Cerebrospinal Fluid Studies of Neurotransmitter Function in Manic and Depressive Illness

Research Diagnostic Criteria

1978 • 6,988 citations

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE

1965 • 3,421 citations

5-HIAA in the Cerebrospinal Fluid

1976 • 1,430 citations

Psychopharmacology : a generation of progress

1978 • 1,168 citations

Norepinephrine in Depressive Reactions

1965 • 1,127 citations

Catecholamines: Basic and Clinical Frontiers

1979 • 730 citations

Animal models in psychiatry and neurology

1978 • 648 citations

Serotonin and Behavior

1973 • 543 citations

Handbook of experimental pharmacology

1971 • 526 citations

Antipsychotic Drugs, Neurotransmitters, and Schizophrenia

1978 • 500 citations

Carbamazepine in manic-depressive illness: a new treatment

1980 • 485 citations

Tricyclic Antidepressants: Long-Term Treatment Increases Responsivity of Rat Forebrain Neurons to Serotonin

1978 • 476 citations

Catecholamines: Basic and clinical frontiers

1981 • 458 citations

Subfornical Organ: Site of Drinking Elicitation by Angiotensin II

1973 • 421 citations

Psychopharmacology: A generation of progress

1978 • 418 citations

5-HYDROXYINDOLE COMPOUNDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH PSYCHIATRIC OR NEUROLOGICAL DISEASES

1966 • 375 citations

Abnormalities of Indoleamines in Affective Disorders

1972 • 307 citations

Long-Term Treatment with Lithium Prevents the Development of Dopamine Receptor Supersensitivity

1978 • 287 citations

CEREBRAL METABOLITES IN CEREBROSPINAL FLUID AS A BIOCHEMICAL APPROACH TO THE BRAIN

1970 • 284 citations

SINGLE SOLUTION FOR ORAL THERAPY OF DIARRHŒA

1975 • 283 citations

Stimulation of Human Periaqueductal Gray for Pain Relief Increases Immunoreactive β-endorphin in Ventricular Fluid

1979 • 282 citations

L-Tryptophan in Mania

1974 • 272 citations

Peptides and behavior

1977 • 272 citations

Central Dopamine Turnover in Schizophrenic Syndromes

1974 • 268 citations

Psychomotor Activity and Cerebrospinal Fluid Amine Metabolites in Affective Illness

1973 • 263 citations

GABA levels in CSF of patients with psychiatric disorders

1980 • 263 citations

Naloxone-induced reversal of schizophrenic hallucinations

1977 • 262 citations

Enkephalin-Like Material Elevated in Ventricular Cerebrospinal Fluid of Pain Patients After Analgetic Focal Stimulation

1978 • 262 citations

Effects of neuroleptics on 3H-haloperidol and 3H-CIS (Z)-flupenthixol binding and on adenylate cyclase activity in vitro

1978 • 261 citations

5-Hydroxyindoleacetic Acid Levels in the Cerebrospinal Fluid of Depressive Patients treated with Probenecid

1970 • 253 citations

Cerebrospinal Fluid Amine Metabolites in Affective Illness: The Probenecid Technique

1973 • 245 citations

Indoleamine metabolites in the cerebrospinal fluid of depressed patients before and during treatment with nortriptyline

1973 • 242 citations

Neuroregulators and psychiatric disorders

1978 • 233 citations

Release of catecholamines and dopamine-β-oxidase from the adrenal medulla

1968 • 228 citations

Memory deficit in rats with hereditary diabetes insipidus

1975 • 224 citations

Behavioral and electrophysiological effects of peptides related to lipotropin (beta-LPH).

1978 • 223 citations

ACID MONOAMINE METABOLITES OF CEREBROSPINAL FLUID IN MENTAL DEPRESSION AND MANIA

1966 • 215 citations

Cerebrospinal fluid 5-hydroxyindoleacetic acid and homovanillic acid in psychiatric patients

1969 • 213 citations

Animal models in psychiatry and neurology

1977 • 213 citations

Cerebrospinal fluid and plasma free cortisol concentrations in depression

1976 • 210 citations

Endorphins in human cerebrospinal fluid: Clinical correlations to some psychotic states

1978 • 208 citations

Cerebrospinal Fluid Amine Metabolites in Acute Schizophrenia

1975 • 202 citations

Biological and behavioral effects of one night's sleep deprivation in depressed patients and normals

