Prevalence and clinical correlations of MLL gene rearrangements in AML- M4/5

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML

1991 • 1,463 citations

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 • 1,371 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Fusion Between Transcription Factor CBFβ/PEBP2β and a Myosin Heavy Chain in Acute Myeloid Leukemia

1993 • 760 citations

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

1992 • 582 citations

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

1993 • 523 citations

Characterization of a Zinc Finger Gene Disrupted by the t(15;17) in Acute Promyelocytic Leukemia

1991 • 464 citations

Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs.

1993 • 297 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 294 citations

Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation.

1993 • 260 citations

Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

1993 • 174 citations

HRX involvement in de novo and secondary leukemias with diverse chromosome 11q23 abnormalities [see comments]

1993 • 166 citations

Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance

1982 • 152 citations

An analysis of leukemic cell chromosomal features in infants

1987 • 148 citations

A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias

1993 • 122 citations

Prognostic importance of cytogenetic subgroups in de novo pediatric acute nonlymphocytic leukemia.

1990 • 121 citations

ALL-1 gene at chromosome 11q23 is consistently altered in acute leukemia of early infancy

1993 • 115 citations

Cloning of cDNAs of the MLL gene that detect DNA rearrangements and altered RNA transcripts in human leukemic cells with 11q23 translocations.

1992 • 110 citations

Clinical characteristics of infant acute leukemia with or without 11q23 translocations.

1988 • 109 citations

Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23

1989 • 107 citations

Significance of abnormalities involving chromosomal segment 11q22–25 in acute leukemia

1984 • 60 citations

Infant acute lymphoblastic leukaemia with t(11;19)

1990 • 56 citations

Structure and expression of the human trithorax-like gene 1 involved in acute leukemias.

1993 • 45 citations

Do terminal deletions of 11q23 exist? Identification of undetected translocations with fluorescence in situ hybridization

1993 • 41 citations

Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.

1993 • 38 citations

Short-term therapy for acute myelogenous leukemia.

1988 • 36 citations

Southern blot analysis of ALL-1 rearrangements at chromosome 11q23 in acute leukemia.

1993 • 31 citations

Human trithorax gene rearrangements in therapy-related acute leukaemia after etoposide treatment.

1994 • 21 citations