Donor lymphocyte infusions for relapse of chronic myeloid leukemia after allogeneic stem cell transplant

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,984 citations

Nonmyeloablative Stem Cell Transplantation and Cell Therapy as an Alternative to Conventional Bone Marrow Transplantation With Lethal Cytoreduction for the Treatment of Malignant and Nonmalignant Hematologic Diseases

1998 • 1,765 citations

CTLA-4 is a second receptor for the B cell activation antigen B7.

1991 • 1,662 citations

Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients

1990 • 1,544 citations

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation.

1997 • 1,290 citations

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia

1997 • 1,180 citations

Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies.

1998 • 967 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

Long–term restoration of immunity against Epstein–Barr virus infection by adoptive transfer of gene–modified virus–specific T lymphocytes

1996 • 852 citations

Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease

1995 • 772 citations

Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells

1996 • 770 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Mismatches of Minor Histocompatibility Antigens between HLA-Identical Donors and Recipients and the Development of Graft-Versus-Host Disease after Bone Marrow Transplantation

1996 • 603 citations

Bone Marrow Transplants from Unrelated Donors for Patients with Chronic Myeloid Leukemia

1998 • 587 citations

Ex Vivo Staining of Metastatic Lymph Nodes by Class I Major Histocompatibility Complex Tetramers Reveals High Numbers of Antigen-experienced Tumor-specific Cytolytic T Lymphocytes

1998 • 534 citations

Induction of Graft-versus-Host Disease as Immunotherapy for Relapsed Chronic Myeloid Leukemia

1994 • 510 citations

Immune surveillance against a solid tumor fails because of immunological ignorance

1999 • 463 citations

Transplantation of Anergic Histoincompatible Bone Marrow Allografts

1999 • 448 citations

Allogeneic cell therapy with donor peripheral blood cells and recombinant human interleukin-2 to treat leukemia relapse after allogeneic bone marrow transplantation

1996 • 439 citations

The Minor Histocompatibility Antigen HA-1: A Diallelic Gene with a Single Amino Acid Polymorphism

1998 • 434 citations

BONE MARROW TRANSPLANTS FROM UNRELATED DONORS FOR PATIENTS WITH CHRONIC MYELOID LEUKEMIA

1998 • 429 citations

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

1995 • 429 citations

Mixed lymphohaemopoietic chimerism and graft-ver suslymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation

1999 • 405 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

Relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: the case for giving donor leukocyte transfusions before the onset of hematologic relapse

1994 • 358 citations

Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose

1993 • 356 citations

CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation

1995 • 341 citations

Toxicity and Efficacy of Defined Doses of CD4+ Donor Lymphocytes for Treatment of Relapse After Allogeneic Bone Marrow Transplant

1998 • 328 citations

Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigens.

1992 • 320 citations

Feasibility of Immunotherapy of Relapsed Leukemia With Ex Vivo–Generated Cytotoxic T Lymphocytes Specific for Hematopoietic System-Restricted Minor Histocompatibility Antigens

1999 • 309 citations

Use of Leukemic Dendritic Cells for the Generation of Antileukemic Cellular Cytotoxicity Against Philadelphia Chromosome-Positive Chronic Myelogenous Leukemia

1997 • 309 citations

Interferon Alfa Versus Chemotherapy for Chronic Myeloid Leukemia: A Meta-analysis of Seven Randomized Trials

1997 • 282 citations

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

1987 • 279 citations

Cytotoxic T Lymphocytes Specific for a Nonpolymorphic Proteinase 3 Peptide Preferentially Inhibit Chronic Myeloid Leukemia Colony-Forming Units

1997 • 245 citations

Cytotoxic T-Lymphocyte–Defined Human Minor Histocompatibility Antigens With a Restricted Tissue Distribution

1998 • 238 citations

A Human Minor Histocompatibility Antigen Specific for B Cell Acute Lymphoblastic Leukemia

1999 • 235 citations

T CELL SUBSETS AND GRAFT-VERSUS-HOST DISEASE

1987 • 223 citations

Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation?

1994 • 220 citations

Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia

1995 • 204 citations

Recognition of BCR-ABL positive leukemic blasts by human CD4+ T cells elicited by primary in vitro immunization with a BCR-ABL breakpoint peptide

1996 • 200 citations

Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation

1996 • 199 citations

Identification of classical minor histocompatibility antigen as cell-derived peptide

1990 • 196 citations

Specific binding of leukemia oncogene fusion protein peptides to HLA class I molecules

1995 • 193 citations

Herpes Simplex Virus Thymidine Kinase Gene Transfer for Controlled Graft-versus-Host Disease and Graft-versus-Leukemia: Clinical Follow-up and Improved New Vectors

1998 • 185 citations

SELECTIVE DEPLETION OF CD8+ CELLS FOR PREVENTION OF GRAFT-VERSUS-HOST DISEASE AFTER BONE MARROW TRANSPLANTATION A RANDOMIZED CONTROLLED TRIAL

1994 • 174 citations

T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect

1998 • 159 citations

Donor leukocyte infusions for chronic myeloid leukemia in relapse after allogeneic bone marrow transplantation [letter]

1992 • 155 citations

Interferon-alpha restores normal adhesion of chronic myelogenous leukemia hematopoietic progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function.

