MOLECULAR TARGETS OF CURCUMIN

Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices

1975 • 2,207 citations

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2002 • 1,849 citations

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)

1995 • 1,352 citations

Phase I Clinical Trial of Oral Curcumin

2004 • 1,170 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Peptide growth factors are multifunctional

1988 • 835 citations

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress

2000 • 834 citations

Protein kinase C signaling and oxidative stress

2000 • 691 citations

Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound.

1995 • 682 citations

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

2003 • 678 citations

Role of life-style and dietary habits in risk of cancer among seventh-day adventists.

1975 • 588 citations

Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.

1991 • 571 citations

Inhibitory effects of dietary curcumin on forestomach, duodenal, and colon carcinogenesis in mice.

1994 • 550 citations

Curcuminoids as Potent Inhibitors of Lipid Peroxidation

1994 • 472 citations

Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt

2003 • 435 citations

Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells

1996 • 405 citations

In Vivo Inhibition of Nitric Oxide Synthase Gene Expression by Curcumin, a Cancer Preventive Natural Product with Anti-Inflammatory Properties

1998 • 395 citations

Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells.

1991 • 381 citations

Caffeic Acid Phenethyl Ester and Curcumin: A Novel Class of Heme Oxygenase-1 Inducers

2002 • 322 citations

Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF- B activation

2003 • 295 citations

Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines

1996 • 279 citations

Inhibitory effects of curcumin on tumor initiation by benzo[a]pyrene and 7,12-dimethylbenz[a]anthracene

1992 • 266 citations

Curcumin-containing diet inhibits diethylnitrosamine-induced murine hepatocarcinogenesis

2000 • 253 citations

Osteopontin Stimulates Tumor Growth and Activation of Promatrix Metalloproteinase-2 through Nuclear Factor-κB-mediated Induction of Membrane Type 1 Matrix Metalloproteinase in Murine Melanoma Cells

2001 • 253 citations

Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells

1993 • 252 citations

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

1999 • 245 citations

Role and Function of the 26S Proteasome in Proliferation and Apoptosis

2002 • 244 citations

Osteopontin Induces Nuclear Factor κB-mediated Promatrix Metalloproteinase-2 Activation through IκBα/IKK Signaling Pathways, and Curcumin (Diferulolylmethane) Down-regulates These Pathways

2003 • 237 citations

Inhibition of Proteasomal Function by Curcumin Induces Apoptosis through Mitochondrial Pathway

2004 • 231 citations

Induction of Apoptosis by Garcinol and Curcumin through Cytochrome c Release and Activation of Caspases in Human Leukemia HL-60 Cells

2001 • 214 citations

Inhibitory effect of topical application of a green tea polyphenol fraction on tumor initiation and promotion in mouse skin

1992 • 212 citations

Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice

2006 • 205 citations

ErbB2 Increases Vascular Endothelial Growth Factor Protein Synthesis via Activation of Mammalian Target of Rapamycin/p70S6K Leading to Increased Angiogenesis and Spontaneous Metastasis of Human Breast Cancer Cells

2006 • 198 citations

Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetateinduced tumor promotion

1995 • 194 citations

Strategy and planning for chemopreventive drug development: Clinical development plans II

1996 • 192 citations

Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

2003 • 191 citations

Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants

1994 • 188 citations

Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin

1991 • 186 citations

Curcuma longa Extract Supplementation Reduces Oxidative Stress and Attenuates Aortic Fatty Streak Development in Rabbits

2002 • 180 citations

Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis

1997 • 163 citations

Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin

1998 • 163 citations

Curcumin (diferuloyl-methane) enhances tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in LNCaP prostate cancer cells.

2003 • 155 citations

Inhibitory effect of curcumin on epidermal growth factor receptor kinase activity in A431 cells

1994 • 153 citations

Inhibition of ligand-induced activation of epidermal growth factor receptor tyrosine phosphorylation by curcumin

1995 • 137 citations

Curcumin Inhibits SK-Hep-1 Hepatocellular Carcinoma Cell Invasion in vitro and Suppresses Matrix Metalloproteinase-9 Secretion

1998 • 134 citations

Some Perspectives on Dietary Inhibition of Carcinogenesis: Studies with Curcumin and Tea

1997 • 129 citations

Progress in cancer chemoprevention: perspectives on agent selection and short-term clinical intervention trials.

1994 • 124 citations

Epidermal growth factor activation of NF-κB is mediated through IκBα degradation and intracellular free calcium

1998 • 123 citations

Effect of curcumin on 12-O-tetradecanoylphorbol-13-acetate- and ultraviolet B light-induced expression of c-Jun and c-Fos in JB6 cells and in mouse epidermis

1994 • 115 citations

Blocking and suppressing mechanisms of chemoprevention by dietary constituents

2000 • 111 citations

Antioxidant Regulation of Protein Kinase C in Cancer Prevention

2002 • 100 citations

Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats

2000 • 99 citations

Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits (-)-benzo(a)pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa.

2002 • 90 citations

Induction ofHSP70 gene expression by modulation of Ca+2 ion and cellular p53 protein by curcumin in colorectal carcinoma cells

1996 • 85 citations

Inhibitory effect of curcumin on xanthine dehydrogenase/oxidase induced by phorbol-12-myristate-13-acetate in NJH3T3 cells

1994 • 82 citations

Inhibition of 8-hydroxydeoxyguanosine formation by curcumin in mouse fibroblast cells

1993 • 64 citations

Inhibition of NF-κB Sensitizes A431 Cells to Epidermal Growth Factor-induced Apoptosis, whereas Its Activation by Ectopic Expression of RelA Confers Resistance

2003 • 63 citations

Induction of G1 Arrest and Apoptosis in Human Jurkat T Cells by Pentagalloylglucose through Inhibiting Proteasome Activity and Elevating p27Kip1, p21Cip1/WAF1, and Bax Proteins

2004 • 61 citations

Molecular Mechanism of Action of Curcumin

1994 • 6 citations

Inhibition of breast cancer cell proliferation by theaflavins from black tea through suppressing proteasomal activities

2006 • 6 citations