Role of the Raphe Nuclei in Stimulation Producing Analgesia

Pain Mechanisms: A New Theory

1965 • 10,272 citations

Advances in Pain Research and Therapy

1980 • 2,255 citations

Sensory Mechanisms of the Spinal Cord

1978 • 1,473 citations

Surgery in the Rat during Electrical Analgesia Induced by Focal Brain Stimulation

1969 • 1,355 citations

Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat

1979 • 1,325 citations

The brain stem of the cat : a cytoarchitectonic atlas with stereotaxic coordinates

1968 • 1,195 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. II. EXPERIMENTALLY INDUCED CHANGES IN THE INTRANEURONAL AMINE LEVELS OF BULBOSPINAL NEURON SYSTEMS.

1965 • 1,004 citations

Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P.

1977 • 887 citations

Brainstem Control of Spinal Pain-Transmission Neurons

1978 • 820 citations

Immunohistochemical localization of enkephalin in rat brain and spinal cord

1978 • 814 citations

Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system

1978 • 809 citations

Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications

1979 • 765 citations

Analgesia from Electrical Stimulation in the Brainstem of the Rat

1971 • 751 citations

Pain Relief by Electrical Stimulation of the Central Gray Matter in Humans and Its Reversal by Naloxone

1977 • 740 citations

Progress in Brain Research.

1965 • 738 citations

Central nervous system mechanisms of analgesia

1976 • 710 citations

Pain reduction by focal electrical stimulation of the brain: An anatomical and behavioral analysis

1974 • 707 citations

Connections of the median and dorsal raphe nuclei in the rat: An autoradiographic and degeneration study

1974 • 675 citations

The Brain Stem of the Cat

1969 • 673 citations

Psychopharmacology. A Generation of Progress

1978 • 668 citations

Antagonism of Stimulation-Produced Analgesia by Naloxone, a Narcotic Antagonist

1976 • 664 citations

The Brain Stem of the Cat: A Cytoarchitectonic Atlas With Stereotaxic Coordinates.

1969 • 664 citations

The raphe nuclei of the cat brain stem: A topographical atlas of their efferent projections as revealed by autoradiography

1976 • 658 citations

Narcotic analgetics: CNS sites and mechanisms of action as revealed by intracerebral injection techniques

1977 • 656 citations

Effects of substance P on functionally identified units in cat spinal cord

1976 • 655 citations

Advances in pain research and therapy

2007 • 653 citations

Three bulbospinal pathways from the rostral medulla of the cat: An autoradiographic study of pain modulating systems

1978 • 637 citations

Opiate receptor: autoradiographic localization in rat brain.

1976 • 612 citations

Autoradiographic localization of opiate receptors in rat brain. II. The brain stem

1977 • 573 citations

The laminar organization of dorsal horn and effects of descending impulses

1967 • 568 citations

Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon

1977 • 566 citations

Nucleus raphe magnus inhibition of spinal cord dorsal horn neurons

1977 • 474 citations

Pain reduction by electrical brain stimulation in man

1977 • 432 citations

Autoradiographic studies of the projections of the midbrain reticular formation: Descending projections of nucleus cuneiformis

1975 • 432 citations

Pain reduction by electrical brain stimulation in man

1977 • 432 citations

Analgesia from electrical stimulation of the periaqueductal gray matter in the cat: behavioral observations and inhibitory effects on spinal cord interneurons

1973 • 425 citations

Behavioral and electrophysiological evidence of pain inhibition from midbrain stimulation in the cat

1974 • 417 citations

Lysergic Acid Diethylamide: Sensitive Neuronal Units in the Midbrain Raphe

1968 • 396 citations

Serotonin-containing neurons: their possible role in pain and analgesia

1977 • 394 citations

Immunohistochemical mapping of enkephalin containing cell bodies, fibers and nerve terminals in the brain stem of the rat

1979 • 382 citations

Afferent projections to the cat locus coeruleus as visualized by the horseradish peroxidase technique

1977 • 379 citations

Effect of substance P in cat dorsal horn neurones activated by noxious stimuli

1977 • 362 citations

Morphine analgesia: Blockade by raphe magnus lesions

1975 • 353 citations

The effect of various neurohumoral modulators on the activity of morphine and the narcotic antagonists in the tail-flick and phenylquinone tests.

1970 • 339 citations

The differential effects of 5-hydroxytryptamine, noradrenaline and raphe stimulation on nociceptive and non-nociceptive dorsal horn interneurones in the cat

1978 • 334 citations

Selective reduction by noradrenaline and 5-hydroxytryptamine of nociceptive responses of cat dorsal horn neurones

1978 • 332 citations

Analgesia induced by electrical stimulation of the inferior centralis nucleus of the raphe in the cat

1975 • 307 citations

Reversal of morphine and stimulus-produced analgesia by subtotal spinal cord lesions

1977 • 303 citations

Antagonism of the analgesic effect of morphine and other drugs by p-chlorophenylalanine, a serotonin depletor

1968 • 301 citations

Opiate and stimulus-produced analgesia: functional anatomy of a medullospinal pathway.

