Role of Free Radicals in Alzheimer’s Disease and Down’s Syndrome

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Amyloid A4 Protein and Its Precursor in Down's Syndrome and Alzheimer's Disease

1989 • 651 citations

Report of the committee on the genetic constitution of the X chromosome (Part 1 of 3)

1990 • 597 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Transgenic mice with increased Cu/Zn-superoxide dismutase activity: animal model of dosage effects in Down syndrome.

1987 • 461 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Critical role of the D21S55 region on chromosome 21 in the pathogenesis of Down syndrome.

1989 • 261 citations

Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Oown's syndrome fetal brain

1984 • 224 citations

Down's syndrome: Abnormal neuromuscular junction in tongue of transgenic mice with elevated levels of human Cu/Zn-superoxide dismutase

1988 • 220 citations

Metabolism of Oxygen Derivatives in Down's Syndrome*

1982 • 199 citations

Trisomie 21 et superoxyde dismutase-1 (IPO-A)

1976 • 175 citations

Dosage effects for superoxide dismutase-1 in nucleated cells aneuploid for chromosome 21.

1977 • 137 citations

Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dimutase-implication for gene dosage effects in down syndrome

1988 • 118 citations

Increase in glutathione peroxidase activity in erythrocytes from trisomy 21 subjects

1975 • 115 citations

Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase, and glutathione transferase activity in cells transfected with a copper-zinc superoxide dismutase expression vector. Explanation for variations in paraquat resistance.

1990 • 112 citations

Neuronal-specific expression of human copper-zinc superoxide dismutase gene in transgenic mice: animal model of gene dosage effects in Down's syndrome

1991 • 105 citations

Trisomy 21 (Down's Syndrome) glutathione peroxidase, hexose monophosphate shunt and I.Q.

1979 • 103 citations

Expression of transfected human CuZn superoxide dismutase gene in mouse L cells and NS20Y neuroblastoma cells induces enhancement of glutathione peroxidase activity

1988 • 96 citations

Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's disease

1988 • 88 citations

MENTAL AND DEVELOPMENTAL MILESTONES OF NONINSTITUTIONALIZED DOWN'S SYNDROME CHILDREN

1973 • 87 citations

Lipid Peroxidation and Superoxide Dismutase-1 and Glutathione Peroxidase Activities in Trisomy 16 Fetal Mice and Human Trisomy 21 Fibroblasts

1987 • 64 citations

Report of the committee on the genetic constitution of chromosomes 20 and 21

1988 • 61 citations

Down syndrome critical region around D21S55 on proximal 21q22.3

2005 • 49 citations

Expression of Human Cu-Zn Superoxide Dismutase Gene in Transgenic Mice: Model for Gene Dosage Effect in Down Syndrome

1991 • 46 citations

Neuronal Localization of Copper-Zinc Superoxide Dismutase Protein and mRNA within the Human Hippocampus from Control and Alzheimer'S Disease Brains

1991 • 44 citations

Report of the committee on the genetic constitution of chromosome 21

1990 • 37 citations

Catalase and glutathione peroxidase activity in cells with trisomy 21

1989 • 29 citations

Localization of copper-zinc superoxide dismutase mRNA in human hippocampus by in situ hybridization

1989 • 26 citations

Report of the committee on the genetic constitution of chromosomes 20 and 21

1989 • 16 citations

Deleted Work

1955 • 0 citations