1979 • 200 citations

Urinary 3-Methoxy-4-Hydroxyphenylglycol Circadian Rhythm

1980 • 197 citations

Somatostatin: Physiological and Clinical Significance

1976 • 196 citations

THE CEREBROSPINAL FLUID AS A PATHWAY IN NEUROENDOCRINE INTEGRATION

1976 • 194 citations

Fundamental Mechanisms in the Release of Catecholamines

1972 • 192 citations

5-hydroxyindoleacetic acid (and homovanillic acid) levels in the cerebrospinal fluid after probenecid application in patiens with manic-depressive psychosis

1969 • 189 citations

Biogenic Amine Metabolites in Cerebrospinal Fluid of Depressed and Manic Patients

1972 • 178 citations

Therapeutic effects of carbamazepine in affective illness: a preliminary report.

1978 • 178 citations

Homovanillic and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid of Depressed Patients

1971 • 177 citations

Cerebral Monoamines and Depression

1973 • 175 citations

Effects of a Dopamine Agonist Piribedil in Depressed Patients

1978 • 169 citations

Haloperidol-induced presynaptic dopamine supersensitivity is blocked by chronic lithium

1978 • 166 citations

Acid monoamine metabolites in human cerebrospinal fluid and their relations to age and sex

1971 • 160 citations

Neuropsychopharmacology

1979 • 159 citations

Central Norepinephrine Metabolism in Affective Illness: MHPG in the Cerebrospinal Fluid

1973 • 156 citations

Somatostatin in Human Cerebrospinal Fluid

1977 • 153 citations

Peptides in Neurobiology

2011 • 153 citations

VASOPRESSIN IN AFFECTIVE ILLNESS

1978 • 152 citations

A dopaminergic mechanism in mania

1976 • 149 citations

Essays in neurochemistry and neuropharmacology

1979 • 148 citations

Chronic, Multiple Tics of Gilles de la Tourette's Disease

1978 • 145 citations

Serum Dopamine-βHydroxylase Activity in the Affective Psychoses and Schizophrenia

1976 • 142 citations

Dopamine metabolism in depressions, psychoses, and Parkinson's disease: the problem of the specificity of biological variables in behaviour disorders

1975 • 140 citations

Thyrotropin releasing hormone (TRH): depressant action on central neuronal activity

1975 • 139 citations

Extrapyramidal reactions and amine metabolites in cerebrospinal fluid during haloperidol and clozapine treatment of schizophrenic patients

1975 • 138 citations

Retarded depression and the dopamine metabolism

1971 • 138 citations

Dopamine and mania: Behavioral and biochemical effects of the dopamine receptor blocker pimozide

1980 • 137 citations

Memory Impairment in Korsakoff's Psychosis: A Correlation with Brain Noradrenergic Activity

1978 • 136 citations

Amine metabolism in the human brain: Further evaluation of the probenecid test

1971 • 135 citations

The Harold E. Himwich Memorial Lecture. Significance of biochemical parameters in the diagnosis, treatment, and prevention of depressive disorders.

1977 • 134 citations

Potentiation of the Antidepressant Action of Clomipramine by Tryptophan

1976 • 134 citations

Dopamine and Serotonin Metabolism in Neuropsychiatrically Disturbed Children

1977 • 132 citations

Time-Dependent Effects of Phenothiazines on Dopamine Turnover in Psychiatric Patients

1975 • 130 citations

Cerebrospinal Fluid Levels of MHPG in Affective Disorders

1972 • 124 citations

Somatostatin — both hormone and neurotransmitter?

1978 • 121 citations

DEPRESSIVE ILLNESS: SOME RESEARCH STUDIES

1973 • 117 citations

5-Hydroxyindolacetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis

1972 • 116 citations

Cerebrospinal fluid norepinephrine in affective illness

1978 • 115 citations

A STUDY OF SELECTED CATECHOLAMINE METABOLIZING ENZYMES: A COMPARISON OF DEPRESSIVE SUICIDES AND ALCOHOLIC SUICIDES WITH CONTROLS¹

1974 • 112 citations

Relationship of Monoamine Metabolites in Human Cerebrospinal Fluid to Age

1968 • 104 citations

Biogenic amine metabolites in cerebrospinal fluid of patients with affective disorders

1978 • 100 citations

Limbic System-Adrenal Cortex Regulation in Depression and Schizophrenia

1976 • 97 citations

Peptides: roles in neuronal excitability.

