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A proposed hypothalamic–thalamic–striatal axis for the integration of energy balance, arousal, and food reward

Data up to Jan 2025

Published2005
Citations337
References130

Total Citations Per Year

Abstract

References (130)

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Affective Neuroscience

1998 • 3,626 citations

Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems

1998 • 3,381 citations

Dopamine, learning and motivation

2004 • 3,146 citations

Drug Addiction, Dysregulation of Reward, and Allostasis

2001 • 2,820 citations

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

2005 • 2,323 citations

Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex

2002 • 2,076 citations

Food reward: Brain substrates of wanting and liking

1996 • 1,831 citations

The Nature of the Arrestin·Receptor Complex Determines the Ultimate Fate of the Internalized Receptor

2003 • 1,744 citations

Handbook of Experimental Pharmacology.

1971 • 1,547 citations

The neostriatal mosaic: multiple levels of compartmental organization

1992 • 1,450 citations

Specificity in the projection patterns of accumbal core and shell in the rat

1991 • 1,186 citations

Striatal interneurones: chemical, physiological and morphological characterization

1995 • 1,174 citations

From Lesions to Leptin

1999 • 1,165 citations

Changes in brain activity related to eating chocolate: From pleasure to aversion

2001 • 1,150 citations

Putting a spin on the dorsal–ventral divide of the striatum

2004 • 1,141 citations

On the significance of subterritories in the “accumbens” part of the rat ventral striatum

1992 • 1,022 citations

Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events

2000 • 962 citations

The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness

2002 • 927 citations

Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning

2004 • 915 citations

Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.

1988 • 913 citations

Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning

1998 • 860 citations

Cerebral hemisphere regulation of motivated behavior11Published on the World Wide Web on 2 November 2000.

2000 • 823 citations

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area

1998 • 817 citations

Dopamine neurons and their role in reward mechanisms

1997 • 757 citations

Dopamine Operates as a Subsecond Modulator of Food Seeking

2004 • 686 citations

The physiology of motivation.

1954 • 663 citations

The thalamostriatal system: a highly specific network of the basal ganglia circuitry

2004 • 580 citations

Coincident but Distinct Messages of Midbrain Dopamine and Striatal Tonically Active Neurons

2004 • 573 citations

Behavioral functions of nucleus accumbens dopamine: Empirical and conceptual problems with the anhedonia hypothesis

1997 • 525 citations

Opioid modulation of taste hedonics within the ventral striatum

2002 • 514 citations

Functional diversity and specificity of neostriatal interneurons

2004 • 502 citations

Synaptic Interaction between Hypocretin (Orexin) and Neuropeptide Y Cells in the Rodent and Primate Hypothalamus: A Novel Circuit Implicated in Metabolic and Endocrine Regulations

1999 • 502 citations

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

1993 • 458 citations

Pharmacological characterization of dopamine systems in the nucleus accumbens core and shell

1992 • 457 citations

The Frontal Cortex-Basal Ganglia System in Primates

1996 • 445 citations

Input from the frontal cortex and the parafascicular nucleus to cholinergic interneurons in the dorsal striatum of the rat

1992 • 444 citations

Neurons in the Thalamic CM-Pf Complex Supply Striatal Neurons With Information About Behaviorally Significant Sensory Events

2001 • 440 citations

Cholinergic interneuron characteristics and nicotinic properties in the striatum

2002 • 428 citations

Neural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat

1983 • 403 citations

Opioid site in nucleus accumbens shell mediates eating and hedonic ‘liking’ for food: map based on microinjection Fos plumes

2000 • 399 citations

CREB and the formation of long-term memory

1996 • 399 citations

Glutamate receptors in the nucleus accumbens shell control feeding behavior via the lateral hypothalamus

1995 • 390 citations

Distribution of m1-m4 muscarinic receptor proteins in the rat striatum: light and electron microscopic immunocytochemistry using subtype- specific antibodies

1994 • 390 citations

The Neuroanatomical Axis for Control of Energy Balance

2002 • 390 citations

Temporal and spatial characteristics of tonically active neurons of the primate's striatum

1995 • 388 citations

GABA in the Nucleus Accumbens Shell Participates in the Central Regulation of Feeding Behavior

1997 • 385 citations

Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean

2001 • 373 citations

Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior

1998 • 366 citations

Switching Memory Systems during Learning: Changes in Patterns of Brain Acetylcholine Release in the Hippocampus and Striatum in Rats

2003 • 330 citations

Coincident Activation of NMDA and Dopamine D1Receptors within the Nucleus Accumbens Core Is Required for Appetitive Instrumental Learning

2000 • 324 citations

Identification of synaptic terminals of thalamic or cortical origin in contact with distinct medium‐size spiny neurons in the rat neostriatum

1988 • 319 citations

Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect

2002 • 310 citations

Evidence of a Functional Relationship between the Nucleus Accumbens Shell and Lateral Hypothalamus Subserving the Control of Feeding Behavior

1999 • 310 citations

Spontaneous activity of neostriatal cholinergic interneurons in vitro.

