Autoregulation of the Heat-Shock Response

THE HEAT-SHOCK PROTEINS

1988 • 5,214 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Protein folding in the cell

1992 • 4,138 citations

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

An hsp70-like protein in the ER: Identity with the 78 kd glucose-regulated protein and immunoglobulin heavy chain binding protein

1986 • 1,457 citations

Cells in Stress: Transcriptional Activation of Heat Shock Genes

1993 • 1,429 citations

Homologous plant and bacterial proteins chaperone oligomeric protein assembly

1988 • 1,316 citations

70K heat shock related proteins stimulate protein translocation into microsomes

1988 • 1,276 citations

The 5′ ends of Drosophila heat shock genes in chromatin are hypersensitive to DNase I

1980 • 1,114 citations

MOLECULAR CHAPERONES

1991 • 1,089 citations

Heat shock, stress proteins, chaperones, and proteotoxicity

1991 • 1,069 citations

Abnormal Proteins Serve as Eukaryotic Stress Signals and Trigger the Activation of Heat Shock Genes

1986 • 904 citations

Polypeptide chain binding proteins: Catalysts of protein folding and related processes in cells

1989 • 884 citations

Expression of wild-type and mutant forms of influenza hemagglutinin: The role of folding in intracellular transport

1986 • 879 citations

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

1991 • 853 citations

The yeast polyubiquitin gene is essential for resistance to high temperatures, starvation, and other stresses

1987 • 850 citations

Escherichia coli DnaJ and GrpE heat shock proteins jointly stimulate ATPase activity of DnaK.

1991 • 835 citations

HSP104 Required for Induced Thermotolerance

1990 • 822 citations

Reduced levels of hsp90 compromise steroid receptor action in vivo

1990 • 794 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

GroE heat-shock proteins promote assembly of foreign prokaryotic ribulose bisphosphate carboxylase oligomers in Escherichia coli

1989 • 703 citations

The groES and groEL heat shock gene products of Escherichia coli are essential for bacterial growth at all temperatures

1989 • 693 citations

THE GENETICS AND REGULATION OF HEAT-SHOCK PROTEINS

1984 • 648 citations

hsp82 is an essential protein that is required in higher concentrations for growth of cells at higher temperatures.

1989 • 624 citations

Heat shock factor and the heat shock response

1991 • 615 citations

Uncoating ATPase is a member of the 70 kilodalton family of stress proteins

1986 • 607 citations

The htpR gene product of E. coli is a sigma factor for heat-shock promoters

1984 • 593 citations

Is hsp70 the cellular thermometer?

1991 • 586 citations

Heat Shock Response

1991 • 576 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

The heat shock response is self-regulated at both the transcriptional and posttranscriptional levels

1982 • 542 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression.

1992 • 525 citations

RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis

1986 • 524 citations

Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells.

1984 • 522 citations

Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins.

1990 • 520 citations

Major heat shock gene of Drosophila and the Escherichia coli heat-inducible dnaK gene are homologous.

1984 • 513 citations

Evidence that the 90-kDa phosphoprotein associated with the untransformed L-cell glucocorticoid receptor is a murine heat shock protein.

1985 • 492 citations

Heat shock factor is regulated differently in yeast and HeLa cells

1987 • 489 citations

Regulation of Heat Shock Factor Trimer Formation: Role of a Conserved Leucine Zipper

1993 • 486 citations

Translational and transcriptional control elements in the untranslated leader of the heat-shock gene hsp22

1986 • 455 citations

Regulation of protein synthesis during heat shock

1981 • 451 citations

Stable binding of Drosophila heat shock factor to head-to-head and tail-to-tail repeats of a conserved 5 bp recognition unit

1989 • 439 citations

Identification of the sigma E subunit of Escherichia coli RNA polymerase: a second alternate sigma factor involved in high-temperature gene expression.

1989 • 422 citations

The heat shock response of E. coli is regulated by changes in the concentration of σ32

1987 • 414 citations

The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner

1990 • 407 citations

hsp70: Nuclear concentration during environmental stress and cytoplasmic storage during recovery

1984 • 400 citations

Characterization of the thermotolerant cell. I. Effects on protein synthesis activity and the regulation of heat-shock protein 70 expression.

1988 • 399 citations

The consequences of expressing hsp70 in Drosophila cells at normal temperatures.

1992 • 398 citations

Cultured animal cells exposed to amino acid analogues or puromycin rapidly synthesize several polypeptides

1980 • 395 citations

Trimerization of a yeast transcriptional activator via a coiled-coil motif

1989 • 392 citations

Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

1991 • 391 citations

Purification and Properties of Drosophila Heat Shock Activator Protein

1987 • 388 citations

Chaperonin-facilitated refolding of ribulose bisphosphate carboxylase and ATP hydrolysis by chaperonin 60 (groEL) are potassium dependent

1990 • 384 citations

Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation

1990 • 375 citations

Transient expression of genes introduced into cultured cells of Drosophila.

