Role of water in the energy of hydrolysis of phosphate compounds — energy transduction in biological membranes

Coupling of Phosphorylation to Electron and Hydrogen Transfer by a Chemi-Osmotic type of Mechanism

1961 • 4,416 citations

THE MITOCHONDRIAL ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION SYSTEM

1985 • 1,599 citations

How crowded is the cytoplasm?

1982 • 807 citations

Oxidative Phosphorylation and Photophosphorylation

1977 • 737 citations

Energy Interconversion by the Ca2+-Dependent ATPase of the Sarcoplasmic Reticulum

1979 • 718 citations

ADENOSINE TRIPHOSPHATE-LINKED CONCENTRATION OF CALCIUM IONS IN A PARTICULATE FRACTION OF RABBIT MUSCLE

1962 • 701 citations

Molecular mechanism of active calcium transport by sarcoplasmic reticulum.

1978 • 586 citations

Mechanism of the Na+, K+ pump protein structure and conformations of the pure

1982 • 500 citations

Mechanism of Calcium Transport

1985 • 453 citations

Muscle Contraction and Free Energy Transduction in Biological Systems

1985 • 446 citations

Mechanism of ATP hydrolysis by beef heart mitochondrial ATPase. Rate constants for elementary steps in catalysis at a single site.

1982 • 409 citations

Cooperative calcium binding and ATPase activation in sarcoplasmic reticulum vesicles.

1980 • 384 citations

The Properties of Water in Biological Systems

1974 • 368 citations

Possible functions of chains of catalysts

1961 • 360 citations

Phase Diagram for the System Water–Dimethylsulphoxide

1968 • 359 citations

The Reactivity of Phosphate Esters. Monoester Hydrolysis

1967 • 324 citations

The Mechanism and Regulation of ATP Synthesis by F1-ATPases

1981 • 310 citations

STRUCTURE AND DYNAMICS OF WATER SURROUNDING BIOMOLECULES

1987 • 296 citations

Standard Gibbs Free Energy, Enthalpy, and Entropy Changes as a Function of pH and pMg for Several Reactions Involving Adenosine Phosphates

1969 • 273 citations

The Phosphorylation of the Membranal Protein of the Sarcoplasmic Vesicles during Active Calcium Transport

2005 • 263 citations

ATP synthesis by the reverse of the sarcoplasmic calcium pump

1971 • 261 citations

The Proton-Translocating Pumps of Oxidative Phosphorylation

1980 • 256 citations

PROTON ATPASES: STRUCTURE AND MECHANISM

1983 • 255 citations

Acetyl Phosphate as Substrate for Ca2+ Uptake in Skeletal Muscle Microsomes

1971 • 252 citations

Phosphorylation of the sarcoplasmic reticulum membrane by orthophosphate. Inhibition by calcium ions

1973 • 243 citations

RELATIONSHIPS BETWEEN CHEMICAL AND MECHANICAL EVENTS DURING MUSCULAR CONTRACTION

1986 • 241 citations

Role of water, hydrogen ion, and temperature on the synthesis of adenosine triphosphate by the sarcoplasmic reticulum adenosine triphosphatase in the absence of a calcium ion gradient

1980 • 238 citations

Ion motive ATPases. II. Energy coupling and work output

1987 • 237 citations

The reversibility of the sarcoplasmic calcium pump

1978 • 222 citations

Phosphorylation by inorganic phosphate of sodium plus potassium ion transport adenosine triphosphatase. Four reactive states

1975 • 218 citations

MECHANISM OF FREE ENERGY COUPLING IN ACTIVE TRANSPORT

1983 • 217 citations

Occurrence and Characteristics of a Rapid Exchange of Phosphate Oxygens Catalyzed by Sarcoplasmic Reticulum Vesicles

1973 • 206 citations

The Nature of Energetic Coupling in Biological Syntheses.

1941 • 204 citations

Inorganic Pyrophosphate: Formation in Bacterial Photophosphorylation

1966 • 196 citations

Energetics and Electrogenicity of the Sarcoplasmic Reticulum Calcium Pump

1983 • 167 citations

Activation of calcium efflux by ADP and inorganic phosphate

1971 • 166 citations

A commentary on alternative hypotheses of protonic coupling in the membrane systems catalysing oxidative and photosynthetic phosphorylation

1977 • 162 citations

Transport and inhibitory Ca2+ binding sites on the ATPase enzyme isolated from the sarcoplasmic reticulum.

