therapeutic exploitation.

1989 • 1,633 citations

THE LARGE-SCALE SEPARATION OF PEROXISOMES, MITOCHONDRIA, AND LYSOSOMES FROM THE LIVERS OF RATS INJECTED WITH TRITON WR-1339

1968 • 1,112 citations

The relevance of tumour pH to the treatment of malignant disease

1984 • 886 citations

Proteolytic degradation of extracellular matrix in tumor invasion

1987 • 484 citations

Cathepsin D and Prognosis in Breast Cancer

1990 • 473 citations

Mannose 6-Phosphate Receptors and Lysosomal Enzyme Targeting

1989 • 473 citations

Cathepsin B1. A lysosomal enzyme that degrades native collagen

1974 • 405 citations

Lysosomal Cathepsin B: Correlation with Metastatic Potential

1981 • 370 citations

Lysosomes: A laboratory handbook

1978 • 367 citations

Effect of hyperthermia on malignant cellsin vivo: A review and a hypothesis

1977 • 349 citations

Release from Density Dependent Growth Inhibition by Proteolytic Enzymes

1970 • 338 citations

Isolation of rat liver lysosomes by isopycnic centrifugation in a metrizamide gradient.

1978 • 335 citations

CATHEPSIN D: AN INDEPENDENT PROGNOSTIC FACTOR FOR METASTASIS OF BREAST CANCER

1989 • 327 citations

The cystatins: a new class of peptidase inhibitors

1987 • 293 citations

Lysosomes: A laboratory handbook

1972 • 282 citations

Oxygen diffusion and the distribution of cellular radiosensitivity in tumours

1972 • 267 citations

Differences in secretion of the proteinase cathepsin B at the edges of human breast carcinomas and fibroadenomas

1978 • 260 citations

ATP-dependent acidification of intact and disrupted lysosomes. Evidence for an ATP-driven proton pump.

1981 • 255 citations

Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer.

1989 • 250 citations

In vitro degradation of extracellular matrix with Mr 52,000 cathepsin D secreted by breast cancer cells.

1988 • 242 citations

Cathepsin B: association with plasma membrane in metastatic tumors.

1986 • 222 citations

Tissue fractionation studies. 10. Influence of ischaemia on the state of some bound enzymes in rat liver

1959 • 214 citations

Estrogen‐induced lysosomal proteases secreted by breast cancer cells: A role in carcinogenesis?

1987 • 209 citations

Expression of cathepsin L in human tumors.

1991 • 208 citations

Enzyme Activity in Invasive Tumors of Human Breast and Colon

1974 • 205 citations

Cathepsin B activity in B16 melanoma cells: a possible marker for metastatic potential.

1982 • 200 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.

1976 • 183 citations

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.

1990 • 181 citations

Cell killing by lysosomotropic detergents.

1983 • 176 citations

Peroxidative and radiation damage to isolated lysosomes

1964 • 167 citations

Secretion of proteinases from malignant and nonmalignant human breast tissue.

1980 • 156 citations

Cysteine proteinase cathepsin L expression correlates closely with the metastatic potential of H-ras-transformed murine fibroblasts.

1987 • 151 citations

Prognostic significance of the estrogen-regulated protein, cathepsin D, in breast cancer. An immunohistochemical study

1990 • 150 citations

Glycosidases in cancer and invasion

1985 • 149 citations

Cloning and characterization of a mouse cysteine proteinase.

1986 • 137 citations

Influence of vitamin A on immunological response.

1972 • 136 citations

Gastrointestinal Radiation Injury

1968 • 132 citations

Biochemical Parameters correlated with Tumour Cell Implantation

1973 • 131 citations

Degradation of laminin by human tumor cathepsin B

1989 • 130 citations

Cysteine protease activities and tumor development in human colorectal carcinoma.

1989 • 123 citations

Lysosomotropic agents. 1. Synthesis and cytotoxic action of lysosomotropic detergents

1979 • 123 citations

The Activity of the Enzymes Sulphatase and β-Glucuronidase in the Urine, Serum and Bladder Tissue

1955 • 113 citations

Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinoma.

1991 • 109 citations

Lysosomal alterations in ischemic myocardium: Result or cause of myocellular damage?

1978 • 104 citations

Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells.

1989 • 103 citations

Plasma N-acetyl-β-glucosaminidase and β-glucuronidase in health and disease

1965 • 101 citations

beta-Glucuronidase activity in human tissues; some correlations with processes of malignant growth and with the physiology of reproduction.

