Brainstem Control of Spinal Pain-Transmission Neurons

The Integrative Action of the Nervous System.

1907 • 4,174 citations

The cytoarchitectonic organization of the spinal cord in the cat

1952 • 1,595 citations

Evidence for the existence of monoamine neurons in the central nervous system

1965 • 1,538 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Analgesia Mediated by a Direct Spinal Action of Narcotics

1976 • 945 citations

Autoradiographic localization of opiate receptors in rat brain. I. Spinal cord and lower medulla

1977 • 863 citations

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

1973 • 811 citations

Analgesia from Electrical Stimulation in the Brainstem of the Rat

1971 • 751 citations

Antagonism of acupuncture analgesia in man by the narcotic antagonist naloxone

1977 • 742 citations

The Brain Stem of the Cat

1969 • 673 citations

Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 • 642 citations

The puzzle of pain

1973 • 582 citations

Cellular Localization of Monoamines in the Spinal Cord

1964 • 528 citations

Opioid Peptides Endorphins in Pituitary and Brain

1976 • 518 citations

Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons

1977 • 474 citations

beta-endorphin is a potent analgesic agent.

1976 • 465 citations

Autoradiographic studies of the projections of the midbrain reticular formation: Descending projections of nucleus cuneiformis

1975 • 432 citations

Cortical, tectal and tegmental fiber connections in the spinal cord of the cat

1967 • 401 citations

CENTRAL INFLUENCES ON SPINAL AFFERENT CONDUCTION

1954 • 372 citations

Morphine analgesia: Blockade by raphe magnus lesions

1975 • 353 citations

Responses of primate spinothalamic tract neurons to natural stimulation of hindlimb.

1974 • 344 citations

Sites of morphine induced analgesia in the primate brain: relation to pain pathways

1974 • 332 citations

The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat

1976 • 321 citations

Inhibitory effects evoked through ventral reticulospinal pathways.

1968 • 314 citations

Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat

1975 • 307 citations

Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor

1968 • 301 citations

THE TREATMENT OF PERSISTENT PAIN OF ORGANIC ORIGIN IN THE LOWER PART OF THE BODY BY DIVISION OF THE ANTEROLATERAL COLUMN OF THE SPINAL CORD

1912 • 287 citations

Inhibition of spinothalamic tract cells and interneurons by brain stem stimulation in the monkey

1977 • 276 citations

An analysis of response properties of spinal cord dorsal horn neurones to nonnoxious and noxious stimuli in the spinal rat

1977 • 268 citations

The regional distribution of a morphine-like factor enkephalin in monkey brain

1976 • 266 citations

The efferent connection of the nucleus raphe dorsalis

1976 • 266 citations

Naloxone reversal of analgesia produced by brain stimulation in the human

1976 • 261 citations

Nociceptor-driven dorsal horn neurones in the lumbar spinal cord of the cat

1976 • 242 citations

The origin of reticulospinal fibers in the cat. An experimental study

1957 • 242 citations

Stimulation of internal capsule for relief of chronic pain

1974 • 232 citations

Opiate antagonist, naloxone, strongly reduces analgesia induced by stimulation of a raphe nucleus (centralis inferior)

1977 • 214 citations

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

1974 • 205 citations

Responses of spinocervical tract neurones to natural stimulation of identified cutaneous receptors

1969 • 198 citations

Depressive effects of morphine upon lamina V cells activities in the dorsal horn of the spinal cat

1975 • 198 citations

Reduced effect of morphine in midbrain raphe lesioned rats

1970 • 197 citations

Location of cells of origin of spinothalamic tract in lumbar enlargement of the monkey.

1973 • 194 citations

Lack of effect of naloxone on pain perception in humans

1976 • 191 citations

Distribution of the tract of lissauer and the dorsal root fibers in the primate spinal cord

1977 • 191 citations

Morphine, enkephalin and the substantia gelatinosa

1976 • 188 citations

The specificity of the neuronal structure and topography of the reticular formation in the brain and spinal cord of carnivora

1963 • 187 citations

Opiate receptor in normal and drug altered brain function*

1975 • 184 citations

Distribution of stereospecific binding of the potent narcotic analgesic etorphine in the human brain: predominance in the limbic system.

