ROLE OF RIBONUCLEASE ACTION IN PHENYLALANINE‐INDUCED DISAGGREGATION OF RAT CEREBRAL POLYRIBOSOMES

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Effects of ingestion of disproportionate amounts of amino acids.

1970 • 1,123 citations

Progress in Brain Research.

1965 • 738 citations

Biochemistry and the Central Nervous System

1972 • 346 citations

Progress in Brain Research

1968 • 324 citations

Amino Acid Metabolism and Genetic Variation.

1968 • 263 citations

Potassium Migration and Amino Acid Transport

1958 • 223 citations

Studies on cellular inhibitors of ribonuclease I. The assay of the ribonuclease-inhibitor system, and the purification of the inhibitor from rat liver

1961 • 210 citations

Ribonuclease V Studies on the properties and distribution of ribonuclease inhibitor in the rat

1956 • 205 citations

The Molecular Basis of Neoplasia

1963 • 203 citations

Ribonucleases

1969 • 191 citations

Protein synthesis in the cat brain after prolonged cerebral ischemia

1971 • 184 citations

A METHOD FOR MEASURING BRAIN PROTEIN SYNTHESIS RATES IN YOUNG AND ADULT RATS

1975 • 177 citations

The metabolic activity of the proteins of the brain

1956 • 173 citations

THE INFLUENCE OF HIGH PHENYLALANINE AND TYROSINE ON THE CONCENTRATIONS OF ESSENTIAL AMINO ACIDS IN BRAIN

1968 • 163 citations

REGULATION OF CEREBRAL METABOLISM OF AMINO ACIDS—IV. INFLUENCE OF AMINO ACID LEVELS ON LEUCINE UPTAKE, UTILIZATION AND INCORPORATION INTO PROTEIN IN VZVO*

1965 • 134 citations

Hyperphenylalaninemia: Disaggregation of Brain Polyribosomes in Young Rats

1970 • 131 citations

Inhibition of 5-Hydroxytryptophan Decarboxylase by Phenylalanine Metabolites

1958 • 128 citations

The specific radioactivity of the tissue free amino acid pool as a basis for measuring the rate of protein synthesis in the rat in vivo

1974 • 110 citations

Effect of phenylalanine on protein synthesis in the developing rat brain

1970 • 99 citations

Inhibition of cerebral protein synthesis by epileptic seizures without motor manifestations

1974 • 94 citations

Fate of a Synthetic Polynucleotide Directing Cell-Free Protein Synthesis I. Characteristics of Degradation

1962 • 93 citations

Electroshock Effects on Brain Protein Synthesis: Relation to Brain Seizures and Retrograde Amnesia

1971 • 90 citations

The lysosomal membrane complex. Focal point of primary steroid hormone action

1971 • 77 citations

Inborn errors of metabolism

1972 • 75 citations

POLYRIBOSOME DISAGGREGATION AND CELL‐FREE PROTEIN SYNTHESIS IN PREPARATIONS FROM CEREBRAL CORTEX OF HYPERPHENYLALANINEMIC RATS¹

1971 • 72 citations

Cerebral Protein Synthesis

1968 • 69 citations

On the significance of ribosome dimers in extracts of animal cells

1967 • 69 citations

DISAGGREGATION OF BRAIN POLYSOMES INDUCED BY ELECTROCONVULSIVE TREATMENT

1968 • 67 citations

INFLUENCE OF PHENYLALANINE ADMINISTRATION ON THE FREE AMINO ACIDS OF BRAIN AND LIVER IN THE RAT

1965 • 63 citations

INHIBITION OF BRAIN PROTEIN SYNTHESIS: AN APPROACH TO THE BIOCHEMICAL BASIS OF NEUROLOGICAL DYSFUNCTION IN THE AMINO‐ACIDURIAS*,†

1966 • 62 citations

L-Dopa: Disaggregation of Brain Polysomes and Elevation of Brain Tryptophan

1971 • 62 citations

Correspondence between ribosome aggregation patterns in rat liver homogenates and in electron micrographs following administration of ethionine

1965 • 62 citations

Cerebral amino acid uptakein vivo in newborn mice

1972 • 58 citations

Cerebral protein synthesis

1966 • 56 citations

Changes in brain polyribosomes following an electro‐convulsive seizure

1970 • 56 citations

MAPLE SYRUP URINE DISEASE METABOLITES STUDIED IN CEREBELLUM CULTURES¹

1969 • 54 citations

Cerebral Protein Synthesis

1971 • 53 citations

Effects of excess phenylalanine onin vitro andin vivo RNA and protein synthesis and polyribosome levels in brains of mice

