Characterization of an altered membrane form of the beta-adrenergic receptor produced during agonist-induced desensitization.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

Receptor-mediated endocytosis: insights from the lipoprotein receptor system.

1979 • 701 citations

ADP ribosylation of the specific membrane protein of C6 cells by islet-activating protein associated with modification of adenylate cyclase activity.

1982 • 600 citations

Identification of the predominant substrate for ADP-ribosylation by islet activating protein.

1983 • 583 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Relationship between the beta-adrenergic receptor and adenylate cyclase.

1977 • 497 citations

[2] Subcellular fractionation of rat liver

1974 • 438 citations

Receptor-Mediated Endocytosis of Hormones in Cultured Cells

1981 • 388 citations

PHOSPHATASES OF LIVER

1950 • 347 citations

Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.

1980 • 342 citations

Agonist-specific refractoriness induced by isoproterenol. Studies with mutant cells.

1976 • 219 citations

Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.

1983 • 191 citations

Requirements for cholera toxin-dependent ADP-ribosylation of the purified regulatory component of adenylate cyclase.

1982 • 172 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.

1979 • 171 citations

Evidence for internalization of the recognition site of β-adrenergic receptors during receptor subsensitivity induced by (-)-isoproterenol

1979 • 157 citations

Catecholamine-Induced Alteration in Sedimentation Behavior of Membrane Bound β-Adrenergic Receptors

1980 • 153 citations

Isolation and characterization of Neurospora crassa plasma membranes.

1975 • 151 citations

Detergent Influence on Rat‐Liver Galactosyltransferase Activities towards Different Acceptors

1977 • 150 citations

Isoproterenol-induced desensitization of adenylate cyclase in human astrocytoma cells. Relation of loss of hormonal responsiveness and decrement in beta-adrenergic receptors.

1979 • 142 citations

Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s).

1982 • 137 citations

Muscarinic cholinergic receptor-mediated activation of phosphodiesterase.

1982 • 133 citations

Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors

1979 • 129 citations

A critical evaluation of plasma membrane fractionation

1973 • 125 citations

Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors.

1980 • 118 citations

Rapid and reversible disappearance of beta-adrenergic cell surface receptors.

1982 • 101 citations

Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis.

1981 • 96 citations

[³H]CGP-12177, A β-Adrenergic Ligand Suitable for Measuring Cell Surface Receptors

1983 • 93 citations

Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization.

1978 • 84 citations

Selective alteration in high affinity agonist binding: a mechanism of beta-adrenergic receptor desensitization.

1979 • 82 citations

Receptor-specific desensitization of the S49 lymphoma cell adenylyl cyclase. Unaltered behavior of the regulatory component.

1981 • 75 citations

A biochemical study of receptor internalization during beta-adrenergic receptor desensitization in frog erythrocytes.

1980 • 73 citations

Golgi fractions from livers of control and ethanol-intoxicated rats. Enzymic and morphologic properties following rapid isolation

1979 • 59 citations

Topographic separation of adenylate cyclase and hormone receptors in the plasma membrane of toad erythrocyte ghosts

1977 • 33 citations

Isolation of adenylate cyclase-enriched membranes from mammalian cells using concanavalin A.

1979 • 22 citations