Role of adhesion molecules in activation signaling in T lymphocytes.

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Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The Immunological Synapse: A Molecular Machine Controlling T Cell Activation

1999 • 3,025 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Lymphocyte responses and cytokines

1994 • 1,860 citations

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1989 • 1,587 citations

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

1995 • 1,202 citations

T Cell Activation Determined by T Cell Receptor Number and Tunable Thresholds

1996 • 1,038 citations

Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1

1999 • 1,000 citations

Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation

2001 • 852 citations

ICOS is essential for effective T-helper-cell responses

2001 • 666 citations

The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling

2000 • 657 citations

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

2001 • 555 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

Enhancement of LFA-1-mediated cell adhesion by triggering through CD2 or CD3 on T lymphocytes

1989 • 482 citations

The Small Gtpase, Rap1, Mediates Cd31-Induced Integrin Adhesion

2000 • 419 citations

The human natural killer cell immune synapse

1999 • 418 citations

Antigen Presentation in Extracellular Matrix

2000 • 409 citations

Differential Clustering of CD4 and CD3ζ During T Cell Recognition

2000 • 364 citations

Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation

2000 • 345 citations

Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.

1996 • 343 citations

Sequential Involvement of Lck and SHP-1 with MHC-Recognizing Receptors on NK Cells Inhibits FcR-Initiated Tyrosine Kinase Activation

1996 • 341 citations

Rap1 Is a Potent Activation Signal for Leukocyte Function-Associated Antigen 1 Distinct from Protein Kinase C and Phosphatidylinositol-3-OH Kinase

2000 • 340 citations

Visualizing the dynamics of T cell activation: Intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels

1998 • 275 citations

Signaling Takes Shape in the Immune System

2000 • 237 citations

LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes

1987 • 223 citations

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity

2000 • 220 citations

Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1

1998 • 197 citations

A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation

2000 • 194 citations

The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila

2000 • 193 citations

Orchestrated Information Transfer Underlying Leukocyte Endothelial Interactions

1996 • 190 citations

Tyrosine-phosphorylated T cell receptor ζ chain associates with the actin cytoskeleton upon Activation of mature T lymphocytes

1995 • 162 citations

A synaptic basis for T-lymphocyte activation

1984 • 149 citations

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

2000 • 119 citations

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte–antigen-presenting cell interface

2000 • 117 citations

The cell biology of CTL killing

1995 • 99 citations

TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1.

1999 • 85 citations

Regulation of T Cell Activation by CD28 and CTLA4

1996 • 84 citations

Cutting Edge: Negative Selection of Immature Thymocytes by a Few Peptide-MHC Complexes: Differential Sensitivity of Immature and Mature T Cells

1999 • 80 citations

T cell differentiation: a mechanistic view

2000 • 77 citations

The Tumor Suppressor PTEN Regulates T Cell Survival and Antigen Receptor Signaling by Acting as a Phosphatidylinositol 3-Phosphatase

2000 • 75 citations

CD98 induces LFA‐1‐mediated cell adhesion in lymphoid cells via activation of Rap1

2001 • 66 citations

Environmental control of immunological synapse formation and duration

2001 • 59 citations

Anchorage dependence of mitogen-induced G1 to S transition in primary T lymphocytes.

1999 • 34 citations