1994 • 153 citations

Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-host tolerance allows for persistent antileukemic reactivity without severe graft-versus-host disease

1995 • 137 citations

Ex Vivo Generation of Human Anti–Pre-B Leukemia-Specific Autologous Cytolytic T Cells

1997 • 131 citations

Peptide-specific cytotoxic T lymphocytes restricted by nonself major histocompatibility complex class I molecules: Reagents for tumor immunotherapy

1996 • 131 citations

Immunological memory

1997 • 124 citations

Depletion of Alloreactive T Cells by a Specific Anti–Interleukin-2 Receptor p55 Chain Immunotoxin Does Not Impair In Vitro Antileukemia and Antiviral Activity

1999 • 122 citations

Comparative Outcomes of T-Cell–Depleted and Non–T-Cell–Depleted Allogeneic Bone Marrow Transplantation for Chronic Myelogenous Leukemia: Impact of Donor Lymphocyte Infusion

1999 • 118 citations

Donor Leukocyte Infusion for Leukemic Relapse After Allogeneic Marrow Transplantation: Lack of Residual Donor Hematopoiesis Predicts Aplasia

1997 • 117 citations

BCR/ABL leukemia oncogene fusion peptides selectively bind to certain HLA-DR alleles and can be recognized by T cells found at low frequency in the repertoire of normal donors

1996 • 115 citations

Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules

1998 • 110 citations

Outcome for patients who relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia. Chronic Leukemia Working Party. European Bone Marrow Transplantation Group

1993 • 96 citations

T cells recognizing leukemic CD34 ⁺ progenitor cells mediate the antileukemic effect of donor lymphocyte infusions for relapsed chronic myeloid leukemia after allogeneic stem cell transplantation

1998 • 94 citations

Therapy with cultured T cells: principles revisited

1997 • 90 citations

Outcome for patients who relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia. Chronic Leukemia Working Party. European Bone Marrow Transplantation Group

1993 • 88 citations

Donor lymphocyte infusions (DLI) in patients with chronic myeloid leukemia following allogeneic bone marrow transplantation

1997 • 87 citations

Graft versus leukemia effect in man: the relapse rate of acute leukemia is lower after allogeneic than after syngeneic marrow transplantation.

1987 • 87 citations

Specific depletion of alloreactive T cells in HLA‐identical siblings: a method for separating graft‐versus‐host and graft‐versus‐leukaemia reactions

1998 • 79 citations

Autografting With Philadelphia Chromosome–Negative Mobilized Hematopoietic Progenitor Cells in Chronic Myelogenous Leukemia

1999 • 79 citations

Chronic myeloid leukemia

1997 • 78 citations

HLA-B8 and HLA-A3 Coexpressed With HLA-B8 Are Associated With a Reduced Risk of the Development of Chronic Myeloid Leukemia

1999 • 77 citations

Adoptive immunotherapy for relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: equal efficacy of lymphocytes from sibling and matched unrelated donors

1998 • 75 citations

CD4(+) cytotoxic T-cell clones specific for bcr-abl b3a2 fusion peptide augment colony formation by chronic myelogenous leukemia cells in a b3a2-specific and HLA-DR-restricted manner

1998 • 72 citations

Treatment with interferon-alpha preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors (CFU-GM) from patients with chronic myeloid leukemia but spares normal CFU-GM.

1998 • 72 citations

Donor leukocyte infusions for recurrent hematologic malignancies after allogeneic bone marrow transplantation: impact of infused and residual donor T cells

1998 • 71 citations

Peptides derived from the whole sequence of BCR‐ABL bind to several class I molecules allowing specific induction of human cytotoxic T lymphocytes

1997 • 64 citations

EFFECTIVE DEPLETION OF ALLOREACTIVE LYMPHOCYTES FROM PERIPHERAL BLOOD MONONUCLEAR CELL PREPARATIONS1,2

1999 • 61 citations

Immunologic Nonresponsiveness to Tumors

1998 • 54 citations

9 Allografting for chronic myeloid leukaemia

1997 • 47 citations

A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo.

1996 • 45 citations

Second transplants for patients with chronic myeloid leukaemia in relapse after original transplant with T‐depleted donor marrow: feasibility of using busulphan alone for re‐conditioning

1992 • 45 citations

The involvement of "tumor suppressor" p53 in normal and chronic myelogenous leukemia hemopoiesis.

1994 • 42 citations

Binding of BCR/ABL junctional peptides to major histocompatibility complex (MHC) class I molecules: studies in antigen-processing defective cell lines.

1994 • 42 citations

Full Activity From Human β-Globin Locus Control Region Transgenes Requires 5′HS1, Distal β-Globin Promoter, and 3′ β-Globin Sequences

1998 • 35 citations

Neonatal tolerance revisited

1989 • 31 citations

Evidence for specific immune response against P210 BCR-ABL in long-term remission CML patients treated with interferon

1998 • 31 citations

Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules

1994 • 26 citations

Chronic myeloid leukemia

1998 • 21 citations

Eradication of residual disease by administration of leukemia-specific T cells after experimental allogeneic bone marrow transplantation.

1998 • 15 citations

Antibody recognition of the tumor-specific b3-a2 junction of bcr-abl chimeric proteins in Philadelphia-chromosome-positive leukemias.

1992 • 13 citations

Helper and cytotoxic lymphocyte responses to chronic myeloid leukaemia: implications for adoptive immunotherapy with T cells.

1996 • 13 citations

Risk of donor lymphocyte infusions following allogeneic bone marrow transplantation.

1997 • 5 citations

T cell recovery following stem cell transplantation in thymectomized and thymus bearing mice

1998 • 2 citations

POSSIBLE INDUCTION OF GRAFT-VERSUS-LEUKEMIA EFFECT AGAINST A LEUKEMIA REFRACTORY TO ANTILEUKEMIA RESPONSE IN ORDINARY MHC-COMPATIBLE, ALLOGENEIC BONE MARROW TRANSPLANTATION1

1998 • 1 citations