1976 • 289 citations

Antagonism of stimulation-produced analgesia by p-CPA, a serotonin synthesis inhibitor

1972 • 284 citations

The raphe nuclei of the brain stem in the cat. II. Efferent connections

1960 • 284 citations

Evidence that raphe-spinal neurons mediate opiate and midbrain stimulation-produced analgesias

1978 • 283 citations

Stimulation of Human Periaqueductal Gray for Pain Relief Increases Immunoreactive β-endorphin in Ventricular Fluid

1979 • 282 citations

Inhibition of spinothalamic tract cells and interneurons by brain stem stimulation in the monkey

1977 • 276 citations

The efferent connection of the nucleus raphe dorsalis

1976 • 266 citations

Enkephalin-Like Material Elevated in Ventricular Cerebrospinal Fluid of Pain Patients After Analgetic Focal Stimulation

1978 • 262 citations

Naloxone reversal of analgesia produced by brain stimulation in the human

1976 • 261 citations

The catecholamine-containing neurons in the cat dorsolateral pontine tegmentum: Distribution of the cell bodies and some axonal projections

1974 • 261 citations

Afferents to brain stem nuclei (brain stem raphe, nucleus reticularis pontis caudalis and nucleus gigantocellularis) in the rat as demonstrated by microiontophoretically applied horseradish peroxidase

1978 • 258 citations

Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat

1979 • 257 citations

Stimulation-produced Analgesia: Development of Tolerance and Cross-Tolerance to Morphine

1975 • 250 citations

Reticulospinal inhibition of transmission in reflex pathways

1968 • 244 citations

Pain in the trigeminal region

1978 • 216 citations

Opiate antagonist, naloxone, strongly reduces analgesia induced by stimulation of a raphe nucleus (centralis inferior)

1977 • 214 citations

The effect of lowering the 5‐hydroxytryptamine content of the rat spinal cord on analgesia produced by morphine

1974 • 205 citations

Location and properties of dorsal horn neurons at origin of spinoreticular tract in lumbar enlargement of the rat

1980 • 200 citations

Reduced effect of morphine in midbrain raphe lesioned rats

1970 • 197 citations

Sensory Functions of the Skin in Primates

1976 • 190 citations

Degeneration studies of long ascending fiber systems in the cat brain stem

1959 • 179 citations

The topographical distribution of serotoninergic terminals in the spinal cord of the cat: biochemical mapping by the combined use of microdissection and microassay procedures

1977 • 178 citations

Differential projections of cat medullary raphe neurons demonstrated by retrograde labelling following spinal cord lesions

1978 • 177 citations

Appearance of beta-endorphin-like immunoreactivity in human ventricular cerebrospinal fluid upon analgesic electrical stimulation.

1978 • 161 citations

Spinal Reflexes and Monoamine Liberation

1964 • 161 citations

Pyramidal tract effects on interneurons in the cat lumbar dorsal horn.

1968 • 159 citations

A map of serotoninergic structures involved in stimulation producing analgesia in unrestrained freely moving cats

1979 • 159 citations

Inhibition of the spinal transmission of nociceptive information by supraspinal stimulation in the cat

1979 • 158 citations

Effects induced by stimulation of the centralis inferior nucleus of the raphe on dorsal horn interneurons in cat's spinal cord

1977 • 158 citations

Studies on the antagonism by raphe lesions of the antinociceptive action of systemic morphine

1977 • 156 citations

Pain in the Trigeminal Region

1978 • 135 citations

Inhibition of the jaw opening reflex by electrical stimulation of the periaqueductal gray matter in the awake, unrestrained cat

1974 • 130 citations

Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine

1978 • 126 citations

Supraspinal Control of Transmission in Reflex Paths to Motoneurones and Primary Afferents

1964 • 125 citations

Inhibition of primate spinothalamic tract neurons by stimulation in the region of the nucleus raphe magnus

1976 • 124 citations

Effects of 5-hydroxytryptamine and bradykinin in cat dorsal horn neurones activated by noxious stimuli

1976 • 124 citations

Effects of stimulating in raphe nuclei and in reticular formation on response of spinothalamic neurons to mechanical stimuli

1979 • 124 citations

Response of medullary raphe neurons to peripheral stimulation and to systemic opiates

1977 • 121 citations

The projection from nucleus raphe magnus and other brainstem nuclei to the spinal cord in the rat: a study using the HRP blue-reaction