1999 • 306 citations

Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action

2001 • 302 citations

Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant‐like effects

2004 • 296 citations

Opiate reward: Sites and substrates

1989 • 291 citations

Neural mechanisms of reward-related motor learning

2003 • 287 citations

Spontaneous Activity of Neostriatal Cholinergic InterneuronsIn Vitro

1999 • 277 citations

Modulation of feeding‐induced activation of mesolimbic dopamine transmission by appetitive stimuli and its relation to motivational state

1999 • 276 citations

Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors.

1993 • 274 citations

Neuronal synchronization of tonically active neurons in the striatum of normal and parkinsonian primates

1996 • 270 citations

Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior

2001 • 266 citations

Nucleus accumbens opioid, GABAergic, and dopaminergic modulation of palatable food motivation: Contrasting effects revealed by a progressive ratio study in the rat.

2003 • 266 citations

Enhanced intake of high-fat food following striatal mu-opioid stimulation: microinjection mapping and Fos expression

2000 • 258 citations

Mind versus metabolism in the control of food intake and energy balance

2004 • 254 citations

The Functional Organization of the Diencephalon

1958 • 250 citations

The lateral hypothalamic area revisited: Neuroanatomy, body weight regulation, neuroendocrinology and metabolism

1993 • 250 citations

The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s)

1993 • 250 citations

Modulation of taste affect by hunger, caloric satiety, and sensory-specific satiety in the rat

1991 • 246 citations

Toward a new neurobiology of energy balance, appetite, and obesity: The anatomists weigh in

1998 • 239 citations

Effects of selective dopamine D1 or D2 receptor blockade within nucleus accumbens subregions on ingestive behavior and associated motor activity

2002 • 221 citations

Neural and psychological mechanisms underlying appetitive learning: links to drug addiction

2004 • 216 citations

Encoding of Palatability and Appetitive Behaviors by Distinct Neuronal Populations in the Nucleus Accumbens

2005 • 214 citations

Opioids and food intake: distributed functional neural pathways?

1999 • 205 citations

Cholinergic synaptic input to different parts of spiny striatonigral neurons in the rat

1988 • 201 citations

Neural integrative activities of nucleus accumbens subregions in relation to learning and motivation

1999 • 196 citations

Naloxone, an opiate blocker, reduces the consumption of sweet high-fat foods in obese and lean female binge eaters

1995 • 189 citations

Feeding induced by opioid stimulation of the ventral striatum: role of opiate receptor subtypes.

1993 • 180 citations

Investigation of the effects of opiate antagonists infused into the nucleus accumbens on feeding and sucrose drinking in rats.

1996 • 177 citations

Involvement of the dorsomedial striatum in behavioral flexibility: role of muscarinic cholinergic receptors

2002 • 171 citations

Lateral hypothalamic electrical stimulation: Does it make animals ‘hungry’?

1974 • 168 citations

Effects of Feeding and Drinking on Acetylcholine Release in the Nucleus Accumbens, Striatum, and Hippocampus of Freely Behaving Rats

1992 • 150 citations

The lateral hypothalamus: a primary site mediating excitatory amino acid-elicited eating

1993 • 148 citations

Hippocampal and midline thalamic fibers and terminals in relation to the choline acetyltransferase‐immunoreactive neurons in nucleus accumbens of the rat: A light and electron microscopic study

1990 • 139 citations

Selective effects of naltrexone on food pleasantness and intake

1996 • 134 citations

Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons

2003 • 134 citations

Arcuate NPY neurons and energy homeostasis in diet-induced obese and resistant rats

1999 • 132 citations

Selective reward deficit in mice lacking beta-endorphin and enkephalin.

2002 • 131 citations

Feeding induced by blockade of AMPA and kainate receptors within the ventral striatum: a microinfusion mapping study

1997 • 130 citations

Activation of a subpopulation of orexin/hypocretin‐containing hypothalamic neurons by GABAA receptor‐mediated inhibition of the nucleus accumbens shell, but not by exposure to a novel environment

2004 • 130 citations

Feeding induced by GABA-sub(A ) receptor stimulation within the nucleus accumbens shell: Regional mapping and characterization of macronutrient and taste preference.

1999 • 130 citations

The Neurobiology of Opiate Reinforcement

1998 • 120 citations

Modulation by Central and Basolateral Amygdalar Nuclei of Dopaminergic Correlates of Feeding to Satiety in the Rat Nucleus Accumbens and Medial Prefrontal Cortex

2002 • 117 citations

Feeding induced by GABAA receptor stimulation within the nucleus accumbens shell: Regional mapping and characterization of macronutrient and taste preference.

