Brain Reward Systems for Food Incentives and Hedonics in Normal Appetite and Eating Disorders

The neural basis of drug craving: An incentive-sensitization theory of addiction

1993 • 7,074 citations

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

1998 • 3,973 citations

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

2005 • 3,624 citations

Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex

2002 • 2,076 citations

Brain dopamine and obesity

2001 • 1,817 citations

Parsing reward

2003 • 1,661 citations

Behavioral Theories and the Neurophysiology of Reward

2005 • 1,605 citations

Physiological Role of Pleasure

1971 • 1,462 citations

Addiction

2002 • 1,444 citations

A role for lateral hypothalamic orexin neurons in reward seeking

2005 • 1,266 citations

The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats

1978 • 1,170 citations

Changes in brain activity related to eating chocolate: From pleasure to aversion

2001 • 1,150 citations

Neural Responses during Anticipation of a Primary Taste Reward

2002 • 1,082 citations

Neurobiology of addiction

1996 • 1,082 citations

Computational roles for dopamine in behavioural control

2004 • 957 citations

Nucleus accumbens shell and core dopamine: differential role in behavior and addiction

2002 • 957 citations

Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning

2004 • 915 citations

The lateral hypothalamic syndrome: Recovery of feeding and drinking after lateral hypothalamic lesions.

1962 • 880 citations

Motivational views of reinforcement: implications for understanding the behavioral functions of nucleus accumbens dopamine

2002 • 783 citations

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

2000 • 760 citations

Corticostriatal-hypothalamic circuitry and food motivation: Integration of energy, action and reward

2005 • 741 citations

Predictability Modulates Human Brain Response to Reward

2001 • 704 citations

Multiple neural systems controlling food intake and body weight

2002 • 701 citations

Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates

2001 • 700 citations

Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns

2000 • 688 citations

Dopamine Operates as a Subsecond Modulator of Food Seeking

2004 • 686 citations

Pleasures of the brain

2003 • 678 citations

Images of desire: food-craving activation during fMRI

2004 • 640 citations

Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?

2005 • 637 citations

Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers

2003 • 608 citations

The taste reactivity test. II. Mimetic responses to gustatory stimuli in chronic thalamic and chronic decerebrate rats

1978 • 582 citations

Hyperdopaminergic Mutant Mice Have Higher “Wanting” But Not “Liking” for Sweet Rewards

2003 • 521 citations

Sensitization of midbrain dopamine neuron reactivity and the self-administration of psychomotor stimulant drugs

2003 • 516 citations

Similarity Between Obesity and Drug Addiction as Assessed by Neurofunctional Imaging

2004 • 500 citations

THE FORM OF THE AUTO‐SHAPED RESPONSE WITH FOOD OR WATER REINFORCERS¹

1973 • 490 citations

An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens

2000 • 479 citations

Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking A PET/[11C]Raclopride Study in Healthy Men

2002 • 475 citations

Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain

2001 • 456 citations

“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect

2002 • 447 citations

Incentive Sensitization by Previous Amphetamine Exposure: Increased Cue-Triggered “Wanting” for Sucrose Reward

2001 • 435 citations

What is an unconscious emotion?(The case for unconscious "liking")

2003 • 423 citations

The role of prelimbic cortex in instrumental conditioning

2003 • 413 citations

Reexamination of the role of the hypothalamus in motivation.

1970 • 388 citations

Positive and Negative Motivation in Nucleus Accumbens Shell: Bivalent Rostrocaudal Gradients for GABA-Elicited Eating, Taste “Liking”/“Disliking” Reactions, Place Preference/Avoidance, and Fear

2002 • 387 citations

Exposure to appetitive food stimuli markedly activates the human brain

2004 • 385 citations

The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose “Liking” and Food Intake

2005 • 379 citations

Overlapping distributions of orexin/hypocretin‐ and dopamine‐β‐hydroxylase immunoreactive fibers in rat brain regions mediating arousal, motivation, and stress

2003 • 343 citations

A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

2005 • 337 citations

The gustofacial response: observation on normal and anencephalic newborn infants.

1973 • 310 citations

Opioid peptides and the control of human ingestive behaviour

2002 • 306 citations

Reward learning: Reinforcement, incentives, and expectations

2000 • 298 citations

Augmentation of drug reward by chronic food restriction

2002 • 296 citations

Dopaminergic correlates of motivated behavior: importance of drive

1995 • 296 citations

Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.

2000 • 290 citations

The Evolution of Cognition

2000 • 290 citations

What psychological process mediates feeding evoked by electrical stimulation of the lateral hypothalamus?

1991 • 282 citations

A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine

2003 • 273 citations

Ventral pallidal neurons code incentive motivation: amplification by mesolimbic sensitization and amphetamine

2005 • 269 citations

Reward without Dopamine

2003 • 269 citations

Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and Fos expression

2000 • 258 citations

Mind versus metabolism in the control of food intake and energy balance

2004 • 254 citations

Dissociation of Pavlovian and instrumental incentive learning under dopamine antagonists.

2000 • 244 citations

Distinguishing Whether Dopamine Regulates Liking, Wanting, and/or Learning About Rewards.

2005 • 243 citations

Brain Stimulation Reward

2015 • 236 citations

Food for thought: hedonic experience beyond homeostasis in the human brain

2004 • 225 citations

Where does damage lead to enhanced food aversion: the ventral pallidum/substantia innominata or lateral hypothalamus?