1976 • 96 citations

Monoamine metabolites in cerebrospinal fluid and serotonin uptake inhibition during treatment with chlorimipramine

1977 • 93 citations

Correlation between cerebrospinal fluid amine metabolites and psychomotor activity in affective disorders

1977 • 92 citations

Effect of diet on urinary MHPG excretion in depressed patients and normal control subjects

1977 • 92 citations

Neuroregulators and Psychiatric Disorders

1978 • 92 citations

Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression

1974 • 89 citations

Effects of clorgyline and pargyline on deaminated metabolites of norepinephrine, dopamine and serotonin in human cerebrospinal fluid

1979 • 88 citations

Initial clinical trial based on biochemical methodology of zimelidine (a serotonin uptake inhibitor) in depressed patients

1977 • 87 citations

Circadian rhythm in cerebrospinal fluid noradrenaline of man and monkey

1976 • 86 citations

Dopaminergic mechanisms in schizophrenia: The antipsychotic effect and the disease process

1978 • 85 citations

Reserpine suppression of dorsal raphe neuronal firing: mediation by adrenergic system

1978 • 84 citations

The activities of brain dopamine-?-hydroxylase and catechol-O-methyl transferase in schizophrenics and controls

1978 • 81 citations

Diurnal and seasonal variations in human platelet serotonin in man

1977 • 79 citations

REM sleep and central monoamine oxidase inhibition

1972 • 76 citations

Psychopharmacology in the practice of medicine

1977 • 75 citations

The Significance of Dopamine for the Mode of Action of Neuroleptics and the Pathogenesis of Schizophrenia

1977 • 75 citations

Controlled study comparing nomifensine and clomipramine in unipolar depression, using the probenecid technique.

1977 • 74 citations

Quantitative determination of 4-hydroxy-3-methoxyphenyl glycol and its conjugates in cerebrospinal fluid by mass fragmentography

1973 • 74 citations

EFFECT OF PHYSICAL ACTIVITY ON URINARY M.H.P.G. EXCRETION IN DEPRESSED PATIENTS

1972 • 71 citations

On the origin of homovanillic acid (HVA) in the cerebrospinal fluid

1973 • 69 citations

3-Methoxy-4-hydroxyphenylglycol in depression

1973 • 67 citations

Clinical Neuropharmacology

1980 • 65 citations

Studies of amine metabolites in affective illness and in schizophrenia: a comparative analysis.

1975 • 64 citations

Dopamine-beta-hydroxylase in the cerebrospinal fluid of psychiatric patients.

1978 • 64 citations

3H-spiperone binding in normal and schizophrenic post-mortem human brain

1978 • 63 citations

Correlation of anxiety and related symptoms with cerebrospinal fluid 5-hydroxyindoleacetic acid in depressed women

1977 • 63 citations

CLINICAL STUDIES OF L-5-HYDROXYTRYPTOPHAN IN DEPRESSION

1973 • 61 citations

Biological aspects of depression

1994 • 60 citations

LUMBAR CSF 5- HYDROXYINDOLEACETIC ACID AND HOMOVANILLIC ACID IN AFFECTIVE SYNDROMES

1974 • 56 citations

Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline

1972 • 56 citations

Approaches to Brain Amines in Psychiatric Patients: A Reevaluation of Cerebrospinal Fluid Studies

1978 • 55 citations

Depressive illness : some research studies

1972 • 55 citations

Homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid related to rated mental and motor impairment in senile and presenile dementia.

1970 • 52 citations

CSF Monoamine Metabolites in Alcoholism: A Comparative Study With Depression

1974 • 52 citations

d-Amphetamine: effects on memory in a depressed population.

1979 • 50 citations

Cerebrospinal fluid GABA in normals and patients with affective disorders

1980 • 50 citations

Effects of Amitriptyline and Imipramine on Amine Metabolites in the Cerebrospinal Fluid of Depressed Patients

1974 • 49 citations

Essays in Neurochemistry and Neuropharmacology

1978 • 49 citations

The circadian variation in dopamine metabolism in the subhuman primate

1977 • 48 citations

Serotonin Metabolism in Depression: Clinical Application of the Probenecid Test1

1974 • 48 citations

Studies on sodium transfer and 5-hydroxyindoles in depressive illness

1963 • 48 citations

Role of biogenic amines in certain pathological conditions

1975 • 48 citations

Towards a Biochemical Typology of Depression?

1974 • 47 citations

Psychomotor activity, sleep, and biogenic amine metabolites in depression.

