Distinct Stages in Adipogenesis Revealed by Retinoid Inhibition of Differentiation after Induction of PPARγ

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancer.

1994 • 2,176 citations

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

1995 • 2,059 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Improved retroviral vectors for gene transfer and expression.

1989 • 1,997 citations

Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

1992 • 1,751 citations

A transcriptional co-repressor that interacts with nuclear hormone receptors

1995 • 1,744 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells.

1991 • 1,684 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

1975 • 1,358 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

An established pre-adipose cell line and its differentiation in culture

1974 • 1,090 citations

LXR, a nuclear receptor that defines a distinct retinoid response pathway.

1995 • 1,089 citations

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers.

1993 • 940 citations

Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins.

1995 • 922 citations

Multiplicity generates diversity in the retinoic acid signalling pathways

1992 • 836 citations

Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation.

1994 • 827 citations

Role of retinoids in differentiation and carcinogenesis.

1983 • 780 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

The retinoid receptors.

1994 • 665 citations

Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.

1995 • 651 citations

Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms.

1995 • 648 citations

Estrogen Receptor-Associated Proteins: Possible Mediators of Hormone-Induced Transcription

1994 • 645 citations

Unique response pathways are established by allosteric interactions among nuclear hormone receptors

1995 • 629 citations

The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.

1995 • 627 citations

Characterization and colocalization of steroid binding and dimerization activities in the mouse estrogen receptor

1990 • 617 citations

Function of retinoic acid receptor γ in the mouse

1993 • 595 citations

Differentiation-induced gene expression in 3T3-L1 preadipocytes: CCAAT/enhancer binding protein interacts with and activates the promoters of two adipocyte-specific genes.

1989 • 587 citations

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

1993 • 575 citations

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

1995 • 569 citations

PPARγ2 Regulates Adipose Expression of the Phosphoenolpyruvate Carboxykinase Gene

1995 • 565 citations

A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1.

1995 • 548 citations

Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induces PPAR gamma and stimulates adipogenesis.

1995 • 527 citations

Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: direct participation of c-fos

1987 • 523 citations

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development.

1983 • 476 citations

Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells.

1994 • 450 citations

CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program.

1994 • 433 citations

Regulation of retinoid signalling by receptor polarity and allosteric control of ligand binding

1994 • 432 citations

Interaction of the peroxisome-proliferator-activated receptor and retinoid X receptor.

1993 • 394 citations

CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes.

1991 • 389 citations

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.

1993 • 351 citations

Retinoids Selective for Retinoid X Receptor Response Pathways

1992 • 342 citations

Promoter context- and response element-dependent specificity of the transcriptional activation and modulating functions of retinoic acid receptors

1992 • 341 citations

Antisense CCAAT/enhancer-binding protein RNA suppresses coordinate gene expression and triglyceride accumulation during differentiation of 3T3-L1 preadipocytes.

1992 • 324 citations

Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor.

1994 • 324 citations

Murine isoforms of retinoic acid receptor gamma with specific patterns of expression.

1990 • 304 citations

Enhancement of adipocyte differentiation by an insulin-sensitizing agent.

1992 • 274 citations

Packaging system for rapid production of murine leukemia virus vectors with variable tropism

1992 • 260 citations

A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects.

1992 • 256 citations

Peroxisome proliferator and retinoid signalingpathways co-regulate preadipocyte phenotype and survival.

1994 • 227 citations

Induction of Rev-ErbA alpha, an orphan receptor encoded on the opposite strand of the alpha-thyroid hormone receptor gene, during adipocyte differentiation

1993 • 199 citations

Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoic acid receptor gene.

1993 • 192 citations

Identification of a novel isoform of the retinoic acid receptor gamma expressed in the mouse embryo.

1990 • 162 citations

The Retinoids: Biology, Chemistry and Medicine, 2nd ed

1994 • 156 citations

Identification of Two mPPAR Related Receptors and Evidence for the Existence of Five Subfamily Members

1993 • 154 citations

Loss of retinoic acid receptor gamma function in F9 cells by gene disruption results in aberrant Hoxa-1 expression and differentiation upon retinoic acid treatment.

1993 • 143 citations

Targeting expression of a dominant-negative retinoic acid receptor mutant in the epidermis of transgenic mice results in loss of barrier function.

1995 • 137 citations

Differentiation of 3T3-F442A Cells into Adipocytes is Inhibited by Retinoic Acid

1982 • 122 citations

Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes.

1993 • 118 citations

Reexpression of retinoic acid receptor (RAR) gamma or overexpression of RAR alpha or RAR beta in RAR gamma-null F9 cells reveals a partial functional redundancy between the three RAR types.

1995 • 101 citations

Preadipocytes possess cellular retinoid binding proteins and their differentiation is inhibited by retinoids

1980 • 86 citations

Gene expression during 3T3-L1 adipocyte differentiation. Characterization of initial responses to the inducing agents and changes during commitment to differentiation.

1992 • 82 citations

The molecular basis for inhibition of adipose conversion of murine 3T3-L1 cells by retinoic acid1 1This investigation is supported by American Cancer Society Grant JFRA-148 to D.A.B.

1990 • 82 citations

Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo.

1994 • 65 citations

Trans-acting factors involved in adipogenic differentiation

1993 • 61 citations

Retinoid X Receptor Acts as a Hormone Receptor in Vivo to Induce a Key Metabolic Enzyme for 1,25-Dihydroxyvitamin D3

1995 • 50 citations

Retinoic acid receptor γ 2 gene expression is up-regulated by retinoic acid in 3T3-L1 preadipocytes

1993 • 46 citations

Endogenous Retinoid X Receptors Can Function as Hormone Receptors in Pituitary Cells

1994 • 41 citations

The prevention of adipose differentiation of 3T3-L1 cells caused by retinoic acid is elicited through retinoic acid receptor alpha

1994 • 36 citations

Fatty Acids and Retinoids Act Synergistically on Adipose Cell Differentiation

1994 • 21 citations

Retinoic acid and dexamethasone interact to regulate S14 gene transcription in 3T3-F442A adipocytes

1992 • 20 citations

Tissue-Specific Distribution of a Novel C-Terminal Truncation Retinoic Acid Receptor Mutant Which Acts as a Negative Repressor in a Promoter- and Cell-Type-Specific Manner

1995 • 12 citations