1975 • 156 citations

Mechanism and Catalysis of Reactions of Acyl Phosphates. II. Hydrolysis¹

1961 • 151 citations

Formation of adenosine triphosphate from Pi and adenosine diphosphate by purified Ca-2+-adenosine triphosphatase.

1975 • 150 citations

Nonenzymatic separation of myocardial cell nuclei from whole heart tissue

1983 • 146 citations

Interaction of magnesium and inorganic phosphate with calcium-deprived sarcoplasmic reticulum adenosine triphosphatase as reflected by organic solvent induced perturbation

1985 • 140 citations

Role of the Ca²⁺ion concentration gradient in the adenosine 5'-triphosphate-inorganic phosphate exchange catalyzed by sarcoplasmic reticulum

1974 • 136 citations

“Squiggle-H2O”. An enquiry into the importance of solvation effects in phosphate ester and anhydride reactions

1970 • 129 citations

Regulation of the mitochondrial ATP synthase/ATPase complex

1986 • 126 citations

Calcium efflux dependent formation of ATP from ADP and orthophosphate by the membranes of the sarcoplasmic vesicles

1971 • 125 citations

Modulation of calcium binding in sarcoplasmic reticulum adenosinetriphosphatase

1981 • 125 citations

The synthesis of enzyme-bound ATP by soluble chloroplast coupling factor 1.

1982 • 122 citations

On a possible mechanism of energy conservation in sarcoplasmic reticulum membrane.

1976 • 121 citations

Thermodynamic Parameters for the Hydrolysis of Inorganic Pyrophosphate at pH 7.4 as a Function of [Mg2+], [K+], and Ionic Strength Determined from Equilibrium Studies of the Reaction

1974 • 116 citations

Thermodynamic Data for the Hydrolysis of Adenosine Triphosphate as a Function of pH, Mg2+ Ion Concentration, and Ionic Strength

1969 • 115 citations

Phosphoprotein formation during osmo‐chemical energy conversion in the membrane of the sarcoplasmic reticulum

1972 • 114 citations

A new mechanism by which an H⁺concentration gradient drives the synthesis of adenosine triphosphate, pH jump, and adenosine triphosphate synthesis by the Ca²⁺ dependent adenosine triphosphatase of sarcoplasmic reticulum

1977 • 110 citations

Adenosine triphosphatase site stoichiometry in sarcoplasmic reticulum vesicles and purified enzyme

1984 • 109 citations

Phosphorylation of solubilized sarcoplasmic reticulum by orthophosphate and its thermodynamic characteristics. The dominant role of entropy in the phosphorylation.

1975 • 108 citations

Twenty Questions Concerning The Reaction Cycle Of The Sarcoplasmic Reticulum Calcium Pum

1984 • 107 citations

[28] The mechanism of action of yeast inorganic pyrophosphatase

1982 • 105 citations

The sarcoplasmic reticulum: Transport and energy transduction

1981 • 104 citations

The history and the hypotheses concerning ATP‐formation by energised protons

1978 • 100 citations

PHOSPHATE-WATER EXCHANGE REACTION CATALYZED BY INORGANIC PYROPHOSPHATASE OF YEAST

1958 • 99 citations

Effects of urea and trimethylamine-N-oxide on enzyme activity and stability

1987 • 97 citations

Calcium Gradient‐Dependent and Calcium Gradient‐Independent Phosphorylation of Sarcoplasmic Reticulum by Orthophosphate

1978 • 92 citations

Evaluation of H₂O activity in the free or phosphorylated catalytic site of Ca²⁺‐ATPase

1983 • 92 citations

Pyrophosphate of high and low energy. Contributions of pH, Ca2+, Mg2+, and water to free energy of hydrolysis.

1984 • 90 citations

Calcium and proton dependence of sarcoplasmic reticulum ATPase

1983 • 89 citations

STRUCTURE OF THE Na, K PUMP: CRYSTALLIZATION OF PURE MEMBRANE‐BOUND Na, K‐ATPase AND IDENTIFICATION OF FUNCTIONAL DOMAINS OF THE α‐SUBUNIT

1982 • 89 citations

Kinetic characterization of detergent-solubilized sarcoplasmic reticulum ATPase

1983 • 87 citations

Theoretical calculations of the hydrolysis energies of some "high-energy" molecules. 2. A survey of some biologically important hydrolytic reactions

1978 • 85 citations

ATP synthesis by sarcoplasmic reticulum ATPase following Ca2+, PH, temperature, and water activity jumps.