1978 • 120 citations

Suppression by LSD of the inhibitory effect exerted by dorsal raphe stimulation on certain spinal cord interneurons in the cat

1973 • 111 citations

An inability to antagonize with naloxone the elevated nociceptive thresholds resulting from electrical stimulation of the mesencephalic central gray

1976 • 106 citations

Inhibition of spinal neuronal responses to noxious skin heating by stimulation of mesencephalic periaqueductal gray in the cat

1979 • 105 citations

Comparison between naloxone reversal of morphine and electrical stimulation induced analgesia in the rat mesencephalon

1976 • 105 citations

Effects of pain-attenuating brain stimulation and morphine on electrical activity in the raphe nuclei of the awake rat

1977 • 101 citations

The influence of naloxone on the C fiber response of dorsal horn neurons and their inhibitory control by raphe magnus stimulation

1979 • 100 citations

Antagonism by methysergide and cinanserin of the antinociceptive action of morphine administered into the periaqueductal gray

1976 • 98 citations

Primary afferent depolarization of identified cutaneous fibers following stimulation in medial brain stem

1979 • 89 citations

Attenuation of morphine analgesia in rats with lesions of the locus coeruleus and dorsal raphe nucleus

1977 • 86 citations

Is the Tonic Decerebrate Inhibition of Reflex Paths Mediated by Monoaminergic Pathways?

1968 • 84 citations

Analgesic electrical stimulation of the feline nucleus raphe magnus: development of tolerance and its reversal by 5-HTP

1978 • 82 citations

Changes in brain and spinal tryptophan and 5-hydroxy-indoleacetic acid levels follwing acute morphine administration in normal and arthritic rats

1979 • 81 citations

New long latency bulbospinal evoked potentials blocked by serotonin antagonists

1974 • 79 citations

Two populations of spinothalamic tract neurons with opposite responses to 5-hydroxytryptamine

1979 • 79 citations

Decreased antinociceptive activity of morphine in rats pretreated intraventricularly with 5,6-dihydroxytryptamine, a long-lasting selective depletor of brain serotonin

1973 • 79 citations

Enkephalin and substance P effects related to trigeminal pain

1978 • 76 citations

An evaluation of stimulation-produced analgesia in the cat

1978 • 75 citations

Descending influences of periaqueductal gray matter and somatosensory cerebral cortex on neurones in trigeminal brain stem nuclei

1976 • 74 citations

Responses of neurons of the nucleus raphe magnus to noxious stimuli

1980 • 66 citations

Trigeminal nociceptive and non-nociceptive neurones: brain stem intranuclear projections and modulation by orofacial, periaqueductal gray and nucleus raphe magnus stimuli

1979 • 66 citations

The effects of 5-hydroxytryptamine antagonists on spinal neuronal activity.

1968 • 64 citations

The depressive effect of morphine on the C fibre response of dorsal horn neurones in the spinal rat pretreated or not by pCPA

1979 • 61 citations

Descending and segmental inhibition of transmission through the spinocervical tract

1973 • 58 citations

Responses of raphespinal and other bulbar raphe neurones to stimulation of the periaqueductal gray in the cat

1978 • 55 citations

Reduction of stimulation-produced analgesia by lysergic acid diethylamide, a depressor of serotonergic neural activity

1977 • 51 citations

Responses of caudal raphe neurons to peripheral somatic stimulation

1976 • 50 citations

The influence of raphe lesions on the effect of morphine on nociception and cortical ACh output

1975 • 50 citations

The relationship between morphine analgesia and the levels of biogenic amines in the mouse brain

1970 • 42 citations

Periaqueductal gray and tooth pulp afferent interaction on units in caudal medulla oblongata

1976 • 41 citations

The opiate antagonist, naloxone, does not affect descending inhibition from midbrain of nociceptive spinal neuronal discharges in the cat

1979 • 40 citations

Effects of stimulation in nucleus reticularis gigantocellularis on the activity of spinothalamic tract neurons in the monkey

1978 • 37 citations

Opiate Analgesia: the Physiology and Pharmacology of Spinal Pain Systems

1979 • 27 citations

ANALGESIC EFFECTS INDUCED BY ELECTRICAL STIMULATION OF THE NUCLEUS RAPHE MAGNUS IN THE RAT: INTERACTION WITH MORPHINE ANALGESIA

1978 • 21 citations

Morphine effects on rat raphé magnus neurones [proceedings].

1977 • 19 citations

Descending influences on spinocervical tract cell discharges evoked by non-myelinated cutaneous afferent nerve fibres

1973 • 14 citations

Meteorite Impact Crater in Central Alaska

1978 • 4 citations

Deleted Work

1955 • 0 citations