Selective modulation of brain antioxidant defense capacity by genetic or metabolic manipulations

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1993 • 6,762 citations

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

GLUTATHIONE

1983 • 5,487 citations

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

1980 • 4,407 citations

Biology of disease: free radicals and tissue injury.

1982 • 3,078 citations

[70] Determination of glutathione and glutathione disulfide in biological samples

1985 • 2,678 citations

The aging process.

1981 • 1,871 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?

1992 • 1,268 citations

Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones.

1978 • 1,073 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Parkinson's disease: A disorder due to nigral glutathione deficiency?

1982 • 746 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Glutathione: interorgan translocation, turnover, and metabolism.

1979 • 601 citations

Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?

1990 • 563 citations

Inactivation of key metabolic enzymes by mixed-function oxidation reactions: Possible implication in protein turnover and ageing

1983 • 467 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains

1990 • 457 citations

Glutathione deficiency leads to mitochondrial damage in brain.

1991 • 428 citations

Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

1992 • 416 citations

Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons

1989 • 414 citations

Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxide.

1990 • 336 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Oxidative stress as a causal factor in differentiation and aging: a unifying hypothesis

1990 • 292 citations

Glutathione contents of tissues in the aging mouse

1980 • 268 citations

Histochemical evaluation of glutathione in brain

1987 • 253 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

Oxygen toxicity protecting enzymes in Parkinson's disease

1988 • 239 citations

Superoxide dismutase-rich bacteria. Paradoxical increase in oxidant toxicity.

1987 • 238 citations

Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Oown's syndrome fetal brain

1984 • 224 citations

Down's syndrome: Abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase

1988 • 220 citations

Antioxidants in Therapy and Preventive Medicine

1990 • 215 citations

Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats

1989 • 204 citations

Metabolism of Oxygen Derivatives in Down's Syndrome*

1982 • 199 citations

Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress.

1991 • 194 citations

Age-related changes in antioxidant enzymes and prooxidant generation in tissues of the rat with special reference to parameters in two insect species

1990 • 193 citations

Age-Correlated Modifications of Copper-Zinc Superoxide Dismutase and Glutathione-Related Enzyme Activities in Human Erythrocytes

1992 • 181 citations

Trisomie 21 et superoxyde dismutase-1 (IPO-A)

1976 • 175 citations

Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains

1986 • 163 citations

Comparison of cytoplasmic superoxide dismutase in liver, heart and brain of aging rats and mice

1976 • 161 citations

The role of oxidative abnormalities in the pathophysiology of Alzheimer's disease.

1991 • 159 citations

Regulation of mitochondrial respiration in senescence

1972 • 135 citations

Age-related changes in antioxidant enzymes and lipid peroxidation in brains of control and transgenic mice overexpressing copper-zinc superoxide dismutase

1992 • 133 citations

Superoxide Dismutase in the Rat and Mouse as a Function of Age and Longevity

1976 • 125 citations

Anti-oxidant defences and peroxidation in liver and brain of aged rats

1990 • 124 citations

Cellular and regional distribution of reduced glutathione in the nervous system of the rat: Histochemical localization by mercury orange and o-phthaldialdehyde-induced histofluorescence

1991 • 122 citations

Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dimutase-implication for gene dosage effects in down syndrome

1988 • 118 citations

Membrane Lipids in the Aging Human Brain

1991 • 118 citations

Superoxide dismutase amplifies organismal sensitivity to ionizing radiation

1989 • 116 citations

Influence of mouse age and erythrocyte age on glutathione metabolism

1978 • 115 citations

Expression of supreoxide dismutase and catalase in rat brain as a function of age

1991 • 111 citations

The Effect of Aging on Glutathione and Cysteine Levels in Different Regions of the Mouse Brain

1989 • 110 citations

Superoxide dismutase isoenzymes in normal brains and in brains from patients with dementia of Alzheimer type

1985 • 110 citations

Glutathione in Parkinson's disease: A link between oxidative stress and mitochondrial damage?