1983 • 370 citations

Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides.

1985 • 365 citations

Thermal response of rat fibroblasts stably transfected with the human 70-kDa heat shock protein-encoding gene.

1991 • 365 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32.

1990 • 356 citations

Translational control of protein synthesis in response to heat shock in D. melanogaster cells

1980 • 356 citations

RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells.

1986 • 355 citations

Varying patterns of protein synthesis in Drosophila during heat shock: Implications for regulation

1980 • 340 citations

A molecular chaperone from a thermophilic archaebacterium is related to the eukaryotic protein t-complex polypeptide-1

1991 • 340 citations

Regulation of the Escherichia coli heat‐shock response

1993 • 338 citations

ClpB is the Escherichia coli heat shock protein F84.1

1991 • 336 citations

The dnaK protein modulates the heat-shock response of Escherichia coli

1983 • 328 citations

Physical interaction between heat shock proteins DnaK, DnaJ, and GrpE and the bacterial heat shock transcription factor σ32

1992 • 314 citations

Protein Folding in the Cell: The Role of Molecular Chaperones Hsp70 and Hsp60

1992 • 306 citations

The 70-kd mammalian heat shock proteins are structurally and functionally related to the uncoating protein that releases clathrin triskelia from coated vesicles.

1985 • 301 citations

ERp99, an abundant, conserved glycoprotein of the endoplasmic reticulum, is homologous to the 90-kDa heat shock protein (hsp90) and the 94-kDa glucose regulated protein (GRP94).

1987 • 294 citations

Initiation of lambda DNA replication with purified host- and bacteriophage-encoded proteins: the role of the dnaK, dnaJ and grpE heat shock proteins.

1989 • 294 citations

The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader

1985 • 291 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

Mutations of the heat inducible 70 kilodalton genes of yeast confer temperature sensitive growth

1984 • 278 citations

Conservation of the regulatory subunit for the Clp ATP-dependent protease in prokaryotes and eukaryotes.

1990 • 275 citations

Hspl04 is a highly conserved protein with two essential nucleotide-binding sites

1991 • 268 citations

Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.

1987 • 257 citations

Structure and expression of a human gene coding for a 71 kd heat shock ‘cognate’ protein

1987 • 254 citations

Cooperative binding of drosophila heat shock factor to arrays of a conserved 5 bp unit

1991 • 250 citations

Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability.

1987 • 248 citations

A Highly Evolutionarily Conserved Mitochondrial Protein Is Structurally Related to the Protein Encoded by the Escherichia coli groEL Gene

1988 • 247 citations

Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases.

1993 • 245 citations

Complex regulation of heat shock- and glucose-responsive genes in human cells.

1988 • 242 citations

SSC1, an Essential Member of the Yeast HSP70 Multigene Family, Encodes a Mitochondrial Protein

1989 • 242 citations

Cellular defects caused by deletion of the Escherichia coli dnaK gene indicate roles for heat shock protein in normal metabolism

1989 • 234 citations

Interspecific nucleotide sequence comparisons used to identify regulatory and structural features of the Drosophila hsp82 gene

1986 • 223 citations

Heat shock proteins in thermotolerance and other cellular processes.

1987 • 220 citations

Heat shock and recovery are mediated by different translational mechanisms.

1982 • 211 citations

DNase I hypersensitive sites in Drosophila chromatin occur at the 5' ends of regions of transcription.

1981 • 210 citations

Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA

1991 • 204 citations

Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation.

1989 • 203 citations

Identification, characterization, and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein

1989 • 199 citations

Induction of heat shock proteins and thermotolerance by ethanol in Saccharomycescerevisiae

1982 • 198 citations

Nucleotide sequence of the heat shock regulatory gene of E. coli suggests its protein product may be a transcription factor

1984 • 198 citations

Drosophila gene related to the major heat shock-induced gene is transcribed at normal temperatures and not induced by heat shock.

1982 • 196 citations

Role of the Escherichia coli DnaK and DnaJ heat shock proteins in the initiation of bacteriophage lambda DNA replication.

1988 • 194 citations

Sequence homologies in the 5' regions of four Drosophila heat-shock genes.

1981 • 188 citations

Identification and sequence analysis of a new member of the mouse HSP70 gene family and characterization of its unique cellular and developmental pattern of expression in the male germ line.

1988 • 184 citations

Scaffolding protein regulates the polymerization of P22 coat subunits into icosahedral shells in vitro

1988 • 183 citations

Induction of a heat shock-like response by unfolded protein in Escherichia coli: dependence on protein level not protein degradation.

