WW (WWP) Domains: From Structure to Function

Complete cloning of the duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals

1987 • 2,353 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel

1994 • 1,238 citations

Structural basis for the binding of proline-rich peptides to SH3 domains

1994 • 1,016 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

A human peptidyl–prolyl isomerase essential for regulation of mitosis

1996 • 891 citations

MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma

1996 • 855 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

Two Binding Orientations for Peptides to the Src SH3 Domain: Development of a General Model for SH3-Ligand Interactions

1994 • 800 citations

Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome

1995 • 743 citations

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1997 • 696 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

1995 • 556 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

1992 • 537 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein

1996 • 480 citations

Tissue-specific expression of three distinct types of rabbit protein kinase C

1987 • 469 citations

Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide

1996 • 426 citations

Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach

1996 • 418 citations

A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion

1963 • 417 citations

Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial Na+ channel

1995 • 408 citations

Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome.

1996 • 397 citations

Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product.

1994 • 390 citations

Role of inscuteable in orienting asymmetric cell divisions in Drosophila

1996 • 389 citations

The WW domain: a signalling site in dystrophin?

1994 • 380 citations

Characterization of a novel protein‐binding module — the WW domain

1995 • 365 citations

A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity.

1995 • 357 citations

NPI1, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin—protein ligase

1995 • 331 citations

Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase

1988 • 324 citations

Identification and Characterization of the Dystrophin Anchoring Site on β-Dystroglycan

1995 • 322 citations

Ubiquitination Mediated by the Npi1p/Rsp5p Ubiquitin-protein Ligase Is Required for Endocytosis of the Yeast Uracil Permease

1996 • 316 citations

A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system.

1995 • 304 citations

GAP1, the general amino acid permease gene of Saccharomyces cerevisiae

1990 • 296 citations

The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein

1995 • 295 citations

Protein Degradation or Regulation: Ub the Judge

1996 • 275 citations

Endocytosis and degradation of the yeast uracil permease under adverse conditions

1994 • 266 citations

SH3 Domain-mediated Interaction of Dystroglycan and Grb2

1995 • 247 citations

Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization

1993 • 229 citations

Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene.

1996 • 226 citations

An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.

1994 • 221 citations

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains.

1996 • 213 citations

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands

1997 • 208 citations

Muscular Dystrophies—Diseases of the Dystrophin-Glycoprotein Complex

1995 • 204 citations

inscuteable,A Neural Precursor Gene ofDrosophila,Encodes a Candidate for a Cytoskeleton Adaptor Protein

1996 • 174 citations

Evidence for a NIMA-like mitotic pathway in vertebrate cells

1995 • 174 citations

Identification of Novel Human WW Domain-containing Proteins by Cloning of Ligand Targets

1997 • 163 citations

Sequence and mutational analysis of ESS1, a gene essential for growth in Saccharomyces cerevisiae

1989 • 161 citations

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.

1996 • 159 citations

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.

1993 • 152 citations

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

1995 • 148 citations

WW domains and retrovirus budding

1996 • 124 citations

The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiae.

1996 • 110 citations

Pub1 acts as an E6-AP-like protein ubiquitiin ligase in the degradation of cdc25.

1996 • 110 citations

Molecular Aspects of Transport Proteins

1992 • 109 citations

Towards prediction of cognate complexes between the WW domain and proline‐rich ligands

1996 • 108 citations

Primary structure of the uracil transport protein of Saccharomyces cerevisiae

1988 • 107 citations

WWP, a New Amino Acid Motif Present in Single or Multiple Copies in Various Proteins Including Dystrophin and the SH3-Binding Yes-Associated Protein YAP65

1994 • 98 citations

A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases

1991 • 97 citations

PTF1 encodes an essential protein in Saccharomyces cerevisiae, which shows strong homology with a new putative family of PPIases

1995 • 97 citations

WW domains

1996 • 84 citations

Chapter 7 Amino acid transporters in yeast: structure, function and regulation

1992 • 72 citations

LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes.

1994 • 71 citations

CD45 Protein-tyrosine Phosphatase Associates with the WW Domain-containing Protein, CD45AP, through the Transmembrane Region

1995 • 64 citations

The rsp5-domain is shared by proteins of diverse functions

1995 • 63 citations

The Yeast Plasma Membrane Uracil Permease Is Stabilized against Stress-Induced Degradation by a Point Mutation in a Cyclin-like "Destruction Box"

1994 • 44 citations

Molecular cloning of the CD45-associated 30-kDa protein.

1994 • 38 citations

Identification of the Sites of Interaction between Lymphocyte Phosphatase-associated Phosphoprotein (LPAP) and CD45

1995 • 31 citations

Binding of the proline-rich region of the epithelial Na+ channel to SH3 domains and its association with specific cellular proteins

1995 • 21 citations

Tolerance of low pH in Schizosaccharomyces pombe requires a functioning pub1 ubiquitin ligase

1997 • 14 citations

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