1982 • 82 citations

Behavior of the Ca2+ transport sites linked with the phosphorylation reaction of ATPase purified from the sarcoplasmic reticulum.

1976 • 77 citations

On “High Energy Phosphate Bonds” of Biochemical Interest¹

1951 • 72 citations

Regulation of steady state level of phosphoenzyme and ATP synthesis in sarcoplasmic reticulum vesicles during reversal of the Ca2+ pump.

1976 • 72 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle

1972 • 71 citations

Thermodynamics, kinetics, and mechanism in yeast inorganic pyrophosphatase catalysis of inorganic pyrophosphate:inorganic phosphate equilibration

1981 • 69 citations

Phosphorylation from Inorganic Phosphate and ATP Synthesis of Sarcoplasmic Membranes

1977 • 66 citations

Proton‐translocating pyrophosphatase of Rhodospirillum rubrum

1972 • 63 citations

Interactions of Water with Nonpolar Solutes

1983 • 63 citations

Electronic structures for energy-rich phosphates

1969 • 62 citations

Factors influencing calcium release from the ADP-sensitive phosphoenzyme intermediate of the sarcoplasmic reticulum ATPase.

1986 • 61 citations

Localization of E1–E2 conformational transitions of sarcoplasmic reticulum Ca-ATPase by tryptic cleavage and hydrophobic labeling

1986 • 60 citations

Energy-linked reactions in photosynthetic bacteria

1971 • 60 citations

Thermodynamics of the hydrolysis of adenosine 5'-triphosphate to adenosine 5'-diphosphate.

1986 • 55 citations

The formation of enzyme-bound and medium pyrophosphate and the molecular basis of the oxygen exchange reaction of yeast inorganic pyrophosphatase.

1979 • 55 citations

The synthesis of enzyme-bound ATP by the F1-ATPase from the thermophilic bacterium PS3 in 50% dimethylsulfoxide

1983 • 52 citations

Possible functions of chains of catalysts II

1962 • 50 citations

Phosphorylation of (Ca2+)-adenosinetriphosphatase by inorganic phosphate: van't Hoff analysis of enthalpy changes

1981 • 49 citations

Phosphorylation of sarcoplasmic reticulum ATPase by orthophosphate in the absence of Ca2+ gradient. Contribution of water activity to the enthalpy and the entropy changes.

1982 • 49 citations

ATP AND ADP MODULATIONS OF CATALYSIS BY F₁ AND Ca², Mg²⁺‐ATPases*

1982 • 48 citations

Binding Change Mechanism for ATP Synthesis by Oxidative Phosphorylation and Photophosphorylation

1984 • 48 citations

Contribution of water to free energy of hydrolysis of pyrophosphate

1985 • 42 citations

Solvent accessibility of the adenosine 5'-triphosphate catalytic site of sarcoplasmic reticulum calcium ATPase

1986 • 41 citations

Characterization of Human Salivary Kallikrein: Reactivities to Human Plasma Kininogens and Proteinase Inhibitors

1983 • 41 citations

ATP synthesis driven by inorganic pyrophosphate in Rhodospirillum rubrum chromatophores

1971 • 40 citations

Inhibition of mitochondrial F₁ ATPase and sarcoplasmic reticulum ATPase by hydrophobic molecules

1988 • 38 citations

Change of water structure by solvents and polymers

1982 • 38 citations

Microbial inorganic pyrophosphatases.