1989 • 180 citations

Assembly of progesterone receptor with heat shock proteins and receptor activation are ATP mediated events.

1992 • 178 citations

The DnaK chaperone modulates the heat shock response of Escherichia coli by binding to the sigma 32 transcription factor.

1992 • 178 citations

The use of promoter fusions in Drosophila genetics: Isolation of mutations affecting the heat shock response

1984 • 172 citations

The yeast heat shock transcription factor contains a transcriptional activation domain whose activity is repressed under nonshock conditions

1990 • 172 citations

Modulation of stability of the Escherichia coli heat shock regulatory factor sigma

1989 • 169 citations

Heat shock but not other stress inducers leads to the disruption of a sub-set of snRNPs and inhibition of in vitro splicing in HeLa cells.

1988 • 168 citations

Translational control in lysates of Drosophila melanogaster cells.

1981 • 167 citations

Calmodulin-regulated binding of the 90-kDa heat shock protein to actin filaments.

1986 • 165 citations

The control of protein synthesis during heat shock in Drosophila cells involves altered polypeptide elongation rates

1983 • 164 citations

A highly evolutionarily conserved mitochondrial protein is structurally related to the protein encoded by the Escherichia coli groEL gene.

1988 • 163 citations

The glucose-regulated protein grp94 is related to heat shock protein hsp90

1987 • 161 citations

Selective translation of heat shock mRNA in Drosophila melanogaster depends on sequence information in the leader.

1985 • 160 citations

Stress proteins in biology and medicine

1991 • 154 citations

Thermotolerance and Heat Shock Proteins in Mammalian Cells

1982 • 148 citations

Mutations in cognate genes of Saccharomyces cerevisiae hsp70 result in reduced growth rates at low temperatures.

1985 • 147 citations

Mutations altering heat shock specific subunit of RNA polymerase suppress major cellular defects of E. coli mutants lacking the DnaK chaperone.

1990 • 146 citations

RNA metabolism: strategies for regulation in the heat shock response

1990 • 142 citations

Changes in hsp70 alter thermotolerance and heat-shock regulation in Drosophila.

1991 • 141 citations

SSC1, an essential member of the yeast HSP70 multigene family, encodes a mitochondrial protein.

1989 • 137 citations

The Chicken Ubiquitin Gene Contains a Heat Shock Promoter and Expresses an Unstable mRNA in Heat-Shocked Cells

1986 • 137 citations

Ordered Assembly of Nucleoprotein Structures at the Bacteriophage λ Replication Origin during the Initiation of DNA Replication

1989 • 135 citations

Translation of glucose-regulated protein 78/immunoglobulin heavy-chain binding protein mRNA is increased in poliovirus-infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited.

1989 • 134 citations

The 90-kilodalton peptide of the heme-regulated eIF-2.alpha. kinase has sequence homology with the 90-kilodalton heat shock protein

1987 • 130 citations

Self-regulation of 70-kilodalton heat shock proteins in Saccharomyces cerevisiae.

1990 • 127 citations

Heat shock proteins affect RNA processing during the heat shock response of Saccharomyces cerevisiae.

1991 • 127 citations

Yeast thermotolerance does not require protein synthesis

1983 • 126 citations

Specialized Nucleoprotein Structures at the Origin of Replication of Bacteriophage λ

1989 • 125 citations

Interaction of hsp90 with steroid receptors: organizing some diverse observations and presenting the newest concepts

1990 • 124 citations

Renaturation of denatured λ repressor requires heat shock proteins

1990 • 123 citations

Regulation of HSP70 synthesis by messenger RNA degradation.

1989 • 121 citations

In vitro translation of drosophila heat-shock and non-heat-shock mRNAs in heterologous and homologous cell-free systems

1981 • 117 citations

A homologue of the bacterial heat-shock gene DnaJ that alters protein sorting in yeast

1991 • 117 citations

Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins.

1982 • 116 citations

Translational efficiency of heat-induced messages in Drosophila melanogaster cells

1980 • 112 citations

Association of the heat shock protein HSP90 with steroid hormone receptors and tyrosine kinase oncogene products

1986 • 110 citations

The Drosophila hsp70 message is rapidly degraded at normal temperatures and stabilized by heat shock

1988 • 109 citations

The activity of sigma 32 is reduced under conditions of excess heat shock protein production in Escherichia coli.

1989 • 109 citations

Amino acid analogs while inducing heat shock proteins sensitize CHO cells to thermal damage

1985 • 108 citations

Translation of Unspliced Transcripts After Heat Shock

1988 • 105 citations

Effects of cycloheximide on thermotolerance expression, heat shock protein synthesis, and heat shock protein mRNA accumulation in rat fibroblasts.

1986 • 102 citations

Mechanism of inhibition of polypeptide chain initiation in heat-shocked Ehrlich cells involves reduction of eukaryotic initiation factor 4F activity.