1973 • 183 citations

An Analog of Enkephalin Having Prolonged Opiate-Like Effects in Vivo

1977 • 159 citations

Analgesia and hyperreactivity produced by intracranial microinjections of morphine into the periaqueductal gray matter of the rat

1974 • 157 citations

The periaqueductal gray: Site of morphine analgesia and tolerance as shown by 2-way cross tolerance between systemic and intracerebral injections

1976 • 157 citations

Neurophysiological characterization of the anterolateral spinal cord neurons contributing to pain perception in man

1975 • 154 citations

Confirmation of the location of spinothalamic neurons in the cat and monkey by the retrograde transport of horseradish peroxidase

1975 • 154 citations

Reticulospinal inhibition of interneurones

1968 • 153 citations

Enkephalin-Induced Depression of Single Neurons in Brain Areas with Opiate Receptors—Antagonism by Naloxone

1976 • 150 citations

Effects of dorsal column stimulation on primate spinothalamic tract neurons

1976 • 146 citations

Lumbar cord neurons at the origin of the spinothalamic tract in the rat

1976 • 146 citations

Identification of cells of origin of non-primary afferents to the dorsal column nuclei of the cat

1977 • 143 citations

Effects of Morphine and Naloxone on Dorsal Horn Neurones in the Cat

1974 • 143 citations

The dorsal column system: II. Functional properties and bulbar relay of the postsynaptic fibres of the cat's fasciculus gracilis

1975 • 139 citations

EFFECTS OF DISCRETE BRAINSTEM LESIONS IN CATS ON PERCEPTION OF NOXIOUS STIMULATION

1958 • 138 citations

Location of cells of origin of the spinothalamic tract in the lumbar enlargement of cat

1972 • 137 citations

THE OPIATE RECEPTOR AND OPIOID PEPTIDES

1977 • 136 citations

Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

1976 • 135 citations

Effects of descending impulses on transmission through the spinocervical tract

1971 • 126 citations

Inhibition of primate spinothalamic tract neurons by stimulation in the region of the nucleus raphe magnus

1976 • 124 citations

Effects of 5-hydroxytryptamine and bradykinin in cat dorsal horn neurones activated by noxious stimuli

1976 • 124 citations

Location and somatotopic organization of the cells of origin of the spino-cervical tract

1973 • 122 citations

Neurophysiological characterization of the anterolateral quadrant neurons subserving pain in M. Mulatta

1975 • 121 citations

Relief of pain by electrical stimulation of the septal area

1967 • 117 citations

The analgesic effect of electrical stimulation of the diencephalon and mesencephalon

1973 • 112 citations

Suppression by LSD of the inhibitory effect exerted by dorsal raphe stimulation on certain spinal cord interneurons in the cat

1973 • 111 citations

Drug interaction in the field of analgesic drugs.

1965 • 106 citations

An inability to antagonize with naloxone the elevated nociceptive thresholds resulting from electrical stimulation of the mesencephalic central gray

1976 • 106 citations

Comparison between naloxone reversal of morphine and electrical stimulation induced analgesia in the rat mesencephalon

1976 • 105 citations

Cells of origin of the spinothalamic tract in the cat and rat

1968 • 105 citations

Non-primary afferents to the cuneate nucleus in the brachial dorsal funiculus of the cat

1974 • 103 citations

The effect of morphine on the activity evoked in ventrolateral tract axons of the cat spinal cord

1976 • 101 citations

Effects of methionine-enkephalin and leucine-enkephalin compared with those of morphine on brainstem neurones in cat

1976 • 94 citations

The course of ascending fibers in the spinal cord of the cat essential to the recognition of painful stimuli

1954 • 92 citations

Characteristics of spinal neurones responding to cutaneous myelinated and unmyelinated fibres*

1972 • 90 citations

Actions of opiates upon single unit activity in the cortex of naive and tolerant rats

1976 • 86 citations

Neurones in the dorsal horn of the rat responding to scrotal skin temperature changes

1973 • 82 citations

Effects of morphine upon the lamina V type cells activities in the dorsal horn of the decerebrate cat

1976 • 78 citations

Labelling of cells in the medulla oblongata and the spinal cord of the monkey after injections of horseradish peroxidase in the thalamus

1975 • 78 citations

Periaqueductal grey lesions reduce morphine analgesia in the rat

1977 • 78 citations

Physiological laminar organization of the dorsal horn of M. mulatta

1974 • 77 citations

Spinal cord coding of graded nonnoxious and noxious temperature increases

1975 • 75 citations

Conduction of the effects of noxious stimulation by short-fiber multisynaptic systems of the spinal cord in the rat

1973 • 73 citations

Isolation of a novel endogenous opiate analgesic from human blood.

