[19] Ferrylmyoglobin: Formation and chemical reactivity toward electron-donating compounds

Nitric oxide as an antioxidant

1991 • 441 citations

Initiation of lipid peroxidation in biological systems

1987 • 385 citations

Initiation of membranal lipid peroxidation by activated metmyoglobin and methemoglobin

1985 • 359 citations

The reaction between metmyoglobin and hydrogen peroxide

1952 • 278 citations

The Mechanism of Metmyoglobin Oxidation

1963 • 261 citations

The Effects of Protein Conformation on the Heme Symmetry in High Spin Ferric Heme Proteins as Studied by Electron Paramagnetic Resonance

1971 • 247 citations

Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products

1990 • 245 citations

The antioxidant action of ergothioneine

1991 • 224 citations

A novel antioxidant role for hemoglobin. The comproportionation of ferrylhemoglobin with oxyhemoglobin.

1990 • 219 citations

Sulfheme Proteins

1971 • 189 citations

Reactions of the Protein Radical in Peroxide-treated Myoglobin

1989 • 183 citations

The myoglobin protein radical. Coupling of Tyr-103 to Tyr-151 in the H2O2-mediated cross-linking of sperm whale myoglobin.

1988 • 180 citations

Epoxidation of styrene by hemoglobin and myoglobin. Transfer of oxidizing equivalents to the protein surface.

1985 • 175 citations

Optical measurements of intracellular oxygen concentration of rat heart in vitro

1978 • 172 citations

Identification of a globin free radical in equine myoglobin treated with peroxides

1991 • 149 citations

Electron spin resonance study on peroxidase- and oxidase-reactions of horse radish peroxidase and methemoglobin

1975 • 119 citations

Free Radical produced in the Reaction of Metmyoglobin with Hydrogen Peroxide

1958 • 118 citations

Intramolecular translocation of the protein radical formed in the reaction of recombinant sperm whale myoglobin with H2O2.

1992 • 117 citations

Detection of Myoglobin-Derived Radicals On Reaction of Metmyoglobin With Hydrogen Peroxide and Other Peroxidic Compounds

1990 • 113 citations

Oxidation of oxymyoglobin to metmyoglobin with hydrogen peroxide: involvement of ferryl intermediate

1987 • 112 citations

Redox cycling of myoglobin and ascorbate: A potential protective mechanism against oxidative reperfusion injury in muscle

1989 • 108 citations

The reactivity of thiols and disulfides with different redox states of myoglobin. Redox and addition reactions and formation of thiyl radical intermediates.

1992 • 107 citations

Myoglobin-catalyzed hydrogen peroxide dependent arachidonic acid peroxidation

1985 • 100 citations

Reaction of Methæmoglobin with Hydrogen Peroxide

1950 • 96 citations

The electron spin resonance spectrum of the tyrosyl radical

1985 • 95 citations

The modulation of ferryl myoglobin formation and its oxidative effects on low density lipoproteins by nitric oxide

1991 • 93 citations

The Suppression of Iron Release from Activated Myoglobin by Physiological Electron Donors and by Desferrioxamine

1989 • 92 citations

The formation of free radicals by cardiac myocytes under oxidative stress and the effects of electron-donating drugs

1991 • 88 citations

The reduction of ferryl myoglobin by ergothioneine: A novel function for ergothioneine

1990 • 85 citations

Lipid peroxidation and oxidation of several compounds by H₂O₂ activated metmyoglobin

1985 • 83 citations

The repair of oxidized amino acids by antioxidants

1984 • 81 citations

Interactions of heme proteins with hydrogen peroxide: Protein crosslinking and covalent binding of benzo[a]pyrene and 17β-estradiol

1983 • 81 citations

Direct detection of a globin-derived radical in leghaemoglobin treated with peroxides

1992 • 79 citations

Ferrylmyoglobin-catalyzed linoleic acid peroxidation

1990 • 77 citations

Electron spin resonance spectrum of Tyr-151 free radical formed in reactions of sperm whale metmyoglobin with ethyl hydroperoxide and potassium irridate

1989 • 73 citations

The interaction of Trolox C, a water-soluble vitamin E analog, with ferrylmyoglobin: Reduction of the oxoferryl moiety

1992 • 72 citations

Desferrioxamine as an Electron Donor. Inhibition of Membranal Lipid Peroxidation Initiated by H₂0₂–Activated Metmyoglobin and Other Peroxidizing Systems