1993 • 221 citations

Endocannabinoids in the regulation of appetite and body weight

2005 • 209 citations

Nucleus accumbens mu-opioids regulate intake of a high-fat diet via activation of a distributed brain network.

2003 • 199 citations

High Dose Pimozide Does Not Block Amphetamine-Induced Euphoria in Normal Volunteers

1997 • 197 citations

Food Restriction Enhances the Central Rewarding Effect of Abused Drugs

1998 • 182 citations

Neural basis of utility estimation

1997 • 180 citations

Nucleus Accumbens μ-Opioids Regulate Intake of a High-Fat Diet via Activation of a Distributed Brain Network

2003 • 177 citations

Amphetamine-sensitized rats show sugar-induced hyperactivity (cross-sensitization) and sugar hyperphagia

2003 • 171 citations

The anhedonia hypothesis: Mark III

1985 • 169 citations

Sugars: hedonic aspects, neuroregulation, and energy balance

2003 • 165 citations

Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after Δ9-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716

2003 • 160 citations

Glutamate motivational ensembles in nucleus accumbens: rostrocaudal shell gradients of fear and feeding

2003 • 160 citations

Molecular and cellular basis of cannabinoid and opioid interactions

2005 • 160 citations

Dopaminergic Correlates of Sensory-Specific Satiety in the Medial Prefrontal Cortex and Nucleus Accumbens of the Rat

1999 • 156 citations

Pimozide Does Not Shift Palatability: Separation of Anhedonia from Sensorimotor Suppression by Taste Reactivity

1997 • 152 citations

Taste-related activity in the human dorsolateral prefrontal cortex

2003 • 151 citations

Locating Reward Cue at Response Manipulandum (CAM) Induces Symptoms of Drug Abuse

1996 • 140 citations

Endogenous cannabinoids and appetite.

2001 • 135 citations

Opioids as agents of reward-related feeding: a consideration of the evidence

2004 • 135 citations

Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons

2003 • 134 citations

The effects of acute haloperidol or risperidone on subjective responses to methamphetamine in healthy volunteers

2002 • 134 citations

Ventral Pallidal Representation of Pavlovian Cues and Reward: Population and Rate Codes

2004 • 131 citations

Activation of a subpopulation of orexin/hypocretin‐containing hypothalamic neurons by GABA_A receptor‐mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment

2004 • 130 citations

Causal Cognition and Goal-Directed Action

2000 • 127 citations

Food-deprivation increases cocaine-induced conditioned place preference and locomotor activity in rats

1997 • 126 citations

Like drugs for chocolate

2002 • 126 citations

Endogenous cannabinoids and appetite

2001 • 121 citations

Two types of aphagia and two types of sensorimotor impairment after lateral hypothalamic lesions: Observations in normal weight, dieted, and fattened rats.

1978 • 117 citations

The amygdala is critical for opioid-mediated binge eating of fat

2004 • 115 citations

Sucrose intake enhances behavioral sensitization produced by cocaine

2004 • 113 citations

Induction of a Salt Appetite Alters Dendritic Morphology in Nucleus Accumbens and Sensitizes Rats to Amphetamine

2002 • 112 citations

Human Gastric Function. An Experimental Study of a Man and His Stomach.

1946 • 111 citations

Appetite: neural and behavioural bases

1994 • 110 citations

Drug receptor subtypes and ingestive behaviour

1996 • 110 citations

Restricted feeding with scheduled sucrose access results in an upregulation of the rat dopamine transporter

2003 • 109 citations

NEUROBIOLOGICAL CONSTRAINTS ON BEHAVIORAL MODELS OF MOTIVATION

1997 • 108 citations

Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: interaction with environmental variables

2002 • 107 citations

AppetiteNeural and Behavioural Bases

1994 • 98 citations

Dopamine ligands and the stimulus effects of amphetamine: animal models versus human laboratory data

1997 • 93 citations

Endocannabinoids and food consumption: comparisons with benzodiazepine and opioid palatability-dependent appetite

2004 • 79 citations

Effect of Δ9-tetrahydrocannabinol on sucrose palatability as measured by the taste reactivity test

2005 • 79 citations

Taste pathways that mediate accumbens dopamine release by sapid sucrose

2005 • 78 citations

Palatability-dependent appetite and benzodiazepines: new directions from the pharmacology of GABAA receptor subtypes

2005 • 70 citations

Sensitization and conditioning of feeding following multiple morphine microinjections into the nucleus accumbens

1994 • 66 citations

Brain stimulation and motivation : research and commentary.

1973 • 57 citations

Approach and withdrawal analysis of the effects of hypothalamic stimulation and lesions in rats.

1979 • 57 citations

Orexin, drugs and motivated behaviors

2005 • 49 citations

Brain Stimulation Reward

2010 • 48 citations

Endocannabinoid Receptor Antagonists

2004 • 36 citations

Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding: A Perspective on the Munchies

2005 • 34 citations

Fast glucocorticoid feedback favors ‘the munchies’

2003 • 33 citations

Drive, incentive, and reinforcement: the antecedents and consequences of motivation.

2004 • 32 citations

Neuropharmacology of appetite and taste preferences

1994 • 30 citations

The Lateral Hypothalamus and Motivated Behavior: An Old Syndrome Reassessed and a New Perspective Gained

1995 • 28 citations

Taste, Salience, and Increased NaCl Ingestion after Repeated Sodium Depletions

2005 • 20 citations