1976 • 73 citations

Origin of spino-thalamic tract in monkeys

1974 • 73 citations

Striatal Influence on Facial Pain

1966 • 70 citations

Escape Elicited By Bulboreticular Stimulation In The Cat

1971 • 68 citations

Somatic and visceral receptive field properties of fibers in ventral quadrant white matter of the cat spinal cord.

1970 • 64 citations

Some properties of spinal connections of the cat's dorsal column nuclei which do not involve the dorsal columns

1973 • 64 citations

Dorsal column nuclei afferents in the lateral funiculus of the cat: Distribution pattern and absence of sprouting after chronic deafferentation

1975 • 63 citations

Morphine: Ability to block neuronal activity evoked by a nociceptive stimulus

1976 • 59 citations

The ascending projections of the dorsolateral funiculus of the spinal cord in the primate

1975 • 58 citations

Reduction of the response of cat spinothalamic neurons to graded mechanical stimuli by electrical stimulation of the lower brain stem

1975 • 53 citations

Responses of caudal raphe neurons to peripheral somatic stimulation

1976 • 50 citations

Responses of spinal cord neurons to graded noxious and non-noxious stimuli

1973 • 50 citations

The influence of raphe lesions on the effect of morphine on nociception and cortical ACh output

1975 • 50 citations

Parametric studies of dorsal horn neurons responding to tactile stimulation

1975 • 50 citations

Effects of phenoperidine on lamina V cells in the cat dorsal horn.

1973 • 45 citations

Differential Supraspinal Control of Inhibitory and Excitatory Actions from, the FRA to Ascending Spinal Pathways

1965 • 42 citations

Effects of activity in non-myelinated afferent fibres on the spinocervical tract

1975 • 41 citations

Periaqueductal gray and tooth pulp afferent interaction on units in caudal medulla oblongata

1976 • 41 citations

The Effect of Reserpine on Transmission in the Spinal Cord

1968 • 41 citations

Effects of morphine and naloxone on renshaw cells and spinal interneurones in morphine dependent and non-dependent rats

1976 • 41 citations

Alteration of nociception by stimulation of cerebellar structures in the monkey

1974 • 40 citations

Autoradiographic studies concerning the supraspinal site of the antinociceptive action of morphine when inhibiting the hindleg flexor reflex in rabbits

1973 • 39 citations

Differentiation between spinal and supraspinal sites of action of morphine when inhibiting the hindleg flexor reflex in rabbits

1973 • 39 citations

Dissociation of the analgesic and rewarding effects of brain stimulation in the rat

1973 • 37 citations

Ein Beitrag zur Kenntnis der Schmerzleitung im RÜckenmark

1914 • 35 citations

Alteration in footshock threshold by low-level septal brain stimulation

1970 • 35 citations

Activation of neurons in the gracile nucleus by two afferent pathways in the rat

1972 • 34 citations

Activation of descending control of the spinocervical tract by impulses ascending the dorsal columns and relaying through the dorsal column nuclei

1973 • 32 citations

Serotonin involvement in the blockade of bulbospinal inhibition of the spinal monosynaptic reflex

1976 • 28 citations

Effects of spinal cord lesions on cutaneously elicited reflexes in the decerebrate cat. Tonic bulbospinal and spinobulbar inhibitory systems

1970 • 24 citations

ANALGESIA PRODUCED BY MORPHINE WHEN ACTING FROM THE LIQUOR SPACE

1976 • 21 citations

Patterns of response in spinocervical tract neurones to different stimuli of long duration

1970 • 20 citations

Spinal cord neuron response to natural stimuli. A microelectrode study

1973 • 12 citations

Macular influences on ascending spinoreticular neurons located in the cervical cord

1974 • 11 citations

Consideration in Loss of Sensory Level After Bilateral Cervical Cordotomy

1960 • 8 citations

Three bulbospinal pathways from the rostral medulla of the cat: an autoradiographic study of pain modulating systems

1979 • 2 citations

Deleted Work

1955 • 0 citations