[6] Tryptase: A mast cell serine protease

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Tryptase Levels as an Indicator of Mast-Cell Activation in Systemic Anaphylaxis and Mastocytosis

1987 • 775 citations

Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis.

1989 • 450 citations

Tryptase from human pulmonary mast cells. Purification and characterization.

1981 • 428 citations

Mast cell tryptase is a mitogen for cultured fibroblasts.

1991 • 392 citations

Synovial procollagenase activation by human mast cell tryptase dependence upon matrix metalloproteinase 3 activation.

1989 • 353 citations

Activation of Pulmonary Mast Cells by Bronchoalveolar Allergen Challenge:In VivoRelease of Histamine and Tryptase in Atopic Subjects with and without Asthma

1988 • 352 citations

Regulation of tryptase from human lung mast cells by heparin. Stabilization of the active tetramer.

1986 • 348 citations

Acid hydrolases and tryptase from secretory granules of dispersed human lung mast cells.

1981 • 332 citations

Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase.

1988 • 301 citations

Immediate and Late Airway Response of Allergic Rhinitis Patients to Segmental Antigen Challenge: Characterization of Eosinophil and Mast Cell Mediators

1991 • 281 citations

Evidence for Elevated Levels of Histamine, Prostaglandin D₂, and Other Bronchoconstricting Prostaglandins in the Airways of Subjects with Mild Asthma

1990 • 254 citations

Increased Dermal Mast Cell Populations in Progressive Systemic Sclerosis: A Link in Chronic Fibrosis?

1985 • 251 citations

Laboratory Investigation of Deaths Due to Anaphylaxis

1991 • 248 citations

Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells

1992 • 238 citations

Cloning and characterization of complementary DNA for human tryptase.

1989 • 207 citations

Degradation of Airway Neuropeptides by Human Lung Tryptase

1990 • 207 citations

The fibrinogenolytic activity of purified tryptase from human lung mast cells.

1985 • 203 citations

Recombinant human stem cell factor stimulates differentiation of mast cells from dispersed human fetal liver cells

1992 • 203 citations

Pericellulars substrates of human mast cell tryptase: 72,000 Dalton gelatinase and fibronectin

1992 • 186 citations

Cloning and characterization of a second complementary DNA for human tryptase.

1990 • 186 citations

Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs.

1989 • 181 citations

Human lung tryptase. Purification and characterization.

1984 • 172 citations

Insect-sting challenge in 138 patients: Relation between clinical severity of anaphylaxis and mast cell activation†

1992 • 169 citations

Tryptase levels in nasal-lavage fluid as an indicator of the immediate allergic response

1988 • 163 citations

Elevated Bronchoalveolar Lavage Fluid Histamine Levels in Allergic Asthmatics Are Associated with Increased Airway Obstruction

1991 • 153 citations

Mast cell numbers in rheumatoid synovial tissues

1987 • 150 citations

Regulation of human mast cell tryptase. Effects of enzyme concentration, ionic strength and the structure and negative charge density of polysaccharides

1987 • 133 citations

Protease composition of exocytosed human skin mast cell protease-proteoglycan complexes. Tryptase resides in a complex distinct from chymase and carboxypeptidase.

1992 • 125 citations

Monoclonal antibodies against human mast cell tryptase demonstrate shared antigenic sites on subunits of tryptase and selective localization of the enzyme to mast cells.

1985 • 118 citations

Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase

1991 • 117 citations

Tryptase and histamine release during aspirin-induced respiratory reactions

1991 • 115 citations

Airway Levels of Mast Cell—derived Mediators in Exercise-induced Asthma

1990 • 111 citations

A new radioimmunoassay for human mast cell tryptase using monoclonal antibodies

1991 • 107 citations

Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates.

1983 • 102 citations

Interactions of human mast cell tryptase with biological protease inhibitors

1990 • 99 citations

Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates.

1987 • 99 citations

The Level of Tryptase in Human Tears

1990 • 98 citations

Human skin tryptase: purification, partial characterization and comparison with human lung tryptase

1988 • 91 citations

Human mast cell tryptase attenuates the vasodilator activity of calcitonin generelated peptide

1992 • 89 citations

Release of tryptase together with histamine during the immediate cutaneous response to allergen

1987 • 88 citations

Ultrastructural analysis of maturing human T and TC mast cells in situ.

1989 • 86 citations

Molecular cloning of dog mast cell tryptase and a related protease: structural evidence of a unique mode of serine protease activation

1989 • 84 citations

Kunitz-type protease inhibitor found in rat mast cells. Purification, properties, and amino acid sequence.

1988 • 81 citations

Immunoassay of tryptase from human mast cells

1986 • 80 citations

Dog mastocytoma tryptase: Affinity purification, characterization, and amino-terminal sequence

1987 • 78 citations

Immunologic and physicochemical evidence for conformational changes occurring on conversion of human mast cell tryptase from active tetramer to inactive monomer. Production of monoclonal antibodies recognizing active tryptase.

1990 • 76 citations

Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases.

1993 • 71 citations

Purification of Tryptase From a Human Mast Cell Line

1990 • 69 citations

Tryptase from human mast cells: biochemistry, biology and clinical utility.

1990 • 66 citations

Release of histamine and tryptase in vivo after prolonged cutaneous challenge with allergen in humans.

1988 • 53 citations

A HISTOCHEMICAL ENZYME KINETIC SYSTEM APPLIED TO THE TRYPSIN-LIKE AMIDASE AND ESTERASE ACTIVITY IN HUMAN MAST CELLS

1963 • 51 citations

Human skin tryptase: Kinetic characterization of its spontaneous inactivation

1993 • 47 citations

Airway Inflammation and Atopic Asthma: A Comparative Bronchoscopic Investigation

1991 • 42 citations

Expression of a Mast Cell Tryptase in the Human Monocytic Cell Lines U‐937 and Mono Mac 6

1993 • 41 citations

Neutral proteases of mast cells

1990 • 39 citations

Tryptase from rat skin: purification and properties

1991 • 36 citations

Localization of rat tryptase to a subset of the connective tissue type of mast cell.

1993 • 29 citations

Inhibition of Human Mast Cell Tryptase by Benzamidine Derivatives

1992 • 28 citations

BOVINE TRYPTASE: PURIFICATION AND CHARACTERIZATION

1992 • 27 citations

Effect of histamine and divalent cations on the activity and stability of tryptase from human mast cells

1989 • 22 citations

The Mast Cell-specific Expression of a Protease Gene, RMCP II, Is Regulated by an Enhancer Element That Binds Specifically to Mast Cell trans-Acting Factors

1989 • 22 citations

Characterization of a Tryptase mRNA Expressed in the Human Basophil Cell Line KU812

1993 • 22 citations

Rat mast cell tryptase

1991 • 17 citations