Effect of aging on glutathione metabolism. Protection by antioxidants

The aging process.

1981 • 1,871 citations

Biochemistry of Oxidative Stress

1986 • 1,307 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

The Free Radical Theory of Aging

2003 • 902 citations

Glutathione : metabolism and physiological functions

1990 • 376 citations

The aging process: major risk factor for disease and death.

1991 • 354 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Glutathione contents of tissues in the aging mouse

1980 • 268 citations

Biological disulfides: the third messenger? Modulation of phosphofructokinase activity by thiol/disulfide exchange.

1982 • 265 citations

Redox control of enzyme activities by thiol/disulfide exchange

1984 • 264 citations

Antioxidants and Aging

2012 • 235 citations

The role of methionine in glutathione biosynthesis by isolated hepatocytes

1977 • 159 citations

Maintenance of glutathione content is isolated hepatocyctes

1978 • 158 citations

Anti-oxidant defences and peroxidation in liver and brain of aged rats

1990 • 124 citations

The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis.

1980 • 106 citations

Glutathione Efflux from Perfused Rat Liver after Phenobarbital Treatment, during Drug Oxidations, and in Selenium Deficiency

1978 • 94 citations

Favorable effects of the antioxidants sodium and magnesium thiazolidine carboxylate on the vitality and life span of Drosophila and mice

1979 • 80 citations

Effect of oral glutathione on hepatic glutathione levels in rats and mice

1989 • 65 citations

Relationship between aging, drug treatment and the cerebral enzymatic antioxidant system

1989 • 46 citations

Changes in glutathione and its metabolizing enzymes in human erythrocytes and lymphocytes with age

1987 • 33 citations

Anti-oxidant supplementation decreases TBA reactants in serum of elderly

1988 • 32 citations

Age-related changes in glutathione synthesis in the eye lens

1990 • 31 citations

Effects of development and ageing on pulmonary NADPH-cytochrome c reductase, glutathione peroxidase, glutathione reductase and thioredoxin reductase activities in male and female rats

1986 • 22 citations

Role of Glutathione in the Aging and Development of Insects

1986 • 21 citations

A Decrease in Cysteine Levels Causes the Glutathione Deficiency of Aging in the Mosquito

1988 • 20 citations

A negative correlation between oxygen uptake and glutathione oxidation in rat liver homogenates

1969 • 16 citations

Senile cataract: a review on free radical related pathogenesis and antioxidant prevention

1991 • 11 citations

Seasonal Variations in Red Cell Glutathione Levels with Aging in Mental Patients and Normal Controls

1970 • 9 citations