1992 • 108 citations

Differential Changes in Superoxide Dismutase Activity in Brain and Liver of Old Rats and Mice

1983 • 105 citations

Superoxide Dismutase, Catalase, and Glutathione Peroxidase Activities in Copper/Zinc‐Superoxide Dismutase Transgenic Mice

1992 • 105 citations

Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice: animal model of gene dosage effects in Down's syndrome

1991 • 105 citations

Differential Localization of Glutathione‐S‐Transferase Y_p and Y_b Subunits in Oligodendrocytes and Astrocytes of Rat Brain

1989 • 101 citations

Gluthathione and lipid peroxidation in the aging rat

1987 • 100 citations

Low glutathione levels in brain regions of aged rats

1989 • 98 citations

Expression of transfected human CuZn superoxide dismutase gene in mouse L cells and NS20Y neuroblastoma cells induces enhancement of glutathione peroxidase activity

1988 • 96 citations

Antioxidant enzymatic systems in neuronal and glial cell-enriched fractions of rat brain during aging

1990 • 93 citations

Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's disease

1988 • 88 citations

Glutathione peroxidase and reductase activities in the aging mouse

1985 • 79 citations

Changes with age in copper and superoxide dismutase levels in brains of C57BL/6J mice

1979 • 74 citations

Hydrogen peroxide production by mitochondria may be a biomarker of aging

1991 • 72 citations

Neuronal Lipofuscin Accumulation in Ageing and Alzheimer Dementia: A Pathogenic Mechanism?

1982 • 67 citations

Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm

1984 • 65 citations

Lipid Peroxidation and Superoxide Dismutase-1 and Glutathione Peroxidase Activities in Trisomy 16 Fetal Mice and Human Trisomy 21 Fibroblasts

1987 • 64 citations

Selenium and Oxygen-Metabolizing Enzymes in Elderly Community Residents: A Pilot Epidemiological Study

1993 • 61 citations

Localization and quantitation of 68 kDa neurofilament and superoxide dismutase-1 mRNA in alzheimer brains

1991 • 54 citations

Age-related effect induced by oxidative stress on the cerebral glutathione system

1989 • 52 citations

Age Dependence of the Level of the Enzymes Involved in the Protection against Active Oxygen Species in the Rat Brain

1987 • 48 citations

Relationship between aging, drug treatment and the cerebral enzymatic antioxidant system

1989 • 46 citations

Glutathione and cysteine depletion in rats and mice following acute intoxication with diethylmaleate

1992 • 46 citations

Expression of Human Cu-Zn Superoxide Dismutase Gene in Transgenic Mice: Model for Gene Dosage Effect in Down Syndrome

1991 • 46 citations

Neuronal Localization of Copper-Zinc Superoxide Dismutase Protein and mRNA within the Human Hippocampus from Control and Alzheimer'S Disease Brains

1991 • 44 citations

Age-Related Changes in Enzymes of Rat Brain

1981 • 41 citations

Cytotoxic effects of expression of human superoxide dismutase in bovine adrenocortical cells

1990 • 40 citations

Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging

1989 • 40 citations

Alzheimer's Disease: a Pathogenic Role for Aluminosilicate-Induced Phagocytic Free Radicals

1989 • 37 citations

Regional distribution of superoxide dismutase in rat brain during postnatal development

1982 • 35 citations

Effect of aging on glutathione metabolism. Protection by antioxidants

1992 • 35 citations

Depletion of Brain Glutathione in Preweanling Mice by L‐Buthionine Sulfoximine

1988 • 35 citations

Intracerebroventricular Administration of <scp>l</scp>‐Buthionine Sulfoximine: A Method for Depleting Brain Glutathione

1989 • 30 citations

Parkinson’s Disease and Alzheimer’s Disease :Neurodegenerative Disorders Due to Brain Antioxidant System Deficiency ?

1990 • 28 citations

Localization of copper-zinc superoxide dismutase mRNA in human hippocampus by in situ hybridization

1989 • 26 citations

Cellular clones and transgenic mice overexpressing copper — zinc superoxide dismutase: Models for the study of free radical metabolism and aging

1992 • 24 citations

Age-related changes in GSH content of eyes in mice--a comparison of senescence-accelerated mouse (SAM) and C57BL/J mice.

1992 • 23 citations

Immunohistochemical localization of glutathione peroxidase in the brain of the rat

1986 • 22 citations

Age-Related Changes in Enzymes of Rat Brain

1982 • 21 citations

Role of Free Radicals in Alzheimer’s Disease and Down’s Syndrome

1992 • 14 citations

Age-related changes in gsh content of eyes in mice—a comparison of senescence-accelerated mouse (Sam) and C57BL/J mice

1992 • 12 citations

[Immunohistochemical localization of glutathione peroxidase in the rat brain].

1986 • 5 citations