A radical approach to enzyme catalysis

Three-dimensional structure of the free radical protein of ribonucleotide reductase

1990 • 833 citations

Structure of ribonucleotide reductase protein R1

1994 • 571 citations

From RNA to DNA, Why So Many Ribonucleotide Reductases?

1993 • 525 citations

How a Protein Binds B ₁₂ : A 3.0 Å X-Ray Structure of B ₁₂ -Binding Domains of Methionine Synthase

1994 • 502 citations

Mechanisms of Coenzyme B ₁₂ -Dependent Rearrangements

1985 • 488 citations

Modern metabolism as a palimpsest of the RNA world.

1989 • 472 citations

Cobalamin‐dependent methionine synthase

1990 • 399 citations

Vitamin B₁₂: Experiments Concerning the Origin of Its Molecular Structure

1988 • 360 citations

The free radical in pyruvate formate-lyase is located on glycine-734.

1992 • 354 citations

Structure of the 5,6-Dimethylbenzimidazolylcobamide Coenzyme

1961 • 313 citations

In vitro evolution of new ribozymes with polynucleotide kinase activity

1994 • 271 citations

Enzymology of the Acetyl-CoA Pathway of CO₂Fixation

1991 • 247 citations

Thermolysis of the cobalt-carbon bond of adenosylcobalamin. 2. Products, kinetics, and cobalt-carbon bond dissociation energy in aqueous solution

1986 • 231 citations

PROTEIN RADICAL INVOLVEMENT IN BIOLOGICAL CATALYSIS?

1989 • 215 citations

A model for the role of multiple cysteine residues involved in ribonucleotide reduction: amazing and still confusing

1992 • 210 citations

Magnetic Field Effects on B ₁₂ Ethanolamine Ammonia Lyase: Evidence for a Radical Mechanism

1994 • 193 citations

In vitro selection of RNA aptamers specific for cyanocobalamin

1994 • 193 citations

Adenosylmethionine-dependent synthesis of the glycyl radical in pyruvate formate-lyase by abstraction of the glycine C-2 pro-S hydrogen atom. Studies of [2H]glycine-substituted enzyme and peptides homologous to the glycine 734 site.

1994 • 169 citations

Use of Isotope Effects to Elucidate Enzyme Mechanism

1982 • 167 citations

Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactorof E. coli Ribonucleotide Reductase. 3. Kinetics of the Limiting Fe2+ Reaction by Optical, EPR, and Moessbauer Spectroscopies

1994 • 160 citations

How Nature Builds the Pigments of Life: the Conquest of Vitamin B ₁₂

1994 • 158 citations

Activation of Methionine Synthetase by a Reduced Triphosphopyridine Nucleotide-dependent Flavoprotein System

1974 • 153 citations

An iron-sulfur center and a free radical in the active anaerobic ribonucleotide reductase of Escherichia coli.

1993 • 147 citations

Cloning and sequencing of glutamate mutase component S from Clostridium tetanomorphum Homologies with other cobalamin‐dependent enzymes

1992 • 125 citations

A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene.

1993 • 122 citations

The Mechanism of Action of Ethanolamine Ammonia-Lyase, a B12-dependent Enzyme

1974 • 110 citations

Flavodoxin Is Required for the Activation of the Anaerobic Ribonucleotide Reductase

1993 • 103 citations

Cloning, sequencing, and expression of the adenosylcobalamin-dependent ribonucleotide reductase from Lactobacillus leichmannii.

1993 • 99 citations

The Redox Centers of Ribonucleotide Reductase of Escherichia coli

1992 • 98 citations

Pyruvate formate-lyase mechanism involving the protein-based glycyl radical

1993 • 95 citations

Lysine 2,3-Aminomutase

1989 • 95 citations

Structure of a substrate radical intermediate in the reaction of lysine 2,3-aminomutase

1992 • 89 citations

Dioxygen is the source of the mu-oxo bridge in iron ribonucleotide reductase.

1994 • 87 citations

Characterization of iron-sulfur clusters in lysine 2,3-aminomutase by electron paramagnetic resonance spectroscopy

1992 • 86 citations

The anaerobic ribonucleotide reductase from Escherichia coli.

