Somatostatin: Physiological and Clinical Significance

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

THE ESSENTIAL ROLE OF GLUCAGON IN THE PATHOGENESIS OF DIABETES MELLITUS

1975 • 574 citations

INHIBITION OF GASTRIN AND GASTRIC-ACID SECRETION BY GROWTH-HORMONE RELEASE-INHIBITING HORMONE

1974 • 565 citations

GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN GASTROINTESTINAL AND PANCREATIC D CELLS

1975 • 520 citations

Growth and Growth Hormone

1968 • 435 citations

Depressant action of TRH, LH-RH and somatostatin on activity of central neurones

1975 • 427 citations

Prevention of Human Diabetic Ketoacidosis by Somatostatin

1975 • 349 citations

Immunoreactive somatostatin is present in discrete cells of the endocrine pancreas.

1975 • 335 citations

Radioimmunoassay for GH-Release Inhibiting Hormone

1975 • 308 citations

Effects of Somatostatin on the Secretion of Thyrotropin and Prolactin

1974 • 297 citations

ACTION OF GROWTH-HORMONE-RELEASE INHIBITORY HORMONE IN HEALTHY MEN AND IN ACROMEGALY

1973 • 288 citations

EFFECTS OF GROWTH-HORMONE RELEASE-INHIBITING HORMONE ON CIRCULATING GLUCAGON, INSULIN, AND GROWTH HORMONE IN NORMAL, DIABETIC, ACROMEGALIC, AND HYPOPITUITARY PATIENTS

1974 • 268 citations

Somatostatin Suppresses Secretin and Pancreatic Exocrine Secretion

1975 • 268 citations

Effects of Somatostatin on Plasma Glucose and Glucagon Levels in Human Diabetes Mellitus

1974 • 238 citations

Inhibition by Somatostatin on the Release of TSH Induced in Man by Thyrotropin-Releasing Factor

1974 • 227 citations

Glucagon: Role in the Hyperglycemia of Diabetes Mellitus

1975 • 225 citations

INHIBITION OF GROWTH HORMONE RELEASE IN HUMANS BY SOMATOSTATIN.

1973 • 204 citations

Primary Structure of Somatostatin, A Hypothalamic Peptide That Inhibits the Secretion of Pituitary Growth Hormone

1973 • 203 citations

Effect of Somatostatin in Patients with Acromegaly

1974 • 188 citations

Immunohistochemical evidence for the localization of somatostatin--like immunoreactivity in a cell population of the pancreatic islets.

1974 • 182 citations

Growth Hormone Release Inhibiting Hormone in Acromegaly

1974 • 152 citations

GLUCAGON CONTROL OF FASTING GLUCOSE IN MAN

1974 • 124 citations

Evidence for a physiologic role of pancreatic glucagon in human glucose homeostasis: Studies with somatostatin

1975 • 120 citations

Inhibition by Somatostatin of Basal Levels of Serum Thyrotropin (TSH) in Normal Men

1975 • 112 citations

Somatostatin blockade of acute and chronic stimuli of the endocrine pancreas and the consequences of this blockade on glucose homeostasis.

1975 • 104 citations

The Amino Acid Sequence of a Peptide with Growth Hormone-releasing Activity Isolated from Porcine Hypothalamus

1971 • 95 citations

Effect of Somatostatin on Plasma Glucose and Insulin Responses to Glucagon and Tolbutamide in Man

1974 • 80 citations

Some Actions of Growth Hormone Release Inhibiting Factor

1973 • 78 citations

Long-term Infusion of Growth Hormone Release Inhibiting Hormone in Acromegaly: Effects on Pituitary and Pancreatic Hormones

1974 • 77 citations

INHIBITION OF THE SLEEP-RELATED PEAK IN PHYSIOLOGIC HUMAN GROWTH HORMONE RELEASE BY SOMATOSTATIN¹

1974 • 74 citations

Inhibition of Pancreatic Glucagon Release by Somatostatin: In Vitro

1974 • 71 citations

Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituirary effects

1975 • 68 citations

Effect of somatostatin on glucose induced insulin release in isolated perfused rat pancreas and isolated rat pancreatic islets

1974 • 66 citations

ACUTE SUPPRESSION OF INSULIN AND GLUCOSE LEVELS BY SYNTHETIC SOMATOSTATIN IN NORMAL HUMAN SUBJECTS¹

1974 • 59 citations

Stimulation of guanosine 3′,5′-cyclic monophosphate accumulation in rat anterior pituitary gland in vitro by synthetic somatostatin

1974 • 54 citations

Effects of Somatostatin on Hemostasis in Baboons

1975 • 54 citations

STUDIES ON THE MECHANISM OF SOMATOSTATIN ACTION ON INSULIN RELEASE IN MAN

1975 • 50 citations

Somatostatin: Newcomer from the Hypothalamus

1974 • 49 citations

IMPAIRMENT OF PLATELET FUNCTION BY GROWTH-HORMONE RELEASE- INHIBITING HORMONE

1975 • 48 citations

Inhibitory Effect of Somatostatin (SRIF) on the Release of Growth Hormone (GH) Induced in the Rat by Electrical Stimulation

1974 • 45 citations

STRUCTURE ACTIVITY STUDIES ON SOMATOSTATIN

1976 • 42 citations

The Inhibition by Somatostatin of the Thyrotropin Response to Thyrotropin-Releasing Hormone in Normal Subjects

1974 • 40 citations

Effect of somatostatin on blood glucose, plasma growth hormone, insulin, and free fatty acids in normal subjects and acromegalic patients

1974 • 38 citations

Effect of Synthetic Somatotropin Release Inhibiting Factor on the Increase in Plasma Growth Hormone Elicited by L-Dopa in the Dog

1974 • 35 citations

The Effect of Somatostatin on Coagulation and Platelet Function in Man

1975 • 34 citations

Synthesis of a proposed growth hormone releasing factor

1971 • 33 citations

FAILURE OF SOMATOSTATIN TO INHIBIT TOLBUTAMIDE-INDUCED INSULIN SECRETION IN PATIENTS WITH INSULINOMAS: A POSSIBLE DIAGNOSTIC TOOL

1975 • 33 citations

FAILURE OF SOMATOSTATIN TO SUPPRESS THYROTROPIN RELEASING FACTOR AND LUTEINIZING HORMONE RELEASING FACTOR-INDUCED GROWTH HORMONE RELEASE IN ACROMEGALY.

1974 • 28 citations

DISAPPEARANCE OF PLASMA GROWTH HORMONE IN ACROMEGALY AND PROTEIN-CALORIE MALNUTRITION AFTER SOMATOSTATIN

1975 • 25 citations

THE EFFECT OF SOMATOSTATIN ON PLATELET AGGREGATION¹

1975 • 13 citations