1985 • 101 citations

Three Escherichia coli heat shock proteins are required for P1 plasmid DNA replication: formation of an active complex between E. coli DnaJ protein and the P1 initiator protein.

1990 • 100 citations

The chicken ubiquitin gene contains a heat shock promoter and expresses an unstable mRNA in heat-shocked cells.

1986 • 94 citations

A novel hsp70-like protein (P70) is present in mouse spermatogenic cells.

1988 • 92 citations

Selective Translation and Degradation of Heat-Shock Messenger RNAs in Drosophila

1990 • 85 citations

Abnormal proteins as the trigger for the induction of stress responses: Heat, diamide, and sodium arsenite

1988 • 79 citations

Identification of the 90 kDa substrate of rat liver type II casein kinase with the heat shock protein which binds steroid receptors

1987 • 77 citations

Effect of heat shock on RNA metabolism in HeLa cells

1988 • 76 citations

Physical interactions between bacteriophage and Escherichia coli proteins required for initiation of lambda DNA replication.

1990 • 75 citations

Mitochondrial and cytoplasmic protein syntheses are not required for heat shock acquisition of ethanol and thermotolerance in yeast

1984 • 74 citations

Unusual behavior of the cytoplasmic transcript of hsr omega: an abundant, stress-inducible RNA that is translated but yields no detectable protein product.

1989 • 68 citations

Heat shock alters nuclear ribonucleoprotein assembly in Drosophila cells.

1983 • 65 citations

Essential roles of 70kDa heat inducible proteins

1989 • 64 citations

Induction of Acquired Thermotolerance in Tetrahymena thermophila: Effects of Protein Synthesis Inhibitors

1985 • 63 citations

Translational regulation of sigma 32 synthesis: requirement for an internal control element

1991 • 62 citations

A developmentally regulated membrane protein gene in Dictyostelium discoideum is also induced by heat shock and cold shock.

1988 • 60 citations

A model of glucocorticoid receptor unfolding and stabilization by a heat shock protein complex

1992 • 59 citations

Inactivation of mRNA cap-binding protein complex in Drosophila melanogaster embryos under heat shock

1991 • 58 citations

Expression of intron-containingC. elegansheat shock genes in mouse cells demonstrates divergence of 3' splice site recognition sequences between nematodes and vertebrates, and an inhibitory effect of heat shock on the mammalian splicing apparatus

1987 • 54 citations

Protein import into mitochondria and peroxisomes

1990 • 53 citations

Synthesis of heat-shock proteins in HeLa cells: Inhibition by virus infection

1984 • 52 citations

Thermotolerance is independent of induction of the full spectrum of heat shock proteins and of cell cycle blockage in the yeast Saccharomyces cerevisiae

1990 • 47 citations

Expression of members of the Saccharomyces cerevisiae hsp70 multigene family

1989 • 45 citations

Synthesis of trypanosome hsp70 mRNA is resistant to disruption of trans-splicing by heat shock

1989 • 44 citations

Induction of acquired thermotolerance in Tetrahymena thermophila: effects of protein synthesis inhibitors.

1985 • 43 citations

Translational control in heat-shocked Drosophila embryos. Evidence for the inactivation of initiation factor(s) involved in the recognition of mRNA cap structure.

1988 • 41 citations

Trypanosome trans-splicing utilizes 2′-5′ branches and a corresponding debranching activity.

1988 • 37 citations

Purification and characterization of mRNA cap-binding protein from Drosophila melanogaster embryos.

1989 • 32 citations

Regulation of protein synthesis in heat-shocked Drosophila cells. Soluble factors control translation in vitro.

1986 • 28 citations

Heat-shock disruption of trans-splicing in trypanosomes: effect on Hsp70, Hsp85 and tubulin mRNA synthesis

1989 • 28 citations

Alterations of transcription during heat shock of Saccharomyces cerevisiae.

1982 • 28 citations

Enzymology of the pre-priming steps in lambda dv DNA replication in vitro.

1987 • 27 citations

A family of related proteins is encoded by the major Drosophila heat shock gene family.

1982 • 24 citations

Coordinate and Noncoordinate Gene Expression during Heat Shock: A Model for Regulation

1985 • 16 citations

The heat‐shock response in Drosophila KC 161 cells

1986 • 16 citations

Heat Shock

1991 • 12 citations

Translational Regulation in the Heat-Shock Response of Drosophila Cells

1987 • 11 citations

Roles and regulation of the heat shock ? factor ?32 in Escherichia coli

1990 • 11 citations

Alteration by heat shock and immunological characterization of Drosophila small nuclear ribonucleoproteins.

1989 • 10 citations

Polar surface distribution of type II insulin-like growth factor receptor in rat hepatocytes

1990 • 4 citations