1993 • 85 citations

Lysine 2,3‐aminomutase: is adenosylmethionine a poor man's adenosylcobalamin?

1993 • 82 citations

The reductive pentose phosphate cycle for photosynthetic CO ₂ assimilation: enzyme modulation

1993 • 80 citations

Ribonucleotide Reductases

1990 • 71 citations

1,2-Migrations in free radicals related to coenzyme B12-dependent rearrangements

1988 • 68 citations

Molecular properties of pyruvate formate-lyase activating enzyme

1993 • 63 citations

Adenosylcobalamin-dependent glutamate mutase from Clostridium tetanomorphum. Overexpression in Escherichia coli, purification, and characterization of the recombinant enzyme.

1994 • 62 citations

Chemical model for the pyridoxal 5'-phosphate dependent lysine aminomutases

1990 • 57 citations

Tryptophan radicals formed by iron/oxygen reaction with Escherichia coli ribonucleotide reductase protein R2 mutant Y122F.

1994 • 55 citations

Cloning, sequencing and expression of the gene encoding the coenzyme B₁₂‐dependent 2‐methyleneglutarate mutase from Clostridium barkeri in Escherichia coli

1994 • 52 citations

Adenosylcobalamin and cob(II)alamin as prosthetic groups of 2‐methyleneglutarate mutase from Clostridium barkeri

1992 • 51 citations

Catalytic‐site mapping of pyruvate formate lyase

1988 • 49 citations

First hydrogen abstraction-rearrangement model for the coenzyme B12-dependent methylmalonyl-CoA to succinyl-CoA carbon skeleton rearrangement reaction

1992 • 47 citations

Extended x-ray absorption fine structure studies on the iron-containing subunit of ribonucleotide reductase from Escherichia coli

1987 • 43 citations

Mechanism of inactivation of Escherichia coli ribonucleotide reductase by 2'-chloro-2'-deoxyuridine 5'-diphosphate: evidence for generation of a 2'-deoxy-3'-ketonucleotide via a net 1,2 hydrogen shift

1985 • 43 citations

Identification of a paramagnetic species as an early intermediate in the coenzyme B₁₂‐dependent glutamate mutase reaction A cob(II)amide?

1992 • 37 citations

The mechanism of action of ethanolamine ammonia-lyase, an adenosylcobalamin-dependent enzyme. Evidence that the hydrogen transfer mechanism involves a second intermediate hydrogen carrier in addition to the cofactor.

1985 • 37 citations

Lysine 2,3‐Aminomutase and the Mechanism of the Interconversion of Lysine and β‐Lysine

1993 • 33 citations

The Enzymic Interconversion of Isobutyryl andn-Butyrylcarba(dethia)-Coenzyme A: A Coenzyme-B₁₂-dependent Carbon Skeleton Rearrangement

1988 • 28 citations

Tritium isotope effects in adenosylcobalamin-dependent glutamate mutase: Implications for the mechanism

1995 • 28 citations

Diol Dehydrase and Glycerol Dehydrase, Coenzyme B12-Dependent Isozymes

2024 • 26 citations

The synthetic substrate succinyl(carbadethia)-CoA generates cob(II)alamin on adenosylcobalamin-dependent methylmalonyl-CoA mutase

1993 • 23 citations

The conserved serine 211 is essential for reduction of the dinuclear iron center in protein R2 of Escherichia coli ribonucleotide reductase.

1994 • 19 citations

Mechanism-based inactivation of pyruvate formate-lyase by acetylphosphinate: evidence for carbon-phosphorus bond cleavage

1991 • 18 citations

Model for the coenzyme B12-dependent glutamate-methylaspartate carbon skeleton rearrangement

1989 • 17 citations

Ribonucleotide reductases: Radical enzymes with suicidal tendencies

1993 • 16 citations

S-Adenosylmethionine-Dependent Radical Formation in Anaerobic Systems

2024 • 4 citations

Adenosylcobalamin (Vitamin B12 Coenzyme)-Dependent Enzymes

2024 • 1 citations

Deleted Work

1955 • 0 citations