1971 • 53 citations

Brain protein synthesis after electroshock

1971 • 52 citations

THE EFFECT OF ELECTROCONVULSIVE SHOCK ON PROTEIN SYNTHESIS IN MOUSE BRAIN

1971 • 49 citations

Cerebral proteolipids in phenylketonuria

1968 • 48 citations

Hyperphenylalanaemia and the exchange of tyrosine in adult rat brain

1971 • 45 citations

Acidic glycolipids and the role of ionic bonds in the structure-linked latency of lysosomal hydrolases

1962 • 41 citations

THE INFLUENCE OF EXCESS METHIONINE ON THE FREE AMINO ACIDS OF BRAIN AND LIVER OF THE WEANLING RAT*

1969 • 41 citations

Dopamine: Mediator of Brain Polysome Disaggregation after L-Dopa

1972 • 40 citations

ELEVATED PLASMA PHENYLALANINE CONCENTRATION AND LYSINE INCORPORATION INTO RIBOSOMAL PROTEIN OF DEVELOPING BRAIN

1968 • 39 citations

Phenylketonuria in Infant Monkeys

1960 • 35 citations

REGULATION OF CEREBRAL METABOLISM OF AMINO ACIDS—II INFLUENCE OF PHENYLALANINE DEFICIENCY ON FREE AND PROTEIN‐BOUND AMINO ACIDS IN RAT CEREBRAL CORTEX: RELATIONSHIP TO PLASMA LEVELS*

1963 • 34 citations

Intranuclear Concentration of Lysosomal Hydrolases in Steroid Target Cells

1974 • 33 citations

Polynucleotidases in animal tissues

1967 • 32 citations

STRUCTURE-LINKED ACTIVITY OF LYSOSOMAL ENZYMES IN THE DEVELOPING MOUSE BRAIN

1968 • 31 citations

β-2-Thienyl-DL-alanine, Internal Standard for Automatic Determination of Amino Acids

1961 • 31 citations

Hyperphenylalaninemia: the effect on cerebral amino acid levels during development

1969 • 31 citations

A REGIONAL STUDY OF SOME OSMOTIC, IONIC AND AGE FACTORS AFFECTING THE STABILITY OF CEREBRAL LYSOSOMES¹

1969 • 29 citations

Maternal phenylketonuria

1969 • 29 citations

Disaggregation of brain polysomes by L-5-hydroxytryptophan: Mediation by serotonin

1973 • 29 citations

BRAIN RIBOSOMES IN INTRACRANIAL HYPERTENSION¹

1974 • 25 citations

Brain stem polysomes and avoidance performance of hypophysectomized rats subjected to peptide treatment

1971 • 24 citations

IN VIVO INHIBITION OF RAT BRAIN PROTEIN SYNTHESIS BY <scp>l</scp>‐DOPA

1974 • 24 citations

Polyribosome degradation as a sensitive assay for endolytic messenger-ribonuclease activity

1974 • 21 citations

A fluorimetric method for the determination of tryptophan in animal tissues

1974 • 20 citations

INTERACTIVE EFFECTS OF CYCLOHEXIMIDE AND PUROMYCIN IN ALTERING BRAIN POLYRIBOSOMES AND NEURAL AND BEHAVIOURAL RESPONSES TO ELECTROSHOCK IN MICE

1973 • 18 citations

Specificity of the natural rat liver ribonuclease inhibitor towards nuclease activities of subcellular fractions

1974 • 17 citations

Brain Ribosomes

1972 • 14 citations

Ultrastructural evidence against in vivo disaggregation of brain polyribosomes after administration of L-dopa or phenylalanine

1973 • 12 citations

The effect of maternal amino acid imbalance on fetal cerebral polyribosomes

1972 • 11 citations

Brain Damage in the Aminoacidurias

1972 • 11 citations

Developmental and regional variations in ribonuclease inhibitor activity in brain

1970 • 11 citations

Abnormal Metabolism of Sulfur-Containing Amino Acids Associated with Brain Dysfunction

1972 • 9 citations

Changes in protease and ribonuclease activities in brain and liver during the life-span of the rat.

1969 • 9 citations

The effect of anoxia on cerebral acid hydrolases in the five-day-old rat

1972 • 8 citations

FREE AMINO ACIDS OF FETAL BRAIN

1969 • 7 citations

A comparative study of ribonuclease hydrolysis of rat brain-cortex and liver membrane-bound ribosomes

1973 • 4 citations

Alterations in cerebral protein-synthesizing systems during maturation

1973 • 3 citations