1999 • 116 citations

The amygdala is critical for opioid-mediated binge eating of fat

2004 • 115 citations

Selective Reward Deficit in Mice Lacking β-Endorphin and Enkephalin

2002 • 112 citations

Dynamic Changes in Acetylcholine Output in the Medial Striatum During Place Reversal Learning

2004 • 99 citations

Psychopharmacology of conditioned reward: evidence for a rewarding signal at D 1 -like dopamine receptors

1999 • 97 citations

Extracellular acetylcholine is increased in the nucleus accumbens following the presentation of an aversively conditioned taste stimulus

1995 • 97 citations

Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro

2004 • 94 citations

Nucleus Accumbens Acetylcholine Regulates Appetitive Learning and Motivation for Food via Activation of Muscarinic Receptors.

2004 • 93 citations

Acetylcholine actions in the dorsomedial striatum support the flexible shifting of response patterns

2003 • 91 citations

Regulation of the subcellular distribution of m4 muscarinic acetylcholine receptors in striatal neurons in vivo by the cholinergic environment: evidence for regulation of cell surface receptors by endogenous and exogenous stimulation.

1999 • 81 citations

Muscarinic receptors regulate striatal neuropeptide gene expression in normal and amphetamine-treated rats

1996 • 74 citations

Glutamate‐Mediated Plasticity in Corticostriatal Networks

2003 • 74 citations

Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects

1997 • 72 citations

Behavior Elicited by Hypothalamic Stimulation

1969 • 72 citations

Multiple opioid receptors mediate feeding elicited by mu and delta opioid receptor subtype agonists in the nucleus accumbens shell in rats

2000 • 71 citations

The Cerebral Cortex and Parafascicular Thalamic Nucleus Facilitate In vivo Acetylcholine Release in the Rat Striatum through Distinct Glutamate Receptor Subtypes

1996 • 70 citations

Differential role of the accumbens Shell and Core subterritories in food-entrained rhythms of rats

2004 • 69 citations

Regulation of the Subcellular Distribution of m4 Muscarinic Acetylcholine Receptors in Striatal NeuronsIn Vivoby the Cholinergic Environment: Evidence for Regulation of Cell Surface Receptors by Endogenous and Exogenous Stimulation

1999 • 67 citations

The associative striatum: cortical and thalamic projections to the dorsocentral striatum in rats

2003 • 65 citations

Role of the parafascicular thalamic nucleus and N-methyl-d-aspartate transmission in the D1-dependent control of in vivo acetylcholine release in rat striatum

1996 • 62 citations

Invertebrate Learning: What Can't a Worm Learn?

2004 • 55 citations

The Dual Peptidase Inhibitor RB101 Induces a Long‐Lasting Increase in the Extracellular Level of Met‐Enkephalin‐Like Material in the Nucleus Accumbens of Freely Moving Rats

1996 • 55 citations

Involvement of Thalamic Paraventricular Nucleus in the Anticipatory Reaction under Food Restriction in the Rat

2004 • 53 citations

Functional opioid pathways are necessary for hypocretin-1 (orexin-A)-induced feeding

2004 • 52 citations

Regulation of Neurotransmitter Interactions in the Ventral Striatum

1999 • 50 citations

Dietary Modulation Of Mu And Kappa Opioid Receptor-mediated Analgesia

1997 • 44 citations

The effect of naloxone on food-motivated behavior in the obese Zucker rat

1999 • 42 citations

Endogenous expression of c-Fos in hypothalamic nuclei of neonatal rabbits coincides with their circadian pattern of suckling-associated arousal

1998 • 41 citations

Acute and Chronic Acetylcholinesterase Inhibition Regulates in Vivo the Localization and Abundance of Muscarinic Receptors m2 and m4 at the Cell Surface and in the Cytoplasm of Striatal Neurons

2002 • 34 citations

Accumbens cholinergic interneurons play a role in the regulation of body weight and metabolism

2000 • 34 citations

Synaptic relationships of enkephalinergic and cholinergic neurons in the nucleus accumbens of the rat

1994 • 24 citations

Cholinergic regulation of tachykinin- and enkephalin-gene expression in the rat striatum

1995 • 23 citations

μ opioid control of the N-methyl-d-aspartate-evoked release of [3h]-acetylcholine in the limbic territory of the rat striatum in vitro: diurnal variations and implication of a dopamine link

2003 • 21 citations

Diurnal rhythm of the in vivo release of enkephalin from the globus pallidus of the rat

1986 • 13 citations

Role of accumbens cholinergic interneurons in the maintenance of body weight.

1997 • 3 citations

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