1947 • 100 citations

Altered distribution of lysosomal cathepsin D in ischemic myocardium.

1977 • 99 citations

Immunodetection of cathepsins b and l present in and secreted from human pre‐malignant and malignant colorectal tumour cell lines

1989 • 97 citations

Uptake and subcellular localization of daunorubicin and adriamycin in cultured fibroblasts

1978 • 88 citations

Increase in Nonspecific Adsorptive Endocytosis in Anthracycline-and Vinca Alkaloid-Resistant Ehrlich Ascites Tumor Cell Lines2

1987 • 87 citations

Chloroquine enhancement of anticancer drug cytotoxicity in multiple drug resistant human leukemic cells

1986 • 85 citations

Relationship between medium pH and that of the lysosomal matrix as studied by two independent methods

1976 • 84 citations

Ultrastructure of a murine mammary carcinoma exposed to hyperthermia in vivo.

1976 • 84 citations

Mechanisms of Human Bladder Tumor Invasion: Role of Protease Cathepsin B

1990 • 84 citations

Membrane-associated cathepsin L: A role in metastasis of melanomas

1989 • 84 citations

Histochemical localization of cathepsin B at the invasion front of the rabbit V2 carcinoma.

1981 • 78 citations

The role of lysosomal enzymes in killing of mammalian cells by the lysosomotropic detergent N-dodecylimidazole.

1987 • 74 citations

Lysosomal enzyme activity in the interstitial fluid of solid mouse tumour transplants

1968 • 71 citations

Lysosomotropic agents reverse multiple drug resistance in human cancer cells

1986 • 70 citations

Enzyme Activity in Relation to Cancer

1957 • 67 citations

Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts.

1990 • 67 citations

The major excreted protein (MEP) of transformed mouse cells and cathepsin L have similar protease specificity

1986 • 66 citations

The effect of lysosomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells.

1988 • 66 citations

Sequential lysosomal alterations during cardiac ischemia. I. Biochemical and immunohistochemical changes.

1978 • 62 citations

Cathepsin B-like enzymes. Subcellular distribution and properties in neoplastic and control cells from human ectocervix.

1981 • 61 citations

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

1986 • 58 citations

Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis

1988 • 57 citations

β Hexosaminidase isozymes in human colonic carcinoma

1977 • 57 citations

A correlation between cell surface sialyltransferase, sialic acid, and glycosidase activities and the implantability of B16 murine melanoma.

1981 • 51 citations

Increased serum α-l-fucosidase and β-N-acetylglucosaminidase activities in diabetic, cirrhotic and gastric cancer patients

1980 • 48 citations

Uptake of Proteins by Malignant Cells

1962 • 47 citations

Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors.

1990 • 47 citations

Structure and Function of the Lysosomes of Human Fibroblasts in Culture: Dependence on Medium pH

1973 • 47 citations

Fetal mouse hearts: a model for studying ischemia.

1975 • 47 citations

Some mechanisms involved in cancer cell detachment by necrotic material

1978 • 45 citations

Periodic activation of lysosomal enzymes during regeneration of the liver

1963 • 44 citations

Cathepsin D assay in ovarian cancer: correlation with pathological features and receptors for oestrogen, progesterone and epidermal growth factor

1991 • 41 citations

Lysosomes in cancer cells

1974 • 41 citations

The effect of x-irradiation on the lysosomes of mouse mammary gland carcinomas.

1967 • 41 citations

Extracellular cysteine proteinase and collagenase activities as a consequence of tumor-host interaction in the rabbit V2 carcinoma.

1984 • 40 citations

The Effect of Whole-Body X-Irradiation on the Activity of Some Acid Hydrolases in Homogenates and Subcellular Fractions of Rat Spleen

1962 • 39 citations

Elevation of lysosomal enzymes in primary Lewis lung tumor correlated with the initiation of metastasis.

1980 • 38 citations

The influence of age on the activities of some acid hydrolases in the rat liver and kidney

1962 • 35 citations

In vitro degradation of extracellular matrix by human ovarian carcinoma cells

1987 • 32 citations

The Uptake of Proteins by Normal and Tumour Cells In Vitro

1964 • 32 citations

Glucuronide Metabolism, with Special Reference to the Steroid Hormones

1956 • 32 citations

The Effect of Total-Body X-Irradiation on the Distribution of Ribonuclease Activity in Subcellular Fractions of Rat Spleen

1959 • 32 citations

Role of glycosidases in human ovarian carcinoma cell mediated degradation of subendothelial extracellular matrix.