1974 • 47 citations

5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis and the effect of probenecid treatment

1973 • 45 citations

Relation of Exercise to MHPG Excretion in Normal Subjects

1973 • 43 citations

Neuroleptics, catecholamines, and psychoses: a study of their interrelations

1975 • 39 citations

Mass spectrometric identification and selected ion monitoring quantitation of γ‐amino‐butyric acid (GABA) in human lumbar cerebrospinal fluid¹

1978 • 38 citations

Central noradrenergic function in man: vanillylmandelic acid in CSF

1975 • 37 citations

The effect of lithium treatment on manic symptoms and levels of monoamine metabolites in cerebrospinal fluid of manic depressive patients

1975 • 37 citations

Psychotropic Drugs

1978 • 35 citations

EFFECTS OF PROBENECID AND EXERCISE ON CEREBROSPINAL-FLUID CYCLIC A.M.P. IN AFFECTIVE ILLNESS

1972 • 34 citations

MONOAMINE METABOLITES IN CSF IN PSYCHIATRIC DISORDERS

1979 • 34 citations

Neurophysiological Measures Related to Levels of 5-Hydroxyindoleacetic Acid, Homovanillic Acid and Tryptophan in Cerebrospinal Fluid of Psychiatric Patients

1976 • 33 citations

Dopamine βHydroxylase in CSF

1980 • 33 citations

An examination of baseline and drug-induced levels of cyclic nucleotides in the cerebrospinal fluid of control and psychiatric patients

1976 • 31 citations

Effect of ECT and imipramine treatment on the concentration of 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) in the cerebrospinal fluid of depressed patients

1975 • 31 citations

THE IMPACT OF CATECHOLAMINE RESEARCH ON MEDICAL SCIENCE AND PRACTICE

1979 • 31 citations

Biologically Active Peptides in the Mammalian Central Nervous System

1977 • 31 citations

Lithium: clinical effects and cerebrospinal fluid acid monoamine metabolites.

1977 • 26 citations

Proceedings of the Sixth International Congress of Pharmacology

1976 • 25 citations

Functional antagonism between dopamine and noradrenaline within the caudate nucleus of cats: A phenomenon of rhythmically changing susceptibility

1978 • 22 citations

The pineal gland

1975 • 22 citations

Central monoamine oxidase inhibition and REM sleep

1971 • 21 citations

Lithium in Psychiatry: A Synopsis

1977 • 19 citations

CSF amine metabolites, clinical symptoms, and body movement in psychiatric patients.

1976 • 19 citations

SIGNIFICANCE OF LUMBAR CSF METABOLITE MEASUREMENTS IN AFFECTIVE ILLNESS

1976 • 18 citations

DISTRIBUTION OF HORMONES BY CEREBROSPINAL FLUID**Supported by U.S.P.H.S. Program Project Grant NS11642.

1975 • 18 citations

Proceedings of the Sixth International Congress of Pharmacology

1976 • 17 citations

Amitriptyline in man: Decreased formation of central 5‐hydroxyindoleacetic acid

1974 • 16 citations

Neuropeptide hormones in cerebrospinal fluid. Experimental and clinical aspects.

1979 • 15 citations

Mood and neuronal functions: a modified amine hypothesis for the etiology of affective illness.

1974 • 15 citations

Psychopharmacology in the Practice of Medicine

1977 • 14 citations

Schizophrenia: Low spinal fluid GABA levels?

1980 • 13 citations

The central noradrenergic system and affective response to MAO inhibitors

1979 • 13 citations

CSF acid monoamine metabolities as a possible reflection of central MAO activity in chronic schizophrenia.

1976 • 12 citations

Serum dopamine-beta-hydroxylase in depressed patients and the effect of electroconvulsive shock treatment

1974 • 12 citations

Dopamine-β-hydroxylase in cerebrospinal fluid and plasma: Effects of α-adrenergic agents

1980 • 12 citations

Clinical approaches to the evaluation of brain amine function in mental illness: some conceptual issues.

1977 • 9 citations

Cerebrospinal fluid content of 5-hydroxyindoleacetic acid and homovanillic acid in manic-depressive psychosis

1973 • 9 citations

Cyclic AMP in cerebrospinal fluid of manic and depressive patients

1977 • 8 citations

A VASOPRESSIN HYPOTHESIS OF AFFECTIVE ILLNESS: PRELIMINARY FINDINGS

1979 • 7 citations

Greenfield's Neuropathology

1977 • 4 citations

Measurement of Biogenic Amines at the Picogram Level

1974 • 1 citations

Gaba CSF levels in schizophrenia

1979 • 1 citations