1983 • 36 citations

Reaction Mechanism of the Ca2+-dependent ATPase of Sarcoplasmic Reticulum from Skeletal Muscle

1973 • 35 citations

Synthesis of ATP by soluble mitochondrial F₁ ATPase and F₁–inhibitor‐protein complex in the presence of organic solvents

1986 • 35 citations

STATIC AND TIME-RESOLVED STRUCTURAL STUDIES OF THE Ca²⁺-ATPase OF ISOLATED SARCOPLASMIC RETICULUM

1982 • 34 citations

Inorganic pyrophosphate‐driven ATP‐synthesis in liposomes containing membrane‐bound inorganic pyrophosphatase and F₀‐F₁ complex from Rhodospirillum rubrum

1983 • 34 citations

Water and metal cations in biological systems

1980 • 34 citations

ATP ↔P_i exchange and membrane phosphorylation in sarcoplasmic reticulum vesicles. Activation by silver in the absence of Ca²⁺ ion concentration gradient

1975 • 34 citations

Solvent water and the biological group-transfer potential of phosphoric and carboxylic anhydrides

1985 • 33 citations

ATP sulfurylase-dependent assays for inorganic pyrophosphate: Applications to determining the equilibrium constant and reverse direction kinetics of the pyrophosphatase reaction, magnesium binding to orthophosphate, and unknown concentrations of pyrophosphate

1986 • 33 citations

Effects of organic solvents, methylamines, and urea on the affinity for Pi of the Ca2+-ATPase of sarcoplasmic reticulum.

1988 • 32 citations

Vapor pressure isotope effects in aqueous systems. VIII. The system dimethyl sulfoxide/H2O/D2O

1976 • 30 citations

Synthesis of adenosine triphosphate by way of potassium‐sensitive phosphoenzyme of sodium, potassium adenosine triphosphatase

1975 • 29 citations

Characteristics of the formation of enzyme-bound ATP from medium inorganic phosphate by mitochondrial F1 adenosine triphosphatase in the presence of dimethyl sulfoxide

1987 • 29 citations

ATP synthesis by the (Na⁺ + K⁺)‐ATPase in the absence of an ionic gradient Effects of organic solvent

1987 • 28 citations

Identification of the Nucleotide-Binding Site for ATP Synthesis and Hydrolysis in Mitochondrial Soluble F1-ATPase1

1984 • 28 citations

Effect of compound 48/80 and ruthenium red on the Ca2+-ATPase of sarcoplasmic reticulum.

1986 • 28 citations

Labeling of a thiol residue in sarcoplasmic reticulum ATPase by pyrene maleimide. Solvent accessibility studied by fluorescence quenching.

1985 • 27 citations

A study on the membrane potential and pH gradient in chromatophores and intact cells of photosynthetic bacteria

1975 • 27 citations

Ligand Interactions with the Substrate Site of Na,K-ATPase: Nucleotides, Vanadate, and Phosphorylation

1983 • 24 citations

Role of water activity on the rates of acetyl phosphate and ATP hydrolysis

1988 • 22 citations

P_i∠ATP exchange in the absence of proton gradient by the H⁺ ‐ATPase from yeast plasma membranes

1987 • 21 citations

Energy-linked Reactions in Photosynthetic Bacteria

1974 • 20 citations

Ab initio structures of phosphorus acids and esters. 3. The phosphorus-oxygen-phosphorus bridged phosphinic compounds H4P2O2n-1 for n = 1 to 4

1988 • 19 citations

ATP-Pi and ITP-Pi exchange by cardiac sarcoplasmic reticulum

1979 • 17 citations

Orthophosphate - pyrophosphate exchange catalyzed by soluble and membrane-bound inorganic pyrophosphatases. Role of H+ gradient

1986 • 17 citations

Synthesis of pyrophosphate by chromatophores of Rhodospirillum rubrum in the light and by soluble yeast inorganic pyrophosphatase in water-organic solvent mixtures

1985 • 16 citations

A Conformational Transition of the Sarcoplasmic Reticulum Calcium Transport ATPase Induced by Vanadate

1983 • 15 citations

Uncoupler-reversible inhibition of mitochondrial ATPase by metal chelates of bathophenanthroline. I. General features

1981 • 13 citations

Electron Microscopic Evidence for the Transmembrane Displa cement of Calcium ATPase

1984 • 13 citations

Change of water structure by polyalcohols. Density and viscosity measurements, 2. Water/polyalcohol solutions

1980 • 12 citations

Exchange between inorganic phosphate and adenosine triphosphate in (Na+,K+)-ATPase

1982 • 12 citations

Effects of organic solvents and orthophosphate on the ATPase activity of F1 ATPase

1987 • 10 citations

Intrinsic regulation of substrate fluxes and energy conservation in Ca²⁺‐ATPase

1985 • 10 citations

Ligand-induced transfer of proteins between phases: dependence upon the strength of ion pair interactions

1980 • 5 citations