1987 • 29 citations

Acid Deoxyribonuclease and Acid Phosphatase Activities in Regenerating Rat Liver after Whole-Body X-Irradiation

1962 • 29 citations

The effect of hyperthermia and radiation on lysosomal enzyme activity of mouse mammary tumours

1979 • 28 citations

Comparison of Different Glycosidase Activities in Conditions of Cancer

1957 • 28 citations

High Oxygen Effect for the Release of Enzymes from Isolated Mammalian Lysosomes After Treatment with Ionizing Radiation

1970 • 28 citations

Cathepsin B-like activity in viable tumor cells isolated from rodent tumors.

1985 • 26 citations

Elevated activity of beta-hexosaminidase and sulfhydryl modification in the B-variant of human lung cancer.

1983 • 25 citations

Heat-induced Thermal Resistance and Its Relationship to Lysosomal Response

1978 • 25 citations

The Effect of Radiation on Tissue Deoxyribonuclease

1959 • 25 citations

Effect of x-irradiation on the functional status of lysosomal enzymes of mouse mammary gland carcinomas.

1971 • 24 citations

Beta-hexosaminidase activities and isoenzymes in normal human ovary and ovarian adenocarcinoma

1982 • 24 citations

Morphology and function of liver after intravenous and intraportal injections of the immunomodulating agent Propionibacterium granulosum

1984 • 23 citations

Alteration of hexosaminidase isozymes in human renal carcinoma.

1979 • 23 citations

Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line

1990 • 22 citations

The role of peptidases in cancer of the rectum and sigmoid colon

1985 • 22 citations

Proteinases and sialyltransferase in human breast tumors

1984 • 21 citations

ON THE CHEMICAL PATHOLOGY OF INTERSTITIAL FLUID

1968 • 20 citations

Proteolytic enzymes and their inhibitors in human gynecological tumors

1965 • 20 citations

The effect of hyperthermia on activation of lysosomal enzymes in HeLa cells

1979 • 20 citations

CHANGES IN HYDROLASE ENZYMORPHOLOGY OF RAT UTERUS AND VAGINA AFTER ESTROGENS; NAPHTHOL AS SUBSTRATES

1964 • 19 citations

Effect of Hyperthermia and Environmental Acidity on the Proteolytic Activity in Murine Ascites Tumor Cells2

1977 • 18 citations

Human serum hexosaminidase: elevated B form isozyme in cancer patients.

1978 • 18 citations

The Effect of X-Irradiation on the Activities of Some Lysosomal Hydrolases of Heart Tissue

1965 • 17 citations

Factors Influencing the Apparent Radiosensitivity and Heat Stability of Isolated Leucocyte Lysosomes

1966 • 15 citations

Response of Isolated Leukocyte Lysosomes to Gamma Irradiation

1966 • 14 citations

The effect of lysosomotropic detergents on the permeability properties of the lysosome membrane

1987 • 14 citations

Acid and neutral cysteine proteinase inhibitor in normal uterine portio and in squamo-epithelial metaplasia, dysplasias and infiltrative carcinoma of the uterine portio

1984 • 14 citations

Does Hyperthermia Produce Increased Lysosomal Enzyme Activity?

1983 • 13 citations

Turnover of Lysosomal Proteins and Induction and Distribution of Rat Liver Proteinases, after Treatment with Triton WR-1339

1975 • 13 citations

New observations on β-glucuronidase in human cervical cancer

1969 • 10 citations

Studies of the Effect of X‐Rays on the Glucuronide Synthesis and β‐Glucuronidase Activity in the Duodenal Mucous Membrane of the Rat

1961 • 10 citations

The relation to invasion of glycosidases in mouse tumours

1965 • 10 citations

Involvement of the Cellular Vacuolar System with the Cytotoxicity of Bleomycin-like Agents

1990 • 9 citations

[Behavior of small molecular cysteine proteinase inhibitors in lung cancers and surrounding tissue].

1984 • 9 citations

The histochemistry of glycosidases in human benign and malignant breast tissue

1984 • 9 citations

Effect of a transitory ischaemia on the structure-linked latency of rat liver acid phosphatase and β-galactosidase

1981 • 9 citations

Serum activities of lysosomal enzymes in patients with liver cell carcinoma

1982 • 9 citations

Das Verhalten der kleinmolekularen Cysteinproteinase-Inhibitoren in Lungencarcinomen und den sie umgebenden Geweben

1984 • 7 citations

Cathepsin B in cells of two rat sarcomas with different rates of spontaneous metastasis.

1989 • 6 citations

Deleted Work

1955 • 0 citations