The antinociceptive action of etorphine in the dorsal horn is due to a direct spinal action and not to activation of descending inhibition

Pain Relief by Intrathecally Applied Morphine in Man

1979 • 944 citations

Three bulbospinal pathways from the rostral medulla of the cat: An autoradiographic study of pain modulating systems

1978 • 637 citations

Studies on the direct spinal action of narcotics in the production of analgesia in the rat.

1977 • 543 citations

Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons

1977 • 474 citations

Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat

1974 • 417 citations

The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat

1978 • 334 citations

Sites of morphine induced analgesia in the primate brain: relation to pain pathways

1974 • 332 citations

Inhibition of spinothalamic tract cells and interneurons by brain stem stimulation in the monkey

1977 • 276 citations

Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat

1979 • 257 citations

Evaluation of the periaqueductal central gray (PAG) as a morphine-specific locus of action and examination of morphine-induced and stimulation-produced analgesia at coincident PAG loci

1977 • 239 citations

Depressive effects of morphine upon lamina V cells activities in the dorsal horn of the spinal cat

1975 • 198 citations

SUPPRESSION OF TRANSMISSION OF NOCICEPTIVE IMPULSES BY MORPHINE: SELECTIVE EFFECTS OF MORPHINE ADMINISTERED IN THE REGION OF THE SUBSTANTIA GELATINOSA

1977 • 195 citations

The contribution of nucleus reticularis paragigantocellularis and nucleus raphe magnus to the analgesia produced by systemically administered morphine, investigated with the microinjection technique

1982 • 181 citations

Effects induced by stimulation of the centralis inferior nucleus of the raphe on dorsal horn interneurons in cat's spinal cord

1977 • 158 citations

Inhibition of the spinal transmission of nociceptive information by supraspinal stimulation in the cat

1979 • 158 citations

The periaqueductal gray: Site of morphine analgesia and tolerance as shown by 2-way cross tolerance between systemic and intracerebral injections

1976 • 157 citations

Inhibition of spinal cord interneurons by narcotic microinjection and focal electrical stimulation in the periaqueductal gray matter

1979 • 154 citations

Reticulospinal inhibition of interneurones

1968 • 153 citations

Lamina-specific Suppression of Dorsal-horn Unit Activity by Morphine Sulfate

1974 • 150 citations

Naloxone-reversible analgesia produced by microstimulation in the rat medulla

1981 • 145 citations

Effects of Morphine and Naloxone on Dorsal Horn Neurones in the Cat

1974 • 143 citations

Analgesia produced by microinjection of baclofen and morphine at brain stem sites

1979 • 134 citations

Differential inhibitory effects of medial and lateral midbrain stimulation on spinal neuronal discharges to noxious skin heating in the cat

1980 • 128 citations

ACTIONS OF ETORPHINE HYDROCHLORIDE, (M99): A POTENT MORPHINE‐LIKE AGENT

1967 • 119 citations

Evidence for a direct spinal mechanism in morphine-induced inhibition of nociceptive reflexes in humans

1980 • 98 citations

MORPHINE AND NEUROTRANSMITTER SUBSTANCES: MICROIONTOPHORETIC STUDY IN THE RAT BRAIN STEM

1974 • 85 citations

Differential excitatory and inhibitory effects of opiates on non-nociceptive and nociceptive neurones in the spinal cord of the cat

1978 • 81 citations

The heat sensitization of polymodal nociceptors in the rabbit and its independence of the local blood flow.

1979 • 75 citations

Does systemic morphine increase descending inhibitory controls of dorsal horn neurones involved in nociception?

1980 • 75 citations

The nucleus reticularis paragigantocellularis as a site of analgesic action of morphine and enkephalin

1979 • 74 citations

Microinjection of morphine within nucleus raphe magnus and dorsal horn neurone activities related to nociception in the rat

1980 • 71 citations

Actions and interactions of narcotic agonists and antagonists on brain stem neurones

1974 • 70 citations

PHARMACOLOGICAL AND ELECTROPHYSIOLOGICAL STUDIES OF MORPHINE AND ENKEPHALIN ON RAT SUPRASPINAL NEURONES AND CAT SPINAL NEURONES

1978 • 66 citations

MORPHINE AND SUPRASPINAL INHIBITION OF SPINAL NEURONES: EVIDENCE THAT MORPHÌNE DECREASES TONIC DESCENDING INHIBITION IN THE ANAESTHETIZED CAT

1980 • 59 citations

Physiological disposition and biotransformation of [allyl-1', 3' - 14C naloxone in the rat and some comparative observations on nalorphine.

1976 • 58 citations

Inhibition by etorphine of the discharge of dorsal horn neurons: Effects on the neuronal response to both high- and low-threshold sensory input in the decerebrate spinal cat

1978 • 50 citations

The relative contribution of direct and supraspinal descending effects upon spinal mechanisms of morphine analgesia.

1978 • 43 citations

Differential effects of systemic versus intracranial injection of opiates on central, orofacial and lower body nociception: somatotypy in bulbar analgesia systems

1980 • 33 citations

Pentobarbital pharmacokinetics in the normal and in the hepatectomized rat.

1975 • 26 citations

Heat pain sensitivity of human skin after mild heat injury and its lack of dependence on the local blood flow

1980 • 11 citations

Descending inhibitions from the nucleus raphe magnus and adjacent reticular formation to the dorsal horn of the rat are not antagonized by bicuculline or strychnine

1981 • 8 citations

Does systemic morphine increase descending inhibitory controls of dorsal horn neurones involved in nociception?

1980 • 7 citations