Modulatory Effects of Descending Systems on Spinal Dorsal Horn Neurons

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Endogenous pain control mechanisms: Review and hypothesis

1978 • 1,217 citations

Brainstem Control of Spinal Pain-Transmission Neurons

1978 • 820 citations

Pain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone

1977 • 740 citations

Central nervous system mechanisms of analgesia

1976 • 710 citations

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

1974 • 707 citations

Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques

1977 • 656 citations

Spinal opiate analgesia: Characteristics and principles of action

1981 • 552 citations

Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons

1977 • 474 citations

Progress in Sensory Physiology

1987 • 445 citations

Pain reduction by electrical brain stimulation in man

1977 • 432 citations

Neurons that subserve the sensory-discriminative aspects of pain

1977 • 429 citations

Segmental and supraspinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuli

1975 • 425 citations

Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioral observations and inhibitory effects on spinal cord interneurons

1973 • 425 citations

Brain Stem Control of Spinal Mechanisms

1982 • 424 citations

The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat

1978 • 334 citations

Nervous outflow from the cat's foot during noxious radiant heat stimulation

1974 • 330 citations

Inhibition of spinothalamic tract cells and interneurons by brain stem stimulation in the monkey

1977 • 276 citations

An analysis of response properties of spinal cord dorsal horn neurones to nonnoxious and noxious stimuli in the spinal rat

1977 • 268 citations

Relative contributions of the nucleus raphe magnus and adjacent medullary reticular formation to the inhibition by stimulation in the periaqueductal gray of a spinal nociceptive reflex in the pentobarbital-anesthetized rat

1984 • 262 citations

Descending inhibitory influences from periaqueductal gray, nucleus raphe magnus, and adjacent reticular formation. II. Effects on medullary dorsal horn nociceptive and nonnociceptive neurons

1983 • 205 citations

Activity evoked by A- and C-afferent fibers in rat dorsal horn neurons and its relation to a flexion reflex

1983 • 202 citations

Characterization of inhibition of a spinal nociceptive reflex by stimulation medially and laterally in the midbrain and medulla in the pentobarbital-anesthetized rat

1984 • 200 citations

Control of Nociceptive Transmission in the Spinal Cord

1982 • 197 citations

The sensitization of high threshold mechanoreceptors with myelinated axons by repeated heating.

1977 • 194 citations

Responses of primate spinothalamic neurons to graded and to repeated noxious heat stimuli

1979 • 189 citations

Opiate and opioid peptide effects on brain stem neurons: Relevance to nociception and antinociceptive mechanisms

1982 • 187 citations

Effects induced by stimulation of the centralis inferior nucleus of the raphe on dorsal horn interneurons in cat's spinal cord

1977 • 158 citations

Inhibition of spinal nociceptive information by stimulation in midbrain of the cat is blocked by lidocaine microinjected in nucleus raphe magnus and medullary reticular formation

1983 • 157 citations

Inhibition of spinal cord interneurons by narcotic microinjection and focal electrical stimulation in the periaqueductal gray matter

1979 • 154 citations

Differential inhibitory effects of medial and lateral midbrain stimulation on spinal neuronal discharges to noxious skin heating in the cat

1980 • 128 citations

Inhibition of primate spinothalamic tract neurons by stimulation in ventral posterior lateral (VPLc) thalamic nucleus: possible mechanisms

1983 • 122 citations

Descending inhibitory influences from periaqueductal gray, nucleus raphe magnus, and adjacent reticular formation. I. Effects on lumbar spinal cord nociceptive and nonnociceptive neurons

1983 • 122 citations

Nucleus raphe magnus modulation of response of rat dorsal horn neurons to unmyelinated fiber inputs: partial involvement of serotonergic pathways

1980 • 117 citations

The periaqueductal gray projections to the rat spinal trigeminal, raphe magnus, gigantocellular pars alpha and paragigantocellular nuclei arise from separate neurons

1983 • 116 citations

A further examination of effects of cortical stimulation on primate spinothalamic tract cells

1983 • 106 citations

Inhibition of spinal neuronal responses to noxious skin heating by stimulation of mesencephalic periaqueductal gray in the cat

1979 • 105 citations

Primary afferent depolarization evoked from the brain stem and the cerebellum.