1987 • 71 citations

Glutathione-dependent reduction of peroxides during ferryl- and met-myoglobin interconversion: A potential protective mechanism in muscle

1989 • 71 citations

Heterolytic versus homolytic peroxide bond cleavage by sperm whale myoglobin and myoglobin mutants

1992 • 70 citations

Sulfheme Proteins

1972 • 68 citations

The role of membrane protein sulfhydryl groups in hydrogen peroxide-mediated membrane damage in human erythrocytes

1988 • 66 citations

The effects of sulfasalazine metabolites on hemoglobin-catalyzed lipid peroxidation

1991 • 66 citations

Structure of the tyrosyl radical in bacteriophage T4-induced ribonucleotide reductase.

1982 • 64 citations

Co-oxidation of salicylate and cholesterol during the oxidation of metmyoglobin by H2O2

1988 • 64 citations

Detection of ferryl myoglobin in the isolated ischemic rat heart

1990 • 64 citations

The roles of His-64, Tyr-103, Tyr-146, and Tyr-151 in the epoxidation of styrene and beta-methylstyrene by recombinant sperm whale myoglobin.

1993 • 62 citations

Autoxidation of oxymyoglobin. An overall stoichiometry including subsequent side reactions.

1987 • 61 citations

Reactions of ferryl lactoperoxidase (compound II) with sulfide and sulfhydryl compounds.

1984 • 57 citations

Sulfheme Proteins

1972 • 50 citations

18O studies of the peroxidase-catalyzed oxidation of N-methylcarbazole. Mechanisms of carbinolamine and carboxaldehyde formation.

1986 • 47 citations

Oxidation of myoglobin in isolated adult rat cardiac myocytes by 15‐hydroperoxy‐5,8,11,13‐eicosatetraenoic acid

1983 • 45 citations

Inhibition of Protein Radical Reactions of Ferrylmyoglobin by the Water-Soluble Analog of Vitamin E, Trolox C

1993 • 44 citations

Oxidation of chlorpromazine by methemoglobin in the presence of hydrogen peroxide. Formation of chlorpromazine radical cation and its covalent binding to methemoglobin

1991 • 43 citations

Ultraviolet difference spectroscopy of myoglobin: assignment of pK values of tyrosyl phenolic groups and the stability of the ferryl derivatives

1981 • 39 citations

The Myoglobin-Derived Radical Formed on Reaction of Metmyoglobin with Hydrogen Peroxide is not a Tyrosine Peroxyl Radical

1992 • 37 citations

Scavenging of Hypochlorous Acid and the Myoglobin-Derived Oxidants By of Cardioprotective Agent Mercaptopropionylglycine

1990 • 31 citations

Characterization by NMR of the heme-myoglobin adduct formed during the reductive metabolism of BrCCl3. Covalent bonding of the proximal histidine to the ring I vinyl group.

1991 • 29 citations

Possible mechanism of inhibition of nitrite-induced oxidation of oxyhemoglobin by ergothioneine and uric acid

1992 • 29 citations

Endothelium-derived relaxing factor (nitric oxide), lipoprotein oxidation and atherosclerosis

1990 • 28 citations

Electron Spin Resonance Spectra of Free Radicals Formed in the Reaction of Metmyoglobins with Ethylhydroperoxide1

1987 • 27 citations

The 2-Electron Reduction of Sperm Whale Ferryl Myoglobin by Ethanol

1986 • 23 citations

Modulation of myoglobin-H2O2-mediated peroxidation reactions by sulfhydryl compounds.

1988 • 21 citations

Reduction of ferrylmyoglobin in rat diaphragm

1990 • 20 citations

Reduction of sperm whale ferrylmyoglobin by endogenous reducing agents: Potential reducible loci of ferrylmyoglobin

1992 • 19 citations

Is hemoglobin a catalyst for sulfoxidation of chlorpromazine?

1989 • 18 citations

Free Radical Reactions with Alpha-Tocopherol and N-Stearoyl Tryptophan Methyl Ester in Micellar Solutions

1986 • 17 citations

Reduction of ferrylmyoglobin to metmyoglobin by quinonoid compounds

1988 • 17 citations

Coupling of dihydroriboflavin oxidation to the formation of the higher valence states of hemeproteins

1991 • 15 citations

Reduction of ferryl- and metmyoglobin to ferrous myoglobin by menadione-glutathione conjugate. Spectrophotometric studies under aerobic and anaerobic conditions

1988 • 13 citations