Heme Protein Radicals

Principles of Fluorescence Spectroscopy

1999 • 27,045 citations

Enzyme structure and mechanism

1978 • 2,897 citations

Principles of fluorescence spectroscopy

1984 • 1,031 citations

Identification by ENDOR of Trp ¹⁹¹ as the Free-Radical Site in Cytochrome c Peroxidase Compound ES

1989 • 469 citations

Further comments on the redox potentials of tryptophan and tyrosine

1987 • 418 citations

The oxidizing nature of the hydroxyl radical. A comparison with the ferryl ion (FeO2+)

1984 • 364 citations

The reaction between metmyoglobin and hydrogen peroxide

1952 • 278 citations

Energetics of interconversion reactions of oxyradicals

1985 • 277 citations

EPR spin-trapping study on the oxidizing species formed in the reaction of the ferrous ion with hydrogen peroxide

1991 • 274 citations

The Mechanism of Metmyoglobin Oxidation

1963 • 261 citations

A novel antioxidant role for hemoglobin. The comproportionation of ferrylhemoglobin with oxyhemoglobin.

1990 • 219 citations

PROTEIN RADICAL INVOLVEMENT IN BIOLOGICAL CATALYSIS?

1989 • 215 citations

Sensitized photooxidation of histidine and its derivatives. Products and mechanism of the reaction

1969 • 199 citations

Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome.

1993 • 197 citations

Reactions of the Protein Radical in Peroxide-treated Myoglobin

1989 • 183 citations

The myoglobin protein radical. Coupling of Tyr-103 to Tyr-151 in the H2O2-mediated cross-linking of sperm whale myoglobin.

1988 • 180 citations

Epoxidation of styrene by hemoglobin and myoglobin. Transfer of oxidizing equivalents to the protein surface.

1985 • 175 citations

Influence of Interior Packing and Hydrophobicity on the Stability of a Protein

1989 • 173 citations

Chemical Reagents for Protein Modification

2020 • 163 citations

Exposure of Hydrophobic Moieties Promotes the Selective Degradation of Hydrogen Peroxide-Modified Hemoglobin by the Multicatalytic Proteinase Complex, Proteasome

1994 • 153 citations

Identification of a globin free radical in equine myoglobin treated with peroxides

1991 • 149 citations

Tryptophan-191 .fwdarw. phenylalanine, a proximal-side mutation in yeast cytochrome c peroxidase that strongly affects the kinetics of ferrocytochrome c oxidation

1988 • 144 citations

Reaction of myoglobin with hydrogen peroxide forms a peroxyl radical which oxidizes substrates.

1994 • 141 citations

Evaluation of the horseradish peroxidase-scopoletin method for the measurement of hydrogen peroxide formation in biological systems

1977 • 135 citations

Electron spin resonance study on peroxidase- and oxidase-reactions of horse radish peroxidase and methemoglobin

1975 • 119 citations

Intramolecular translocation of the protein radical formed in the reaction of recombinant sperm whale myoglobin with H2O2.

1992 • 117 citations

Free radical combination reactions involving phenoxyl radicals

1993 • 113 citations

The Generation of Ferryl or Hydroxyl Radicals During Interaction of Haemproteins with Hydrogen Peroxide

1988 • 109 citations

Self-peroxidation of Metmyoglobin Results in Formation of an Oxygen-reactive Tryptophan-centered Radical

1995 • 106 citations

Formation of Hydroxyl Radicals in Biological Systems. Does Myoglobin Stimulate Hydroxyl Radical Formation from Hydrogen Peroxide?

1988 • 102 citations

Amino acid free radicals in oxidised metmyoglobin

1967 • 98 citations

Compound I radical in site-directed mutants of cytochrome c peroxidase as probed by electron paramagnetic resonance and electron-nuclear double resonance

1991 • 95 citations

Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis.

1994 • 95 citations

Detection and reactions of the globin radical in haemoglobin

1993 • 91 citations

Influence of nitrogen base ligation and hydrogen bonding on the rate constants for oxygen transfer from percarboxylic acids and alkyl hydroperoxides to (meso-tetraphenylporphinato)manganese(III) chloride

1986 • 87 citations

X-ray absorption studies of myoglobin peroxide reveal functional differences between globins and heme enzymes

1986 • 86 citations

The repair of oxidized amino acids by antioxidants

1984 • 81 citations

[19] Ferrylmyoglobin: Formation and chemical reactivity toward electron-donating compounds

1994 • 81 citations

Redox chemistry of substituted benzenes: the one-electron reduction potentials of methoxy-substituted benzene radical cations

1993 • 76 citations

A possible structure for the higher oxidation state of metmyoglobin

1955 • 73 citations

Electron spin resonance spectrum of Tyr-151 free radical formed in reactions of sperm whale metmyoglobin with ethyl hydroperoxide and potassium irridate

1989 • 73 citations

6 Cytochrome c Peroxidase

1976 • 73 citations

Oxidative modification by low levels of HOOH can transform myoglobin to an oxidase.

1991 • 72 citations

The interaction of Trolox C, a water-soluble vitamin E analog, with ferrylmyoglobin: Reduction of the oxoferryl moiety

1992 • 72 citations

Structure of the tyrosyl radical in bacteriophage T4-induced ribonucleotide reductase.

1982 • 64 citations

Detection of ferryl myoglobin in the isolated ischemic rat heart

1990 • 64 citations

Site-specific oxidation of angiotensin I by copper(II) and l-ascorbate: Conversion of histidine residues to 2-imidazolones

1990 • 63 citations

The roles of His-64, Tyr-103, Tyr-146, and Tyr-151 in the epoxidation of styrene and beta-methylstyrene by recombinant sperm whale myoglobin.

1993 • 62 citations

Long‐Range Electron Transfer in Myoblobina

1988 • 62 citations

Protein‐radical enzymes

1993 • 58 citations

Importance of a conserved hydrogen-bonding network in cytochromes c to their redox potentials and stabilities

1991 • 48 citations

Oxidation of myoglobin in isolated adult rat cardiac myocytes by 15‐hydroperoxy‐5,8,11,13‐eicosatetraenoic acid

1983 • 45 citations

Inhibition of Protein Radical Reactions of Ferrylmyoglobin by the Water-Soluble Analog of Vitamin E, Trolox C

1993 • 44 citations

A radical approach to enzyme catalysis

1995 • 42 citations

Ultraviolet difference spectroscopy of myoglobin: assignment of pK values of tyrosyl phenolic groups and the stability of the ferryl derivatives

1981 • 39 citations

Cytochrome c Peroxidase

1970 • 38 citations

Protein dynamics and reaction rates: mode-specific chemistry in large molecules?

1988 • 31 citations

Oxidation of Dimethylsulphoxide to Formaldehyde by Oxyhaemoglobin and Oxyleghaemoglobin in the Presence of Hydrogen Peroxide is Not Mediated by “Free” Hydroxyl Radicals

1989 • 19 citations

Photolysis of L-Histidine

1965 • 11 citations

AUTOÖXIDATION OF L-ASCORBIC ACID AND IMIDAZOLE NUCLEUS

1955 • 11 citations

Temperature Effects on the Formation and Reactions of Free Radicals in Gamma-Irradiated Dry Enzymes

1968 • 10 citations

Reduction potentials determination of some biochemically important free radicals. Pulse radiolysis and electrochemical methods

1993 • 8 citations