1966 • 105 citations

Inhibition in spinal cord of nociceptive information by electrical stimulation and morphine microinjection at identical sites in midbrain of the cat

1984 • 103 citations

Inhibition of nociceptive and nonnociceptive responses of primate spinothalamic cells by stimulation in medial brain stem.

1981 • 101 citations

Postsynaptic inhibition of primate spinothalamic neurons by stimulation in nucleus raphe magnus

1981 • 95 citations

Stimulation sites in periaqueductal gray, nucleus raphe magnus and adjacent regions effective in suppressing oral-facial reflexes

1982 • 94 citations

Inhibition and excitation of primate spinothalamic tract neurons by stimulation in region of nucleus reticularis gigantocellularis

1980 • 94 citations

Effects of stimulation of sensorimotor cortex on primate spinothalamic neurons

1974 • 92 citations

Primary afferent depolarization of identified cutaneous fibers following stimulation in medial brain stem

1979 • 89 citations

Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial hypothalamic stimulation in the cat.

1982 • 87 citations

Inhibition of primate spinothalamic tract neurons by stimulation in periaqueductal gray or adjacent midbrain reticular formation

1984 • 87 citations

Prolonged, naloxone-reversible inhibition of the flexion reflex in the cat

1983 • 87 citations

Current topics in pain research and therapy

1984 • 84 citations

Quantitative comparison of inhibition in spinal cord of nociceptive information by stimulation in periaqueductal gray or nucleus raphe magnus of the cat

1983 • 80 citations

New long latency bulbospinal evoked potentials blocked by serotonin antagonists

1974 • 79 citations

Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by medial preoptic and septal stimulation in the cat

1982 • 79 citations

Effects of morphine upon the lamina V type cells activities in the dorsal horn of the decerebrate cat

1976 • 78 citations

Spinal cord coding of graded nonnoxious and noxious temperature increases

1975 • 75 citations

Stimulation-produced analgesia: Evidence for somatotopic organization in the midbrain

1982 • 74 citations

Microinjection of morphine within nucleus raphe magnus and dorsal horn neurone activities related to nociception in the rat

1980 • 71 citations

Segmental and descending influences on intraspinal thresholds of single C-fibers

1979 • 71 citations

The Raphe—Spinal System

1984 • 69 citations

Progress in sensory physiology

1982 • 68 citations

Inhibition of nociceptive neuronal responses in the catʼs spinal dorsal horn by electrical stimulation and morphine microinjection in nucleus raphe magnus

1984 • 58 citations

The effects of lesions of medullary midline and lateral reticular areas on inhibition in the dorsal horn produced by periaqueductal grey stimulation in the cat

1984 • 55 citations

Descending inhibition from medial and lateral midbrain of spinal dorsal horn neuronal responses to noxious and nonnoxious cutaneous stimuli in the cat.

1981 • 51 citations

Role of the Raphe Nuclei in Stimulation Producing Analgesia

1981 • 51 citations

Effects of analgesic midbrain stimulation on reflex withdrawal and thermal escape in the rat.

1976 • 50 citations

Light pentobarbital anesthesia diminishes the antininoceptive potency of morphine administered intracranially but not intrathecally in the rat

1984 • 44 citations

Current topics in pain research and therapy

1986 • 44 citations

Inhibition of spinal dorsal horn neuronal responses to noxious skin heating by lateral hypothalamic stimulation in the cat

1983 • 41 citations

The relative significance of spinal and supraspinal actions in the antinociceptive effect of morphine in the dorsal horn: an evaluation of the microinjection technique

1983 • 39 citations

Suppression of Noxiously Evoked WDR Dorsal Horn Neuronal Activity by Spinally Administered Morphine

1983 • 37 citations

Encoding in dorsal horn interneurons receiving noxious and non noxious afferents.

1977 • 32 citations

Brainstem influences on transmission of somatosensory information in the spinocervicothalamic pathway

1984 • 24 citations

Pontomedullary raphe neurons: Intracellular responses to central and peripheral electrical stimulation

1984 • 22 citations

The antinociceptive action of etorphine in the dorsal horn is due to a direct spinal action and not to activation of descending inhibition

1983 • 22 citations

Progress in sensory physiology, Vol. 3.. Control of Nociceptive transmission in the spinal cord.

1983 • 12 citations